- Title
- The effect of regularization on drug-reaction relationships
- Creator
- Mammadov, Musa; Zhao, L.; Zhang, Jianjun
- Date
- 2012
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/34453
- Identifier
- vital:4646
- Identifier
-
https://doi.org/10.1080/02331934.2011.641547
- Identifier
- ISSN:0233-1934
- Abstract
- The least-squares method is a standard approach used in data fitting that has important applications in many areas in science and engineering including many finance problems. In the case when the problem under consideration involves large-scale sparse matrices regularization methods are used to obtain more stable solutions by relaxing the data fitting. In this article, a new regularization algorithm is introduced based on the Karush-Kuhn-Tucker conditions and the Fisher-Burmeister function. The Newton method is used for solving corresponding systems of equations. The advantages of the proposed method has been demonstrated in the establishment of drug-reaction relationships based on the Australian Adverse Drug Reaction Advisory Committee database. © 2012 Copyright Taylor and Francis Group, LLC.
- Relation
- Optimization Vol. 61, no. 4 (2012), p. 405-422
- Rights
- Copyright Taylor and Francis Group, LLC.
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0103 Numerical and Computational Mathematics; 0102 Applied Mathematics; Adverse drug reaction; Data classification; Ill-posed problem; Optimization; Regularization method
- Full Text
- Reviewed
- Hits: 3470
- Visitors: 3789
- Downloads: 192
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Accepted Version | 267 KB | Adobe Acrobat PDF | View Details Download |