- Title
- Epigenetic changes in leukocytes after 8 weeks of resistance exercise training
- Creator
- Denham, Joshua; Marques, Francine; Bruns, Emma; O'Brien, Brendan; Charchar, Fadi
- Date
- 2016
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/157881
- Identifier
- vital:11679
- Identifier
-
https://doi.org/10.1007/s00421-016-3382-2
- Identifier
- ISSN:1439-6319
- Abstract
- PURPOSE: Regular engagement in resistance exercise training elicits many health benefits including improvement to muscular strength, hypertrophy and insulin sensitivity, though the underpinning molecular mechanisms are poorly understood. The purpose of this study was to determine the influence 8 weeks of resistance exercise training has on leukocyte genome-wide DNA methylation and gene expression in healthy young men. METHODS: Eight young (21.1 +/- 2.2 years) men completed one repetition maximum (1RM) testing before completing 8 weeks of supervised, thrice-weekly resistance exercise training comprising three sets of 8-12 repetitions with a load equivalent to 80 % of 1RM. Blood samples were collected at rest before and after the 8-week training intervention. Genome-wide DNA methylation and gene expression were assessed on isolated leukocyte DNA and RNA using the 450K BeadChip and HumanHT-12 v4 Expression BeadChip (Illumina), respectively. RESULTS: Resistance exercise training significantly improved upper and lower body strength concurrently with diverse genome-wide DNA methylation and gene expression changes (p
- Relation
- European Journal of Applied Physiology Vol. 116, no. 6 (2016), p. 1245-1253; http://purl.org/au-research/grants/nhmrc/1009490
- Rights
- © Springer-Verlag Berlin Heidelberg 2016
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1106 Human Movement and Sports Science; Epigenome; Transcriptome; Strength training; mRNA expression; DNA methylation
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