- Title
- The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties
- Creator
- Gugasyan, Raffi; Horat, Elisha; Kinkel, Sarah; Ross, Fiona; Grigoriadis, George; Gray, Daniel; O'Keeffe, Meredith; Berzins, Stuart; Belz, Gabrielle; Grumont, Raelene; Banerjee, Ashish; Strasser, Andreas; Godfrey, Dale; Tsichlis, Phillip; Gerondakis, Steve
- Date
- 2012
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/103331
- Identifier
- vital:10906
- Identifier
-
https://doi.org/10.1038/emboj.2011.435
- Identifier
- ISSN:02614189
- Abstract
- The role of specific members of the NF-κB family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-κB1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF + thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-κB1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8 + thymocytes with memory cell characteristics. © 2012 European Molecular Biology Organization | All Rights Reserved.
- Relation
- EMBO Journal Vol. 31, no. 3 (2012), p. 692-706
- Rights
- © 2012 European Molecular Biology Organization | All Rights Reserved
- Rights
- This metadata is freely available under a CCO license
- Subject
- Memory CD8 T cells; NF-kB; NF-kB1; p50; T-cell development; Immunoglobulin enhancer binding protein; Immunoglobulin enhancer binding protein 1; Interleukin 4; Major histocompatibility antigen class 1; Unclassified drug; Animal cell; Animal experiment; Animal tissue; CD8+ T lymphocyte; Cell population; Controlled study; Female; Hematopoietic cell; Male; Memory T lymphocyte; Mouse; Nonhuman; Phenotype; Priority journal; Protein expression; Signal transduction; Thymocyte; Thymus; CD8-Positive T-Lymphocytes; Extracellular Signal-Regulated MAP Kinases; Humans; Immunologic Memory; Immunophenotyping; Interleukin-4; NF-kappa B; Thymus Gland; Mus; 06 Biological Sciences; 11 Medical and Health Sciences
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