- Title
- Effects of cyclodextrins on the antimicrobial activity of plant-derived essential oil compounds
- Creator
- Liang, Hao; Yuan, Qipeng; Vriesekoop, Frank; Lv, Fei
- Date
- 2012
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/101848
- Identifier
- vital:10724
- Identifier
- ISSN:0308-8146
- Abstract
- Essential oils (EOs) from plants are considered to be a safer alternative when compared to synthetic antimicrobial food additives. However, a major drawback of many EOs is their hydrophobic nature, which makes them insoluble in water based media and matrices. Although cyclodextrins (CDs) can increase the solubility of EO compounds, the effects of CDs on the antimicrobial activity of EOs have not been reported. In this paper, four different EO compounds (carvacrol, eugenol, linalool and 2-pentanoylfuran) were chosen to study the influence of CDs on the solubility and antimicrobial activity on bacteria and yeast. The greatest enhancement with regards to solubility of the four test compounds was achieved by hydroxypropyl-β-CD. In most instances, not only were the minimal antimicrobial concentrations of EO compounds decreased, but the interactivity of two combined EO compounds could be strengthened by the co-addition of CDs. Furthermore, the combination of carvacrol with hydroxypropyl-β-CD caused a marked change in the major membrane lipid composition of all microorganisms investigated; while scanning electron microscopy revealed that cellular integrity was significantly affected by 2× MIC, ultimately resulting in cell lysis. © 2012 Elsevier Ltd. All rights reserved.
- Relation
- Food Chemistry Vol. 135, no. 3 (2012), p. 1020-1027
- Rights
- Copyright Elsevier
- Rights
- This metadata is freely available under a CCO license
- Subject
- Antimicrobial activity; Carvacrol; Cyclodextrins; Essential oils; Membrane toxicity; Anti-microbial activity; CdS; Cell lysis; Coaddition; Essential oil compounds; Hydrophobic nature; Interactivity; Membrane lipid composition; Water-based media; Microorganisms; Scanning electron microscopy; Solubility; 2 hydroxypropyl beta cyclodextrin; 2 pentanoylfuran; Cyclodextrin; Essential oil; Eugenol; Linalool; Membrane lipid; Unclassified drug; Saccharomyces cerevisiae; Staphylococcus aureus; Anti-Infective Agents; Bacteria; Fungi; Oils, Volatile; Plant Oils; Bacteria (microorganisms); MD Multidisciplinary
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