Twin removal in genetic algorithms for protein structure prediction using low-resolution model
- Authors: Hoque, Md Tamjidul , Chetty, Madhu , Lewis, Andrew , Sattar, Abdul
- Date: 2011
- Type: Text , Journal article
- Relation: IEEE/ACM Transactions on Computational Biology and Bioinformatics Vol. 8, no. 1 (2011), p. 234-245
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- Description: This paper presents the impact of twins and the measures for their removal from the population of genetic algorithm (GA) when applied to effective conformational searching. It is conclusively shown that a twin removal strategy for a GA provides considerably enhanced performance when investigating solutions to complex ab initio protein structure prediction (PSP) problems in low-resolution model. Without twin removal, GA crossover and mutation operations can become ineffectual as generations lose their ability to produce significant differences, which can lead to the solution stalling. The paper relaxes the definition of chromosomal twins in the removal strategy to not only encompass identical, but also highly correlated chromosomes within the GA population, with empirical results consistently exhibiting significant improvements solving PSP problems.
DFS based partial pathways in GA for protein structure prediction
- Authors: Hoque, Md Tamjidul , Chetty, Madhu , Lewis, Andrew , Sattar, Abdul
- Date: 2008
- Type: Text , Conference paper
- Relation: Third IAPR International Conference, PRIB 2008
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- Description: Nondeterministic conformational search techniques, such as Genetic Algorithms (GAs) are promising for solving protein structure prediction (PSP) problem. The crossover operator of a GA can underpin the formation of potential conformations by exchanging and sharing potential sub-conformations, which is promising for solving PSP. However, the usual nature of an optimum PSP conformation being compact can produce many invalid conformations (by having non-self-avoiding-walk) using crossover. While a crossover-based converging conformation suffers from limited pathways, combining it with depth-first search (DFS) can partially reveal potential pathways. DFS generates random conformations increasingly quickly with increasing length of the protein sequences compared to random-move-only-based conformation generation. Random conformations are frequently applied for maintaining diversity as well as for initialization in many GA variations.
Major depression and generalised anxiety disorder: An analysis of the effects of remission status and comorbidity on mother‐infant emotional availability in the perinatal period
- Authors: Aran, Pavitra , Lewis, Andrew , Watson, Stuart , Galbally, Megan
- Date: 2022
- Type: Text , Journal article
- Relation: Journal of Clinical Psychology Vol. 78, no. 4 (2022), p. 570-589
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- Description: Background The effects of maternal depression on mother‐infant relationship quality likely vary according to depression heterogeneity. We investigated the effects of different presentations of major depression on mother‐infant emotional availability (EA). Methods Data were obtained from 115 mother‐infant dyads from a longitudinal pregnancy cohort. Disorders, symptoms, and antidepressant use were assessed in pregnancy and postpartum, and EA was observed 6‐month postpartum. Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) were assessed using the Structured Clinical Interview for the DSM‐5. A series of multivariate analyses of covariance analyses' examining the effects of disorder on EA were conducted. Results After controlling for maternal age, antidepressant use, and postpartum depressive symptoms, MDD accounted for 20% of the variance in EA. In the MDD/GAD group, 93% of interactions were rated as emotionally unavailable, nearly threefold the comparison group rate. Conclusions Findings demonstrate that different presentations of major depression are associated with observed differences in mother‐infant EA. HIGHLIGHTS Lifetime major depression predicted mother‐infant emotional availability, independent of antidepressant use or postpartum depressive symptoms The risk of emotional unavailability varied according to different presentations of major depression Comorbid generalized anxiety disorder was associated with the greatest risk of emotional unavailability
An Australian adaptation of the strengthening families program: Parent and child mental health outcomes from a pilot study
- Authors: Burn, Michele , Lewis, Andrew , McDonald, Louise , Toumbourou, John
- Date: 2019
- Type: Text , Journal article
- Relation: Australian psychologist Vol. 54, no. 4 (2019), p. 261-271
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- Description: This is the first pilot study to examine the Australian adaptation of the Strengthening Families Program (SFP), a manualised family intervention recommended internationally in evidence reviews to improve family functioning and child mental health. The study compared two versions (8 vs. 14-session) and longitudinally evaluated outcomes for child emotional and behavioural difficulties, and parental psychological distress. Fifty-eight families from disadvantaged primary schools in regional Victoria with children 8-12-years (80.6% of initially enrolled families, 62 parents and 74 children) completed the program and evaluation measures. Measures were repeated at pre-, post-, and 3-month follow-up and included the Kessler 6, the Strengths and Difficulties Questionnaire, and subscales adapted from the Longitudinal Study of Australian Children and Communities that Care Youth Survey. The program showed significant reductions in child difficulties and parental psychological distress from pre- to post-measurements that were sustained at follow-up. Reductions in parental psychological distress were significantly associated with reductions in child difficulties at follow-up. The 8- and 14-session formats were not found to be significantly different in reducing child difficulties or parental psychological distress. Effect sizes for the Australian version were similar to those reported in previous U.S. trials. Findings support the feasibility and effectiveness of an Australian adaptation of the SFP. The current study is unique in identifying similar outcomes for shorter and longer versions of the intervention. It is recommended that the 8-session Australian version is examined in a larger randomised controlled trial where children present with behavioural and emotional problems.
Dimensions of religious/spiritual well-being in relation to personality and stress coping: Initial results from Bosnian young adults
- Authors: Malinovic, Alen , Fink, Andreas , Lewis, Andrew , Unterrainer, Human-Friedrich
- Date: 2016
- Type: Text , Journal article
- Relation: Journal of spirituality in mental health Vol. 18, no. 1 (2016), p. 43-54
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- Description: The aim of this study was to examine possible relationships between religious/spiritual well-being (RSWB), the Big Five personality factors, and stress coping strategies among Bosnian young adults. Therefore, a first Bosnian translation of the Multidimensional Inventory of Religious/Spiritual Well-being was applied on a sample of 290 (181 females) Bosnian undergraduate students. RSWB dimensions such as hope, forgiveness, or general religiosity were found to be substantially related with more favorable personality dimensions as well as with more adequate stress coping. As a conclusion RSWB dimensions were confirmed as being an important resource for mental health for this sample of Bosnian adolescents.
Prenatal maternal mental health and fetal growth restriction: a systematic review
- Authors: Lewis, Andrew , Austin, Emma , Galbally, Megan
- Date: 2016
- Type: Journal article
- Relation: Journal of Developmental Origins of Health and Disease Vol. 7, no. 4 (2016), p. 416-428
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- Description: Maternal mental disorders during pregnancy are associated with a range of adverse health outcomes for offspring. This systematic review examines studies reporting on the relationship between maternal depression, anxiety or stress during pregnancy and fetal growth measured during pregnancy using ultrasound biometry. A systematic search of PsycINFO, Medline, Scopus, Web of Science and Embase was conducted and 1575 records were identified, with nine studies meeting inclusion criteria gathering data from over 7000 participants. All studies measured depression, six examined anxiety and depression, and five examined all three exposures. The majority measured symptoms rather than clinically diagnosable disorder. Studies consistently reported significant associations between maternal mental health, particularly anxiety symptoms, and reduced fetal head growth. Other fetal growth parameters showed inconsistent findings. A number of studies suggest that cortisol dysregulation associated with maternal mental health may play a role in fetal growth restriction. However, heterogeneity in the timing of growth measurement, assessment measures used for mental health and inconsistencies in adjustment for confounders, limits the synthesis and interpretation of findings. Future studies should consider differences in the timing, intensity and duration of mental health symptoms over pregnancy and should employ diagnostic assessment of mental disorders. Fetal growth should be repeatedly measured and further work is needed to establish the biological mechanisms involved.
Breastfeeding, antidepressants, and depression in the mercy pregnancy and emotional well-being study
- Authors: Galbally, Megan , Watson, Stuart , Ball, Helen , Lewis, Andrew
- Date: 2019
- Type: Text , Journal article
- Relation: Journal of Human Lactation Vol. 35, no. 1 (2019), p. 127-136
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- Description: Background: Depression is consistently shown to predict lower rates of breastfeeding. In a handful of studies, breastfeeding has predicted lower depression symptoms. However, studies demonstrating the latter are limited in their measurement of both depression and breastfeeding and have not followed participants from pregnancy across the postpartum period. Research Aim: The primary aim of this study was to describe breastfeeding intentions and behaviors for the first 12 months postpartum among nonmedicated depressed, antidepressant-exposed, and control participants. The secondary aim was to examine group differences in the association between depressive symptoms and breastfeeding duration up to 12 months postpartum. Methods: First-trimester women (N = 212) were recruited into a prospective longitudinal study. Depressive disorders at baseline were diagnosed using the Structured Clinical Interview for DSM-IV Axis I Disorders, and depressive symptoms were measured at the first and second trimesters and 6 and 12 months postpartum using the Edinburgh Postnatal Depression Scale. Breastfeeding duration, support from family and employers, and perceptions of participants’ experience were measured. Results: Depressed women and antidepressant-exposed women reported a trend toward lower rates of intention, initiation, and duration, but this did not reach statistical significance. There was a statistically significant difference on depressive symptoms for women taking antidepressants during pregnancy, compared with controls, when they continued to breastfeed for 12 months postpartum. Conclusions: This study did not find a strong association between depression or antidepressant use and intention to breastfeed, partner breastfeeding support, or initiation or duration of breastfeeding. However, for women who took antidepressants, there was evidence that breastfeeding for 12 months was associated with lower depressive symptoms.
A psychometric study of the Emotional Availability Scales: Construct validity and measurement invariance between depressed and nondepressed mother-infant dyads
- Authors: Aran, Pavitra , Lewis, Andrew , Watson, Stuart , MacMillan, Kelli , Power, Josephine , Galbally, Megan
- Date: 2022
- Type: Text , Journal article
- Relation: Psychological Assessment Vol. 34, no. 1 (2022), p. 70-81
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- Description: The Emotional Availability Scales (EAS) are the most widely reported observational assessment measure of parent-child relationships and has been of particular interest in understanding differences between samples of depressed and nondepressed mothers and their offspring. Despite its widespread use, psychometric validation of the factor structure in normative samples and the measurement of invariance within clinical samples has not been published. We evaluated the internal structure (dimensionality, reliability, convergent, and discriminant validity) of the EAS fourth edition using a nondepressed sample of 157 Australian women and their infants aged 6 months, including testing the measurement invariance of the EAS between the same nondepressed sample (n = 157), and a depressed group (n = 185) of mother-infant dyads, using MPlus. Participants were recruited from tertiary hospitals, and depression status was established using a diagnostic measure. Higher-order confirmatory factor analyses on the EAS' six dimensions supported a unidimensional factor solution in our data. Full measurement invariance was not demonstrated due to metric noninvariance of the maternal nonintrusiveness and child responsiveness dimensions. Full scalar invariance supported mean comparisons, and a medium effect of .78SD lower mean emotional availability for the depressed group was found Cohen's d = .63, 95% CI [.41, .85]. While arguments exist for the clinical utility of differentiating between multiple dimensions of emotional availability, the current findings do not support a multidimensional factor structure or full multigroup measurement invariance of the EAS. Similar psychometric investigations of the EAS in clinical and nonclinical samples are needed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Examining differences in placental efficiency following exposure to antidepressants and current depression: Findings from an Australian pregnancy cohort study
- Authors: Galbally, Megan , Watson, Stuart , Spigset, Olav , Lappas, Martha , Walker, Susan , Lewis, Andrew
- Date: 2022
- Type: Text , Journal article
- Relation: Placenta Vol. 119, no. (2022), p. 44-51
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- Description: Placental dysfunction and inefficiency, is important in understanding fetal growth restriction and low birth weight. Two recent studies have examined the relationship between antidepressant use in pregnancy and placental weight ratios one found lower placental weight ratio associated with antidepressant use and the other found a higher ratio. This study examined 342 women recruited in early pregnancy, including 75 taking antidepressants, 29 with current depression and 238 controls. Antidepressant use was measured through self-report in early and late pregnancy, hospital records at delivery and drug concentrations in umbilical cord and maternal blood obtained at delivery. Maternal depression was measured using the Structured Clinical Interview for the DSM IV (SCID) at recruitment. Placentas were collected at delivery and weighed, and infant birth weight recorded. Placental efficiency was measured using standardised placental weight residuals and included as the outcome in general linear models (ANOVA/ANCOVA) to test hypotheses. While placental weight was higher for those on antidepressants compared to controls (z=.30 c.f. Z=-0.08, p=.012), there were no significant differences between the three groups after adjusting for maternal body mass index at recruitment. When comparing antidepressant groups separately there were small-to-moderate positive associations between (SSRI) concentrations and placental weight (rho's > 0.20, p's > 0.05), which did not reach significance. Antidepressant use in pregnancy was not associated with significant changes in placental efficiency after adjustment for confounding variables. Future research should expand on this to examine other aspects of placental function and include a wide range of potential confounding variables to draw clinically meaningful conclusions. •Birth weight to placental weight ratio is often used as a proxy for placental dysfunction.•Placental dysfunction may underlie the association between antenatal antidepressant use and low infant birth weight.•Two studies found the opposite relationship between antidepressants and placental weight but did not adjust for confounders.•We found placental weight, when adjusted for confounders, was not significantly different for those on antidepressants.
Major depression as a predictor of the intergenerational transmission of attachment security: Findings from a pregnancy cohort study
- Authors: Galbally, Megan , Watson, Stuart J. , Tharner, Anne , Luijk, Maartje , Blankley, Gaynor , MacMillan, Kelli K. , Power, Josephine , Lewis, Andrew
- Date: 2022
- Type: Text , Journal article
- Relation: Australian and New Zealand Journal of Psychiatry Vol. 56, no. 8 (2022), p. 1006-1016
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- Description: OBJECTIVE: Understanding the relationship between attachment and mental health has an important role in informing management of perinatal mental disorders and for infant mental health. It has been suggested that experiences of attachment are transmitted from one generation to the next. Maternal sensitivity has been proposed as a mediator, although findings have not been as strong as hypothesised. A meta-analysis suggested that this intergenerational transmission of attachment may vary across populations with lower concordance between parent and infant attachment classifications in clinical compared to community samples. However, no previous study has examined major depression and adult attachment in pregnancy as predictors of infant-parent attachment classification at 12 months postpartum. METHODS: Data were obtained on 52 first-time mothers recruited in early pregnancy, which included 22 women who met diagnostic criteria for current major depression using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders. The Adult Attachment Interview was also administered before 20 weeks of pregnancy. A history of early trauma was measured using the Childhood Trauma Questionnaire and maternal sensitivity was measured at 6 months postpartum using the observational measure of the Emotional Availability Scales. Infant-parent attachment was measured using the Strange Situation Procedure at 12 months. RESULTS: Overall, we found no significant association between the Adult Attachment Interview and the Strange Situation Procedure classifications. However, a combination of maternal non-autonomous attachment on the Adult Attachment Interview and major depression was a significant predictor of insecure attachment on the Strange Situation Procedure. We did not find that maternal sensitivity mediated parental and infant attachment security in this sample. CONCLUSION: While previous meta-analyses identified lower concordance in clinical samples, our findings suggest women with major depression and non-autonomous attachment have a greater concordance with insecure attachment on the Strange Situation Procedure. These findings can guide future research and suggest a focus on depression in pregnancy may be important for subsequent infant attachment.
Maternal trauma but not perinatal depression predicts infant-parent attachment
- Authors: Galbally, Megan , Watson, Stuart , van Ijzendoorn, Marinus , Tharner, Anne , Luijk, Maartje , Lewis, Andrew
- Date: 2022
- Type: Text , Journal article
- Relation: Archives of Women's Mental Health Vol. 25, no. 1 (2022), p. 215-225
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- Description: Understanding if maternal depression is a predictor of infant-parent attachment classification is important to furthering knowledge about the early pathways and predictors of socio-emotional development. Yet few studies that have utilised the Strange Situation Procedure, the gold standard for measurement of infant-parent attachment, have examined antenatal depression as a predictor of attachment, and none has also included a measure of maternal trauma. This study uses data on 224 women recruited in early pregnancy and followed up until 12 months postpartum. Maternal depression was measured in pregnancy using the Structured Clinical Interview for the DSM and repeat Edinburgh Postnatal Depression Scale as well as Stressful Life Events scale across pregnancy and postpartum including items on domestic violence. A past history of trauma was measured using the Childhood Trauma Questionnaire. Attachment was measured using the Strange Situation Procedure (SSP) at 12 months postpartum. We found that maternal depression was not associated with insecure or disorganized attachment. However, a maternal history of childhood trauma and current domestic violence both predicted insecure-avoidant attachment at 12 months, whereas increased number of stressful life events prior to conception and in pregnancy was associated with insecure-resistant attachment. Neither trauma, past or current, nor depression predicted disorganized attachment. In the first study to have included measures of antenatal depression, maternal childhood trauma, and current stressful events as predictors of infant attachment measured using the SSP, we found maternal experiences of past and current trauma but not depression were significant predictors of infant-parent attachment security.
Methamphetamine exposure during pregnancy: A meta-analysis of child developmental outcomes
- Authors: Kunkler, Chelsea , Lewis, Andrew , Almeida, Renita
- Date: 2022
- Type: Text , Journal article
- Relation: Neuroscience and Biobehavioral Reviews Vol. 138, no. (2022), p. 104714-104714
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- Description: This paper examines developmental outcomes for children prenatally exposed to methamphetamine through maternal use. PSYCHINFO, Scopus, PubMed and ERIC databases were systematically searched for studies up to December 2020. The search identified 38 articles examining cognitive, language, motor and neuroanatomical outcomes in children from birth to 16 years. Study quality was appraised using the Newcastle Ottawa Quality Assessment Scale. Findings from neuroanatomical studies suggested that prenatal methamphetamine exposure may alter whole brain microstructure and reduce subcortical volumes across multiple brain regions. Meta-analysis of 14 studies using a random-effects model revealed associations between exposure and poorer intellectual functioning (Cohen’s d = 0.89, 95 % CI: 0.47–1.30), problem solving skills (Cohen’s d = 0.82, 95 % CI: 0.07 −1.56), short-term memory (Cohen’s d = 0.91, 95 % CI: 0.38–1.43), and language development (Cohen’s d = 0.74, 95 % CI: 0.30–1.18). These results emphasise the significant impact of intrauterine methamphetamine exposure across multiple areas of child development, noting that limited total sample size, heterogeneity between studies and control for confounds suggested further studies are required. There is a need for further intervention studies to identify effective prevention and harm minimisation approaches. •Prenatal meth exposure relates to poorer intellectual functioning, memory, and language development.•Exposed children show persistent cognitive deficits across the lifespan.•In utero meth exposure is associated with whole brain microstructural alterations and reduced subcortical volumes.
Maternal trauma and emotional availability in early mother-infant interaction: findings from the Mercy Pregnancy and Emotional Well-being Study (MPEWS) cohort
- Authors: MacMillan, Kelli , Lewis, Andrew , Watson, Stuart , Jansen, Brendan , Galbally, Megan
- Date: 2021
- Type: Text , Journal article
- Relation: Attachment and Human Development Vol. 23, no. 6 (2021), p. 853-875
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- Description: Understanding how a mother's traumatic experiences influence her interactions with her infant may have importance for understanding infant development and mental health. Data for this study were drawn from an Australian pregnancy cohort, the Mercy Pregnancy and Emotional Wellbeing Study. Maternal trauma from Childhood, Childbirth Experiences, and Stressful Life Events were examined. At six-months postpartum, 211 predominantly first-time mothers (mean age 31.5 years), and their infants, were video-recorded interacting for 40 minutes. Interactions were assessed with the Emotional Availability (EA) Scales. Using structural equation modelling to test multiple mediation pathways, moderate-to-severe childhood trauma had only a direct effect on reducing maternal EA with the infant (β=−.17, p=.031), as did current stressful life events (β=−.19, p=.019), after controlling for maternal depression, age, and tertiary education. This highlights that proximate trauma specific to the perinatal period may not account for the effect of distal childhood trauma on maternal EA at six-months postpartum.
Emotional availability in women with bipolar disorder and major depression: A longitudinal pregnancy cohort study
- Authors: Aran, Pavitra , Lewis, Andrew , Watson, Stuart , Nguyen, Thinh , Galbally, Megan
- Date: 2021
- Type: Text , Journal article
- Relation: Australian and New Zealand Journal of Psychiatry Vol. 55, no. 11 (2021), p. 1079-1088
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- Description: Objective: Poorer mother–infant interaction quality has been identified among women with major depression however, there is a dearth of research examining the impact of bipolar disorder. This study sought to compare mother–infant emotional availability at 6 months postpartum among women with perinatal major depressive disorder, bipolar disorder and no disorder (control). Methods: Data were obtained for 127 mother–infant dyads from an Australian pregnancy cohort. The Structured Clinical Interview for the DSM-5 was used to diagnose major depressive disorder (n = 60) and bipolar disorder (n = 12) in early pregnancy (less than 20 weeks) and review diagnosis at 6 months postpartum. Prenatal and postnatal depressive symptoms were measured using the Edinburgh Postnatal Depression Scale, along with self-report psychotropic medication use. Mother and infant’s interaction quality was measured using the Emotional Availability Scales when infants reached 6 months of age. Multivariate analyses of covariance examining the effects of major depressive disorder and bipolar disorder on maternal emotional availability (sensitivity, structuring, non-intrusiveness, non-hostility) and child emotional availability (responsiveness, involvement) were conducted. Results: After controlling for maternal age and postpartum depressive symptoms, perinatal disorder (major depressive disorder, bipolar disorder) accounted for 17% of the variance in maternal and child emotional availability combined. Compared to women with major depressive disorder and their infants, women with bipolar disorder and their infants displayed lower ratings across all maternal and child emotional availability qualities, with the greatest mean difference seen in non-intrusiveness scores. Conclusions: Findings suggest that perinatal bipolar disorder may be associated with additional risk, beyond major depressive disorder alone, to a mother and her offspring’s emotional availability at 6 months postpartum, particularly in maternal intrusiveness.
Fetal programming pathway from maternal mental health to infant cortisol functioning: The role of placental 11β-HSD2 mRNA expression
- Authors: Galbally, Megan , Watson, Stuart , Lappas, Martha , de Kloet, E. , van Rossum, Elisabeth , Wyrwoll, Caitlin , Mark, Peter , Lewis, Andrew
- Date: 2021
- Type: Text , Journal article
- Relation: Psychoneuroendocrinology Vol. 127, no. (2021), p. 105197-105197
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- Description: Placental 11β-HSD2 has been a focus of research for understanding potential fetal programming associated with maternal emotional disorders. This study examined the pathway from antenatal mental health via placental 11β-HSD2 mRNA to cortisol regulation in the infant offspring. This study reports on data obtained from 236 participants in the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS). At term, placental tissue was collected within 30 min of birth from 52 participants meeting current criteria for a depressive disorder, and 184 control participants. Depressive disorders were diagnosed using the SCID-IV. In addition, antidepressant use, depressive and anxiety symptoms were measured in early and late pregnancy. Placental 11β-HSD2 mRNA expression was measured using qRT-PCR. Infant salivary cortisol samples were taken at 12 months of age. Women on antidepressant medication and with higher trait anxiety had higher placental 11β-HSD2 expression compared to women not taking medication. Furthermore, the offspring of women taking an antidepressant and who also had a current depressive disorder and high trait anxiety had high cortisol reactivity at 12 months of age and this was mediated through 11β-HSD2 mRNA expression. In contrast, offspring of women not taking antidepressant medication with depressive disorder and high anxiety there was low cortisol reactivity observed. Our findings suggest that the relationship between maternal antenatal depression and anxiety and infant cortisol reactivity is mediated through placental 11β-HSD2 mRNA expression. Furthermore, the direction differed for women taking antidepressants, where infant cortisol reactivity was high whereas when compared to those with unmedicated depression and anxiety, where infant cortisol reactivity was low. •There has been substantial research understanding placental role in fetal programming pathways for maternal mental health.•Placental 11β-HSD2 has one area of focus given the role in cortisol regulation across the placenta.•Placental 11β-HSD2 mRNA expression in this study was found to be lower in those with depression and anxiety.•This study also found that antidepressant use increased placental 11β-HSD2 mRNA expression.•Infant cortisol reactivity was mediated through 11β-HSD2 mRNA expression and this differed by mental health and antidepressants use.
Antidepressant exposure in pregnancy and child sensorimotor and visuospatial development
- Authors: Galbally, Megan , Watson, Stuart , Spigset, Olav , Boyce, Philip , Oberlander, Tim , Lewis, Andrew
- Date: 2021
- Type: Text , Journal article
- Relation: Journal of psychiatric research Vol. 143, no. (2021), p. 485-491
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- Description: Motor development underlies many aspects of education and learning. There has been uncertainty about the impact of exposure of antidepressant medication in pregnancy on child motor outcomes. This paper examines whether exposure to antidepressants in utero increases the risk of poorer motor development in two areas: sensorimotor and visuospatial processing. Data were obtained from 195 women and children across 3 groups: women with untreated depression in pregnancy, women treated with antidepressants and control women. Data were collected across pregnancy, postpartum and until 4 years for mother and child. Maternal depression was established at baseline with the Structured Clinical Interview for DSM-IV. Antidepressant exposure, including type, dose and timing, was measured through repeated self-report across pregnancy and the postpartum, medical records at delivery and in cord blood samples collected at delivery. Child sensorimotor and visuospatial outcomes were assessed at 4 years of age with four subtests from the NEPSY-II. Our study found for sensorimotor development, visuomotor precision completion time was associated with better performance for antidepressant-exposed children compared to those with mothers with untreated depression. Yet another measure of sensorimotor development, motor manual sequences, was poorer in those exposed to antidepressants. One subtest for visuospatial processing, block construction, was associated with poorer performance in antidepressant-exposed children who had poor neonatal adaptation and those exposed to a higher dose of antidepressant. These findings suggest an inconsistent association between sensorimotor development and antidepressant use in pregnancy. However, the findings for visuospatial processing would support further exploration of antidepressant associated poor neonatal adaption and later motor development.
The relationship between oxytocin blood concentrations and antidepressants over pregnancy and the postpartum
- Authors: Galbally, Megan , Watson, Stuart , Keelan, Jeffrey , Spigset, Olav , Lewis, Andrew
- Date: 2021
- Type: Text , Journal article
- Relation: Progress in Neuro-Psychopharmacology and Biological Psychiatry Vol. 109, no. (2021), p. 110218-110218
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- Description: Antidepressant treatment of perinatal depression is increasingly common and accepted in clinical guidelines. It has been suggested that serotonergic antidepressants may effect changes in the oxytocinergic system, including oxytocin levels, and that this may be one of the beneficial mechanisms of action for these drugs. Furthermore, oxytocin has been associated with the quality of the parent-child relationship, which may be important in treatment of perinatal depression. This study will explore if there is a relationship between antidepressant use over the perinatal period and oxytocin levels. Data from a pregnancy cohort study are used from 279 women across three groups: women taking antidepressants in pregnancy (n = 48), women with untreated depression (n = 31) and healthy control women (n = 200). Data included antidepressant use, maternal depression and oxytocin plasma concentrations in pregnancy and up to 12 months postpartum. We found that concurrent oxytocin blood concentrations were not associated with perinatal antidepressant use. However, oxytocin blood concentrations increased more steeply in those on antidepressants across the perinatal period compared to control women. A steeper increase for Selective Serotonergic Reuptake Inhibitors was observed, however, this effect was on the boarder of statistical significance. In conclusion, although antidepressant use and oxytocin was not associated at any time point, women taking antidepressants during pregnancy had larger increases in oxytocin over the perinatal period. Future research could examine specific agents and class of antidepressant and the relationship to parenting. •Animal studies have suggested that SSRI antidepressants may be associated with increased oxytocin levels•Oxytocin levels increased for women from early pregnancy to 12 months postpartum•Differences in cross-sectional perinatal oxytocin blood concentrations were not associated with antidepressant use•Antidepressant blood concentrations and oxytocin blood concentrations were not associated•Antidepressants across pregnancy and the postpartum were assocaited with a steeper increase in levels of oxytocin
Maternal social support, depression and emotional availability in early mother-infant interaction: Findings from a pregnancy cohort
- Authors: MacMillan, Kelli , Lewis, Andrew , Watson, Stuart , Bourke, Declan , Galbally, Megan
- Date: 2021
- Type: Text , Journal article
- Relation: Journal of affective disorders Vol. 292, no. (2021), p. 757-765
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- Description: •Maternal depression in pregnancy was not predictive of postpartum maternal emotional availability (EA).•Maternal depression in pregnancy was not associated with perceived social support.•Depressive symptoms negatively predict maternal EA when partner support is low.•Depressive symptoms negatively predict maternal EA when family support is low.•Support from friends is not a moderator between depressive symptoms and maternal EA. Social support theory suggests that parental social support may influence the nature of early parenting behaviours and specifically the mother-infant relationship. This study examines whether support from a partner, friends or family is associated with differences in quality of mother-infant interactions in the context of maternal depression. 210 women were followed from early pregnancy to six months postpartum within Australian pregnancy cohort, the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS). Mother-infant interactions within a standardised observation at six months postpartum were measured by the Emotional Availability (EA) Scales using total scores of the parental scales. In early and late pregnancy and at six months postpartum, mothers rated perceived maternal social support from a partner, family and friends using subscales of the Multidimensional Scale of Perceived Social Support. Depression was measured in early pregnancy and at six months postpartum using the Structured Clinical Interview for the DSM-IV-TR, with repeated measurement of depressive symptoms by the Edinburgh Postnatal Depression Scale (EPDS). Data was analysed using structural equation models. There were significant interactions between depressive symptoms in early pregnancy and perceived maternal support from a partner (B = .18, 95% CI = 03, .31) and separately from family (B = .12, 95% CI = .03, .32) in predicting maternal emotional availability. No such interaction was found for support from friends. While partner and family support moderated the association between early depressive symptoms and emotional availability, there were no direct associations between maternal depressive disorder in early pregnancy and perceived support, and further, maternal depression was not a significant predictor of emotional availability. Future studies should consider extending measurement of the mother-infant relationship beyond the EA Scales, inclusion of a measure of maternal childhood trauma, and replicating our findings. Maternal perception of partner and family support in the postpartum is a predictor of the association between early pregnancy depressive symptoms and maternal emotional availability.
“Bumps in the Road”: A Pilot study of a therapeutic technique for the integration of unresolved family loss and trauma
- Authors: Watts, Gabriella , Lewis, Andrew , Serfaty, Irene
- Date: 2021
- Type: Text , Journal article
- Relation: Frontiers in psychology Vol. 12, no. (2021), p. 635574-635574
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- Description: The ability to sustain a coherent narrative about experiences of trauma and loss is a prominent feature of secure-autonomous attachment states of mind as assessed in narrative tasks such as the Adult Attachment Interview. The current study examines the clinical application of the concepts of narrative coherence and discourse segregation within a therapeutic intervention for whole families. Bumps in the Road is a family drawing task, which aims to facilitate the co-construction of family narratives about adversities such as trauma, loss and hardship. The technique aims to increase the family’s narrative coherence about such challenging events. The paper first presents a description of the task itself together with the discourse theories of defensive processing of adverse events. The study also presents pilot quantitative findings from 19 parents on the psychometric properties of a coding system of the families’ discourses in undertaking the task and the therapist’s techniques in administering the task. The predictive association of coding of the narratives were examined as predictors of change in internalising and externalising symptoms in the referred child, using the Child Behaviour Checklist. Findings showed that therapist competence in administration of the task did significantly predict the magnitude of treatment efficacy. The current study is the first presentation of this novel therapeutic task and sets a platform for further research on the use of narrative tasks and the formal coding of discourse in therapeutic work with children and families.
Parenting stress, maternal depression and child mental health in a Melbourne cohort before and during the COVID-19 pandemic
- Authors: Galbally, Megan , Watson, Stuart , Lewis, Andrew , van Ijzendoorn, Marinus
- Date: 2022
- Type: Text , Journal article
- Relation: Journal of Paediatrics and Child Health Vol. 58, no. 11 (2022), p. 2051-2057
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- Description: Aim: This paper aims to examine the maternal and child mental health and parenting outcomes in the context of COVID-19 pandemic conditions using a sample from Melbourne, Australia – a city exposed to one of the longest lockdowns world-wide in response to the pandemic. Methods: This study utilises observational data from a prospective, pregnancy cohort, Mercy Pregnancy Emotional Wellbeing Study and includes 468 women and their children followed up in Melbourne to 3–4 years postpartum pre-COVID pandemic and compared to those followed up during the COVID-19 pandemic. Results: When compared to mothers followed up at 3–4 years postpartum pre-pandemic, those followed up during the COVID-19 pandemic showed higher depressive symptoms with a steep incline in their symptom trajectory (EMMdifference = 1.72, Bonferroni-corrected P < 0.01, d = 0.35) and had a three times higher risk of scoring 13 or above on the EPDS (aRR = 3.22, Bonferroni-corrected P < 0.01). Although this increase was not associated with the variation in the duration of exposure to pandemic conditions, the steep increase in depressive symptoms was more pronounced in those with pre-existing depressive disorders. There was no difference in parenting stress or adjusted childhood mental health symptoms or disorder. Conclusions: Our findings highlight the vulnerability of those with pre-existing clinical mental health disorders and the need for adequate clinical care for this vulnerable group. Equally, our study indicates the possibility that parenting and early childhood mental health outcomes, at least in the short term, may be resilient. © 2022 The Authors. Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians).