- Title
- A novel plasmid-mediated polymyxin resistance determinant (mcr-1.8) in escherichia coli recovered from broiler chickens in Brunei Darussalam
- Creator
- Momin, Abdul; Liakopoulos, Apostolos; Bean, David; Phee, Lynette; Wareham, David
- Date
- 2019
- Type
- Text; Journal article; Letter
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/170979
- Identifier
- vital:14237
- Identifier
-
https://doi.org/10.1093/jac/dkz352
- Identifier
- ISBN:0305-7453
- Abstract
- Sir, MDR Gram-negative bacteria are identified as critical pathogens and their effective treatment increasingly relies on the polymyxins (polymyxin B, colistin), either alone or as part of unorthodox combination therapies.1 The rapid emergence of polymyxin resistance due to mutations/insertions in genes involved in LPS modifications (lpxCAD, pmrA/B, mgrB, phoP/Q, ccrAB) has been reported among individuals exposed to or treated with polymyxins.1Of greater concern are increasing reports of resistance due to the acquisition of phosphoethanolamine (PEtN) transferases, enzymes that catalyse the addition of phosphoethanolamine to lipid A, resulting in lower binding affinity of polymyxins.1 Since the first identification in China,1 multiple gene variants have been reported in diverse bacterial genera recovered from a range of human, retail food, foodproducing animal and environmental sources.2 Here, we report a novel variant of PEtN transferase, designated MCR-1.8, and its genetic context in an MDR Escherichia coli isolate recovered from poultry in Brunei Darussalam.
- Publisher
- Oxford University Press
- Relation
- Journal of Antimicrobial Chemotherapy Vol. 74, no. 11 (2019), p. 3392-3394
- Rights
- @The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy
- Rights
- This metadata is freely available under a CCO license
- Rights
- Open Access
- Subject
- 0605 Microbiology; 1108 Medical Microbiology; 1115 Pharmacology and Pharmaceutical Sciences; Beta lactamase CTX M; Beta lactamase TEM 1; Colistin; Fosfomycin; Phosphoethanolamine; Polymyxin B; Sulfonamide; Trimethoprim
- Full Text
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