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Detection of low pathogenicity influenza a(H7n3) virus during duck mortality event, Cambodia, 2017

- Suttie, Annika, Yann, Sokhoun, Phalla, Y., Tum, Sothyra, Deng, Yi-Mo, Hul, Vibol, Horm, Viseth, Barr, Ian, Greenhill, Andrew, Horwood, Paul, Osbjer, Kristina, Karlsson, Erik, Dussart, Philippe

Influenza A(H5N1) viruses with A(H9N2) single gene (matrix or PB1) reassortment isolated from Cambodian live bird markets

- Suttie, Annika, Karlsson, Erik, Deng, Yi-Mo, Horm, Srey, Yann, Sokhoun, Tok, Songha, Sorn, San, Holl, Davun, Tum, Sothyra, Hurt, Aeron, Greenhill, Andrew, Barr, Ian, Horwood, Paul, Dussart, Philippe

  • Authors: Suttie, Annika , Karlsson, Erik , Deng, Yi-Mo , Horm, Srey , Yann, Sokhoun , Tok, Songha , Sorn, San , Holl, Davun , Tum, Sothyra , Hurt, Aeron , Greenhill, Andrew , Barr, Ian , Horwood, Paul , Dussart, Philippe
  • Date: 2018
  • Type: Text , Journal article
  • Relation: Virology Vol. 523, no. (2018), p. 22-26
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  • Description: Live bird market surveillance for avian influenza viruses in Cambodia in 2015 has led to the detection of two 7:1 reassortant influenza A(H5N1) clade 2.3.2.1c viruses. These reassortant strains, designated A/duck/Cambodia/Z564W35M1/2015 and A/chicken/Cambodia/Z850W49M1/2015, both contained a single gene (PB1 and matrix gene, respectively) from concurrently circulating A(H9N2) influenza viruses. All other viral genes from both isolates clustered with A(H5N1) clade 2.3.2.1 viruses. Continued and prolonged co-circulation of influenza A(H5N1) and A(H9N2) viruses in Cambodian live bird markets may present a risk for the emergence of novel influenza reassortant viruses with negative agricultural and/or public health implications. © 2018

Co-circulation of influenza A H5, H7, and H9 viruses and co-infected poultry in live bird markets, Cambodia

- Horwood, Paul, Horm, Srey, Suttie, Annika, Thet, Sopheak, Rith, Phalla, Sorn, San, Holl, Davun, Tum, Sothyra, Ly, Sowath, Karlsson, Erik, Tarantola, Arnaud, Dussart, Philippe

Inventory of molecular markers affecting biological characteristics of avian influenza A viruses

- Suttie, Annika, Deng, Yi-Mo, Greenhill, Andrew, Dussart, Philippe, Horwood, Paul, Karlsson, Erik

  • Authors: Suttie, Annika , Deng, Yi-Mo , Greenhill, Andrew , Dussart, Philippe , Horwood, Paul , Karlsson, Erik
  • Date: 2019
  • Type: Text , Journal article , Review
  • Relation: Virus Genes Vol. 55, no. 6 (2019), p. 739-768
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  • Description: Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing sustained human-to-human infection; however, AIVs are still a high risk as future pandemic strains, especially if they acquire further mutations that facilitate human infection and/or increase pathogenesis. Molecular characterization of sequencing data for known genetic markers associated with AIV adaptation, transmission, and antiviral resistance allows for fast, efficient assessment of AIV risk. Here we summarize and update the current knowledge on experimentally verified molecular markers involved in AIV pathogenicity, receptor binding, replicative capacity, and transmission in both poultry and mammals with a broad focus to include data available on other AIV subtypes outside of A/H5N1 and A/H7N9. © 2019, The Author(s).

Avian influenza in the Greater Mekong Subregion, 2003–2018

- Suttie, Annika, Karlsson, Erik, Deng, Yi-Mo, Hurt, Aeron, Greenhill, Andrew, Barr, Ian, Dussart, Philippe, Horwood, Paul

  • Authors: Suttie, Annika , Karlsson, Erik , Deng, Yi-Mo , Hurt, Aeron , Greenhill, Andrew , Barr, Ian , Dussart, Philippe , Horwood, Paul
  • Date: 2019
  • Type: Text , Journal article , Review
  • Relation: Infection, Genetics and Evolution Vol. 74, no. (2019), p.
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  • Description: The persistent circulation of avian influenza viruses (AIVs) is an ongoing problem for many countries in South East Asia, causing large economic losses to both the agricultural and health sectors. This review analyses AIV diversity, evolution and the risk of AIV emergence in humans in countries of the Greater Mekong Subregion (GMS): Cambodia, Laos, Myanmar, Thailand and Vietnam (excluding China). The analysis was based on AIV sequencing data, serological studies, published journal articles and AIV outbreak reports available from January 2003 to December 2018. All countries of the GMS have suffered losses due repeated outbreaks of highly pathogenic (HP) H5N1 that has also caused human cases in all GMS countries. In Laos, Myanmar and Vietnam AIV outbreaks in domestic poultry have also been caused by clade 2.3.4.4 H5N6. A diverse range of low pathogenic AIVs (H1-H12) have been detected in poultry and wild bird species, though surveillance for and characterization of these subtypes is limited. Subtype H3, H4, H6 and H11 viruses have been detected over prolonged periods; whilst H1, H2, H7, H8, H10 and H12 viruses have only been detected transiently. H9 AIVs circulate endemically in Cambodia and Vietnam with seroprevalence data indicating human exposure to H9 AIVs in Cambodia, Thailand and Vietnam. As surveillance studies focus heavily on the detection of H5 AIVs in domestic poultry further research is needed to understand the true level of AIV diversity and the risk AIVs pose to humans in the GMS. © 2019

Aerosol exposure of live bird market workers to viable influenza A/H5N1 and A/H9N2 viruses, Cambodia

- Horwood, Paul, Horm, Srey, Yann, Sokhoun, Tok, Songha, Chan, Malen, Suttie, Annika, Phalla, Y, Rith, Sareth, Siegers, Jurre, San, Sorn, Davun, Holl, Tum, Sothyra, Ly, Sowath, Tarantola, Arnaud, Dussart, Philippe, Karlsson, Erik

  • Authors: Horwood, Paul , Horm, Srey , Yann, Sokhoun , Tok, Songha , Chan, Malen , Suttie, Annika , Phalla, Y , Rith, Sareth , Siegers, Jurre , San, Sorn , Davun, Holl , Tum, Sothyra , Ly, Sowath , Tarantola, Arnaud , Dussart, Philippe , Karlsson, Erik
  • Date: 2023
  • Type: Text , Journal article
  • Relation: Zoonoses and Public Health Vol. 70, no. 2 (2023), p. 171-175
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  • Description: Live bird markets (LBMs) have been identified as key factors in the spread, persistence and evolution of avian influenza viruses (AIVs). In addition, these settings have been associated with human infections with AIVs of pandemic concern. Exposure to aerosolised AIVs by workers in a Cambodian LBM was assessed using aerosol impact samplers. LBM vendors were asked to wear an air sampler for 30 min per day for 1 week while continuing their usual activities in the LBM during a period of high AIV circulation (February) and a period of low circulation (May). During the period of high circulation, AIV RNA was detected from 100% of the air samplers using molecular methods and viable AIV (A/H5N1 and/or A/H9N2) was isolated from 50% of air samplers following inoculation into embryonated chicken eggs. In contrast, AIV was not detected by molecular methods or successfully isolated during the period of low circulation. This study demonstrates the increased risk of aerosol exposure of LBM workers to AIVs during periods of high circulation and highlights the need for interventions during these high-risk periods. Novel approaches, such as environmental sampling, should be further explored at key high-risk interfaces as a potentially cost-effective alternative for monitoring pandemic threats. © 2022 The Authors. Zoonoses and Public Health published by Wiley-VCH GmbH.
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