- Title
- Analysis of the impact of sex and age on the variation in the prevalence of antinuclear autoantibodies in Polish population : a nationwide observational, cross-sectional study
- Creator
- Krzemie; Kasperczyk, Sławomir; Banach, Maciej; Kasperczyk, Aleksandra; Dobrakowski, Michał; Tomasik, Tomasz; Windak, Adam; Mastej, Mirosław; Catapano, Alberico; Ray, Kausik; Mikhailidis, Dimitri; Toth, Peter; Howard, George; Lip, Gregory; Tomaszewski, Macie; Charchar, Fadi; Sattar, Naveed; Williams, Bryan; MacDonald, Thomas; Penson, Peter; Al-Shaer, B; Andrusewicz, W.; Anusz-Gaszewska, E.; Balawajder, P.; Bańka, G.; Barańska-Skubisz E.; Przyczyna, B.; Bartkowiak S.
- Date
- 2022
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/184756
- Identifier
- vital:16571
- Identifier
-
https://doi.org/10.1007/s00296-021-05033-9
- Identifier
- ISSN:0172-8172 (ISSN)
- Abstract
- The detection of antinuclear autoantibody (ANA) is dependent on many factors and varies between the populations. The aim of the study was first to assess the prevalence of ANA in the Polish adult population depending on age, sex and the cutoff threshold used for the results obtained. Second, we estimated the occurrence of individual types of ANA-staining patterns. We tested 1731 patient samples using commercially available IIFA using two cutoff thresholds of 1:100 and 1:160. We found ANA in 260 participants (15.0%), but the percentage of positive results strongly depended on the cutoff level. For a cutoff threshold 1:100, the positive population was 19.5% and for the 1:160 cutoff threshold, it was 11.7%. The most prevalent ANA-staining pattern was AC-2 Dense Fine speckled (50%), followed by AC-21 Reticular/AMA (14.38%) ANA more common in women (72%); 64% of ANA-positive patients were over 50 years of age. ANA prevalence in the Polish population is at a level observed in other highly developed countries and is more prevalent in women and elderly individuals. To reduce the number of positive results released, we suggest that Polish laboratories should set 1:160 as the cutoff threshold. © 2021, The Author(s). **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliate “Fadi Charchar" is provided in this record**
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Relation
- Rheumatology International Vol. 42, no. 2 (2022), p. 261-271
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- http://creativecommons.org/licenses/by/4.0/.
- Rights
- Copyright © 2021, The Author(s)
- Rights
- Open Access
- Subject
- 3202 Clinical sciences; 4201 Allied health and rehabilitation science; Age; Antinuclear antibodies; Cutoff threshold; Indirect immunofluorescence assay; Prevalence; Sex
- Full Text
- Reviewed
- Funder
- The present study was an initiative of the Polish Lipid Association (PoLA) and the College of Family Physician in Poland (CFPiP). The present study was funded by an unrestricted educational grant from Valeant (Warsaw, Poland). Valeant had no role in study design, data analysis, data interpretation, or writing of the report. The present study was also supported by Silesian Analytical Laboratories (SLA), CHDE, BIO-RAD, Euroimmun. Publication of the paper was funded by the Medical University of Silesia.
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