- Title
- Thermodynamic analysis questions claims of improved cardiac efficiency by dietary fish oil
- Creator
- Loiselle, Denis; Han, June-Chiew; Goo, Eden; Chapman, Brian; Barclay, Christopher; Hickey, Anthony; Taberner, Andrew
- Date
- 2016
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/154647
- Identifier
- vital:11145
- Identifier
-
https://doi.org/10.1085/jgp.201611620
- Identifier
- ISSN:0022-1295
- Abstract
- Studies in the literature describe the ability of dietary supplementation by omega-3 fish oil to increase the pumping efficiency of the left ventricle. Here we attempt to reconcile such studies with our own null results. We undertake a quantitative analysis of the improvement that could be expected theoretically, subject to physiological constraints, by posing the following question: By how much could efficiency be expected to increase if inefficiencies could be eliminated? Our approach utilizes thermodynamic analyses to investigate the contributions, both singly and collectively, of the major components of cardiac energetics to total cardiac efficiency. We conclude that it is unlikely that fish oils could achieve the required diminution of inefficiencies without greatly compromising cardiac performance.
- Publisher
- Rockefeller University Press
- Relation
- Journal of General Physiology Vol. 148, no. 3 (2016), p. 183-193
- Rights
- Copyright © 2016 Loiselle et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0606 Physiology; 1116 Medical Physiology; Myocardial oxygen-consumption; Cross-bridge model; Isolated rat-heart; Skeletal-muscle; Mouse hearts; Energetics; Contraction; Recovery; Metabolism; Eskimos
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