- Title
- The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levels
- Creator
- Sim, Marc; Dawson, Brian; Landers, Grant; Wiegerinck, Erwin; Swinkels, Dorine; Townsend, Mary-Anne; Trinder, Debbie; Peeling, Peter
- Date
- 2012
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/157968
- Identifier
- vital:11745
- Identifier
-
https://doi.org/10.1007/s00421-011-2156-0
- Identifier
- ISSN:1439-6319
- Abstract
- The effect of carbohydrate (CHO) consumption during prolonged endurance running on post-exercise inflammation and hepcidin levels was investigated. Eleven well-trained male endurance athletes completed a graded exercise test, followed by two experimental running trials in a randomized order. The two experimental trials consisted of a 90 min run at 75% of the peak oxygen uptake velocity (vVO(2peak)), while consuming a solution with either 6% CHO or a placebo (PLA) equivalent at 3 ml kg(-1) every 20 min. Serum interleukin-6 (IL-6), free hemoglobin (Hb), haptoglobin (Hp), hepcidin and iron parameters were assessed throughout the post-run recovery period. Serum iron and IL-6 were significantly elevated immediately post-run in both CHO and PLA (p = 0.05), with no differences between trials. Serum-free Hb increased and Hp decreased significantly immediately post-run in both conditions (p = 0.05). Serum soluble transferrin receptor levels were significantly below the baseline at 3 and 24 h post-run in both conditions (p = 0.05). Serum hepcidin concentration recorded 3 h post-run in both conditions was significantly elevated (p = 0.05), and had returned to the baseline by 24 h post-run (p = 0.05). The use of a 6% CHO solution at 3 ml kg(-1) 20 min(-1) during endurance running did not attenuate the inflammatory response and subsequent increase in serum hepcidin levels during the post-run recovery period.
- Relation
- European Journal of Applied Physiology Vol. 112, no. 5 (2012), p. 1889-1898
- Rights
- © Springer-Verlag 2011
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1106 Human Movement and Sports Science; Iron deficiency; Cytokines; Exercise; Endurance running; Hemolysis
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