Defending SDN against packet injection attacks using deep learning
- Phu, Anh, Li, Bo, Ullah, Faheem, Ul Huque, Tanvir, Naha, Ranesh, Babar, Muhammad, Nguyen, Hung
- Authors: Phu, Anh , Li, Bo , Ullah, Faheem , Ul Huque, Tanvir , Naha, Ranesh , Babar, Muhammad , Nguyen, Hung
- Date: 2023
- Type: Text , Journal article
- Relation: Computer Networks Vol. 234, no. (2023), p.
- Full Text:
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- Description: The (logically) centralized architecture of software-defined networks makes them an easy target for packet injection attacks. In these attacks, the attacker injects malicious packets into the SDN network to affect the services and performance of the SDN controller and overflows the capacity of the SDN switches. Such attacks have been shown to ultimately stop the network functioning in real-time, leading to network breakdowns. There have been significant works on detecting and defending against similar DoS attacks in non-SDN networks, but detection and protection techniques for SDN against packet injection attacks are still in their infancy. Furthermore, many of the proposed solutions have been shown to be easily bypassed by simple modifications to the attacking packets or by altering the attacking profile. In this paper, we develop novel Graph Convolutional Neural Network models and algorithms for grouping network nodes/users into security classes by learning from network data. We start with two simple classes — nodes that engage in suspicious packet injection attacks and nodes that are not. From these classes, we then partition the network into separate segments with different security policies using distributed Ryu controllers in an SDN network. We show in experiments on an emulated SDN that our detection solution outperforms alternative approaches with above 99% detection accuracy for various types (both old and new) of injection attacks. More importantly, our mitigation solution maintains continuous functions of non-compromised nodes while isolating compromised/suspicious nodes in real-time. All code and data are publicly available for the reproducibility of our results. © 2023 The Author(s)
- Authors: Phu, Anh , Li, Bo , Ullah, Faheem , Ul Huque, Tanvir , Naha, Ranesh , Babar, Muhammad , Nguyen, Hung
- Date: 2023
- Type: Text , Journal article
- Relation: Computer Networks Vol. 234, no. (2023), p.
- Full Text:
- Reviewed:
- Description: The (logically) centralized architecture of software-defined networks makes them an easy target for packet injection attacks. In these attacks, the attacker injects malicious packets into the SDN network to affect the services and performance of the SDN controller and overflows the capacity of the SDN switches. Such attacks have been shown to ultimately stop the network functioning in real-time, leading to network breakdowns. There have been significant works on detecting and defending against similar DoS attacks in non-SDN networks, but detection and protection techniques for SDN against packet injection attacks are still in their infancy. Furthermore, many of the proposed solutions have been shown to be easily bypassed by simple modifications to the attacking packets or by altering the attacking profile. In this paper, we develop novel Graph Convolutional Neural Network models and algorithms for grouping network nodes/users into security classes by learning from network data. We start with two simple classes — nodes that engage in suspicious packet injection attacks and nodes that are not. From these classes, we then partition the network into separate segments with different security policies using distributed Ryu controllers in an SDN network. We show in experiments on an emulated SDN that our detection solution outperforms alternative approaches with above 99% detection accuracy for various types (both old and new) of injection attacks. More importantly, our mitigation solution maintains continuous functions of non-compromised nodes while isolating compromised/suspicious nodes in real-time. All code and data are publicly available for the reproducibility of our results. © 2023 The Author(s)
Depth-based sampling and steering constraints for memoryless local planners
- Nguyen, Binh, Nguyen, Linh, Choudhury, Tanveer, Keogh, Kathleen, Murshed, Manzur
- Authors: Nguyen, Binh , Nguyen, Linh , Choudhury, Tanveer , Keogh, Kathleen , Murshed, Manzur
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Intelligent and Robotic Systems: Theory and Applications Vol. 109, no. 3 (2023), p.
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- Description: By utilizing only depth information, the paper introduces a novel two-stage planning approach that enhances computational efficiency and planning performances for memoryless local planners. First, a depth-based sampling technique is proposed to identify and eliminate a specific type of in-collision trajectories among sampled candidates. Specifically, all trajectories that have obscured endpoints are found through querying the depth values and will then be excluded from the sampled set, which can significantly reduce the computational workload required in collision checking. Subsequently, we apply a tailored local planning algorithm that employs a direction cost function and a depth-based steering mechanism to prevent the robot from being trapped in local minima. Our planning algorithm is theoretically proven to be complete in convex obstacle scenarios. To validate the effectiveness of our DEpth-based both Sampling and Steering (DESS) approaches, we conducted experiments in simulated environments where a quadrotor flew through cluttered regions with multiple various-sized obstacles. The experimental results show that DESS significantly reduces computation time in local planning compared to the uniform sampling method, resulting in the planned trajectory with a lower minimized cost. More importantly, our success rates for navigation to different destinations in testing scenarios are improved considerably compared to the fixed-yawing approach. © 2023, The Author(s).
- Authors: Nguyen, Binh , Nguyen, Linh , Choudhury, Tanveer , Keogh, Kathleen , Murshed, Manzur
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Intelligent and Robotic Systems: Theory and Applications Vol. 109, no. 3 (2023), p.
- Full Text:
- Reviewed:
- Description: By utilizing only depth information, the paper introduces a novel two-stage planning approach that enhances computational efficiency and planning performances for memoryless local planners. First, a depth-based sampling technique is proposed to identify and eliminate a specific type of in-collision trajectories among sampled candidates. Specifically, all trajectories that have obscured endpoints are found through querying the depth values and will then be excluded from the sampled set, which can significantly reduce the computational workload required in collision checking. Subsequently, we apply a tailored local planning algorithm that employs a direction cost function and a depth-based steering mechanism to prevent the robot from being trapped in local minima. Our planning algorithm is theoretically proven to be complete in convex obstacle scenarios. To validate the effectiveness of our DEpth-based both Sampling and Steering (DESS) approaches, we conducted experiments in simulated environments where a quadrotor flew through cluttered regions with multiple various-sized obstacles. The experimental results show that DESS significantly reduces computation time in local planning compared to the uniform sampling method, resulting in the planned trajectory with a lower minimized cost. More importantly, our success rates for navigation to different destinations in testing scenarios are improved considerably compared to the fixed-yawing approach. © 2023, The Author(s).
Determination of munsell soil colour using smartphones
- Nodi, Sadia, Paul, Manoranjan, Robinson, Nathan, Wang, Liang, Rehman, Sabih
- Authors: Nodi, Sadia , Paul, Manoranjan , Robinson, Nathan , Wang, Liang , Rehman, Sabih
- Date: 2023
- Type: Text , Journal article
- Relation: Sensors Vol. 23, no. 6 (2023), p.
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- Description: Soil colour is one of the most important factors in agriculture for monitoring soil health and determining its properties. For this purpose, Munsell soil colour charts are widely used by archaeologists, scientists, and farmers. The process of determining soil colour from the chart is subjective and error-prone. In this study, we used popular smartphones to capture soil colours from images in the Munsell Soil Colour Book (MSCB) to determine the colour digitally. These captured soil colours are then compared with the true colour determined using a commonly used sensor (Nix Pro-2). We have observed that there are colour reading discrepancies between smartphone and Nix Pro-provided readings. To address this issue, we investigated different colour models and finally introduced a colour-intensity relationship between the images captured by Nix Pro and smartphones by exploring different distance functions. Thus, the aim of this study is to determine the Munsell soil colour accurately from the MSCB by adjusting the pixel intensity of the smartphone-captured images. Without any adjustment when the accuracy of individual Munsell soil colour determination is only (Formula presented.) for the top 5 predictions, the accuracy of the proposed method is (Formula presented.), which is significant. © 2023 by the authors.
- Authors: Nodi, Sadia , Paul, Manoranjan , Robinson, Nathan , Wang, Liang , Rehman, Sabih
- Date: 2023
- Type: Text , Journal article
- Relation: Sensors Vol. 23, no. 6 (2023), p.
- Full Text:
- Reviewed:
- Description: Soil colour is one of the most important factors in agriculture for monitoring soil health and determining its properties. For this purpose, Munsell soil colour charts are widely used by archaeologists, scientists, and farmers. The process of determining soil colour from the chart is subjective and error-prone. In this study, we used popular smartphones to capture soil colours from images in the Munsell Soil Colour Book (MSCB) to determine the colour digitally. These captured soil colours are then compared with the true colour determined using a commonly used sensor (Nix Pro-2). We have observed that there are colour reading discrepancies between smartphone and Nix Pro-provided readings. To address this issue, we investigated different colour models and finally introduced a colour-intensity relationship between the images captured by Nix Pro and smartphones by exploring different distance functions. Thus, the aim of this study is to determine the Munsell soil colour accurately from the MSCB by adjusting the pixel intensity of the smartphone-captured images. Without any adjustment when the accuracy of individual Munsell soil colour determination is only (Formula presented.) for the top 5 predictions, the accuracy of the proposed method is (Formula presented.), which is significant. © 2023 by the authors.
Developing entrustable professional activities to enhance application of an aggression prevention protocol
- Maguire, Tessa, Willetts, Georgina, McKenna, Brian, Daffern, Michael, Garvey, Loretta
- Authors: Maguire, Tessa , Willetts, Georgina , McKenna, Brian , Daffern, Michael , Garvey, Loretta
- Date: 2023
- Type: Text , Journal article
- Relation: Nurse Education in Practice Vol. 73, no. (2023), p.
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- Reviewed:
- Description: Aim: The research aim of this study was to seek feedback from prevention of aggression training experts about the suitability of Entrustable Professional Activities (EPAs) as an assessment tool for an Aggression Prevention Protocol. The protocol was designed to structure intervention to prevent aggression and reduce the use of restrictive practices following risk assessment using a validated instrument (the Dynamic Appraisal of Situational Aggression). Background: Preventing aggression and limiting the use of restrictive practices are key priorities for inpatient mental health services. Assessing clinical activities using a competence framework has limitations, particularly when determining complex interventions. EPAs could provide a suitable method for assessing complex clinical activities like de-escalation and limit setting, which comprise some of the interventions in the Aggression Prevention Protocol. EPAs are new to forensic mental health nursing; therefore, feedback was sought regarding the utility of EPAs to assess aggression prevention interventions. Methods: Data were collected via focus groups including 11 aggression prevention experts from Australia and New Zealand. A thematic analysis, comparative analysis and a Strength, Weakness, Opportunity and Threats analysis was conducted. Results: Three themes were interpreted from the data: 1) Frameworks such as the APP are needed to work towards elimination of restrictive practices; 2) APP-EPAs afford an opportunity to set the standard for practice; and 3) ‘who watches the watchers’, were identified by the experts as well as areas to enhance EPAs prior to introduction into practice. Conclusions: EPAs address a practice-gap and offer a framework to assist movement towards elimination of restrictive practices, while prompting best-practice, self-reflection and practice improvement guidance. © 2023
- Authors: Maguire, Tessa , Willetts, Georgina , McKenna, Brian , Daffern, Michael , Garvey, Loretta
- Date: 2023
- Type: Text , Journal article
- Relation: Nurse Education in Practice Vol. 73, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Aim: The research aim of this study was to seek feedback from prevention of aggression training experts about the suitability of Entrustable Professional Activities (EPAs) as an assessment tool for an Aggression Prevention Protocol. The protocol was designed to structure intervention to prevent aggression and reduce the use of restrictive practices following risk assessment using a validated instrument (the Dynamic Appraisal of Situational Aggression). Background: Preventing aggression and limiting the use of restrictive practices are key priorities for inpatient mental health services. Assessing clinical activities using a competence framework has limitations, particularly when determining complex interventions. EPAs could provide a suitable method for assessing complex clinical activities like de-escalation and limit setting, which comprise some of the interventions in the Aggression Prevention Protocol. EPAs are new to forensic mental health nursing; therefore, feedback was sought regarding the utility of EPAs to assess aggression prevention interventions. Methods: Data were collected via focus groups including 11 aggression prevention experts from Australia and New Zealand. A thematic analysis, comparative analysis and a Strength, Weakness, Opportunity and Threats analysis was conducted. Results: Three themes were interpreted from the data: 1) Frameworks such as the APP are needed to work towards elimination of restrictive practices; 2) APP-EPAs afford an opportunity to set the standard for practice; and 3) ‘who watches the watchers’, were identified by the experts as well as areas to enhance EPAs prior to introduction into practice. Conclusions: EPAs address a practice-gap and offer a framework to assist movement towards elimination of restrictive practices, while prompting best-practice, self-reflection and practice improvement guidance. © 2023
Developing rights-based standards for children having tests, treatments, examinations and interventions: using a collaborative, multi-phased, multi-method and multi-stakeholder approach to build consensus
- Bray, Lucy, Carter, Bernie, Kiernan, Joann, Horowicz, Ed, Dixon, Katie, Ridley, James, Robinson, Carol, Simmons, Anna, Craske, Jennie, Sinha, Stephanie, Morton, Liza, Nafria, Begonya, Forsner, Maria, Rullander, Anna-Clara, Nilsson, Stefan, Darcy, Laura, Karlsson, Katarina, Hubbuck, Cath, Brenner, Maria, Spencer-Little, Sian, Evans, Kath, Rowland, Andrew, Hilliard, Carol, Preston, Jennifer, Leroy, Piet, Roland, Damian, Booth, Lisa, Davies, Jean, Saron, Holly, Peck, Blake
- Authors: Bray, Lucy , Carter, Bernie , Kiernan, Joann , Horowicz, Ed , Dixon, Katie , Ridley, James , Robinson, Carol , Simmons, Anna , Craske, Jennie , Sinha, Stephanie , Morton, Liza , Nafria, Begonya , Forsner, Maria , Rullander, Anna-Clara , Nilsson, Stefan , Darcy, Laura , Karlsson, Katarina , Hubbuck, Cath , Brenner, Maria , Spencer-Little, Sian , Evans, Kath , Rowland, Andrew , Hilliard, Carol , Preston, Jennifer , Leroy, Piet , Roland, Damian , Booth, Lisa , Davies, Jean , Saron, Holly , Peck, Blake
- Date: 2023
- Type: Text , Journal article
- Relation: European Journal of Pediatrics Vol. 182, no. 10 (2023), p. 4707-4721
- Full Text:
- Reviewed:
- Description: Children continue to experience harm when undergoing clinical procedures despite increased evidence of the need to improve the provision of child-centred care. The international ISupport collaboration aimed to develop standards to outline and explain good procedural practice and the rights of children within the context of a clinical procedure. The rights-based standards for children undergoing tests, treatments, investigations, examinations and interventions were developed using an iterative, multi-phased, multi-method and multi-stakeholder consensus building approach. This consensus approach used a range of online and face to face methods across three phases to ensure ongoing engagement with multiple stakeholders. The views and perspectives of 203 children and young people, 78 parents and 418 multi-disciplinary professionals gathered over a two year period (2020–2022) informed the development of international rights-based standards for the care of children having tests, treatments, examinations and interventions. The standards are the first to reach international multi-stakeholder consensus on definitions of supportive and restraining holds. Conclusion: This is the first study of its kind which outlines international rights-based procedural care standards from multi-stakeholder perspectives. The standards offer health professionals and educators clear evidence-based tools to support discussions and practice changes to challenge prevailing assumptions about holding or restraining children and instead encourage a focus on the interests and rights of the child. What is Known: • Children continue to experience short and long-term harm when undergoing clinical procedures despite increased evidence of the need to improve the provision of child-centred care. • Professionals report uncertainty and tensions in applying evidence-based practice to children’s procedural care. What is New: • This is the first study of its kind which has developed international rights-based procedural care standards from multi-stakeholder perspectives. • The standards are the first to reach international multi-stakeholder consensus on definitions of supportive and restraining holds. © 2023, The Author(s). **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliate “Blake Peck” is provided in this record**
- Authors: Bray, Lucy , Carter, Bernie , Kiernan, Joann , Horowicz, Ed , Dixon, Katie , Ridley, James , Robinson, Carol , Simmons, Anna , Craske, Jennie , Sinha, Stephanie , Morton, Liza , Nafria, Begonya , Forsner, Maria , Rullander, Anna-Clara , Nilsson, Stefan , Darcy, Laura , Karlsson, Katarina , Hubbuck, Cath , Brenner, Maria , Spencer-Little, Sian , Evans, Kath , Rowland, Andrew , Hilliard, Carol , Preston, Jennifer , Leroy, Piet , Roland, Damian , Booth, Lisa , Davies, Jean , Saron, Holly , Peck, Blake
- Date: 2023
- Type: Text , Journal article
- Relation: European Journal of Pediatrics Vol. 182, no. 10 (2023), p. 4707-4721
- Full Text:
- Reviewed:
- Description: Children continue to experience harm when undergoing clinical procedures despite increased evidence of the need to improve the provision of child-centred care. The international ISupport collaboration aimed to develop standards to outline and explain good procedural practice and the rights of children within the context of a clinical procedure. The rights-based standards for children undergoing tests, treatments, investigations, examinations and interventions were developed using an iterative, multi-phased, multi-method and multi-stakeholder consensus building approach. This consensus approach used a range of online and face to face methods across three phases to ensure ongoing engagement with multiple stakeholders. The views and perspectives of 203 children and young people, 78 parents and 418 multi-disciplinary professionals gathered over a two year period (2020–2022) informed the development of international rights-based standards for the care of children having tests, treatments, examinations and interventions. The standards are the first to reach international multi-stakeholder consensus on definitions of supportive and restraining holds. Conclusion: This is the first study of its kind which outlines international rights-based procedural care standards from multi-stakeholder perspectives. The standards offer health professionals and educators clear evidence-based tools to support discussions and practice changes to challenge prevailing assumptions about holding or restraining children and instead encourage a focus on the interests and rights of the child. What is Known: • Children continue to experience short and long-term harm when undergoing clinical procedures despite increased evidence of the need to improve the provision of child-centred care. • Professionals report uncertainty and tensions in applying evidence-based practice to children’s procedural care. What is New: • This is the first study of its kind which has developed international rights-based procedural care standards from multi-stakeholder perspectives. • The standards are the first to reach international multi-stakeholder consensus on definitions of supportive and restraining holds. © 2023, The Author(s). **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliate “Blake Peck” is provided in this record**
Development of a long-term climatology of tropical 1 cyclones and depressions for the South Pacific 2 Ocean basin
- Authors: Yeasmin, Alea
- Date: 2023
- Type: Text , Thesis , PhD
- Full Text:
- Description: Tropical cyclones (TCs) are one of the most destructive synoptic systems that can cause enormous loss of life and property damages in the South Pacific Island nations. The impact of tropical depressions (TDs, i.e., weaker systems that do not develop into TCs) can also be staggering in the region in terms of heavy flooding and landslides, but a lack of complete records (reliable data prior to 1950) often hinders research involving TD impacts. A methodology has been developed here to detect TDs in the ERA-5 (the fifth generation European Centre for Medium-Range Weather Forecasts-ECMWF atmospheric reanalysis of the global climate) and 20CR (the Twentieth Century Reanalysis) dataset using the Okubo–Weiss–Zeta parameter (OWZP) detection scheme. The new South Pacific Enhanced Archive for Tropical Cyclones dataset (SPEArTC), the Dvorak analysis of satellite-based cloud patterns over the South Pacific Ocean basin, rainfall dataset for various stations in the South Pacific and historical archives have been utilised to validate ERA5/20CR-derived TCs and TDs. Results indicate that the OWZP method shows substantial skill in capturing the realistic climatological distribution of TCs and TDs for the South Pacific Ocean in both reanalyses dataset. The 20CR-derived TCs and TDs resemble several key characteristics of the observational records, including spatial distribution of genesis locations and track shapes. This gives us confidence that the 20CR-derived long-term records of TCs and TDs can serve as an effective tool for examining historical changes in various characteristics of TCs and TDs, particularly in the context of anthropogenic climate change. Utilizing the reconstructed proxies of TCs and TDs, their climatic connections with the El Niño Southern Oscillation (ENSO), the Interdecadal Pacific Oscillation (IPO), and the combined ENSO-IPO phases have been examined. Results show clear spatial shifts in TC activity between La Niña and El Niño phases with activity in the region 1400-1700E (1700-2200E) occurring during La Niña (El Niño) events. However, when IPO is considered synergistically with ENSO phases, we found that the combination of El Niño and the positive phase of IPO (+IPO) substantially enhances TC numbers (may be artifact influence) in both domains, noting the modulation between the two phases themselves. Similarly, La Niña and the negative phase of the IPO (-IPO) is found to enhance TC numbers in 1400-1700E. It is shown for the first time that the combined phases of El Niño and +IPO account for increased TC activity, as opposed to the combined phase of La Niña and -IPO, in the eastern sub-region. Similarly, the combined phase of La Niña and +IPO, as opposed to the combined phase of El Niño and -IPO, account for increased TC activity in the western sub-region. However, unlike TCs, the patterns of ENSO variability seem to be reversed for TDs. Changes in large-scale environmental conditions, such as environmental vertical wind shear, low-level cyclonic relative vorticity, mid-tropospheric relative humidity and sea surface temperature are linked to the various modes of variability patterns and their synergistic relationships. Results can have substantial implications, particularly on the predictability of TCs and TDs associated with the two important modes of natural variability in the South Pacific.
- Description: Doctor of Philosophy
- Authors: Yeasmin, Alea
- Date: 2023
- Type: Text , Thesis , PhD
- Full Text:
- Description: Tropical cyclones (TCs) are one of the most destructive synoptic systems that can cause enormous loss of life and property damages in the South Pacific Island nations. The impact of tropical depressions (TDs, i.e., weaker systems that do not develop into TCs) can also be staggering in the region in terms of heavy flooding and landslides, but a lack of complete records (reliable data prior to 1950) often hinders research involving TD impacts. A methodology has been developed here to detect TDs in the ERA-5 (the fifth generation European Centre for Medium-Range Weather Forecasts-ECMWF atmospheric reanalysis of the global climate) and 20CR (the Twentieth Century Reanalysis) dataset using the Okubo–Weiss–Zeta parameter (OWZP) detection scheme. The new South Pacific Enhanced Archive for Tropical Cyclones dataset (SPEArTC), the Dvorak analysis of satellite-based cloud patterns over the South Pacific Ocean basin, rainfall dataset for various stations in the South Pacific and historical archives have been utilised to validate ERA5/20CR-derived TCs and TDs. Results indicate that the OWZP method shows substantial skill in capturing the realistic climatological distribution of TCs and TDs for the South Pacific Ocean in both reanalyses dataset. The 20CR-derived TCs and TDs resemble several key characteristics of the observational records, including spatial distribution of genesis locations and track shapes. This gives us confidence that the 20CR-derived long-term records of TCs and TDs can serve as an effective tool for examining historical changes in various characteristics of TCs and TDs, particularly in the context of anthropogenic climate change. Utilizing the reconstructed proxies of TCs and TDs, their climatic connections with the El Niño Southern Oscillation (ENSO), the Interdecadal Pacific Oscillation (IPO), and the combined ENSO-IPO phases have been examined. Results show clear spatial shifts in TC activity between La Niña and El Niño phases with activity in the region 1400-1700E (1700-2200E) occurring during La Niña (El Niño) events. However, when IPO is considered synergistically with ENSO phases, we found that the combination of El Niño and the positive phase of IPO (+IPO) substantially enhances TC numbers (may be artifact influence) in both domains, noting the modulation between the two phases themselves. Similarly, La Niña and the negative phase of the IPO (-IPO) is found to enhance TC numbers in 1400-1700E. It is shown for the first time that the combined phases of El Niño and +IPO account for increased TC activity, as opposed to the combined phase of La Niña and -IPO, in the eastern sub-region. Similarly, the combined phase of La Niña and +IPO, as opposed to the combined phase of El Niño and -IPO, account for increased TC activity in the western sub-region. However, unlike TCs, the patterns of ENSO variability seem to be reversed for TDs. Changes in large-scale environmental conditions, such as environmental vertical wind shear, low-level cyclonic relative vorticity, mid-tropospheric relative humidity and sea surface temperature are linked to the various modes of variability patterns and their synergistic relationships. Results can have substantial implications, particularly on the predictability of TCs and TDs associated with the two important modes of natural variability in the South Pacific.
- Description: Doctor of Philosophy
Device agent assisted blockchain leveraged framework for Internet of Things
- Nasrullah, Tarique, Islam, Md Manowarul, Uddin, Md Ashraf, Khan, Md Anisauzzaman, Layek, Md Abu, Stranieri, Andrew, Huh, Eui-Nam
- Authors: Nasrullah, Tarique , Islam, Md Manowarul , Uddin, Md Ashraf , Khan, Md Anisauzzaman , Layek, Md Abu , Stranieri, Andrew , Huh, Eui-Nam
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Access Vol. 11, no. (2023), p. 1254-1268
- Full Text:
- Reviewed:
- Description: Blockchain (BC) is a burgeoning technology that has emerged as a promising solution to peer-to-peer communication security and privacy challenges. As a revolutionary technology, blockchain has drawn the attention of academics and researchers. Cryptocurrencies have already effectively utilized BC technology. Many researchers have sought to implement this technique in different sectors, including the Internet of Things. To store and manage IoT data, we present in this paper a lightweight BC-based architecture with a modified raft algorithm-based consensus protocol. We designed a Device Agent that executes a novel registration procedure to connect IoT devices to the blockchain. We implemented the framework on Docker using the Go programming language. We have simulated the framework on a Linux environment hosted in the cloud. We have conducted a detailed performance analysis using a variety of measures. The results demonstrate that our suggested solution is suitable for facilitating the management of IoT data with increased security and privacy. In terms of throughput and block generation time, the results indicate that our solution might be 40% to 45% faster than the existing blockchain. © 2013 IEEE.
- Authors: Nasrullah, Tarique , Islam, Md Manowarul , Uddin, Md Ashraf , Khan, Md Anisauzzaman , Layek, Md Abu , Stranieri, Andrew , Huh, Eui-Nam
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Access Vol. 11, no. (2023), p. 1254-1268
- Full Text:
- Reviewed:
- Description: Blockchain (BC) is a burgeoning technology that has emerged as a promising solution to peer-to-peer communication security and privacy challenges. As a revolutionary technology, blockchain has drawn the attention of academics and researchers. Cryptocurrencies have already effectively utilized BC technology. Many researchers have sought to implement this technique in different sectors, including the Internet of Things. To store and manage IoT data, we present in this paper a lightweight BC-based architecture with a modified raft algorithm-based consensus protocol. We designed a Device Agent that executes a novel registration procedure to connect IoT devices to the blockchain. We implemented the framework on Docker using the Go programming language. We have simulated the framework on a Linux environment hosted in the cloud. We have conducted a detailed performance analysis using a variety of measures. The results demonstrate that our suggested solution is suitable for facilitating the management of IoT data with increased security and privacy. In terms of throughput and block generation time, the results indicate that our solution might be 40% to 45% faster than the existing blockchain. © 2013 IEEE.
Dexamethasone leads to Zn2+ accumulation and increased unbound Zn2+ in C2C12 muscle and 3T3-L1 adipose cells
- Maier, Michelle, Nankervis, Scott, Wallace, Morgan, Develyn, Tamekha, Myers, Mark
- Authors: Maier, Michelle , Nankervis, Scott , Wallace, Morgan , Develyn, Tamekha , Myers, Mark
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Cellular Biochemistry Vol. 124, no. 3 (2023), p. 409-420
- Full Text:
- Reviewed:
- Description: Skeletal muscle atrophy is associated with increases in circulating glucocorticoid levels and insulin resistance. Zinc accumulates in atrophic muscle, but the relationship between atrophy, insulin resistance, and Zn2+ homeostasis remains unclear. In this study, the effect of the glucocorticoid dexamethasone (DEX) on insulin and Zn2+ homeostasis was explored. Treatment of differentiated C2C12 skeletal myotubes and 3T3-L1 adipocytes with DEX significantly increased mRNA expression of the metal-binding proteins Mt1 and 2 and altered energy storage as shown by the increased size of lipid droplets in 3T3-L1 cells. In C2C12 cells the total cellular Zn2+ was higher after DEX treatment, and in both C2C12 and 3T3-L1 adipocytes, free unbound Zn2+ was increased. Insulin treatment led to a gradual increase in free Zn2+ in C2C12 cells, and no significant change in DEX-treated cells such that concentrations were similar 10 min after insulin treatment. These data demonstrate that DEX disturbs Zn2+ homeostasis in muscle and fat cells. Further study of the molecular pathways involved to identify novel therapeutic targets for treatment of skeletal muscle atrophy is warranted. © 2023 The Authors. Journal of Cellular Biochemistry published by Wiley Periodicals LLC.
- Authors: Maier, Michelle , Nankervis, Scott , Wallace, Morgan , Develyn, Tamekha , Myers, Mark
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Cellular Biochemistry Vol. 124, no. 3 (2023), p. 409-420
- Full Text:
- Reviewed:
- Description: Skeletal muscle atrophy is associated with increases in circulating glucocorticoid levels and insulin resistance. Zinc accumulates in atrophic muscle, but the relationship between atrophy, insulin resistance, and Zn2+ homeostasis remains unclear. In this study, the effect of the glucocorticoid dexamethasone (DEX) on insulin and Zn2+ homeostasis was explored. Treatment of differentiated C2C12 skeletal myotubes and 3T3-L1 adipocytes with DEX significantly increased mRNA expression of the metal-binding proteins Mt1 and 2 and altered energy storage as shown by the increased size of lipid droplets in 3T3-L1 cells. In C2C12 cells the total cellular Zn2+ was higher after DEX treatment, and in both C2C12 and 3T3-L1 adipocytes, free unbound Zn2+ was increased. Insulin treatment led to a gradual increase in free Zn2+ in C2C12 cells, and no significant change in DEX-treated cells such that concentrations were similar 10 min after insulin treatment. These data demonstrate that DEX disturbs Zn2+ homeostasis in muscle and fat cells. Further study of the molecular pathways involved to identify novel therapeutic targets for treatment of skeletal muscle atrophy is warranted. © 2023 The Authors. Journal of Cellular Biochemistry published by Wiley Periodicals LLC.
Differences between DSM-5-TR and ICD-11 revisions of attention deficit/hyperactivity disorder : a commentary on implications and opportunities
- Gomez, Rapson, Chen, Wai, Houghton, Stephen
- Authors: Gomez, Rapson , Chen, Wai , Houghton, Stephen
- Date: 2023
- Type: Text , Journal article
- Relation: World J Psychiatry Vol. 13, no. 5 (2023), p. 138-143
- Full Text:
- Reviewed:
- Description: Current ICD-11 descriptions for attention deficit hyperactivity disorder (ADHD) were recently published online, in the same year as the DSM-5-TR (text revised edition) was released. In this commentary, we compare and contrast the DSM-5/DSM-5-TR and ICD-11 diagnostic criteria, summarize important differences, and underscore their clinical and research implications. Overall, three major differences emerge: (1) The number of diagnostic criteria for inattention (IA), hyperactivity (HY) and impulsivity (IM) symptoms ( , DSM-5-TR has nine IA and nine HY/IM symptoms, whereas ICD-11 has 11 IA and 11 HY/IM sym-ptoms) (2) the clarity and standardization of diagnostic thresholds ( , the diagnostic thresholds for symptom count in IA and HY/IM domains are explicitly specified in DSM-5-TR, whereas in ICD-11 they are not) and (3) the partitioning of HY and IM symptoms into sub-dimensions ( , difference in partitioning HY and IM symptom domains relates to the differences between the current and previous editions of DSM and ICD, and this has important research implications). Currently, no ICD-11 based ADHD rating scales exist and while this absence represents an obstacle for respective research and clinical practice, it also presents opportunities for research development. This article highlights these challenges, possible remedies and novel research opportunities.
- Authors: Gomez, Rapson , Chen, Wai , Houghton, Stephen
- Date: 2023
- Type: Text , Journal article
- Relation: World J Psychiatry Vol. 13, no. 5 (2023), p. 138-143
- Full Text:
- Reviewed:
- Description: Current ICD-11 descriptions for attention deficit hyperactivity disorder (ADHD) were recently published online, in the same year as the DSM-5-TR (text revised edition) was released. In this commentary, we compare and contrast the DSM-5/DSM-5-TR and ICD-11 diagnostic criteria, summarize important differences, and underscore their clinical and research implications. Overall, three major differences emerge: (1) The number of diagnostic criteria for inattention (IA), hyperactivity (HY) and impulsivity (IM) symptoms ( , DSM-5-TR has nine IA and nine HY/IM symptoms, whereas ICD-11 has 11 IA and 11 HY/IM sym-ptoms) (2) the clarity and standardization of diagnostic thresholds ( , the diagnostic thresholds for symptom count in IA and HY/IM domains are explicitly specified in DSM-5-TR, whereas in ICD-11 they are not) and (3) the partitioning of HY and IM symptoms into sub-dimensions ( , difference in partitioning HY and IM symptom domains relates to the differences between the current and previous editions of DSM and ICD, and this has important research implications). Currently, no ICD-11 based ADHD rating scales exist and while this absence represents an obstacle for respective research and clinical practice, it also presents opportunities for research development. This article highlights these challenges, possible remedies and novel research opportunities.
Digital twin for risk and uncertainty analysis in complex industrial control and automation systems using artificial intelligence and machine learning
- Authors: Siddiqui, Muhammad
- Date: 2023
- Type: Text , Thesis , Masters
- Full Text:
- Description: Industrial control systems play a crucial role in enabling advanced manufacturing operations. However, these systems are inherently susceptible to failure. Detecting faults at an early stage is of paramount importance, as it can prevent the occurrence of fatal and catastrophic consequences resulting from equipment failures. Moreover, timely detection and resolution of faults can save significant costs and time for organizations. The failure of these systems not only poses risks to operators but can also lead to substantial delays in the advanced manufacturing process, imposing substantial financial burdens on organizations. Therefore, a methodology is needed that can be used to avoid the adverse effects of equipment failure of industrial control systems to achieve smooth advanced manufacturing operations. To achieve this, the methodology should be able to detect the abnormal behaviour of the system at very early stages for predictive maintenance. This methodology can be designed using an extremely popular concept known as the Digital Twin, which has gained significant importance in the era of Industry 4.0. In this research, artificial intelligence techniques will be employed to develop a highly accurate and detailed digital twin model. This model will serve as a valuable tool for predictive maintenance in complex industrial control systems, facilitating the achievement of smooth and uninterrupted advanced manufacturing processes. Also, the performance of the proposed Digital Twin model will be compared with state-of-the-art anomaly detection approaches. The digital twin, utilizing the proposed algorithms, will not only be able to detect anomalies but also quantify their severity, classifying them into different levels such as minor, severe, and faulty operations. Furthermore, the research addresses the generalization challenges faced by state-of-the-art approaches, showcasing the digital twin's ability to effectively classify unseen data as healthy or anomalous. The results obtained from the analysis and comparison of state-of-the-art approaches with the proposed algorithms clearly demonstrate the methodology's capability to detect anomalies, quantify their level, and classify them accurately and effectively in real-world data. This validation underscores the robustness and reliability of the developed methodology, further solidifying its potential as a valuable tool for predictive maintenance in complex industrial control systems.
- Description: Masters by Research
- Authors: Siddiqui, Muhammad
- Date: 2023
- Type: Text , Thesis , Masters
- Full Text:
- Description: Industrial control systems play a crucial role in enabling advanced manufacturing operations. However, these systems are inherently susceptible to failure. Detecting faults at an early stage is of paramount importance, as it can prevent the occurrence of fatal and catastrophic consequences resulting from equipment failures. Moreover, timely detection and resolution of faults can save significant costs and time for organizations. The failure of these systems not only poses risks to operators but can also lead to substantial delays in the advanced manufacturing process, imposing substantial financial burdens on organizations. Therefore, a methodology is needed that can be used to avoid the adverse effects of equipment failure of industrial control systems to achieve smooth advanced manufacturing operations. To achieve this, the methodology should be able to detect the abnormal behaviour of the system at very early stages for predictive maintenance. This methodology can be designed using an extremely popular concept known as the Digital Twin, which has gained significant importance in the era of Industry 4.0. In this research, artificial intelligence techniques will be employed to develop a highly accurate and detailed digital twin model. This model will serve as a valuable tool for predictive maintenance in complex industrial control systems, facilitating the achievement of smooth and uninterrupted advanced manufacturing processes. Also, the performance of the proposed Digital Twin model will be compared with state-of-the-art anomaly detection approaches. The digital twin, utilizing the proposed algorithms, will not only be able to detect anomalies but also quantify their severity, classifying them into different levels such as minor, severe, and faulty operations. Furthermore, the research addresses the generalization challenges faced by state-of-the-art approaches, showcasing the digital twin's ability to effectively classify unseen data as healthy or anomalous. The results obtained from the analysis and comparison of state-of-the-art approaches with the proposed algorithms clearly demonstrate the methodology's capability to detect anomalies, quantify their level, and classify them accurately and effectively in real-world data. This validation underscores the robustness and reliability of the developed methodology, further solidifying its potential as a valuable tool for predictive maintenance in complex industrial control systems.
- Description: Masters by Research
Discriminative ability of lower limb strength and power measures in lacrosse athletes
- Talpey, Scott, Axtell, Robert, Gardner, Elizabeth, Maloney, Maggie, Newman, Thomas, Cordone, Jason, O'Grady, Mathew
- Authors: Talpey, Scott , Axtell, Robert , Gardner, Elizabeth , Maloney, Maggie , Newman, Thomas , Cordone, Jason , O'Grady, Mathew
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Sports Medicine Vol. 44, no. 1 (2023), p. 29-37
- Full Text:
- Reviewed:
- Description: The objective of this investigation was to compare isokinetic strength, countermovement jump and drop jump variables between high-contributors and low-contributors within NCAA Division I Men's and Women's lacrosse athletes. Men's (N=36) and Women's (N=30) NCAA Division I lacrosse athletes completed strength testing of the quadriceps and hamstring across three speeds (60°·s -1, 180°·s -1, 300°·s -1), countermovement and drop jumps. To determine the discriminative ability of select lower-limb strength and power characteristics participants were categorized as high-contributors (Males N=18, age=20.3±0.4 yrs, height=183.9±5.5 cm, mass=90.8±5.8 kg; Females N=15, age=20.8±0.8 yrs, height=169.3±6.7 cm, mass=64.1±7.2 kg) or low-contributors (Males N=18, age=19.5±0.2 yrs, height=184.1±5.6 cm; mass=87.9±8.1 kg; Females N=15, age=19.7±0.2 yrs, height=169.8±7.0 cm, mass=62.9±7.7 kg) based upon the number of games the participants competed in during the regular season. Within the male cohort, moderate significant (p<0.05) differences were observed between high-contributors and low-contributors in isokinetic hamstring strength of the left leg at 300°·s -1(d=0.69) and peak power in countermovement jump (d= 0.68). Within the women's cohort a large (d= 0.87) significant difference (p<0.05) in isokinetic strength of the left hamstring was observed between high-contributors and low-contributors at 60°·s -1. Hamstring strength and lower-limb power are important strength measures for lacrosse performance and should be prioritized in training prescription for lacrosse athletes. © 2023 Georg Thieme Verlag. All rights reserved.
- Authors: Talpey, Scott , Axtell, Robert , Gardner, Elizabeth , Maloney, Maggie , Newman, Thomas , Cordone, Jason , O'Grady, Mathew
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Sports Medicine Vol. 44, no. 1 (2023), p. 29-37
- Full Text:
- Reviewed:
- Description: The objective of this investigation was to compare isokinetic strength, countermovement jump and drop jump variables between high-contributors and low-contributors within NCAA Division I Men's and Women's lacrosse athletes. Men's (N=36) and Women's (N=30) NCAA Division I lacrosse athletes completed strength testing of the quadriceps and hamstring across three speeds (60°·s -1, 180°·s -1, 300°·s -1), countermovement and drop jumps. To determine the discriminative ability of select lower-limb strength and power characteristics participants were categorized as high-contributors (Males N=18, age=20.3±0.4 yrs, height=183.9±5.5 cm, mass=90.8±5.8 kg; Females N=15, age=20.8±0.8 yrs, height=169.3±6.7 cm, mass=64.1±7.2 kg) or low-contributors (Males N=18, age=19.5±0.2 yrs, height=184.1±5.6 cm; mass=87.9±8.1 kg; Females N=15, age=19.7±0.2 yrs, height=169.8±7.0 cm, mass=62.9±7.7 kg) based upon the number of games the participants competed in during the regular season. Within the male cohort, moderate significant (p<0.05) differences were observed between high-contributors and low-contributors in isokinetic hamstring strength of the left leg at 300°·s -1(d=0.69) and peak power in countermovement jump (d= 0.68). Within the women's cohort a large (d= 0.87) significant difference (p<0.05) in isokinetic strength of the left hamstring was observed between high-contributors and low-contributors at 60°·s -1. Hamstring strength and lower-limb power are important strength measures for lacrosse performance and should be prioritized in training prescription for lacrosse athletes. © 2023 Georg Thieme Verlag. All rights reserved.
Discussion : effects of plastic waste materials on geotechnical properties of clayey soil [doi: 10.1007/s40515-020-00145-4]
- O’Kelly, Brendan, Soltani, Amin
- Authors: O’Kelly, Brendan , Soltani, Amin
- Date: 2023
- Type: Text , Journal article
- Relation: Transportation Infrastructure Geotechnology Vol. 10, no. 2 (2023), p. 359-362
- Full Text:
- Reviewed:
- Authors: O’Kelly, Brendan , Soltani, Amin
- Date: 2023
- Type: Text , Journal article
- Relation: Transportation Infrastructure Geotechnology Vol. 10, no. 2 (2023), p. 359-362
- Full Text:
- Reviewed:
Disordered social media use during COVID-19 predicts perceived stress and depression through indirect effects via fear of COVID-19
- Tillman, Gabriel, March, Evita, Lavender, Andrew, Braund, Taylor, Mesagno, Christopher
- Authors: Tillman, Gabriel , March, Evita , Lavender, Andrew , Braund, Taylor , Mesagno, Christopher
- Date: 2023
- Type: Text , Journal article
- Relation: Behavioral Sciences Vol. 13, no. 9 (2023), p.
- Full Text:
- Reviewed:
- Description: The 2019 novel coronavirus disease (COVID-19) is a global threat that can have an adverse effect on an individuals’ physical and mental health. Here, we investigate if disordered social media use predicts user stress and depression symptoms indirectly via fear of COVID-19. A total of 359 (timepoint 1 = 171, timepoint 2 = 188) participants were recruited via social media and snowball sampling. They completed an online survey that measured disordered social media use, fear of COVID-19, perceived stress, and depression symptomatology at two cross-sectional timepoints. We found that disordered social media use predicts depression indirectly through fear of COVID-19 at both timepoints. We also found that disordered social media use predicts perceived stress indirectly through fear of COVID-19, but only at timepoint 1. Taken together with previous research, our findings indicate that disordered social media use may lead to increased fear of COVID-19, which in turn may lead to poorer psychological wellbeing outcomes. Overall, there is evidence that the impact of the COVID-19 pandemic is affecting the physical, psychological, and emotional health of individuals worldwide. Moreover, this impact may be exacerbated by disordered use of social media. © 2023 by the authors.
- Authors: Tillman, Gabriel , March, Evita , Lavender, Andrew , Braund, Taylor , Mesagno, Christopher
- Date: 2023
- Type: Text , Journal article
- Relation: Behavioral Sciences Vol. 13, no. 9 (2023), p.
- Full Text:
- Reviewed:
- Description: The 2019 novel coronavirus disease (COVID-19) is a global threat that can have an adverse effect on an individuals’ physical and mental health. Here, we investigate if disordered social media use predicts user stress and depression symptoms indirectly via fear of COVID-19. A total of 359 (timepoint 1 = 171, timepoint 2 = 188) participants were recruited via social media and snowball sampling. They completed an online survey that measured disordered social media use, fear of COVID-19, perceived stress, and depression symptomatology at two cross-sectional timepoints. We found that disordered social media use predicts depression indirectly through fear of COVID-19 at both timepoints. We also found that disordered social media use predicts perceived stress indirectly through fear of COVID-19, but only at timepoint 1. Taken together with previous research, our findings indicate that disordered social media use may lead to increased fear of COVID-19, which in turn may lead to poorer psychological wellbeing outcomes. Overall, there is evidence that the impact of the COVID-19 pandemic is affecting the physical, psychological, and emotional health of individuals worldwide. Moreover, this impact may be exacerbated by disordered use of social media. © 2023 by the authors.
Disseminating sleep education to graduate psychology programs online : a knowledge translation study to improve the management of insomnia
- Meaklim, Hailey, Meltzer, Lisa, Rehm, Imogen, Junge, Moira, Monfries, Melissa, Kennedy, Gerard, Bucks, Romola, Graco, Marnie, Jackson, Melinda
- Authors: Meaklim, Hailey , Meltzer, Lisa , Rehm, Imogen , Junge, Moira , Monfries, Melissa , Kennedy, Gerard , Bucks, Romola , Graco, Marnie , Jackson, Melinda
- Date: 2023
- Type: Text , Journal article
- Relation: Sleep Vol. 46, no. 10 (2023), p.
- Full Text:
- Reviewed:
- Description: Study Objectives: Despite the negative impact of poor sleep on mental health, evidence-based insomnia management guidelines have not been translated into routine mental healthcare. Here, we evaluate a state-wide knowledge translation effort to disseminate sleep and insomnia education to graduate psychology programs online using the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) evaluation framework. Methods: Using a non-randomized waitlist control design, graduate psychology students attended a validated 6-hour online sleep education workshop delivered live as part of their graduate psychology program in Victoria, Australia. Sleep knowledge, attitudes, and practice assessments were conducted pre- and post-program, with long-term feedback collected at 12 months. Results: Seven out of ten graduate psychology programs adopted the workshop (adoption rate = 70%). The workshop reached 313 graduate students, with a research participation rate of 81%. The workshop was effective at improving students’ sleep knowledge and self-efficacy to manage sleep disturbances using cognitive behavioral therapy for insomnia (CBT-I), compared to the waitlist control with medium-to-large effect sizes (all p < .001). Implementation feedback was positive, with 96% of students rating the workshop as very good-to-excellent. Twelve-month maintenance data demonstrated that 83% of students had used the sleep knowledge/skills learned in the workshop in their clinical practice. However, more practical training is required to achieve CBT-I competency. Conclusions: Online sleep education workshops can be scaled to deliver cost-effective foundational sleep training to graduate psychology students. This workshop will accelerate the translation of insomnia management guidelines into psychology practice to improve sleep and mental health outcomes nationwide. © The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society.
- Authors: Meaklim, Hailey , Meltzer, Lisa , Rehm, Imogen , Junge, Moira , Monfries, Melissa , Kennedy, Gerard , Bucks, Romola , Graco, Marnie , Jackson, Melinda
- Date: 2023
- Type: Text , Journal article
- Relation: Sleep Vol. 46, no. 10 (2023), p.
- Full Text:
- Reviewed:
- Description: Study Objectives: Despite the negative impact of poor sleep on mental health, evidence-based insomnia management guidelines have not been translated into routine mental healthcare. Here, we evaluate a state-wide knowledge translation effort to disseminate sleep and insomnia education to graduate psychology programs online using the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) evaluation framework. Methods: Using a non-randomized waitlist control design, graduate psychology students attended a validated 6-hour online sleep education workshop delivered live as part of their graduate psychology program in Victoria, Australia. Sleep knowledge, attitudes, and practice assessments were conducted pre- and post-program, with long-term feedback collected at 12 months. Results: Seven out of ten graduate psychology programs adopted the workshop (adoption rate = 70%). The workshop reached 313 graduate students, with a research participation rate of 81%. The workshop was effective at improving students’ sleep knowledge and self-efficacy to manage sleep disturbances using cognitive behavioral therapy for insomnia (CBT-I), compared to the waitlist control with medium-to-large effect sizes (all p < .001). Implementation feedback was positive, with 96% of students rating the workshop as very good-to-excellent. Twelve-month maintenance data demonstrated that 83% of students had used the sleep knowledge/skills learned in the workshop in their clinical practice. However, more practical training is required to achieve CBT-I competency. Conclusions: Online sleep education workshops can be scaled to deliver cost-effective foundational sleep training to graduate psychology students. This workshop will accelerate the translation of insomnia management guidelines into psychology practice to improve sleep and mental health outcomes nationwide. © The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society.
Distinct subpopulations of DN1 thymocytes exhibit preferential gamma delta T lineage potential
- Oh, Seungyoul, Liu, Xin, Tomei, Sara, Luo, Mengxiao, Skinner, Jarrod, Berzins, Stuart, Naik, Shalin, Gray, Daniel, Chong, Mark
- Authors: Oh, Seungyoul , Liu, Xin , Tomei, Sara , Luo, Mengxiao , Skinner, Jarrod , Berzins, Stuart , Naik, Shalin , Gray, Daniel , Chong, Mark
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Immunology Vol. 14, no. (2023), p.
- Full Text:
- Reviewed:
- Description: The
- Authors: Oh, Seungyoul , Liu, Xin , Tomei, Sara , Luo, Mengxiao , Skinner, Jarrod , Berzins, Stuart , Naik, Shalin , Gray, Daniel , Chong, Mark
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Immunology Vol. 14, no. (2023), p.
- Full Text:
- Reviewed:
- Description: The
DMD-associated dilated cardiomyopathy : genotypes, phenotypes, and phenocopies
- Johnson, Renee, Otway, Robyn, Chin, Ephrem, Horvat, Claire, Ohanian, Monique, Wilcox, Jon, Su, Zheng, Prestes, Priscilla, Smolnikov, Andrei, Soka, Magdalena, Guo, Guanglan, Rath, Emma, Chakravorty, Samya, Chrzanowski, Lukasz, Hayward, Christopher, Keogh, Anne, MacDonald, Peter, Giannoulatou, Eleni, Chang, Alex, Oates, Emily, Charchar, Fadi, Seidman, Jonathan, Seidman, Christine, Hegde, Madhuri, Fatkin, Diane
- Authors: Johnson, Renee , Otway, Robyn , Chin, Ephrem , Horvat, Claire , Ohanian, Monique , Wilcox, Jon , Su, Zheng , Prestes, Priscilla , Smolnikov, Andrei , Soka, Magdalena , Guo, Guanglan , Rath, Emma , Chakravorty, Samya , Chrzanowski, Lukasz , Hayward, Christopher , Keogh, Anne , MacDonald, Peter , Giannoulatou, Eleni , Chang, Alex , Oates, Emily , Charchar, Fadi , Seidman, Jonathan , Seidman, Christine , Hegde, Madhuri , Fatkin, Diane
- Date: 2023
- Type: Text , Journal article
- Relation: Circulation: Genomic and Precision Medicine Vol. 16, no. 5 (2023), p. 421-430
- Full Text:
- Reviewed:
- Description: Background: Variants in the DMD gene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heart failure, heart transplantation, and ventricular arrhythmias. Improved early detection of individuals at risk is needed. Methods: Genetic testing of 40 male probands with a potential X-linked genetic cause of primary DCM was undertaken using multi-gene panel sequencing, multiplex polymerase chain reaction, and array comparative genomic hybridization. Variant location was assessed with respect to dystrophin isoform patterns and exon usage. Telomere length was evaluated as a marker of myocardial dysfunction in left ventricular tissue and blood. Results: Four pathogenic/likely pathogenic DMD variants were found in 5 probands (5/40: 12.5%). Only one rare variant was identified by gene panel testing with 3 additional multi-exon deletion/duplications found following targeted assays for structural variants. All of the pathogenic/likely pathogenic DMD variants involved dystrophin exons that had percent spliced-in scores >90, indicating high levels of constitutive expression in the human adult heart. Fifteen DMD variant-negative probands (15/40: 37.5%) had variants in autosomal genes including TTN, BAG3, LMNA, and RBM20. Myocardial telomere length was reduced in patients with DCM irrespective of genotype. No differences in blood telomere length were observed between genotype-positive family members with/without DCM and controls. Conclusions: Primary genetic testing using multi-gene panels has a low yield and specific assays for structural variants are required if DMD-associated cardiomyopathy is suspected. Distinguishing X-linked causes of DCM from autosomal genes that show sex differences in clinical presentation is crucial for informed family management. © 2023 American Heart Association, Inc.
- Authors: Johnson, Renee , Otway, Robyn , Chin, Ephrem , Horvat, Claire , Ohanian, Monique , Wilcox, Jon , Su, Zheng , Prestes, Priscilla , Smolnikov, Andrei , Soka, Magdalena , Guo, Guanglan , Rath, Emma , Chakravorty, Samya , Chrzanowski, Lukasz , Hayward, Christopher , Keogh, Anne , MacDonald, Peter , Giannoulatou, Eleni , Chang, Alex , Oates, Emily , Charchar, Fadi , Seidman, Jonathan , Seidman, Christine , Hegde, Madhuri , Fatkin, Diane
- Date: 2023
- Type: Text , Journal article
- Relation: Circulation: Genomic and Precision Medicine Vol. 16, no. 5 (2023), p. 421-430
- Full Text:
- Reviewed:
- Description: Background: Variants in the DMD gene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heart failure, heart transplantation, and ventricular arrhythmias. Improved early detection of individuals at risk is needed. Methods: Genetic testing of 40 male probands with a potential X-linked genetic cause of primary DCM was undertaken using multi-gene panel sequencing, multiplex polymerase chain reaction, and array comparative genomic hybridization. Variant location was assessed with respect to dystrophin isoform patterns and exon usage. Telomere length was evaluated as a marker of myocardial dysfunction in left ventricular tissue and blood. Results: Four pathogenic/likely pathogenic DMD variants were found in 5 probands (5/40: 12.5%). Only one rare variant was identified by gene panel testing with 3 additional multi-exon deletion/duplications found following targeted assays for structural variants. All of the pathogenic/likely pathogenic DMD variants involved dystrophin exons that had percent spliced-in scores >90, indicating high levels of constitutive expression in the human adult heart. Fifteen DMD variant-negative probands (15/40: 37.5%) had variants in autosomal genes including TTN, BAG3, LMNA, and RBM20. Myocardial telomere length was reduced in patients with DCM irrespective of genotype. No differences in blood telomere length were observed between genotype-positive family members with/without DCM and controls. Conclusions: Primary genetic testing using multi-gene panels has a low yield and specific assays for structural variants are required if DMD-associated cardiomyopathy is suspected. Distinguishing X-linked causes of DCM from autosomal genes that show sex differences in clinical presentation is crucial for informed family management. © 2023 American Heart Association, Inc.
Do health service waiting areas contribute to the health literacy of consumers? A scoping review
- McDonald, Cassie, Voutier, Catherine, Govil, Dhruv, D'Souza, Aruska, Truong, Dominic, Abo, Shaza, Remedios, Louisa, Granger, Catherine
- Authors: McDonald, Cassie , Voutier, Catherine , Govil, Dhruv , D'Souza, Aruska , Truong, Dominic , Abo, Shaza , Remedios, Louisa , Granger, Catherine
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Health Promotion International Vol. 38, no. 4 (2023), p.
- Full Text:
- Reviewed:
- Description: Health service waiting areas commonly provide health information, resources and supports for consumers; however, the effect on health literacy and related outcomes remains unclear. This scoping review of the literature aimed to explore the use of waiting areas as a place to contribute to the health literacy and related outcomes of consumers attending health appointments. Articles were included if they focussed on health literacy or health literacy responsiveness (concept) in outpatient or primary care health service waiting areas (context) for adult consumers (population) and were published after 2010. Ten bibliographic databases, one full-text archive, dissertation repositories and web sources were searched. The search yielded 5095 records. After duplicate removal, 3942 title/abstract records were screened and 360 full-text records assessed. Data were charted into a standardized data extraction tool. A total of 116 unique articles (published empirical and grey literature) were included. Most articles were set in primary and community care (49%) waiting areas. A diverse range of health topics and resource types were available, but results demonstrated they were not always used by consumers. Outcomes measured in intervention studies were health knowledge, intentions and other psychological factors, self-reported and observed behaviours, clinical outcomes and health service utilization. Intervention studies overall demonstrated positive trends in health literacy-related outcomes, although the benefit declined after 3-6 months. Research on using waiting areas for health literacy purposes is increasing globally. Future research investigating the needs of consumers to inform optimal intervention design is needed. © 2023 The Author(s). Published by Oxford University Press.
- Authors: McDonald, Cassie , Voutier, Catherine , Govil, Dhruv , D'Souza, Aruska , Truong, Dominic , Abo, Shaza , Remedios, Louisa , Granger, Catherine
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Health Promotion International Vol. 38, no. 4 (2023), p.
- Full Text:
- Reviewed:
- Description: Health service waiting areas commonly provide health information, resources and supports for consumers; however, the effect on health literacy and related outcomes remains unclear. This scoping review of the literature aimed to explore the use of waiting areas as a place to contribute to the health literacy and related outcomes of consumers attending health appointments. Articles were included if they focussed on health literacy or health literacy responsiveness (concept) in outpatient or primary care health service waiting areas (context) for adult consumers (population) and were published after 2010. Ten bibliographic databases, one full-text archive, dissertation repositories and web sources were searched. The search yielded 5095 records. After duplicate removal, 3942 title/abstract records were screened and 360 full-text records assessed. Data were charted into a standardized data extraction tool. A total of 116 unique articles (published empirical and grey literature) were included. Most articles were set in primary and community care (49%) waiting areas. A diverse range of health topics and resource types were available, but results demonstrated they were not always used by consumers. Outcomes measured in intervention studies were health knowledge, intentions and other psychological factors, self-reported and observed behaviours, clinical outcomes and health service utilization. Intervention studies overall demonstrated positive trends in health literacy-related outcomes, although the benefit declined after 3-6 months. Research on using waiting areas for health literacy purposes is increasing globally. Future research investigating the needs of consumers to inform optimal intervention design is needed. © 2023 The Author(s). Published by Oxford University Press.
Do maturation, anthropometrics and leg muscle qualities influence repeated change of direction performance in adolescent boys and girls?
- Giuriato, Matteo, Pellino, Vittoria, Lovecchio, Nicola, Codella, Roberto, Vandoni, Matteo, Talpey, Scott
- Authors: Giuriato, Matteo , Pellino, Vittoria , Lovecchio, Nicola , Codella, Roberto , Vandoni, Matteo , Talpey, Scott
- Date: 2023
- Type: Text , Journal article
- Relation: Biology of Sport Vol. 40, no. 4 (2023), p. 1033-1038
- Full Text:
- Reviewed:
- Description: The ability to change direction rapidly is a key fitness quality especially in invasive sports where young players perform approximately 300 changes of direction in a game. There is currently limited understanding of how anthropometric characteristics and maturation status influence change of direction ability in adolescent. Therefore, the purpose of this investigation is to assess the influence of anthropometrics and maturation status on change of direction ability in young people. The study involved 706 adolescents (367 girls) aged 14-19-year-old attending the same high school in Northern Italy. Stature, body mass, seated height and leg length were measured to determine the anthropometrics and maturation status of the participants. Repeated change of direction ability (10 × 5 m shuttle run test), lower limb power and muscle strength were evaluated using field tests from the Eurofit test battery. Maturity offset was calculated separately for boys and girls, in accord with the equation proposed by Mirwald. Preliminary analysis with 10 × 5 m as a dependent variable and sex and PHV as a fixed factor, suggests a significant difference between sex (p < 0.001; d = 0.35) but not with PHV (p = 0.986; d = 0.000) and interaction PHV × sex (p = 0.836; d = 0.000). Our results suggested that repeated change of direction performance was influenced by anthropometrics, maturation and muscle qualities in adolescent boys and girls. © 2023 Institute of Sport. All rights reserved.
- Authors: Giuriato, Matteo , Pellino, Vittoria , Lovecchio, Nicola , Codella, Roberto , Vandoni, Matteo , Talpey, Scott
- Date: 2023
- Type: Text , Journal article
- Relation: Biology of Sport Vol. 40, no. 4 (2023), p. 1033-1038
- Full Text:
- Reviewed:
- Description: The ability to change direction rapidly is a key fitness quality especially in invasive sports where young players perform approximately 300 changes of direction in a game. There is currently limited understanding of how anthropometric characteristics and maturation status influence change of direction ability in adolescent. Therefore, the purpose of this investigation is to assess the influence of anthropometrics and maturation status on change of direction ability in young people. The study involved 706 adolescents (367 girls) aged 14-19-year-old attending the same high school in Northern Italy. Stature, body mass, seated height and leg length were measured to determine the anthropometrics and maturation status of the participants. Repeated change of direction ability (10 × 5 m shuttle run test), lower limb power and muscle strength were evaluated using field tests from the Eurofit test battery. Maturity offset was calculated separately for boys and girls, in accord with the equation proposed by Mirwald. Preliminary analysis with 10 × 5 m as a dependent variable and sex and PHV as a fixed factor, suggests a significant difference between sex (p < 0.001; d = 0.35) but not with PHV (p = 0.986; d = 0.000) and interaction PHV × sex (p = 0.836; d = 0.000). Our results suggested that repeated change of direction performance was influenced by anthropometrics, maturation and muscle qualities in adolescent boys and girls. © 2023 Institute of Sport. All rights reserved.
Does multisession cathodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex prime the effects of cognitive behavioral therapy on fear of pain, fear of movement, and disability in patients with nonspecific low back pain? A randomized clinical trial study
- Ehsani, Fatemeh, Hafez Yousefi, Mohaddeseh, Jafarzadeh, Abbas, Zoghi, Maryam, Jaberzadeh, Shapour
- Authors: Ehsani, Fatemeh , Hafez Yousefi, Mohaddeseh , Jafarzadeh, Abbas , Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2023
- Type: Text , Journal article
- Relation: Brain Sciences Vol. 13, no. 10 (2023), p.
- Full Text:
- Reviewed:
- Description: Many studies have shown that low back pain (LBP) is associated with psychosomatic symptoms which may lead to brain changes. This study aimed to investigate the effect of the concurrent application of cognitive behavioral therapy (CBT) and transcranial direct electrical stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on fear of pain, fear of movement, and disability in patients with nonspecific LBP. This study was performed on 45 LBP patients (23 women, 22 men; mean age 33.00 ± 1.77 years) in three groups: experimental (2 mA cathodal tDCS (c-tDCS)), sham (c-tDCS turned off after 30 s), and control (only received CBT). In all groups, CBT was conducted for 20 min per session, with two sessions per week for four weeks. Fear of pain, fear of movement, and disability were evaluated using questionnaires at baseline, immediately after, and one month after completion of interventions. Results indicated that all three different types of intervention could significantly reduce fear and disability immediately after intervention (p > 0.05). However, improvement in the experimental group was significantly higher than in the other groups immediately after and at the one-month follow-up after interventions (p < 0.05). DLPFC c-tDCS can prime the immediate effects of CBT and also the lasting effects on the reduction in the fear of pain, fear of movement, and disability in LBP patients. © 2023 by the authors.
- Authors: Ehsani, Fatemeh , Hafez Yousefi, Mohaddeseh , Jafarzadeh, Abbas , Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2023
- Type: Text , Journal article
- Relation: Brain Sciences Vol. 13, no. 10 (2023), p.
- Full Text:
- Reviewed:
- Description: Many studies have shown that low back pain (LBP) is associated with psychosomatic symptoms which may lead to brain changes. This study aimed to investigate the effect of the concurrent application of cognitive behavioral therapy (CBT) and transcranial direct electrical stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on fear of pain, fear of movement, and disability in patients with nonspecific LBP. This study was performed on 45 LBP patients (23 women, 22 men; mean age 33.00 ± 1.77 years) in three groups: experimental (2 mA cathodal tDCS (c-tDCS)), sham (c-tDCS turned off after 30 s), and control (only received CBT). In all groups, CBT was conducted for 20 min per session, with two sessions per week for four weeks. Fear of pain, fear of movement, and disability were evaluated using questionnaires at baseline, immediately after, and one month after completion of interventions. Results indicated that all three different types of intervention could significantly reduce fear and disability immediately after intervention (p > 0.05). However, improvement in the experimental group was significantly higher than in the other groups immediately after and at the one-month follow-up after interventions (p < 0.05). DLPFC c-tDCS can prime the immediate effects of CBT and also the lasting effects on the reduction in the fear of pain, fear of movement, and disability in LBP patients. © 2023 by the authors.
Domestic load management with coordinated photovoltaics, battery storage and electric vehicle operation
- Das, Narottam, Haque, Akramul, Zaman, Hasneen, Morsalin, Sayidul, Islam, Syed
- Authors: Das, Narottam , Haque, Akramul , Zaman, Hasneen , Morsalin, Sayidul , Islam, Syed
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Access Vol. 11, no. (2023), p. 12075-12087
- Full Text:
- Reviewed:
- Description: Coordinated power demand management at residential or domestic levels allows energy participants to efficiently manage load profiles, increase energy efficiency and reduce operational cost. In this paper, a hierarchical coordination framework to optimally manage domestic load using photovoltaic (PV) units, battery-energy-storage-systems (BESs) and electric vehicles (EVs) is presented. The bidirectional power flow of EV with vehicle to grid (V2G) operation manages real-time domestic load profile and takes appropriate coordinated action using its controller when necessary. The proposed system has been applied to a real power distribution network and tested with real load patterns and load dynamics. This also includes various test scenarios and prosumer's preferences e.g., with or without EVs, number of EV owners, number of households, and prosumer's daily activities. This is a combined hybrid system for hierarchical coordination that consists of PV units, BES systems and EVs. The system performance was analyzed with different commercial EV types with charging/ discharging constraints and the result shows that the domestic load demand on the distribution grid during the peak period has been reduced significantly. In the end, this proposed system's performance was compared with the prediction-based test techniques and the financial benefits were estimated. © 2013 IEEE.
- Authors: Das, Narottam , Haque, Akramul , Zaman, Hasneen , Morsalin, Sayidul , Islam, Syed
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Access Vol. 11, no. (2023), p. 12075-12087
- Full Text:
- Reviewed:
- Description: Coordinated power demand management at residential or domestic levels allows energy participants to efficiently manage load profiles, increase energy efficiency and reduce operational cost. In this paper, a hierarchical coordination framework to optimally manage domestic load using photovoltaic (PV) units, battery-energy-storage-systems (BESs) and electric vehicles (EVs) is presented. The bidirectional power flow of EV with vehicle to grid (V2G) operation manages real-time domestic load profile and takes appropriate coordinated action using its controller when necessary. The proposed system has been applied to a real power distribution network and tested with real load patterns and load dynamics. This also includes various test scenarios and prosumer's preferences e.g., with or without EVs, number of EV owners, number of households, and prosumer's daily activities. This is a combined hybrid system for hierarchical coordination that consists of PV units, BES systems and EVs. The system performance was analyzed with different commercial EV types with charging/ discharging constraints and the result shows that the domestic load demand on the distribution grid during the peak period has been reduced significantly. In the end, this proposed system's performance was compared with the prediction-based test techniques and the financial benefits were estimated. © 2013 IEEE.