Application of high voltage transmission electron microscopy to the study of ultra-fine grained ores
- Authors: McKnight, Stafford
- Date: 2004
- Type: Text , Conference paper
- Relation: Paper presented at The Minerals Industry - Future Directions for New Leaders', Ballarat, Victoria : 21st March, 2004
- Full Text: false
- Reviewed:
- Description: E1
- Description: 2003000706
Risk assessment of SARS-CoV-2 in Antarctic wildlife
- Authors: Barbosa, Andres , Varsani, Arvind , Morandini, Virginia , Grimaldi, Wray , Vanstreels, Ralph , Diaz, Julia , Boulinier, Thierry , Dewar, Meagan , González-Acuña, Daniel , Gray, Rachael , McMahon, Clive , Miller, Gary , Power, Michelle , Gamble, Amandine , Wille, Michelle
- Date: 2021
- Type: Text , Journal article
- Relation: Science of the Total Environment Vol. 755, no. 2 (2021), p. 1-8
- Full Text:
- Reviewed:
- Description: The coronavirus disease 2019 (COVID-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pathogen has spread rapidly across the world, causing high numbers of deaths and significant social and economic impacts. SARS-CoV-2 is a novel coronavirus with a suggested zoonotic origin with the potential for cross-species transmission among animals. Antarctica can be considered the only continent free of SARS-CoV-2. Therefore, concerns have been expressed regarding the potential human introduction of this virus to the continent through the activities of research or tourism to minimise the effects on human health, and the potential for virus transmission to Antarctic wildlife. We assess the reverse-zoonotic transmission risk to Antarctic wildlife by considering the available information on host susceptibility, dynamics of the infection in humans, and contact interactions between humans and Antarctic wildlife. The environmental conditions in Antarctica seem to be favourable for the virus stability. Indoor spaces such as those at research stations, research vessels or tourist cruise ships could allow for more transmission among humans and depending on their movements between different locations the virus could be spread across the continent. Among Antarctic wildlife previous in silico analyses suggested that cetaceans are at greater risk of infection whereas seals and birds appear to be at a low infection risk. However, caution needed until further research is carried out and consequently, the precautionary principle should be applied. Field researchers handling animals are identified as the human group posing the highest risk of transmission to animals while tourists and other personnel pose a significant risk only when in close proximity (< 5 m) to Antarctic fauna. We highlight measures to reduce the risk as well as identify of knowledge gaps related to this issue. © 2020 The Authors
“It runs in your blood” : reflections from treatment seeking gamblers on their family history of gambling
- Authors: Dowling, Nicki , Francis, K. , Dixon, R. , Merkouris, Stephanie , Thomas, Shane
- Date: 2021
- Type: Text , Journal article
- Relation: Journal of Gambling Studies Vol. 37, no. 2 (2021), p. 689-710
- Full Text: false
- Reviewed:
- Description: There are considerable gaps in our understanding of the familial transmission of gambling problems. This convergent mixed-methods study aimed to explore the: (1) sources of heterogeneity in the familial (paternal, maternal, and sibling) transmission of gambling problems; (2) degree to which family-of-origin characteristics are associated with family-of-origin problem gambling; and (3) beliefs of gamblers about the nature of the familial transmission of problem gambling. The sample consisted of 97 treatment-seeking gamblers in Australia. One-quarter (25.5%) of participants reported that at least one family member (16.5% father, 7.5% mother, 7.6% siblings) living with them when they were growing up had a gambling problem. Most participants reported that family members with a positive history of problem gambling were biological relatives, lived with them full-time, and experienced long-term difficulties with gambling. Participants with a family history of problem gambling were young (less than 12 years of age) at the onset of parental, but not sibling, problem gambling, were women, and reported difficulties with the same gambling activity as their family member. Participants raised in families with problem gambling were more likely to report parental separation (risk ratio [RR] = 2.32) and divorce (RR = 2.83), and extreme family financial hardship (RR = 1.80), as well as low levels of paternal authoritative parenting than participants raised in non-problem gambling families. Qualitatively, both social learning and genetics were perceived to play a central role in the familial transmission of gambling problems. These findings inform theories of the familial transmission of gambling problems and the design of targeted prevention and intervention strategies. © 2020, Springer Science+Business Media, LLC, part of Springer Nature. **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Shane Thomas” is provided in this record**
Pathogenesis, humoral immune responses, and transmission between cohoused animals in a ferret model of human respiratory syncytial virus infection
- Authors: Chan, Kok Fei , Carolan, Louise , Druce, Julian , Chappell, Keith , Watterson, Daniel , Young, Paul , Korenkov, Daniil , Subbarao, Kanta , Barr, Ian , Laurie, Karen , Reading, Patrick
- Date: 2018
- Type: Text , Journal article
- Relation: Journal of Virology Vol. 92, no. 4 (2018), p.
- Full Text: false
- Reviewed:
- Description: Small-animal models have been used to obtain many insights regarding the pathogenesis and immune responses induced following infection with human respiratory syncytial virus (hRSV). Among those described to date, infections in cotton rats, mice, guinea pigs, chinchillas, and Syrian hamsters with hRSV strains Long and/or A2 have been well characterized, although clinical isolates have also been examined. Ferrets are also susceptible to hRSV infection, but the pathogenesis and immune responses elicited following infection have not been well characterized. Here, we describe the infection of adult ferrets with hRSV Long or A2 via the intranasal route and characterized virus replication, as well as cytokine induction, in the upper and lower airways. Virus replication and cytokine induction during the acute phase of infection (days 0 to 15 postinfection) were similar between the two strains, and both elicited high levels of F glycoprotein-specific binding and neutralizing antibodies following virus clearance (days 16 to 22 postinfection). Importantly, we demonstrate transmission from experimentally infected donor ferrets to cohoused naive recipients and have characterized virus replication and cytokine induction in the upper airways of infected contact animals. Together, these studies provide a direct comparison of the pathogenesis of hRSV Long and A2 in ferrets and highlight the potential of this animal model to study serological responses and examine interventions that limit transmission of hRSV. Ferrets have been widely used to study pathogenesis, immunity, and transmission following human influenza virus infections however, far less is known regarding the utility of the ferret model to study hRSV infections. Following intranasal infection of adult ferrets with the well-characterized Long or A2 strain of hRSV, we report virus replication and cytokine induction in the upper and lower airways, as well as the development of virus-specific humoral responses. Importantly, we demonstrate transmission of hRSV from experimentally infected donor ferrets to cohoused naive recipients. Together, these findings significantly enhance our understanding of the utility of the ferret as a small-animal model to investigate aspects of hRSV pathogenesis and immunity.