A nethack learning environment language wrapper for autonomous agents
- Goodger, Nikolaj, Vamplew, Peter, Foale, Cameron, Dazeley, Richard
- Authors: Goodger, Nikolaj , Vamplew, Peter , Foale, Cameron , Dazeley, Richard
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Open Research Software Vol. 11, no. (2023), p.
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- Description: This paper describes a language wrapper for the NetHack Learning Environment (NLE) [1]. The wrapper replaces the non-language observations and actions with comparable language versions. The NLE offers a grand challenge for AI research while MiniHack [2] extends this potential to more specific and configurable tasks. By providing a language interface, we can enable further research on language agents and directly connect language models to a versatile environment. © 2023 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
- Authors: Goodger, Nikolaj , Vamplew, Peter , Foale, Cameron , Dazeley, Richard
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Open Research Software Vol. 11, no. (2023), p.
- Full Text:
- Reviewed:
- Description: This paper describes a language wrapper for the NetHack Learning Environment (NLE) [1]. The wrapper replaces the non-language observations and actions with comparable language versions. The NLE offers a grand challenge for AI research while MiniHack [2] extends this potential to more specific and configurable tasks. By providing a language interface, we can enable further research on language agents and directly connect language models to a versatile environment. © 2023 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
A new era of integration between multiomics and spatio-temporal analysis for the translation of EMT towards clinical applications in cancer
- Fonseca Teixeira, Adilson, Wu, Siqi, Luwor, Rodney, Zhu, Hong-Jian
- Authors: Fonseca Teixeira, Adilson , Wu, Siqi , Luwor, Rodney , Zhu, Hong-Jian
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Cells Vol. 12, no. 23 (2023), p.
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- Description: Epithelial-mesenchymal transition (EMT) is crucial to metastasis by increasing cancer cell migration and invasion. At the cellular level, EMT-related morphological and functional changes are well established. At the molecular level, critical signaling pathways able to drive EMT have been described. Yet, the translation of EMT into efficient diagnostic methods and anti-metastatic therapies is still missing. This highlights a gap in our understanding of the precise mechanisms governing EMT. Here, we discuss evidence suggesting that overcoming this limitation requires the integration of multiple omics, a hitherto neglected strategy in the EMT field. More specifically, this work summarizes results that were independently obtained through epigenomics/transcriptomics while comprehensively reviewing the achievements of proteomics in cancer research. Additionally, we prospect gains to be obtained by applying spatio-temporal multiomics in the investigation of EMT-driven metastasis. Along with the development of more sensitive technologies, the integration of currently available omics, and a look at dynamic alterations that regulate EMT at the subcellular level will lead to a deeper understanding of this process. Further, considering the significance of EMT to cancer progression, this integrative strategy may enable the development of new and improved biomarkers and therapeutics capable of increasing the survival and quality of life of cancer patients. © 2023 by the authors.
- Authors: Fonseca Teixeira, Adilson , Wu, Siqi , Luwor, Rodney , Zhu, Hong-Jian
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Cells Vol. 12, no. 23 (2023), p.
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- Description: Epithelial-mesenchymal transition (EMT) is crucial to metastasis by increasing cancer cell migration and invasion. At the cellular level, EMT-related morphological and functional changes are well established. At the molecular level, critical signaling pathways able to drive EMT have been described. Yet, the translation of EMT into efficient diagnostic methods and anti-metastatic therapies is still missing. This highlights a gap in our understanding of the precise mechanisms governing EMT. Here, we discuss evidence suggesting that overcoming this limitation requires the integration of multiple omics, a hitherto neglected strategy in the EMT field. More specifically, this work summarizes results that were independently obtained through epigenomics/transcriptomics while comprehensively reviewing the achievements of proteomics in cancer research. Additionally, we prospect gains to be obtained by applying spatio-temporal multiomics in the investigation of EMT-driven metastasis. Along with the development of more sensitive technologies, the integration of currently available omics, and a look at dynamic alterations that regulate EMT at the subcellular level will lead to a deeper understanding of this process. Further, considering the significance of EMT to cancer progression, this integrative strategy may enable the development of new and improved biomarkers and therapeutics capable of increasing the survival and quality of life of cancer patients. © 2023 by the authors.
A novel dynamic software-defined networking approach to neutralize traffic burst
- Sharma, Aakanksha, Balasubramanian, Venki, Kamruzzaman, Joarder
- Authors: Sharma, Aakanksha , Balasubramanian, Venki , Kamruzzaman, Joarder
- Date: 2023
- Type: Text , Journal article
- Relation: Computers Vol. 12, no. 7 (2023), p.
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- Description: Software-defined networks (SDN) has a holistic view of the network. It is highly suitable for handling dynamic loads in the traditional network with a minimal update in the network infrastructure. However, the standard SDN architecture control plane has been designed for single or multiple distributed SDN controllers facing severe bottleneck issues. Our initial research created a reference model for the traditional network, using the standard SDN (referred to as SDN hereafter) in a network simulator called NetSim. Based on the network traffic, the reference models consisted of light, modest and heavy networks depending on the number of connected IoT devices. Furthermore, a priority scheduling and congestion control algorithm is proposed in the standard SDN, named extended SDN (eSDN), which minimises congestion and performs better than the standard SDN. However, the enhancement was suitable only for the small-scale network because, in a large-scale network, the eSDN does not support dynamic SDN controller mapping. Often, the same SDN controller gets overloaded, leading to a single point of failure. Our literature review shows that most proposed solutions are based on static SDN controller deployment without considering flow fluctuations and traffic bursts that lead to a lack of load balancing among the SDN controllers in real-time, eventually increasing the network latency. Therefore, to maintain the Quality of Service (QoS) in the network, it becomes imperative for the static SDN controller to neutralise the on-the-fly traffic burst. Thus, our novel dynamic controller mapping algorithm with multiple-controller placement in the SDN is critical to solving the identified issues. In dSDN, the SDN controllers are mapped dynamically with the load fluctuation. If any SDN controller reaches its maximum threshold, the rest of the traffic will be diverted to another controller, significantly reducing delay and enhancing the overall performance. Our technique considers the latency and load fluctuation in the network and manages the situations where static mapping is ineffective in dealing with the dynamic flow variation. © 2023 by the authors.
- Authors: Sharma, Aakanksha , Balasubramanian, Venki , Kamruzzaman, Joarder
- Date: 2023
- Type: Text , Journal article
- Relation: Computers Vol. 12, no. 7 (2023), p.
- Full Text:
- Reviewed:
- Description: Software-defined networks (SDN) has a holistic view of the network. It is highly suitable for handling dynamic loads in the traditional network with a minimal update in the network infrastructure. However, the standard SDN architecture control plane has been designed for single or multiple distributed SDN controllers facing severe bottleneck issues. Our initial research created a reference model for the traditional network, using the standard SDN (referred to as SDN hereafter) in a network simulator called NetSim. Based on the network traffic, the reference models consisted of light, modest and heavy networks depending on the number of connected IoT devices. Furthermore, a priority scheduling and congestion control algorithm is proposed in the standard SDN, named extended SDN (eSDN), which minimises congestion and performs better than the standard SDN. However, the enhancement was suitable only for the small-scale network because, in a large-scale network, the eSDN does not support dynamic SDN controller mapping. Often, the same SDN controller gets overloaded, leading to a single point of failure. Our literature review shows that most proposed solutions are based on static SDN controller deployment without considering flow fluctuations and traffic bursts that lead to a lack of load balancing among the SDN controllers in real-time, eventually increasing the network latency. Therefore, to maintain the Quality of Service (QoS) in the network, it becomes imperative for the static SDN controller to neutralise the on-the-fly traffic burst. Thus, our novel dynamic controller mapping algorithm with multiple-controller placement in the SDN is critical to solving the identified issues. In dSDN, the SDN controllers are mapped dynamically with the load fluctuation. If any SDN controller reaches its maximum threshold, the rest of the traffic will be diverted to another controller, significantly reducing delay and enhancing the overall performance. Our technique considers the latency and load fluctuation in the network and manages the situations where static mapping is ineffective in dealing with the dynamic flow variation. © 2023 by the authors.
A pilot comparison of fixatives for hookworm real-time polymerase chain reaction
- Bradbury, Richard, Inagaki, Kengo, Singh, Gurbaksh, Agana, Urita, Patterson, Kayla, Malloch, Lacy, Rodriguez, Eduardo, Qvarnstrom, Yvonne, Hobbs, Charlotte
- Authors: Bradbury, Richard , Inagaki, Kengo , Singh, Gurbaksh , Agana, Urita , Patterson, Kayla , Malloch, Lacy , Rodriguez, Eduardo , Qvarnstrom, Yvonne , Hobbs, Charlotte
- Date: 2023
- Type: Text , Journal article
- Relation: American Journal of Tropical Medicine and Hygiene Vol. 108, no. 2 (2023), p. 335-339
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- Description: Polymerase chain reaction (PCR) is increasingly used in the diagnosis of soil-transmitted helminth infections. Despite this, few studies have evaluated the impact of different fecal fixatives on the outcome of fecal helminth qPCR analysis, and none have evaluated the effect of commercial parasitology fixatives commonly used in diagnostic laboratories. We fixed dog feces containing Ancylostoma spp. hookworm eggs in zinc polyvinyl alcohol (Zn-PVA) and Total-Fix, and with 70% ethanol (EtOH) as a control. DNA was extracted at timepoints 11, 33, 64, and 94 days and subjected to Ancylostoma spp. quantitative PCR (qPCR). A linear regression model was created to assess the effect of preservative types on the temporal change of qPCR quantification cycle number (Cq) values, accounting for variances among individual animals. Fixation in 70% EtOH least affected Cq values over 94 days. Total-Fix preservation yielded a higher Cq overall, but there was no significant difference compared with 70% EtOH fixation. Fixation in Zn-PVA resulted in significantly (P < 0.001) higher Cq values than 70% EtOH after only 33 days and loss of amplification at 64 days. Consistent with other helminth fixation studies, 70% EtOH performed well in preserving hookworm DNA over 94 days. Total-Fix provided a comparable alternative for qPCR analysis for hookworm. Fixation in Zn-PVA resulted in loss of detectable hookworm DNA at 64 days, as determined by qPCR. Copyright © 2023 The American Society of Tropical Medicine and Hygiene.
- Authors: Bradbury, Richard , Inagaki, Kengo , Singh, Gurbaksh , Agana, Urita , Patterson, Kayla , Malloch, Lacy , Rodriguez, Eduardo , Qvarnstrom, Yvonne , Hobbs, Charlotte
- Date: 2023
- Type: Text , Journal article
- Relation: American Journal of Tropical Medicine and Hygiene Vol. 108, no. 2 (2023), p. 335-339
- Full Text:
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- Description: Polymerase chain reaction (PCR) is increasingly used in the diagnosis of soil-transmitted helminth infections. Despite this, few studies have evaluated the impact of different fecal fixatives on the outcome of fecal helminth qPCR analysis, and none have evaluated the effect of commercial parasitology fixatives commonly used in diagnostic laboratories. We fixed dog feces containing Ancylostoma spp. hookworm eggs in zinc polyvinyl alcohol (Zn-PVA) and Total-Fix, and with 70% ethanol (EtOH) as a control. DNA was extracted at timepoints 11, 33, 64, and 94 days and subjected to Ancylostoma spp. quantitative PCR (qPCR). A linear regression model was created to assess the effect of preservative types on the temporal change of qPCR quantification cycle number (Cq) values, accounting for variances among individual animals. Fixation in 70% EtOH least affected Cq values over 94 days. Total-Fix preservation yielded a higher Cq overall, but there was no significant difference compared with 70% EtOH fixation. Fixation in Zn-PVA resulted in significantly (P < 0.001) higher Cq values than 70% EtOH after only 33 days and loss of amplification at 64 days. Consistent with other helminth fixation studies, 70% EtOH performed well in preserving hookworm DNA over 94 days. Total-Fix provided a comparable alternative for qPCR analysis for hookworm. Fixation in Zn-PVA resulted in loss of detectable hookworm DNA at 64 days, as determined by qPCR. Copyright © 2023 The American Society of Tropical Medicine and Hygiene.
A qualitative study on undergraduate student nurses’ experience of mental health simulation preclinical placement
- Olasoji, Michael, Garvey, Loretta, Sadoughi, Navideh, Willetts, Georgina
- Authors: Olasoji, Michael , Garvey, Loretta , Sadoughi, Navideh , Willetts, Georgina
- Date: 2023
- Type: Text , Journal article
- Relation: Clinical Simulation in Nursing Vol. 84, no. (2023), p.
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- Description: Background: Simulations allow students to be challenged and supported while gaining both technical and non-technical skills within a clinical learning environment. Working in a mental health setting can be quite challenging and confronting at times for undergraduate nursing students in clinical placement. The study aims to explore nursing students’ perceptions of a mental health simulation workshop's impact before clinical placement, which provides a supportive environment to gain technical and non-technical skills while being challenged and supported. Sample: Participants were a second-year cohort (n = 89) of undergraduate nursing students enrolled in a mental health unit. Methods: Descriptive survey design. The researchers thematically analysed narrative responses of a pre- and post-simulation survey from an immersive simulation using a descriptive survey design. Results: The researchers identified six key themes: two from the pre-simulation survey – communication with and assessment of mental health patients, and the opportunity for placement preparation; and four from the post-simulation survey – the opportunity for debriefing, the realism of the simulation, increased confidence levels, and the perception of a safe learning environment. Conclusion: Effective skill acquisition is essential to advance recruitment and retention into mental health environments. The use of mental health simulation that comprises of realism and immersion working with simulated patients provided opportunity to advance this. © 2023
- Authors: Olasoji, Michael , Garvey, Loretta , Sadoughi, Navideh , Willetts, Georgina
- Date: 2023
- Type: Text , Journal article
- Relation: Clinical Simulation in Nursing Vol. 84, no. (2023), p.
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- Description: Background: Simulations allow students to be challenged and supported while gaining both technical and non-technical skills within a clinical learning environment. Working in a mental health setting can be quite challenging and confronting at times for undergraduate nursing students in clinical placement. The study aims to explore nursing students’ perceptions of a mental health simulation workshop's impact before clinical placement, which provides a supportive environment to gain technical and non-technical skills while being challenged and supported. Sample: Participants were a second-year cohort (n = 89) of undergraduate nursing students enrolled in a mental health unit. Methods: Descriptive survey design. The researchers thematically analysed narrative responses of a pre- and post-simulation survey from an immersive simulation using a descriptive survey design. Results: The researchers identified six key themes: two from the pre-simulation survey – communication with and assessment of mental health patients, and the opportunity for placement preparation; and four from the post-simulation survey – the opportunity for debriefing, the realism of the simulation, increased confidence levels, and the perception of a safe learning environment. Conclusion: Effective skill acquisition is essential to advance recruitment and retention into mental health environments. The use of mental health simulation that comprises of realism and immersion working with simulated patients provided opportunity to advance this. © 2023
A reevaluation of the factor structure, reliability, and validity of the spiritual well-being questionnaire (SWBQ)
- Gomez, Rapson, Watson, Shaun
- Authors: Gomez, Rapson , Watson, Shaun
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Religion and Health Vol. 62, no. 3 (2023), p. 2112-2130
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- Description: The 20-item Gomez and Fisher (Personal Individ Differ 35:1975–1991, 2003) Spiritual Well-Being Questionnaire (SWBQ) is a widely used measure of spiritual well-being. Its theoretical model is a higher-order model with primary factors for personal, communal, environmental, and transcendental well-being, and a secondary global spiritual well-being factor. The current study, conducted in Australia, reevaluated the factor structure of the SWBQ. Unlike previous studies, the current study also used exploratory structural equation modeling (ESEM) to examine the factor structure of the SWBQ and selected the preferred model using not only global model fit values, but also the clarity, reliabilities, and validities of the factors in the models. A total of 227 adults (males = 63; females = 164; M age = 26.1 years; SD = 5.2 years) completed the SWBQ. Based on the model selection criteria applied in the study, the ESEM model with four group factors was selected as the preferred model. However, there was also adequate support for the proposed theoretical higher-order model and the first-order oblique model with the four well-being factors. Concerning our preferred model, its factors showed reasonable clarity for factor loadings and (omega) reliabilities. However, only the communal domain scale was supported empirically for external validity. The implications of the findings for the theoretical model, the use of the SWBQ, and future studies are discussed. In this respect, there are three potential models (theorized higher-order model, 4-factor first-order oblique model, and the ESEM model proposed in this study) that warrant further detailed investigation with a larger, more representative population and additional validation measures. © 2022, The Author(s).
- Authors: Gomez, Rapson , Watson, Shaun
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Religion and Health Vol. 62, no. 3 (2023), p. 2112-2130
- Full Text:
- Reviewed:
- Description: The 20-item Gomez and Fisher (Personal Individ Differ 35:1975–1991, 2003) Spiritual Well-Being Questionnaire (SWBQ) is a widely used measure of spiritual well-being. Its theoretical model is a higher-order model with primary factors for personal, communal, environmental, and transcendental well-being, and a secondary global spiritual well-being factor. The current study, conducted in Australia, reevaluated the factor structure of the SWBQ. Unlike previous studies, the current study also used exploratory structural equation modeling (ESEM) to examine the factor structure of the SWBQ and selected the preferred model using not only global model fit values, but also the clarity, reliabilities, and validities of the factors in the models. A total of 227 adults (males = 63; females = 164; M age = 26.1 years; SD = 5.2 years) completed the SWBQ. Based on the model selection criteria applied in the study, the ESEM model with four group factors was selected as the preferred model. However, there was also adequate support for the proposed theoretical higher-order model and the first-order oblique model with the four well-being factors. Concerning our preferred model, its factors showed reasonable clarity for factor loadings and (omega) reliabilities. However, only the communal domain scale was supported empirically for external validity. The implications of the findings for the theoretical model, the use of the SWBQ, and future studies are discussed. In this respect, there are three potential models (theorized higher-order model, 4-factor first-order oblique model, and the ESEM model proposed in this study) that warrant further detailed investigation with a larger, more representative population and additional validation measures. © 2022, The Author(s).
A smart healthcare framework for detection and monitoring of COVID-19 using IoT and cloud computing
- Nasser, Nidal, Emad-ul-Haq, Qazi, Imran, Muhammad, Ali, Asmaa, Razzak, Imran, Al-Helali, Abdulaziz
- Authors: Nasser, Nidal , Emad-ul-Haq, Qazi , Imran, Muhammad , Ali, Asmaa , Razzak, Imran , Al-Helali, Abdulaziz
- Date: 2023
- Type: Text , Journal article
- Relation: Neural Computing and Applications Vol. 35, no. 19 (2023), p. 13775-13789
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- Description: Coronavirus (COVID-19) is a very contagious infection that has drawn the world’s attention. Modeling such diseases can be extremely valuable in predicting their effects. Although classic statistical modeling may provide adequate models, it may also fail to understand the data’s intricacy. An automatic COVID-19 detection system based on computed tomography (CT) scan or X-ray images is effective, but a robust system design is challenging. In this study, we propose an intelligent healthcare system that integrates IoT-cloud technologies. This architecture uses smart connectivity sensors and deep learning (DL) for intelligent decision-making from the perspective of the smart city. The intelligent system tracks the status of patients in real time and delivers reliable, timely, and high-quality healthcare facilities at a low cost. COVID-19 detection experiments are performed using DL to test the viability of the proposed system. We use a sensor for recording, transferring, and tracking healthcare data. CT scan images from patients are sent to the cloud by IoT sensors, where the cognitive module is stored. The system decides the patient status by examining the images of the CT scan. The DL cognitive module makes the real-time decision on the possible course of action. When information is conveyed to a cognitive module, we use a state-of-the-art classification algorithm based on DL, i.e., ResNet50, to detect and classify whether the patients are normal or infected by COVID-19. We validate the proposed system’s robustness and effectiveness using two benchmark publicly available datasets (Covid-Chestxray dataset and Chex-Pert dataset). At first, a dataset of 6000 images is prepared from the above two datasets. The proposed system was trained on the collection of images from 80% of the datasets and tested with 20% of the data. Cross-validation is performed using a tenfold cross-validation technique for performance evaluation. The results indicate that the proposed system gives an accuracy of 98.6%, a sensitivity of 97.3%, a specificity of 98.2%, and an F1-score of 97.87%. Results clearly show that the accuracy, specificity, sensitivity, and F1-score of our proposed method are high. The comparison shows that the proposed system performs better than the existing state-of-the-art systems. The proposed system will be helpful in medical diagnosis research and healthcare systems. It will also support the medical experts for COVID-19 screening and lead to a precious second opinion. © 2021, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
- Authors: Nasser, Nidal , Emad-ul-Haq, Qazi , Imran, Muhammad , Ali, Asmaa , Razzak, Imran , Al-Helali, Abdulaziz
- Date: 2023
- Type: Text , Journal article
- Relation: Neural Computing and Applications Vol. 35, no. 19 (2023), p. 13775-13789
- Full Text:
- Reviewed:
- Description: Coronavirus (COVID-19) is a very contagious infection that has drawn the world’s attention. Modeling such diseases can be extremely valuable in predicting their effects. Although classic statistical modeling may provide adequate models, it may also fail to understand the data’s intricacy. An automatic COVID-19 detection system based on computed tomography (CT) scan or X-ray images is effective, but a robust system design is challenging. In this study, we propose an intelligent healthcare system that integrates IoT-cloud technologies. This architecture uses smart connectivity sensors and deep learning (DL) for intelligent decision-making from the perspective of the smart city. The intelligent system tracks the status of patients in real time and delivers reliable, timely, and high-quality healthcare facilities at a low cost. COVID-19 detection experiments are performed using DL to test the viability of the proposed system. We use a sensor for recording, transferring, and tracking healthcare data. CT scan images from patients are sent to the cloud by IoT sensors, where the cognitive module is stored. The system decides the patient status by examining the images of the CT scan. The DL cognitive module makes the real-time decision on the possible course of action. When information is conveyed to a cognitive module, we use a state-of-the-art classification algorithm based on DL, i.e., ResNet50, to detect and classify whether the patients are normal or infected by COVID-19. We validate the proposed system’s robustness and effectiveness using two benchmark publicly available datasets (Covid-Chestxray dataset and Chex-Pert dataset). At first, a dataset of 6000 images is prepared from the above two datasets. The proposed system was trained on the collection of images from 80% of the datasets and tested with 20% of the data. Cross-validation is performed using a tenfold cross-validation technique for performance evaluation. The results indicate that the proposed system gives an accuracy of 98.6%, a sensitivity of 97.3%, a specificity of 98.2%, and an F1-score of 97.87%. Results clearly show that the accuracy, specificity, sensitivity, and F1-score of our proposed method are high. The comparison shows that the proposed system performs better than the existing state-of-the-art systems. The proposed system will be helpful in medical diagnosis research and healthcare systems. It will also support the medical experts for COVID-19 screening and lead to a precious second opinion. © 2021, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
A step toward restoring hand functions in patients with multiple sclerosis—a study protocol
- Zoghi, Maryam, Jaberzadeh, Shapour
- Authors: Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Rehabilitation Sciences Vol. 4, no. (2023), p.
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- Description: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammation, demyelination of axons, and oligodendrocyte loss in the central nervous system. This leads to neurological dysfunction, including hand impairment, which is prevalent among patients with MS. However, hand impairment is the least targeted area for neurorehabilitation studies. Therefore, this study proposes a novel approach to improve hand functions compared to current strategies. Studies have shown that learning new skills in the motor cortex (M1) can trigger the production of oligodendrocytes and myelin, which is a critical mechanism for neuroplasticity. Transcranial direct current stimulation (tDCS) has been used to enhance motor learning and function in human subjects. However, tDCS induces non-specific effects, and concurrent behavioral training has been found to optimize its benefits. Recent research indicates that applying tDCS during motor learning can have priming effects on the long-term potentiation mechanism and prolong the effects of motor training in health and disease. Therefore, this study aims to assess whether applying repeated tDCS during the learning of a new motor skill in M1 can be more effective in improving hand functions in patients with MS than current neurorehabilitation strategies. If this approach proves successful in improving hand functions in patients with MS, it could be adopted as a new approach to restore hand functions. Additionally, if the application of tDCS demonstrates an accumulative effect in improving hand functions in patients with MS, it could provide an adjunct intervention during rehabilitation for these patients. This study will contribute to the growing body of literature on the use of tDCS in neurorehabilitation and could have a significant impact on the quality of life of patients with MS. 2023 Zoghi and Jaberzadeh.
- Authors: Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Rehabilitation Sciences Vol. 4, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammation, demyelination of axons, and oligodendrocyte loss in the central nervous system. This leads to neurological dysfunction, including hand impairment, which is prevalent among patients with MS. However, hand impairment is the least targeted area for neurorehabilitation studies. Therefore, this study proposes a novel approach to improve hand functions compared to current strategies. Studies have shown that learning new skills in the motor cortex (M1) can trigger the production of oligodendrocytes and myelin, which is a critical mechanism for neuroplasticity. Transcranial direct current stimulation (tDCS) has been used to enhance motor learning and function in human subjects. However, tDCS induces non-specific effects, and concurrent behavioral training has been found to optimize its benefits. Recent research indicates that applying tDCS during motor learning can have priming effects on the long-term potentiation mechanism and prolong the effects of motor training in health and disease. Therefore, this study aims to assess whether applying repeated tDCS during the learning of a new motor skill in M1 can be more effective in improving hand functions in patients with MS than current neurorehabilitation strategies. If this approach proves successful in improving hand functions in patients with MS, it could be adopted as a new approach to restore hand functions. Additionally, if the application of tDCS demonstrates an accumulative effect in improving hand functions in patients with MS, it could provide an adjunct intervention during rehabilitation for these patients. This study will contribute to the growing body of literature on the use of tDCS in neurorehabilitation and could have a significant impact on the quality of life of patients with MS. 2023 Zoghi and Jaberzadeh.
A study on critical failure factors of Design for Six Sigma in Indian companies : results from a pilot survey
- Bhat, Shreeranga, Antony, Jiju, Gijo, E., Koul, Rajesh, Cudney, Elizabeth, Chakraborty, Ayon
- Authors: Bhat, Shreeranga , Antony, Jiju , Gijo, E. , Koul, Rajesh , Cudney, Elizabeth , Chakraborty, Ayon
- Date: 2023
- Type: Text , Journal article
- Relation: TQM Journal Vol. 35, no. 4 (2023), p. 1072-1093
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- Description: Purpose: While Six Sigma (SS) has been deployed effectively in Indian manufacturing and service sectors as a process improvement methodology, the implementation of Design for Six Sigma (DFSS) for robust product and service development has not shown noticeable results. Therefore, this article aims to determine the critical failure factors (CFFs) of DFSS in the Indian context. Design/methodology/approach: The paper presents the results of a pilot survey on the CFFs of DFSS in Indian companies. The survey participants were specialists in DFSS who have been involved in DFSS projects in their past and present companies. Moreover, the pilot study participants were DFSS Champions, Master Black Belts, Black Belts and Green Belts from the manufacturing and service sectors. Findings: Company-wide applications of DFSS are very limited in India. Most of the DFSS project failures are reported in the Analyse phase of the project. The results indicated that all 18 CFFs used in the survey have a significant impact on project failures. Also, it was determined that all CFFs are positively correlated with each other. Further, a strong correlation was observed between the voice of the customer (VOC) and project selection and prioritisation. In addition, effective training showed a strong correlation with the right selection of tools. Research limitations/implications: The pilot survey was based on a limited sample size. Moreover, the study is confined to only the Indian context and data were collected through the authors' networks. However, respondents were proficient, certified and involved in DFSS project deployment in the manufacturing and service sectors. Therefore, the study's findings are useful and meaningful to draw robust inferences. Originality/value: To the best of the authors' knowledge, this is the first empirical study conducted in the Indian context to identify the reasons for DFSS project failures. The study's findings can aid academicians and practitioners in comprehending and critically examining the CFFs of DFSS before executing a project. Moreover, the research outcome motivates policymakers to create an ecosystem to effectively adopt DFSS for start-ups and micro, small and medium enterprises (MSME) to ensure a circular economy and support the “Atmanirbhar Bharat” initiative. © 2022, Emerald Publishing Limited.
- Authors: Bhat, Shreeranga , Antony, Jiju , Gijo, E. , Koul, Rajesh , Cudney, Elizabeth , Chakraborty, Ayon
- Date: 2023
- Type: Text , Journal article
- Relation: TQM Journal Vol. 35, no. 4 (2023), p. 1072-1093
- Full Text:
- Reviewed:
- Description: Purpose: While Six Sigma (SS) has been deployed effectively in Indian manufacturing and service sectors as a process improvement methodology, the implementation of Design for Six Sigma (DFSS) for robust product and service development has not shown noticeable results. Therefore, this article aims to determine the critical failure factors (CFFs) of DFSS in the Indian context. Design/methodology/approach: The paper presents the results of a pilot survey on the CFFs of DFSS in Indian companies. The survey participants were specialists in DFSS who have been involved in DFSS projects in their past and present companies. Moreover, the pilot study participants were DFSS Champions, Master Black Belts, Black Belts and Green Belts from the manufacturing and service sectors. Findings: Company-wide applications of DFSS are very limited in India. Most of the DFSS project failures are reported in the Analyse phase of the project. The results indicated that all 18 CFFs used in the survey have a significant impact on project failures. Also, it was determined that all CFFs are positively correlated with each other. Further, a strong correlation was observed between the voice of the customer (VOC) and project selection and prioritisation. In addition, effective training showed a strong correlation with the right selection of tools. Research limitations/implications: The pilot survey was based on a limited sample size. Moreover, the study is confined to only the Indian context and data were collected through the authors' networks. However, respondents were proficient, certified and involved in DFSS project deployment in the manufacturing and service sectors. Therefore, the study's findings are useful and meaningful to draw robust inferences. Originality/value: To the best of the authors' knowledge, this is the first empirical study conducted in the Indian context to identify the reasons for DFSS project failures. The study's findings can aid academicians and practitioners in comprehending and critically examining the CFFs of DFSS before executing a project. Moreover, the research outcome motivates policymakers to create an ecosystem to effectively adopt DFSS for start-ups and micro, small and medium enterprises (MSME) to ensure a circular economy and support the “Atmanirbhar Bharat” initiative. © 2022, Emerald Publishing Limited.
A systematic literature review of workplace physical activity programs : an exploration of barriers and enabling factors
- Dabkowski, Elissa, Porter, Joanne, Barbagallo, Michael, Prokopiv, Val, Snell, Christopher, Missen, Karen
- Authors: Dabkowski, Elissa , Porter, Joanne , Barbagallo, Michael , Prokopiv, Val , Snell, Christopher , Missen, Karen
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Cogent Psychology Vol. 10, no. 1 (2023), p.
- Full Text:
- Reviewed:
- Description: Physical inactivity continues to be a global issue with many adolescents and adults failing to meet the recommendations for daily exercise. Efforts to reduce physical inactivity in adults include the incorporation of strategies such as workplace physical activity programs, especially for sedentary workers. In this systematic literature review we examined current literature about the efficacy of workplace physical activity programs, as well as the barriers and enablers to these programs. Six EBSCO databases were searched (Academic Search Complete, CINAHL Complete, MEDLINE, APA PsycInfo, APA PsycArticles and SPORTDiscus with full text) between a ten year period (2011 to 2021). The search terms used were “physical activity”, “workplace” and “program” along with their variations. Following a systematic process, eighteen papers met the eligibility criteria. The authors analysed the findings using a narrative synthesis, in which four themes emerged from the data. These include Benefits to physical health, Benefits to mental health, Barriers to workplace physical activity and Workplace activity enablers. These findings provided several recommendations for organizations that endeavour to improve the health of workplace employees. Generalised workplace physical activity programs were viewed favourably by both employees and employers. Incorporating these practices into daily work structures may provide favourable outcomes such as increased work productivity and reduced physical inactivity. © 2023 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.
- Authors: Dabkowski, Elissa , Porter, Joanne , Barbagallo, Michael , Prokopiv, Val , Snell, Christopher , Missen, Karen
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Cogent Psychology Vol. 10, no. 1 (2023), p.
- Full Text:
- Reviewed:
- Description: Physical inactivity continues to be a global issue with many adolescents and adults failing to meet the recommendations for daily exercise. Efforts to reduce physical inactivity in adults include the incorporation of strategies such as workplace physical activity programs, especially for sedentary workers. In this systematic literature review we examined current literature about the efficacy of workplace physical activity programs, as well as the barriers and enablers to these programs. Six EBSCO databases were searched (Academic Search Complete, CINAHL Complete, MEDLINE, APA PsycInfo, APA PsycArticles and SPORTDiscus with full text) between a ten year period (2011 to 2021). The search terms used were “physical activity”, “workplace” and “program” along with their variations. Following a systematic process, eighteen papers met the eligibility criteria. The authors analysed the findings using a narrative synthesis, in which four themes emerged from the data. These include Benefits to physical health, Benefits to mental health, Barriers to workplace physical activity and Workplace activity enablers. These findings provided several recommendations for organizations that endeavour to improve the health of workplace employees. Generalised workplace physical activity programs were viewed favourably by both employees and employers. Incorporating these practices into daily work structures may provide favourable outcomes such as increased work productivity and reduced physical inactivity. © 2023 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.
A systematic review of industrial wastewater management : evaluating challenges and enablers
- Singh, Bikram, Chakraborty, Ayon, Sehgal, Rippin
- Authors: Singh, Bikram , Chakraborty, Ayon , Sehgal, Rippin
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Journal of Environmental Management Vol. 348, no. (2023), p.
- Full Text:
- Reviewed:
- Description: The study provides a systematic literature review (SLR) encompassing industrial wastewater management research from the past decade, examining enablers, challenges, and prevailing practices. Originating from manufacturing, energy production, and diverse industrial processes, industrial wastewater's handling is critical due to its potential to impact the environment and public health. The research aims to comprehend the current state of industrial wastewater management, pinpoint gaps, and outline future research prospects. The SLR methodology involves scouring the Scopus database, yielding an initial pool of 253 articles. Refinement via search code leaves 101 articles, followed by abstract screening that reduces articles to 79, and finally 66 well-focused articles left for thorough full-text examination. Results underscore the significance of regulatory frameworks, technological innovation, and sustainability considerations as cornerstones for effective wastewater management. However, substantial impediments like; inadequate infrastructure, resource constraints and the necessity for stakeholder collaboration still exist. The study highlights emerging research domains, exemplified by advanced technologies like nanotechnology and bioremediation, alongside the pivotal role of circular economy principles in wastewater management. The SLR offers an exhaustive view of contemporary industrial wastewater management, accentuating the imperative of an all-encompassing approach that integrates regulatory, technological, and sustainability facets. Notably, the research identifies gaps and opportunities for forthcoming exploration, advocating for interdisciplinary research and intensified stakeholder collaboration. The study's insights cater to policymakers, practitioners, and researchers, equipping them to address the challenges and capitalize on prospects in industrial wastewater management effectively. © 2023 The Author(s)
- Authors: Singh, Bikram , Chakraborty, Ayon , Sehgal, Rippin
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Journal of Environmental Management Vol. 348, no. (2023), p.
- Full Text:
- Reviewed:
- Description: The study provides a systematic literature review (SLR) encompassing industrial wastewater management research from the past decade, examining enablers, challenges, and prevailing practices. Originating from manufacturing, energy production, and diverse industrial processes, industrial wastewater's handling is critical due to its potential to impact the environment and public health. The research aims to comprehend the current state of industrial wastewater management, pinpoint gaps, and outline future research prospects. The SLR methodology involves scouring the Scopus database, yielding an initial pool of 253 articles. Refinement via search code leaves 101 articles, followed by abstract screening that reduces articles to 79, and finally 66 well-focused articles left for thorough full-text examination. Results underscore the significance of regulatory frameworks, technological innovation, and sustainability considerations as cornerstones for effective wastewater management. However, substantial impediments like; inadequate infrastructure, resource constraints and the necessity for stakeholder collaboration still exist. The study highlights emerging research domains, exemplified by advanced technologies like nanotechnology and bioremediation, alongside the pivotal role of circular economy principles in wastewater management. The SLR offers an exhaustive view of contemporary industrial wastewater management, accentuating the imperative of an all-encompassing approach that integrates regulatory, technological, and sustainability facets. Notably, the research identifies gaps and opportunities for forthcoming exploration, advocating for interdisciplinary research and intensified stakeholder collaboration. The study's insights cater to policymakers, practitioners, and researchers, equipping them to address the challenges and capitalize on prospects in industrial wastewater management effectively. © 2023 The Author(s)
A systematic review of preceptor's experience in supervising undergraduate nursing students : lessons learned for mental health nursing
- Benny, Jessy, Porter, Joanne, Joseph, Bindu
- Authors: Benny, Jessy , Porter, Joanne , Joseph, Bindu
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Nursing Open Vol. 10, no. 4 (2023), p. 2003-2014
- Full Text:
- Reviewed:
- Description: Background: Preceptorship in nursing has been a valued concept in nursing. Speciality area such as mental health nursing has a massive gap in research study. To develop sturdy mental health nursing workforce, it is necessary to conduct more studies. Aim: This literature review aims to explore preceptor's experience in precepting undergraduate nursing students in mental health. Design: Systematic review of literature. Methods: The systematic review was conducted from January 2021 to August 2021. Population of the studies included Registered Nurses supervising nursing students in the clinical area. Only studies conducted in English were included. A systematic search using EBSCO Host databases, CINAHL Complete, MEDLINE APA Psycinfo & APA PsycArticles, has been used in this review paper. Papers were also selected from the citation reference of included papers. The new version of the PRISMA 2020 guidelines used to represent the process of selection of papers has been incorporated as part of this review. The final set of data included 14 original papers meeting the eligibility criteria which involved quantitative (n = 5), qualitative (n = 4) and mixed-method studies (n = 5). Result: Results were presented under three major themes: time-consuming, lack of recognition and need extra support. Further research is required in the mental health clinical setting to effectively explore the impact of relationships between preceptors and the preceptees. Conclusion: Preceptors reported supervising students in the clinical area has many benefits. However, some challenges they raised were increase in workload, requiring some guidance and acknowledgement from the organization. © 2022 The Authors. Nursing Open published by John Wiley & Sons Ltd.
- Authors: Benny, Jessy , Porter, Joanne , Joseph, Bindu
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Nursing Open Vol. 10, no. 4 (2023), p. 2003-2014
- Full Text:
- Reviewed:
- Description: Background: Preceptorship in nursing has been a valued concept in nursing. Speciality area such as mental health nursing has a massive gap in research study. To develop sturdy mental health nursing workforce, it is necessary to conduct more studies. Aim: This literature review aims to explore preceptor's experience in precepting undergraduate nursing students in mental health. Design: Systematic review of literature. Methods: The systematic review was conducted from January 2021 to August 2021. Population of the studies included Registered Nurses supervising nursing students in the clinical area. Only studies conducted in English were included. A systematic search using EBSCO Host databases, CINAHL Complete, MEDLINE APA Psycinfo & APA PsycArticles, has been used in this review paper. Papers were also selected from the citation reference of included papers. The new version of the PRISMA 2020 guidelines used to represent the process of selection of papers has been incorporated as part of this review. The final set of data included 14 original papers meeting the eligibility criteria which involved quantitative (n = 5), qualitative (n = 4) and mixed-method studies (n = 5). Result: Results were presented under three major themes: time-consuming, lack of recognition and need extra support. Further research is required in the mental health clinical setting to effectively explore the impact of relationships between preceptors and the preceptees. Conclusion: Preceptors reported supervising students in the clinical area has many benefits. However, some challenges they raised were increase in workload, requiring some guidance and acknowledgement from the organization. © 2022 The Authors. Nursing Open published by John Wiley & Sons Ltd.
A systematic review of wheelchair and mobility scooter containment systems used internationally on public transit buses
- Unsworth, Carolyn, Timmer, Amanda
- Authors: Unsworth, Carolyn , Timmer, Amanda
- Date: 2023
- Type: Text , Journal article , Review
- Relation: International Journal of Environmental Research and Public Health Vol. 20, no. 20 (2023), p.
- Full Text:
- Reviewed:
- Description: Despite the daily need for people to travel on public transit buses using their wheeled mobility devices, relatively little information is available regarding the most efficacious, affordable, and independent approaches to assist passengers with keeping their mobility devices in the designated wheelchair access space. A systematic review was undertaken to summarize this literature, place it within a geographical and temporal context, appraise its quality, and establish common themes. Key academic and grey literature transportation databases and government websites searched from 1990 to May 2022 identified 33 documents, which were appraised using the Mixed Methods Appraisal Tool (MMAT) or the Authority, Accuracy, Coverage, Objectivity, Date, Significance (AACODS) tool. Overall, the documents included were of good quality. The literature retrieved focused on the development and testing of the active containment systems favored for use in North America with a contrastingly small examination of the effectiveness of passive or semi-passive containment systems. Almost no literature was retrieved in English from European researchers documenting the use or effectiveness of rearward-facing passive systems. While tip or slide events are relatively rare among mobility device users, the effective use of containment systems is vital to minimize these. Further research is required to support transport policy makers, operators, and bus drivers to identify and correctly implement optimal containment systems to promote safety for all passengers on public buses. © 2023 by the authors.
- Authors: Unsworth, Carolyn , Timmer, Amanda
- Date: 2023
- Type: Text , Journal article , Review
- Relation: International Journal of Environmental Research and Public Health Vol. 20, no. 20 (2023), p.
- Full Text:
- Reviewed:
- Description: Despite the daily need for people to travel on public transit buses using their wheeled mobility devices, relatively little information is available regarding the most efficacious, affordable, and independent approaches to assist passengers with keeping their mobility devices in the designated wheelchair access space. A systematic review was undertaken to summarize this literature, place it within a geographical and temporal context, appraise its quality, and establish common themes. Key academic and grey literature transportation databases and government websites searched from 1990 to May 2022 identified 33 documents, which were appraised using the Mixed Methods Appraisal Tool (MMAT) or the Authority, Accuracy, Coverage, Objectivity, Date, Significance (AACODS) tool. Overall, the documents included were of good quality. The literature retrieved focused on the development and testing of the active containment systems favored for use in North America with a contrastingly small examination of the effectiveness of passive or semi-passive containment systems. Almost no literature was retrieved in English from European researchers documenting the use or effectiveness of rearward-facing passive systems. While tip or slide events are relatively rare among mobility device users, the effective use of containment systems is vital to minimize these. Further research is required to support transport policy makers, operators, and bus drivers to identify and correctly implement optimal containment systems to promote safety for all passengers on public buses. © 2023 by the authors.
A true triaxial strength criterion for rocks by gene expression programming
- Zhou, Jian, Zhang, Rui, Qiu, Yingui, Khandelwal, Manoj
- Authors: Zhou, Jian , Zhang, Rui , Qiu, Yingui , Khandelwal, Manoj
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Rock Mechanics and Geotechnical Engineering Vol. 15, no. 10 (2023), p. 2508-2520
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- Reviewed:
- Description: Rock strength is a crucial factor to consider when designing and constructing underground projects. This study utilizes a gene expression programming (GEP) algorithm-based model to predict the true triaxial strength of rocks, taking into account the influence of rock genesis on their mechanical behavior during the model building process. A true triaxial strength criterion based on the GEP model for igneous, metamorphic and magmatic rocks was obtained by training the model using collected data. Compared to the modified Weibols-Cook criterion, the modified Mohr-Coulomb criterion, and the modified Lade criterion, the strength criterion based on the GEP model exhibits superior prediction accuracy performance. The strength criterion based on the GEP model has better performance in R2, RMSE and MAPE for the data set used in this study. Furthermore, the strength criterion based on the GEP model shows greater stability in predicting the true triaxial strength of rocks across different types. Compared to the existing strength criterion based on the genetic programming (GP) model, the proposed criterion based on GEP model achieves more accurate predictions of the variation of true triaxial strength (
- Authors: Zhou, Jian , Zhang, Rui , Qiu, Yingui , Khandelwal, Manoj
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Rock Mechanics and Geotechnical Engineering Vol. 15, no. 10 (2023), p. 2508-2520
- Full Text:
- Reviewed:
- Description: Rock strength is a crucial factor to consider when designing and constructing underground projects. This study utilizes a gene expression programming (GEP) algorithm-based model to predict the true triaxial strength of rocks, taking into account the influence of rock genesis on their mechanical behavior during the model building process. A true triaxial strength criterion based on the GEP model for igneous, metamorphic and magmatic rocks was obtained by training the model using collected data. Compared to the modified Weibols-Cook criterion, the modified Mohr-Coulomb criterion, and the modified Lade criterion, the strength criterion based on the GEP model exhibits superior prediction accuracy performance. The strength criterion based on the GEP model has better performance in R2, RMSE and MAPE for the data set used in this study. Furthermore, the strength criterion based on the GEP model shows greater stability in predicting the true triaxial strength of rocks across different types. Compared to the existing strength criterion based on the genetic programming (GP) model, the proposed criterion based on GEP model achieves more accurate predictions of the variation of true triaxial strength (
Access and engagement of First Nations women in maternal and child health services
- Authors: Austin, Catherine
- Date: 2023
- Type: Text , Thesis , PhD
- Full Text:
- Description: This thesis explores and describes the engagement of First Nations women, with children from birth to five years of age, with Maternal and Child Health (MCH) services in Victoria, Australia. Identification of the factors that facilitate, support or hinder these women’s engagement with MCH services could strengthen the model of care to effectively engage First Nations women with these services. Access in the early years of a child’s life to integrated, effective, community-based services is a well-established predictor of a child’s successful transition to school and their lifelong education and employment outcomes. Such access is crucial in a child’s first 2,000 days (the period from conception to the child’s fifth year), which forms the foundation for a child’s lifetime development and health. Prior evaluative studies have shown that participation in MCH services in Victoria improves the health outcomes for children and families, particularly First Nations families. However, First Nations women and their children in Victoria show poorer health outcomes and lower participation in MCH services compared to non-Indigenous persons; this suggests a need to improve the current Victorian MCH service model. This thesis contributes recommendations for such improvements. The literature review (Chapter 2) identified the absence of a synthesis of qualitative studies of models of care to help guide MCH practice and innovation for all families, especially those at risk of child abuse and neglect. To address this gap, a three-phase qualitative study was conducted in the Glenelg Shire, Victoria, Australia, using narrative inquiry integrated with the Indigenous philosophy ‘Dadirri’. ‘Dadirri’, which emphasises deep and respectful listening, guided the development of the research design; this methodology assisted in understanding Indigenous culture and its sensitivities, building trust with the First Nations peoples involved in the studies, developing open-ended and conversational dialogue, and building respectful relationships. This method enabled First Nations women’s voices to be heard and the collection of rich data based on participants’ perspectives of and experiences with MCH services in Victoria. Study One (Chapter 4) recruited First Nations women residing in the Glenelg Shire, with at least one child aged birth to five years, to explore their perceptions and experiences of MCH services and barriers to accessing and engaging with MCH services. Study Two (Chapter 5) compared Study One data with accounts from MCH nurses working in Glenelg Shire. Study Three (Chapter 6) reviewed a piloting of the Early Assessment Referral Links (EARL) concept (developed by the researcher) that aims to improve First Nations women and their children’s access to and engagement with MCH services. EARL involved the core principles of narrative inquiry integrated with ‘Dadirri’. Study One and Two found that enabling factors for access and engagement include interventions that are culturally sensitive and effective; recognise the social determinates of health (SDOH) and social and emotional wellbeing; are timely, appropriate, culturally strong, flexible, holistic and community-based; support continuity of care and communication; and encourage early identification of risk, particularly of family violence (FV), and further assessment, intervention, referral and support in the child’s first 2,000 days. Barriers to access and engagement include an ineffective service model built on mistrust, poor communication due to cultural differences between client and provider (particularly around identification and disclosure of woman’s risk of FV), lack of continuity of care between services, limited flexibility of service delivery to suit individual needs, and a service model that does not recognise the importance of the SDOH and social and emotional wellbeing. Study Three results showed that participation of First Nations families in MCH services was consistently above the state average during the pilot period, and several First Nations families were referred to EARL stakeholders and other health professionals during the pilot. Further, there were increases in First Nations children being breastfed, fully immunised and attending Early Start Kindergarten, and identification of First Nations children at risk of abuse or neglect improved (with a significant increase in referrals for FV and child protection and significant decrease in episodes of out-of-home care). This thesis’s findings can support policy development. This research shows that timely, effective, holistic engagement with First Nations women in their child’s first 2,000 days, that respects their culture and facilitates genuine partnerships built on co-design and shared decision-making with the Indigenous community, needs to be an essential part of the MCH service model. Additionally, this thesis recommends adopting a strengths-based approach that respects First Nations peoples’ child-rearing practices and culture, and providing necessary training to MCH nurses who work with First Nations families. Keywords: child family health, continuity of care, First Nations women
- Description: Doctor of Philosophy
- Authors: Austin, Catherine
- Date: 2023
- Type: Text , Thesis , PhD
- Full Text:
- Description: This thesis explores and describes the engagement of First Nations women, with children from birth to five years of age, with Maternal and Child Health (MCH) services in Victoria, Australia. Identification of the factors that facilitate, support or hinder these women’s engagement with MCH services could strengthen the model of care to effectively engage First Nations women with these services. Access in the early years of a child’s life to integrated, effective, community-based services is a well-established predictor of a child’s successful transition to school and their lifelong education and employment outcomes. Such access is crucial in a child’s first 2,000 days (the period from conception to the child’s fifth year), which forms the foundation for a child’s lifetime development and health. Prior evaluative studies have shown that participation in MCH services in Victoria improves the health outcomes for children and families, particularly First Nations families. However, First Nations women and their children in Victoria show poorer health outcomes and lower participation in MCH services compared to non-Indigenous persons; this suggests a need to improve the current Victorian MCH service model. This thesis contributes recommendations for such improvements. The literature review (Chapter 2) identified the absence of a synthesis of qualitative studies of models of care to help guide MCH practice and innovation for all families, especially those at risk of child abuse and neglect. To address this gap, a three-phase qualitative study was conducted in the Glenelg Shire, Victoria, Australia, using narrative inquiry integrated with the Indigenous philosophy ‘Dadirri’. ‘Dadirri’, which emphasises deep and respectful listening, guided the development of the research design; this methodology assisted in understanding Indigenous culture and its sensitivities, building trust with the First Nations peoples involved in the studies, developing open-ended and conversational dialogue, and building respectful relationships. This method enabled First Nations women’s voices to be heard and the collection of rich data based on participants’ perspectives of and experiences with MCH services in Victoria. Study One (Chapter 4) recruited First Nations women residing in the Glenelg Shire, with at least one child aged birth to five years, to explore their perceptions and experiences of MCH services and barriers to accessing and engaging with MCH services. Study Two (Chapter 5) compared Study One data with accounts from MCH nurses working in Glenelg Shire. Study Three (Chapter 6) reviewed a piloting of the Early Assessment Referral Links (EARL) concept (developed by the researcher) that aims to improve First Nations women and their children’s access to and engagement with MCH services. EARL involved the core principles of narrative inquiry integrated with ‘Dadirri’. Study One and Two found that enabling factors for access and engagement include interventions that are culturally sensitive and effective; recognise the social determinates of health (SDOH) and social and emotional wellbeing; are timely, appropriate, culturally strong, flexible, holistic and community-based; support continuity of care and communication; and encourage early identification of risk, particularly of family violence (FV), and further assessment, intervention, referral and support in the child’s first 2,000 days. Barriers to access and engagement include an ineffective service model built on mistrust, poor communication due to cultural differences between client and provider (particularly around identification and disclosure of woman’s risk of FV), lack of continuity of care between services, limited flexibility of service delivery to suit individual needs, and a service model that does not recognise the importance of the SDOH and social and emotional wellbeing. Study Three results showed that participation of First Nations families in MCH services was consistently above the state average during the pilot period, and several First Nations families were referred to EARL stakeholders and other health professionals during the pilot. Further, there were increases in First Nations children being breastfed, fully immunised and attending Early Start Kindergarten, and identification of First Nations children at risk of abuse or neglect improved (with a significant increase in referrals for FV and child protection and significant decrease in episodes of out-of-home care). This thesis’s findings can support policy development. This research shows that timely, effective, holistic engagement with First Nations women in their child’s first 2,000 days, that respects their culture and facilitates genuine partnerships built on co-design and shared decision-making with the Indigenous community, needs to be an essential part of the MCH service model. Additionally, this thesis recommends adopting a strengths-based approach that respects First Nations peoples’ child-rearing practices and culture, and providing necessary training to MCH nurses who work with First Nations families. Keywords: child family health, continuity of care, First Nations women
- Description: Doctor of Philosophy
Acupuncture for comorbid depression and insomnia in perimenopause : a feasibility patient-assessor-blinded, randomized, and sham-controlled clinical trial
- Zhao, Fei, Zheng, Zhen, Fu, Qiang-Qiang, Conduit, Russell, Xu, Hong, Wang, Hui-ru, Huang, Yu-Ling, Jiang, Ting, Zhang, Wen-Jing, Kennedy, Gerard
- Authors: Zhao, Fei , Zheng, Zhen , Fu, Qiang-Qiang , Conduit, Russell , Xu, Hong , Wang, Hui-ru , Huang, Yu-Ling , Jiang, Ting , Zhang, Wen-Jing , Kennedy, Gerard
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Public Health Vol. 11, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background and objective: Whilst acupuncture is widely used for treating psychosomatic diseases, there is little high-quality evidence supporting its application in comorbid perimenopausal depression (PMD) and insomnia (PMI) which are common complaints during climacteric. This feasibility, patient-assessor-blinded, randomized, sham-controlled clinical trial addresses this gap by investigating the efficacy and safety of acupuncture on depressed mood and poor sleep in women with comorbid PMD and PMI. Methods: Seventy eligible participants were randomly assigned to either real-acupuncture (RA) or sham-acupuncture (SA) groups. Either RA or SA treatment were delivered in 17 sessions over 8 weeks. The primary outcomes for mood and sleep were changes on 17-items Hamilton Depression Rating Scale (HAM-D17) and Pittsburgh Sleep Quality Index (PSQI) scores, from baseline to 16-week follow-up. Secondary outcome measures involved anxiety symptoms, perimenopausal symptoms, quality of life, participants' experience of and satisfaction with the acupuncture treatment. Blood samples were taken to measure reproductive hormone levels. Intention-To-Treat and Per-Protocol analyses were conducted with linear mixed-effects models. The James' and Bang's blinding indices were used to assess the adequacy of blinding. Results: Sixty-five participants completed all treatment sessions, and 54 and 41 participants completed the eight- and 16-week follow-ups, respectively. At post-treatment and 8-week follow-up, the RA group showed a significantly greater reduction in PSQI scores than the SA group did; although the reduction of HAM-D17 scores in RA group was significant, the change was not statistically different from that of SA. There were no significant mean differences between baseline and 16-week follow-up in either HAM-D17 or PSQI in either group. There were no significant between-group differences in serum reproductive hormone levels. All treatments were tolerable and no serious adverse events were reported, and the blinding was successful. Conclusion: Acupuncture is safe and can contribute to clinically relevant improvements in comorbid PMD and PMI, with satisfactory short-and medium-term effects. Whether the anti-depressive benefit of acupuncture is specific or non-specific remains to be determined. No evidence was found for any longer-term benefit of acupuncture compared to sham at 16 weeks. Further research is required to elucidate mechanisms underlying the short to medium term effects of acupuncture. Copyright © 2023 Zhao, Zheng, Fu, Conduit, Xu, Wang, Huang, Jiang, Zhang and Kennedy.
- Authors: Zhao, Fei , Zheng, Zhen , Fu, Qiang-Qiang , Conduit, Russell , Xu, Hong , Wang, Hui-ru , Huang, Yu-Ling , Jiang, Ting , Zhang, Wen-Jing , Kennedy, Gerard
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Public Health Vol. 11, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background and objective: Whilst acupuncture is widely used for treating psychosomatic diseases, there is little high-quality evidence supporting its application in comorbid perimenopausal depression (PMD) and insomnia (PMI) which are common complaints during climacteric. This feasibility, patient-assessor-blinded, randomized, sham-controlled clinical trial addresses this gap by investigating the efficacy and safety of acupuncture on depressed mood and poor sleep in women with comorbid PMD and PMI. Methods: Seventy eligible participants were randomly assigned to either real-acupuncture (RA) or sham-acupuncture (SA) groups. Either RA or SA treatment were delivered in 17 sessions over 8 weeks. The primary outcomes for mood and sleep were changes on 17-items Hamilton Depression Rating Scale (HAM-D17) and Pittsburgh Sleep Quality Index (PSQI) scores, from baseline to 16-week follow-up. Secondary outcome measures involved anxiety symptoms, perimenopausal symptoms, quality of life, participants' experience of and satisfaction with the acupuncture treatment. Blood samples were taken to measure reproductive hormone levels. Intention-To-Treat and Per-Protocol analyses were conducted with linear mixed-effects models. The James' and Bang's blinding indices were used to assess the adequacy of blinding. Results: Sixty-five participants completed all treatment sessions, and 54 and 41 participants completed the eight- and 16-week follow-ups, respectively. At post-treatment and 8-week follow-up, the RA group showed a significantly greater reduction in PSQI scores than the SA group did; although the reduction of HAM-D17 scores in RA group was significant, the change was not statistically different from that of SA. There were no significant mean differences between baseline and 16-week follow-up in either HAM-D17 or PSQI in either group. There were no significant between-group differences in serum reproductive hormone levels. All treatments were tolerable and no serious adverse events were reported, and the blinding was successful. Conclusion: Acupuncture is safe and can contribute to clinically relevant improvements in comorbid PMD and PMI, with satisfactory short-and medium-term effects. Whether the anti-depressive benefit of acupuncture is specific or non-specific remains to be determined. No evidence was found for any longer-term benefit of acupuncture compared to sham at 16 weeks. Further research is required to elucidate mechanisms underlying the short to medium term effects of acupuncture. Copyright © 2023 Zhao, Zheng, Fu, Conduit, Xu, Wang, Huang, Jiang, Zhang and Kennedy.
Adaptive phase-field modelling of fracture propagation in poroelastic media using the scaled boundary finite element method
- Wijesinghe, Dakshith, Natarajan, Sundararajan, You, Greg, Khandelwal, Manoj, Dyson, Ashley, Song, Chongmin, Ooi, Ean Tat
- Authors: Wijesinghe, Dakshith , Natarajan, Sundararajan , You, Greg , Khandelwal, Manoj , Dyson, Ashley , Song, Chongmin , Ooi, Ean Tat
- Date: 2023
- Type: Text , Journal article
- Relation: Computer Methods in Applied Mechanics and Engineering Vol. 411, no. (2023), p.
- Full Text:
- Reviewed:
- Description: A scaled boundary finite element-based phase field formulation is proposed to model two-dimensional fracture in saturated poroelastic media. The mechanical response of the poroelastic media is simulated following Biot's theory, and the fracture surface evolution is modelled according to the phase field formulation. To avoid the application of fine uniform meshes that are constrained by the element size requirement when adopting phase field models, an adaptive refinement strategy based on quadtree meshes is adopted. The unique advantage of the scaled boundary finite element method is conducive to the application of quadtree adaptivity, as it can be directly formulated on quadtree meshes without the need for any special treatment of hanging nodes. Efficient computation is achieved by exploiting the unique patterns of the quadtree cells. An appropriate scaling is applied to the relevant matrices and vectors according the physical size of the cells in the mesh during the simulations. This avoids repetitive calculations of cells with the same configurations. The proposed model is validated using a benchmark with a known analytical solution. Numerical examples of hydraulic fractures driven by the injected fluid in cracks are modelled to illustrate the capabilities of the proposed model in handling crack propagation problems involving complex geometries. © 2023 The Author(s)
- Authors: Wijesinghe, Dakshith , Natarajan, Sundararajan , You, Greg , Khandelwal, Manoj , Dyson, Ashley , Song, Chongmin , Ooi, Ean Tat
- Date: 2023
- Type: Text , Journal article
- Relation: Computer Methods in Applied Mechanics and Engineering Vol. 411, no. (2023), p.
- Full Text:
- Reviewed:
- Description: A scaled boundary finite element-based phase field formulation is proposed to model two-dimensional fracture in saturated poroelastic media. The mechanical response of the poroelastic media is simulated following Biot's theory, and the fracture surface evolution is modelled according to the phase field formulation. To avoid the application of fine uniform meshes that are constrained by the element size requirement when adopting phase field models, an adaptive refinement strategy based on quadtree meshes is adopted. The unique advantage of the scaled boundary finite element method is conducive to the application of quadtree adaptivity, as it can be directly formulated on quadtree meshes without the need for any special treatment of hanging nodes. Efficient computation is achieved by exploiting the unique patterns of the quadtree cells. An appropriate scaling is applied to the relevant matrices and vectors according the physical size of the cells in the mesh during the simulations. This avoids repetitive calculations of cells with the same configurations. The proposed model is validated using a benchmark with a known analytical solution. Numerical examples of hydraulic fractures driven by the injected fluid in cracks are modelled to illustrate the capabilities of the proposed model in handling crack propagation problems involving complex geometries. © 2023 The Author(s)
Addressing global disparities in blood pressure control : perspectives of the International Society of Hypertension
- Schutte, Aletta, Jafar, Tazeen, Poulter, Neil, Damasceno, Albertino, Khan, Nadia, Nilsson, Peter, Alsaid, Jafar, Neupane, Dinesh, Kario, Kazuomi, Beheiry, Hind, Brouwers, Sofie, Burger, Dylan, Charchar, Fadi, Cho, Myeong-Chan, Guzik, Tomasz, Haji Al-Saedi, Ghazi, Ishaq, Muhammad, Itoh, Hiroshi, Jones, Erika, Khan, Taskeen, Kokubo, Yoshihiro, Kotruchin, Praew, Muxfeldt, Elizabeth, Odili, Augustine, Patil, Mansi, Ralapanawa, Udaya, Romero, Cesar, Schlaich, Markus, Shehab, Abdulla, Mooi, Ching
- Authors: Schutte, Aletta , Jafar, Tazeen , Poulter, Neil , Damasceno, Albertino , Khan, Nadia , Nilsson, Peter , Alsaid, Jafar , Neupane, Dinesh , Kario, Kazuomi , Beheiry, Hind , Brouwers, Sofie , Burger, Dylan , Charchar, Fadi , Cho, Myeong-Chan , Guzik, Tomasz , Haji Al-Saedi, Ghazi , Ishaq, Muhammad , Itoh, Hiroshi , Jones, Erika , Khan, Taskeen , Kokubo, Yoshihiro , Kotruchin, Praew , Muxfeldt, Elizabeth , Odili, Augustine , Patil, Mansi , Ralapanawa, Udaya , Romero, Cesar , Schlaich, Markus , Shehab, Abdulla , Mooi, Ching
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Cardiovascular Research Vol. 119, no. 2 (2023), p. 381-409
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- Description: Raised blood pressure (BP) is the leading cause of preventable death in the world. Yet, its global prevalence is increasing, and it remains poorly detected, treated, and controlled in both high- and low-resource settings. From the perspective of members of the International Society of Hypertension based in all regions, we reflect on the past, present, and future of hypertension care, highlighting key challenges and opportunities, which are often region-specific. We report that most countries failed to show sufficient improvements in BP control rates over the past three decades, with greater improvements mainly seen in some high-income countries, also reflected in substantial reductions in the burden of cardiovascular disease and deaths. Globally, there are significant inequities and disparities based on resources, sociodemographic environment, and race with subsequent disproportionate hypertension-related outcomes. Additional unique challenges in specific regions include conflict, wars, migration, unemployment, rapid urbanization, extremely limited funding, pollution, COVID-19-related restrictions and inequalities, obesity, and excessive salt and alcohol intake. Immediate action is needed to address suboptimal hypertension care and related disparities on a global scale. We propose a Global Hypertension Care Taskforce including multiple stakeholders and societies to identify and implement actions in reducing inequities, addressing social, commercial, and environmental determinants, and strengthening health systems implement a well-designed customized quality-of-care improvement framework. © 2022 The Author(s). Published by Oxford University Press on behalf of the European Society of Cardiology. **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliate “Fadi Charchar” is provided in this record**
- Authors: Schutte, Aletta , Jafar, Tazeen , Poulter, Neil , Damasceno, Albertino , Khan, Nadia , Nilsson, Peter , Alsaid, Jafar , Neupane, Dinesh , Kario, Kazuomi , Beheiry, Hind , Brouwers, Sofie , Burger, Dylan , Charchar, Fadi , Cho, Myeong-Chan , Guzik, Tomasz , Haji Al-Saedi, Ghazi , Ishaq, Muhammad , Itoh, Hiroshi , Jones, Erika , Khan, Taskeen , Kokubo, Yoshihiro , Kotruchin, Praew , Muxfeldt, Elizabeth , Odili, Augustine , Patil, Mansi , Ralapanawa, Udaya , Romero, Cesar , Schlaich, Markus , Shehab, Abdulla , Mooi, Ching
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Cardiovascular Research Vol. 119, no. 2 (2023), p. 381-409
- Full Text:
- Reviewed:
- Description: Raised blood pressure (BP) is the leading cause of preventable death in the world. Yet, its global prevalence is increasing, and it remains poorly detected, treated, and controlled in both high- and low-resource settings. From the perspective of members of the International Society of Hypertension based in all regions, we reflect on the past, present, and future of hypertension care, highlighting key challenges and opportunities, which are often region-specific. We report that most countries failed to show sufficient improvements in BP control rates over the past three decades, with greater improvements mainly seen in some high-income countries, also reflected in substantial reductions in the burden of cardiovascular disease and deaths. Globally, there are significant inequities and disparities based on resources, sociodemographic environment, and race with subsequent disproportionate hypertension-related outcomes. Additional unique challenges in specific regions include conflict, wars, migration, unemployment, rapid urbanization, extremely limited funding, pollution, COVID-19-related restrictions and inequalities, obesity, and excessive salt and alcohol intake. Immediate action is needed to address suboptimal hypertension care and related disparities on a global scale. We propose a Global Hypertension Care Taskforce including multiple stakeholders and societies to identify and implement actions in reducing inequities, addressing social, commercial, and environmental determinants, and strengthening health systems implement a well-designed customized quality-of-care improvement framework. © 2022 The Author(s). Published by Oxford University Press on behalf of the European Society of Cardiology. **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliate “Fadi Charchar” is provided in this record**
ADHD symptoms among adolescents : measurement invariance across mother and adolescent self-ratings
- Gomez, Rapson, Houghton, Stephen
- Authors: Gomez, Rapson , Houghton, Stephen
- Date: 2023
- Type: Text , Journal article
- Relation: Personality and Individual Differences Vol. 213, no. (2023), p.
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- Description: This study employed confirmatory factor analysis (CFA) to examine measurement invariance (configural, metric, and scalar) across mother and adolescent self-ratings of ADHD symptoms [inattention (IA), hyperactivity (HY), and impulsivity (IM)] as presented in the Disruptive Behavior Rating Scale (DBRS; Barkley & Murphy, 1998). The ADHD model used for this analysis was the ICD-10 3-factor model, with factors for IA, HY and IM. Findings supported configural invariance. Of the 18 ADHD symptoms, 4 symptoms (three of which were IA symptoms) lacked metric invariance. Nine thresholds (1 IA symptom, 6 HY symptoms, and 2 IM symptoms) lacked scalar invariance, with six being for the first thresholds. The psychometric and practical implications of the findings are discussed. © 2023 The Authors
- Authors: Gomez, Rapson , Houghton, Stephen
- Date: 2023
- Type: Text , Journal article
- Relation: Personality and Individual Differences Vol. 213, no. (2023), p.
- Full Text:
- Reviewed:
- Description: This study employed confirmatory factor analysis (CFA) to examine measurement invariance (configural, metric, and scalar) across mother and adolescent self-ratings of ADHD symptoms [inattention (IA), hyperactivity (HY), and impulsivity (IM)] as presented in the Disruptive Behavior Rating Scale (DBRS; Barkley & Murphy, 1998). The ADHD model used for this analysis was the ICD-10 3-factor model, with factors for IA, HY and IM. Findings supported configural invariance. Of the 18 ADHD symptoms, 4 symptoms (three of which were IA symptoms) lacked metric invariance. Nine thresholds (1 IA symptom, 6 HY symptoms, and 2 IM symptoms) lacked scalar invariance, with six being for the first thresholds. The psychometric and practical implications of the findings are discussed. © 2023 The Authors
Aerosol delivery of palivizumab in a neonatal lamb model of respiratory syncytial virus infection
- Edirisinghe, Hasindu, Rajapaksa, Anushi, Royce, Simon, Sourial, Magdy, Bischof, Robert, Anderson, Jeremy, Sarila, Gulcan, Nguyen, Cattram, Mulholland, Kim, Do, Lien, Licciardi, Paul
- Authors: Edirisinghe, Hasindu , Rajapaksa, Anushi , Royce, Simon , Sourial, Magdy , Bischof, Robert , Anderson, Jeremy , Sarila, Gulcan , Nguyen, Cattram , Mulholland, Kim , Do, Lien , Licciardi, Paul
- Date: 2023
- Type: Text , Journal article
- Relation: Viruses Vol. 15, no. 11 (2023), p.
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- Description: (1) Background: Palivizumab has been an approved preventative monoclonal antibody for respiratory syncytial virus (RSV) infection for over two decades. However, due to its high cost and requirement for multiple intramuscular injections, its use has been limited mostly to high-income countries. Following our previous study showing the successful lung deposition of aerosolised palivizumab in lambs, this current study evaluated the “proof-of-principle” effect of aerosolised palivizumab delivered as a therapeutic to neonatal lambs following RSV infection. (2) Methods: Neonatal lambs were intranasally inoculated with RSV-A2 on day 0 (day 3 post-birth) and treated with aerosolised palivizumab 3 days later (day 3 post-inoculation). Clinical symptoms, RSV viral load and inflammatory response were measured post-inoculation. (3) Results: Aerosolised therapeutic delivery of palivizumab did not reduce RSV viral loads in the nasopharynx nor the bronchoalveolar lavage fluid, but resulted in a modest reduction in inflammatory response at day 6 post-inoculation compared with untreated lambs. (4) Conclusions: This proof-of-principle study shows some evidence of aerosolised palivizumab reducing RSV inflammation, but further studies using optimized protocols are needed in order to validate these findings. © 2023 by the authors.
- Authors: Edirisinghe, Hasindu , Rajapaksa, Anushi , Royce, Simon , Sourial, Magdy , Bischof, Robert , Anderson, Jeremy , Sarila, Gulcan , Nguyen, Cattram , Mulholland, Kim , Do, Lien , Licciardi, Paul
- Date: 2023
- Type: Text , Journal article
- Relation: Viruses Vol. 15, no. 11 (2023), p.
- Full Text:
- Reviewed:
- Description: (1) Background: Palivizumab has been an approved preventative monoclonal antibody for respiratory syncytial virus (RSV) infection for over two decades. However, due to its high cost and requirement for multiple intramuscular injections, its use has been limited mostly to high-income countries. Following our previous study showing the successful lung deposition of aerosolised palivizumab in lambs, this current study evaluated the “proof-of-principle” effect of aerosolised palivizumab delivered as a therapeutic to neonatal lambs following RSV infection. (2) Methods: Neonatal lambs were intranasally inoculated with RSV-A2 on day 0 (day 3 post-birth) and treated with aerosolised palivizumab 3 days later (day 3 post-inoculation). Clinical symptoms, RSV viral load and inflammatory response were measured post-inoculation. (3) Results: Aerosolised therapeutic delivery of palivizumab did not reduce RSV viral loads in the nasopharynx nor the bronchoalveolar lavage fluid, but resulted in a modest reduction in inflammatory response at day 6 post-inoculation compared with untreated lambs. (4) Conclusions: This proof-of-principle study shows some evidence of aerosolised palivizumab reducing RSV inflammation, but further studies using optimized protocols are needed in order to validate these findings. © 2023 by the authors.