Inference of gene expression networks using memetic gene expression programming
- Authors: Zarnegar, Armita , Vamplew, Peter , Stranieri, Andrew
- Date: 2009
- Type: Text , Conference paper
- Relation: Paper presented at Thirty-Second Australasian Computer Science Conference (ACSC 2009), Wellington, New Zealand : Vol. 91, p. 17-23
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- Description: In this paper we aim to infer a model of genetic networks from time series data of gene expression profiles by using a new gene expression programming algorithm. Gene expression networks are modelled by differential equations which represent temporal gene expression relations. Gene Expression Programming is a new extension of genetic programming. Here we combine a local search method with gene expression programming to form a memetic algorithm in order to find not only the system of differential equations but also fine tune its constant parameters. The effectiveness of the proposed method is justified by comparing its performance with that of conventional genetic programming applied to this problem in previous studies.
Data Mining and Analytics 2011: Proceedings of the Ninth Australasian Data Mining Conference
- Authors: Vamplew, Peter , Stranieri, Andrew , Ong, Kok-Leong , Christen, Peter , Kennedy, Paul
- Date: 2011
- Type: Text , Edited book
- Full Text: false
Patient admission prediction using a pruned fuzzy min-max neural network with rule extraction
- Authors: Wang, Jin , Lim, Cheepeng , Creighton, Douglas , Khorsavi, Abbas , Nahavandi, Saeid , Ugon, Julien , Vamplew, Peter , Stranieri, Andrew , Martin, Laura , Freischmidt, Anton
- Date: 2015
- Type: Text , Journal article
- Relation: Neural Computing and Applications Vol. 26, no. 2 (2015), p. 277-289
- Full Text: false
- Reviewed:
- Description: A useful patient admission prediction model that helps the emergency department of a hospital admit patients efficiently is of great importance. It not only improves the care quality provided by the emergency department but also reduces waiting time of patients. This paper proposes an automatic prediction method for patient admission based on a fuzzy min–max neural network (FMM) with rules extraction. The FMM neural network forms a set of hyperboxes by learning through data samples, and the learned knowledge is used for prediction. In addition to providing predictions, decision rules are extracted from the FMM hyperboxes to provide an explanation for each prediction. In order to simplify the structure of FMM and the decision rules, an optimization method that simultaneously maximizes prediction accuracy and minimizes the number of FMM hyperboxes is proposed. Specifically, a genetic algorithm is formulated to find the optimal configuration of the decision rules. The experimental results using a large data set consisting of 450740 real patient records reveal that the proposed method achieves comparable or even better prediction accuracy than state-of-the-art classifiers with the additional ability to extract a set of explanatory rules to justify its predictions.
Integrating biological heuristics and gene expression data for gene regulatory network inference
- Authors: Zarnegar, Armita , Jelinek, Herbert , Vamplew, Peter , Stranieri, Andrew
- Date: 2019
- Type: Text , Conference proceedings , Conference paper
- Relation: 2019 Australasian Computer Science Week Multiconference, ACSW 2019; Sydney, Australia; 29th-31st January 2019 p. 1-10
- Full Text: false
- Reviewed:
- Description: Gene Regulatory Networks (GRNs) offer enhanced insight into the biological functions and biochemical pathways of cells associated with gene regulatory mechanisms. However, obtaining accurate GRNs that explain gene expressions and functional associations remains a difficult task. Only a few studies have incorporated heuristics into a GRN discovery process. Doing so has the potential to improve accuracy and reduce the search space and computational time. A technique for GRN discovery that integrates heuristic information into the discovery process is advanced. The approach incorporates three elements: 1) a novel 2D visualized coexpression function that measures the association between genes; 2) a post-processing step that improves detection of up, down and self-regulation and 3) the application of heuristics to generate a Hub network as the backbone of the GRN. Using available microarray and next generation sequencing data from Escherichia coli, six synthetic benchmark GRN datasets were generated with the neighborhood addition and cluster addition methods available in SynTReN. Results of the novel 2D-visualization co-expression function were compared with results obtained using Pearson's correlation and mutual information. The performance of the biological genetics-based heuristics consisting of the 2D-Visualized Co-expression function, post-processing and Hub network was then evaluated by comparing the performance to the GRNs obtained by ARACNe and CLR. The 2D-Visualized Co-expression function significantly improved gene-gene association matching compared to Pearson's correlation coefficient (t = 3.46, df = 5, p = 0.02) and Mutual Information (t = 4.42, df = 5, p = 0.007). The heuristics model gave a 60% improvement against ARACNe (p = 0.02) and CLR (p = 0.019). Analysis of Escherichia coli data suggests that the GRN discovery technique proposed is capable of identifying significant transcriptional regulatory interactions and the corresponding regulatory networks.
A heuristic gene regulatory networks model for cardiac function and pathology
- Authors: Zarnegar, Armita , Vamplew, Peter , Stranieri, Andrew , Jelinek, Herbert
- Date: 2016
- Type: Text , Conference proceedings
- Relation: 2016 Computing in Cardiology Conference (CinC); Vancouver; 11-14th Sept, 2016
- Full Text: false
- Reviewed:
- Description: Genome-wide association studies (GWAS) and next-generation sequencing (NGS) has led to an increase in information about the human genome and cardiovascular disease. Understanding the role of genes in cardiac function and pathology requires modeling gene interactions and identification of regulatory genes as part of a gene regulatory network (GRN). Feature selection and data reduction not sufficient and require domain knowledge to deal with large data. We propose three novel innovations in constructing a GRN based on heuristics. A 2D Visualised Co-regulation function. Post-processing to identify gene-gene interactions. Finally a threshold algorithm is applied to identify the hub genes that provide the backbone of the GRN. The 2D Visualized Co-regulation function performed significantly better compared to the Pearson's correlation for measuring pairwise associations (t=3.46, df=5, p=0.018). The F-measure, improved from 0.11 to 0.12. The hub network provided a 60% improvement to that reported in the literature. The performance of the hub network was then also compared against ARACNe and performed significantly better (p=0.024). We conclude that a heuristics approach in developing GRNs has potential to improve our understanding of gene regulation and interaction in diverse biological function and disease.
Automatic sleep stage identification: difficulties and possible solutions
- Authors: Sukhorukova, Nadezda , Stranieri, Andrew , Ofoghi, Bahadorreza , Vamplew, Peter , Saleem, Muhammad Saad , Ma, Liping , Ugon, Adrien , Ugon, Julien , Muecke, Nial , Amiel, Hélène , Philippe, Carole , Bani-Mustafa, Ahmed , Huda, Shamsul , Bertoli, Marcello , Levy, P , Ganascia, J.G
- Date: 2010
- Type: Text , Conference proceedings
- Full Text:
- Description: The diagnosis of many sleep disorders is a labour intensive task that involves the specialised interpretation of numerous signals including brain wave, breath and heart rate captured in overnight polysomnogram sessions. The automation of diagnoses is challenging for data mining algorithms because the data sets are extremely large and noisy, the signals are complex and specialist's analyses vary. This work reports on the adaptation of approaches from four fields; neural networks, mathematical optimisation, financial forecasting and frequency domain analysis to the problem of automatically determing a patient's stage of sleep. Results, though preliminary, are promising and indicate that combined approaches may prove more fruitful than the reliance on a approach.