Climate change, energy security, pollution and increasing unemployment in the face of automation are four critical challenges facing every region in the twenty-first century, including the Latrobe Valley in Victoria, Australia. The Valley – location of the largest brown coal deposits and forest industry in the southern hemisphere – is undergoing unprecedented and rapid changes. Its ageing brown coal power plants are retiring and replacements are not planned, leading to job insecurity. Solutions are needed that ensure continued economic activity in the region whilst allowing for the Valley to contribute its fair share in the fight against the climate change. The aim of this study is to investigate a possible local solution that could help tackle these issues of the Latrobe Valley in addition to plastic pollution and energy insecurity. Transitioning from linear to circular materials flow is one possible solution that favours sustainability and job security. Consequently, a multiproduct succinic acid biorefinery is modelled, acting as an industrial hub in a potential Latrobe Valley circular economy. This allows for employment creation in the value-addition of its platform chemicals into carbon negative and environment-friendly products. Additionally, such a biorefinery concept has the capacity to tackle Post-combustion CO2 Capture (PCC) industry’s wastes. It is anticipated that any future utilisation of brown coal as an energy vector would entail PCC to ensure carbon neutrality. A PCC industry produces CO2 and amine wastes that require adequate disposal. The modelled biorefinery has the capacity to valorise both. The simulation and the techno-economic analysis show the modelled Carbon Negative Biorefinery consumes 656,000 metric tonnes (t) of pulp logs and 42,000 t of CO2 to produce 220,000 t of succinic acid, 115,000 t of acetic acid and 900 t of dimethyl ether, annually. Biorefinery’s CAPEX and OPEX stand at AU$ 635,000,000 and $ 180,000,000 respectively. The calculated Minimum Selling Price for succinic acid is $ 990/t, only 6.4% higher than a typical biorefinery. Subsequently, biorefinery’s capacity as an anchor tenant is also simulated via technical evaluations of four value-added products: • Poly(butylene succinate) as biodegradable polymer replacing petro-plastics – simulation results show 1 t of succinic acid produces 0.19 t of tetrahydrofuran and 0.44 t of poly(butylene succinate); • Carbon fibre for insulation products, sporting goods and foams – 1 t of lignin and 0.8 t of acetic anhydride produce 0.8 t of carbon fibre; • Succinylated lignin adhesive for replacing urea-formaldehyde in the wood industry – simulation results show the biorefinery concept having the capacity to valorise both waste amine and CO2 from a PCC plant; and • Renewable fuels like hydrogen as energy vectors – a small biorefinery can potentially provide dozens of gigawatt hours of stored power for backup and peak demands, annually. In summary, results of this research are: • A biorefinery can valorise PCC plant wastes; • Multiproduct succinic acid biorefinery is economically viable; • Renewable fuels are ideally suited as energy storage vectors for a renewable energy grid both in developing and developed countries; • Bioproducts can reduce CO2 emissions thereby mitigate climate change; • Bioproducts can replace petro-products and reduce pollution; • Bioproducts can replace construction industry materials associated with CO2 emissions; • Biorefineries can help a region transition from a linear to a circular economy; and • Circular economies have the potential to generate secure jobs. In conclusion, this research identifies platform biochemicals as potential key drivers in a linear economy’s transition to a circular economy.