Preparation of starch-based nanoparticles through high-pressure homogenization and miniemulsion cross-linking: Influence of various process parameters on particle size and stability
- Authors: Shi, Aimin , Li, Dong , Wang, Li Ming , Li, Bingzheng , Adhikari, Benu
- Date: 2010
- Type: Text , Journal article
- Relation: Carbohydrate Polymers Vol. 83, no. 4 (2010), p. 1604-1610
- Full Text: false
- Reviewed:
- Description: A new and convenient synthetic route using high-pressure homogenization combined with water-in-oil (w/o) miniemulsion cross-linking technique was used to prepare sodium trimetaphosphate (STMP)-cross-linked starch nanoparticles. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) revealed that starch nanoparticles had narrow size distribution, good dispersibility and spherical shape. Effect of process parameters (surfactant content, water/oil ratio, starch concentration, homogenization pressure and cycles) on the starch nanoparticle size in miniemulsion was evaluated. We show that there is an optimal surfactant concentration giving rise to smaller starch nanoparticles and better stability. Apart from the water/oil ratio and starch concentration, the homogenization pressure and cycles (passes) also significantly affect the size of starch nanoparticles (p < 0.05). The stability analysis of starch nanoparticles in water for 2 h to 2 days and in temperature ranges of 25-45 °C showed firm structure and good stability. These nanoparticles are expected to be exploited as drug carriers. © 2010 Elsevier Ltd. All rights reserved.
- Description: 2003008433
Effects of high-pressure homogenization on the properties of starch-plasticizer dispersions and their films
- Authors: Fu, Z. Q. , Wang, Li J. , Li, Dong , Wei, Q. , Adhikari, Benu
- Date: 2011
- Type: Text , Journal article
- Relation: Carbohydrate Polymers Vol. 86, no. 1 (2011), p. 202-207
- Full Text: false
- Reviewed:
- Description: The properties of starch-plasticizer (glycerol:xylitol = 1:1) dispersions obtained with and without high-pressure homogenization and their corresponding films were investigated. The fully gelatinized dispersions with or without homogenization were subsequently converted into films using solution casting. The apparent viscosity of the dispersions with or without homogenization was determined. The water vapor permeability, opacity, crystalline/amorphous nature, and mechanical properties of these starch-based films were determined. The high-pressure homogenization greatly reduced the apparent viscosity of the dispersions and altered the flow behavior from shear-thinning into Newtonian one. The films obtained from high-pressure homogenized dispersions had better moisture barrier property, better film transparency and higher tensile strength but lower elongation. © 2011 Elsevier Ltd All rights reserved.