- Title
- Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in females
- Creator
- Sim, Marc; Dawson, Brian; Landers, Grant; Swinkels, Dorine; Tjalsma, Harold; Yeap, Bu; Trinder, Debbie; Peeling, Peter
- Date
- 2015
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/158069
- Identifier
- vital:11743
- Identifier
-
https://doi.org/10.1016/j.jsams.2013.11.008
- Identifier
- ISSN:1878-1861
- Abstract
- OBJECTIVES: The post-exercise interleukin-6 (IL-6) and hepcidin response was investigated during the hormone-deplete and hormone-replete phases of an estradiol and progestogen regulated oral contraceptive cycle (OCC). DESIGN: Counterbalanced, repeated measures cross-over study. METHODS: Ten active female monophasic oral contraceptive pill (OCP) users completed two 40 min treadmill running trials at 75% of their pre-determined peak oxygen uptake velocity (vVO2peak). These trials were randomly performed in two specific phases of the OCC: (a) Day 2-4, representing a hormone-free withdrawal period (D-0); (b) Day 12-14, representing the end of the first week of active hormone therapy (D+7). Venous blood samples were drawn pre-, post- and 3h post-exercise. RESULTS: In both trials, serum IL-6 was significantly elevated (p<0.05) immediately post-exercise, while serum hepcidin was significantly elevated (p<0.05) 3h post-exercise, with no significant differences recorded between trials. CONCLUSIONS: These findings suggest that exercise performed during the different phases (D-0 vs. D+7) of a monophasic OCP regulated cycle does not alter exercise induced IL-6 or hepcidin production. As such, future studies looking to investigate similar variables post-exercise, may not need to 'control' for different phases of the OCC, provided participants are current monophasic OCP users.
- Relation
- Journal of Science and Medicine in Sport Vol. 18, no. 1 (2015), p. 8-12
- Rights
- © 2013 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1106 Human Movement and Sports Science; 1117 Public Health and Health Services; Oestrogen; Progesterone; Running; Iron deficiency
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