- Title
- Effect of cognitive-existential group therapy on survival in early-stage breast cancer
- Creator
- Kissane, David; Love, Anthony; Hatton, Allison; Bloch, Sidney; Smith, Graeme; Clarke, David; Miach, Patricia; Ikin, Jill; Ranieri, Nadia; Snyder, Raymond
- Date
- 2004
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/34803
- Identifier
- vital:3153
- Identifier
-
https://doi.org/10.1200/jco.2004.12.129
- Identifier
- ISSN:0732-183X
- Abstract
- PURPOSE: Cognitive-existential group therapy (CEGT) was developed to improve mood and mental attitude toward cancer in women with early-stage breast cancer receiving adjuvant chemotherapy. Given the debate about group therapy's association with increased survival in women with metastatic breast cancer, we were curious to check its effect at a much earlier stage in the cancer journey. PATIENTS AND METHODS: We randomly assigned 303 women with early-stage breast cancer who were receiving adjuvant chemotherapy to either 20 sessions of weekly group therapy plus three relaxation classes (n = 154) or to a control condition of three relaxation classes alone (n = 149). The primary outcome was survival. RESULTS: CEGT did not extend survival; the median survival time was 81.9 months (95% CI, 64.8 to 99.0 months) in the group-therapy women and 85.5 months (95% CI, 67.5 to 103.6 months) in the control arm. The hazard ratio for death was 1.35 (95% CI, 0.76 to 2.39; P = .31). In contrast, histology and axillary lymph node status were significant predictors of survival. Low-grade histology yielded a hazard ratio of 0.342 (95% CI, 0.17 to 0.69), and axillary lymph node-negative status yielded a hazard ratio of 0.397 (95% CI, 0.20 to 0.78). CONCLUSION: CEGT does not prolong survival in women with early-stage breast cancer.
- Publisher
- American Society of Clinical Oncology
- Relation
- Journal of Clinical Oncology Vol. 22, no. 21 (2004), p. 4255-4260
- Rights
- Copyright American Society of Clinical Oncology
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1112 Oncology and Carcinogenesis
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