- Title
- Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus
- Creator
- Kumarasingha, Rasika; Preston, Sarah; Yeo, Tiong-Chia; Lim, Diana; Tu, Chu-Lee; Palombo, Enzo; Shaw, Jillian; Gasser, Robin; Boag, Peter
- Date
- 2016
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/160676
- Identifier
- vital:12277
- Identifier
-
https://doi.org/10.1186/s13071-016-1458-9
- Identifier
- ISBN:1756-3305
- Abstract
- Background: Parasitic roundworms (nematodes) cause substantial morbidity and mortality in livestock animals globally, and considerable productivity losses to farmers. The control of these nematodes has relied largely on the use of a limited number of anthelmintics. However, resistance to many of these these anthelmintics is now widespread, and, therefore, there is a need to find new drugs to ensure sustained and effective treatment and control into the future. Methods: Recently, we developed a screening assay to test natural, plant extracts with known inhibitory effects against the free-living worm Caenorhabditis elegans. Using this assay, we assessed here the effects of the extracts on motility and development of parasitic larval stages of Haemonchus contortus, one of the most important nematodes of small ruminants worldwide. Results: The study showed that two of five extracts from Picria fel-terrae Lour. have a significant inhibitory effect (at concentrations of 3-5 mg/ml) on the motility and development of H. contortus larvae. Although the two extracts originated from the same plant, they displayed different levels of inhibition on motility and development, which might relate to the presence of various active constituents in these extracts, or the same constituents at different concentrations in distinct parts of the plant. Conclusions: These results suggest that extracts from P. fel-terrae Lour. have promising anthelmintic activity and that more broadly, plant extracts are a potential rich source of anthelmintics to combat helminthic diseases. © 2016 Kumarasingha et al.
- Publisher
- BioMed Central Ltd.
- Relation
- Parasites and Vectors Vol. 9, no. 1 (2016), p. 1-7
- Rights
- http://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2016 Kumarasingha et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1108 Medical Microbiology; 1117 Public Health and Health Services; Anthelmintic activity; Developmental assay; In vitro-assay; Medicinal plant extracts
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