Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling
- Authors: Fernandez Rojo, Manuel , Gongora, Milena , Fitzsimmons, Rebecca L. , Martel, Nick , Martin, Sheree D. , Nixon, Susan , Brooks, Andrew J. , Ikonomopoulou, Maria P. , Martin, Sally , Lo, Harriet P. , Myers, Stephen , Restall, Christina , Ferguson, Charles , Pilch, Paul F. , McGee, Sean , Anderson, Robin L. , Waters, Michael J. , Hancock, John F. , Grimmond, Sean M. , Muscat, George , Parton, Robert G.
- Date: 2013
- Type: Text , Journal article
- Relation: Cell Reports Vol. 4, no. 2 (2013), p. 238-247
- Full Text: false
- Reviewed:
- Description: Highlights • Lipid metabolism is the major cell and tissue process affected by CAV1 • CAV1 is necessary for hepatic PPAR
β-Adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues
- Authors: Myers, Stephen , Eriksson, Natalie , Burow, Rachel , Wang, Mary Shu-Ching , Muscat, George
- Date: 2009
- Type: Text , Journal article
- Relation: Molecular and Cellular Endocrinology Vol. 309, no. 1-2 (2009), p. 101-108
- Full Text: false
- Reviewed:
- Description: The nuclear hormone receptor (NR) 4A subgroup of orphan nuclear receptors includes three members, Nur77 (NR4A1), Nurr1 (NR4A2) and Nor-1 (NR4A3). Previously we have identified the rapid and robust (in vitro and in vivo) induction of the NR4A subgroup following β-adrenergic stimulation in mouse skeletal muscle. This was concomitant with changes in the expression of genes involved in the regulation of nutrient metabolism. We have isolated mouse tissue of cardiovascular, endocrine and gastrointestinal origin at 1, 4, 8 and 24 h after a single intraperitoneal injection of the β-adrenergic agonist, isoprenaline. We similarly identified the significant induction (between 1 and 4 h) of the NR4A genes in many of these tissues. Moreover, we have utilized TaqMan ® Low Density Arrays to determine the β-adrenergic-sensitive metabolic gene expression in liver, white adipose and heart. In summary, cross-talk between β-adrenergic and NR4A signaling occurs in several tissues, and is accompanied by modulation of metabolic gene expression. © 2009 Elsevier Ireland Ltd. All rights reserved.