- Title
- The many facets of metzincins and their endogenous inhibitors : Perspectives on ovarian cancer progression
- Creator
- Escalona, Ruth; Chan, Emily; Kannourakis, George; Findlay, Jock; Ahmed, Nuzhat
- Date
- 2018
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/164415
- Identifier
- vital:13055
- Identifier
-
https://doi.org/10.3390/ijms19020450
- Identifier
- ISBN:1661-6596
- Abstract
- Approximately sixty per cent of ovarian cancer patients die within the first five years of diagnosis due to recurrence associated with chemoresistance. The metzincin family of metalloproteinases is enzymes involved in matrix remodeling in response to normal physiological changes and diseased states. Recently, there has been a mounting awareness of these proteinases and their endogenous inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), as superb modulators of cellular communication and signaling regulating key biological processes in cancer progression. This review investigates the role of metzincins and their inhibitors in ovarian cancer. We propose that understanding the metzincins and TIMP biology in ovarian cancer may provide valuable insights in combating ovarian cancer progression and chemoresistance-mediated recurrence in patients. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
- Publisher
- MDPI AG
- Relation
- International Journal of Molecular Sciences Vol. 19, no. 2 (2018), p. 1-33
- Rights
- http://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences; ADAM proteases with thrombospondin motifs (ADAMTS); Disintegrin and metalloproteinases (ADAMs); Matrix metalloproteinases (MMPs); Metastasis; Metzincins; Ovarian cancer; TIMPs
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