Showing items 1 - 20 of 162

Your selections:

Can optimum solar radiation exposure or supplemented vitamin D intake reduce the severity of COVID-19 symptoms?

- Abraham, Joji, Dowling, Kim, Florentine, Singarayer

  • Authors: Abraham, Joji , Dowling, Kim , Florentine, Singarayer
  • Date: 2021
  • Type: Text , Journal article , Review
  • Relation: International Journal of Environmental Research and Public Health Vol. 18, no. 2 (2021), p. 1-21
  • Full Text:
  • Reviewed:
  • Description: The foremost mortality-causing symptom associated with COVID-19 is acute respiratory distress syndrome (ARDS). A significant correlation has been identified between the deficiency in vitamin D and the risk of developing ARDS. It has been suggested that if we can reduce or modify ARDS in COVID-19 patients, we may significantly reduce the severity of COVID-19 symptoms and associated mortality rates. The increased mortality of dark-skinned people, who have a reduced UV absorption capacity, may be consistent with diminished vitamin D status. The factors associated with COVID-19 mortality, such as old age, ethnicity, obesity, hypertension, cardiovascular diseases, and diabetes, are all found to be linked with vitamin D deficiency. Based on this review and as a precautionary measure, it is suggested that the adoption of appropriate and safe solar exposure and vitamin D enriched foods and supplements should be considered to reduce the possible severity of COVID-19 symptoms. Safe sun exposure is deemed beneficial globally, specifically in low and middle- income countries, as there is no cost involved. It is also noted that improved solar exposure and vitamin D levels can reduce the impact of other diseases as well, thus assisting in maintaining general human well-being. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Medicinal value of three agricultural weed species of the asteraceae family : a review

- Jayasundera, Mithila, Florentine, Singarayer, Tennakoon, Kushan, Chauhan, Bhagirath

  • Authors: Jayasundera, Mithila , Florentine, Singarayer , Tennakoon, Kushan , Chauhan, Bhagirath
  • Date: 2021
  • Type: Text , Journal article , Review
  • Relation: Pharmacognosy Journal Vol. 13, no. 1 (2021), p. 264-277
  • Full Text:
  • Reviewed:
  • Description: Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. are well known plant species of the Asteraceae family that are considered weeds in intensive agriculture. These weeds are traditionally known to have medicinal properties and have been used for therapeutic treatments. However, it is only the lack of proper knowledge, awareness and screening that have limited their use in pharmaceutical sectors. This review attempts to consolidate the traditional, phytochemical and pharmacological studies that have been carried out on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L., which we note are widely spread throughout the world. This study was conducted through a coherent search on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. with respect to traditional uses, phytochemical and pharmacological studies that have been performed on these three agricultural weeds all over the world. An exploration of reported descriptions of the potential medical importance of three agricultural weed species (A. conyzoides, T. procumbens and B. pilosa) has been presented. The present review would encourage further clinical investigations into these three plants and their extracts to more closely define the range of uses of these herbs for clinical applications. This, in turn, would give a clear understanding whether these weed species might be targeted to be conserved in a sustainable manner rather than eradicated. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Model predictive control of microgrids – An overview

- Hu, Jiefeng, Shan, Yinghao, Guerrero, Josep, Ioinovici, Adrian, Chan, Ka, Rodriguez, Jose

  • Authors: Hu, Jiefeng , Shan, Yinghao , Guerrero, Josep , Ioinovici, Adrian , Chan, Ka , Rodriguez, Jose
  • Date: 2021
  • Type: Text , Journal article , Review
  • Relation: Renewable and Sustainable Energy Reviews Vol. 136, no. (2021), p.
  • Full Text: false
  • Reviewed:
  • Description: The development of microgrids is an advantageous option for integrating rapidly growing renewable energies. However, the stochastic nature of renewable energies and variable power demand have created many challenges like unstable voltage/frequency and complicated power management and interaction with the utility grid. Recently, predictive control with its fast transient response and flexibility to accommodate different constraints has presented huge potentials in microgrid applications. This paper provides a comprehensive review of model predictive control (MPC) in individual and interconnected microgrids, including both converter-level and grid-level control strategies applied to three layers of the hierarchical control architecture. This survey shows that MPC is at the beginning of the application in microgrids and that it emerges as a competitive alternative to conventional methods in voltage regulation, frequency control, power flow management and economic operation optimization. Also, some of the most important trends in MPC development have been highlighted and discussed as future perspectives. © 2020 Elsevier Ltd
  • Description: This work was supported by School of Engineering, IT and Physical Sciences, Federation University Australia , under Project RGS20-5 .

A guide to the short, long and circular RNAs in hypertension and cardiovascular disease

- Prestes, Priscilla, Maier, Michelle, Woods, Bradley, Charchar, Fadi

  • Authors: Prestes, Priscilla , Maier, Michelle , Woods, Bradley , Charchar, Fadi
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: International Journal of Molecular Sciences Vol. 21, no. 10 (2020)
  • Full Text:
  • Reviewed:
  • Description: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including hypertension, coronary artery disease and atherosclerosis. Studies in animal models and human studies have elucidated the contribution of many genetic factors, including non-coding RNAs. Non-coding RNAs are RNAs not translated into protein, involved in gene expression regulation post-transcriptionally and implicated in CVD. Of these, circular RNAs (circRNAs) and microRNAs are relevant. CircRNAs are created by the back-splicing of pre-messenger RNA and have been underexplored as contributors to CVD. These circRNAs may also act as biomarkers of human disease, as they can be extracted from whole blood, plasma, saliva and seminal fluid. CircRNAs have recently been implicated in various disease processes, including hypertension and other cardiovascular disease. This review article will explore the promising and emerging roles of circRNAs as potential biomarkers and therapeutic targets in CVD, in particular hypertension. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

A role for MAIT cells in colorectal cancer

- Berzins, Stuart, Wallace, Morgan, Kannourakis, George, Kelly, Jason

  • Authors: Berzins, Stuart , Wallace, Morgan , Kannourakis, George , Kelly, Jason
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Frontiers in Immunology Vol. 11, no. (2020), p.
  • Full Text:
  • Reviewed:
  • Description: MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their response and whether they are contributing to anti-tumor immunity, or to the progression of the disease. We have reviewed the current state of knowledge about the role of MAIT cells in colorectal cancer, including their likely influence when activated and potential sources of stimulation in the tumor microenvironment. The prospects for MAIT cells being used in clinical settings as biomarkers or as targets of new immunotherapies designed to harness their function are discussed. © Copyright © 2020 Berzins, Wallace, Kannourakis and Kelly.

Communities of practice : a systematic review and meta-synthesis of what it means and how it really works among nursing students and novices

- Terry, Daniel, Nguyen, Hoang, Peck, Blake, Smith, Andrew, Phan, Hoang

  • Authors: Terry, Daniel , Nguyen, Hoang , Peck, Blake , Smith, Andrew , Phan, Hoang
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Journal of Clinical Nursing Vol. 29, no. 3-4 (2020), p. 370-380
  • Full Text:
  • Reviewed:
  • Description: Aims and objectives: To evaluate the enablers, barriers and impact that communities of practice have on novice nurses and students learning to become registered nurses. Background: Communities of practice have formed the basis for conceptualising the process of learning that occurs among groups of people within a place of work—a mainstay of healthcare practice. There is a dearth of literature that focuses specifically on the outcomes from student and novice engagement with existing communities of practice. Design: Systematic review and Meta-synthesis. Methods: MEDLINE, PubMed, EMBASE, CINAHL, ProQuest, Scopus and PsycINFO databases were accessed between 1997–2019. The screening and selection of studies were based on eligibility criteria and methodological quality assessment using the Critical Appraisal Skills Programme tool for qualitative research. Meta-synthesis was grounded in the original experiences and collectively synthesised into meaningful themes. The review follows the PRISMA reporting guidelines and PRISMA checklist. Results: The findings highlight three major themes and included enablers for successful communities of practice, barriers to successful communities of practice, and success in action as described by students and novice nurses. Discussion: We suggest successful communities of practice occur when safe and supported spaces ensure students and novices feel comfortable to experiment with their learning, and we emphasise the benefits of having more novice nurses situated within close proximity and under the direct influence of the established practices of more experienced or core group of peers. Relevance to clinical practice: Communities of practice that function successfully create an environment that prioritises the embedding of novices into the broader group. In so doing, students and novice nurses feel supported, welcomed, empowered, and able to make the transition from student to colleague and novice nurse to more experienced nurse. It allows them to experiment with ever new ways of fulfilling the role, while aiding better clinical outcomes. © 2019 John Wiley & Sons Ltd

Comparative effectiveness of three exercise types to treat clinical depression in older adults : a systematic review and network meta-analysis of randomised controlled trials

- Miller, Kyle, Gonçalves-Bradley, Daniela, Areerob, Pinyadapat, Hennessy, Declan, Mesagno, Christopher, Grace, Fergal

  • Authors: Miller, Kyle , Gonçalves-Bradley, Daniela , Areerob, Pinyadapat , Hennessy, Declan , Mesagno, Christopher , Grace, Fergal
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Ageing Research Reviews Vol. 58 (2020).
  • Full Text:
  • Reviewed:
  • Description: Background: Few studies have directly compared the effects of different exercise therapies on clinical depression in older adults. Thus, we conducted a systematic review and network meta-analysis of current evidence from randomised controlled trials (RCTs) to compare the effectiveness of three major exercise types (aerobic, resistance, and mind-body exercise) in clinically depressed older adults. Methods: We followed PRISMA-NMA guidelines and searched databases for eligible RCTs (inception – September 12th, 2019). RCTs were eligible if they included clinically depressed adults aged >65 years, implemented one or more exercise therapy arms using aerobic, resistance, or mind-body exercise, and assessed depressive symptoms at baseline and follow-up using a validated clinical questionnaire. Results: A network meta-analysis was performed on 15 eligible RCTs comprising 596 participants (321 treatment and 275 controls), including aerobic (n = 6), resistance (n = 5), and mind-body (n = 4) exercise trials. Compared with controls, mind-body exercise showed the largest improvement on depressive symptoms (g = −0.87 to −1.38), followed by aerobic exercise (g = −0.51 to −1.02), and resistance exercise (g = −0.41 to −0.92). Notably, there were no statistically significant differences between exercise types: aerobic versus resistance (g = −0.10, PrI = −2.23, 2.03), mind-body versus aerobic (g = −0.36, PrI = −2.69, 1.97), or mind-body versus resistance (g = −0.46, PrI = −2.75, 1.83). Conclusions: These findings should guide optimal exercise prescription for allied health professionals and stakeholders in clinical geriatrics. Notably, clinically depressed older adults may be encouraged to self-select their preferred exercise type in order to achieve therapeutic benefit on symptoms of depression. In coalition with high levels of compliance, these data provide encouraging evidence for the antidepressant effect of either aerobic, resistance, or mind-body exercise as effective treatment adjucts for older adults presenting with clinical depression. © 2019

Financing sustainable development goals : A review of challenges and mitigation strategies

- Barua, Suborna

  • Authors: Barua, Suborna
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Business Strategy and Development Vol. 3, no. 3 (2020), p. 277-293
  • Full Text: false
  • Reviewed:
  • Description: Sustainable development goal (SDG) implementation is still at an early stage globally. Implementation of the SDGs in developing countries particularly appears very complex and challenging. A key challenge encountered by policymakers at the national and international levels is the prevailing huge financing gap. The current level of SDG-related financing and investing is far less than what is needed, and there is a growing concern on how to close this gap. This paper explores the key challenges in SDG financing and potential way-out to mitigate them, particularly in the context of developing countries. The paper reviews the existing literature and practitioner documents, identifies the key challenges, and provides a suggestive mapping of potential strategies to overcome those. The paper argues that given the current level of SDG progress and financing, the world needs immediate action to mobilize adequate financing to achieve the SDGs by the set time line of 2030.

High intensity interval training (HIIT) improves cardiorespiratory fitness (CRF) in healthy, overweight and obese adolescents : a systematic review and meta-analysis of controlled studies

- Martin-Smith, Rhona, Cox, Ashley, Buchan, Duncan, Baker, Julien, Grace, Fergal, Sculthorpe, Nicholas

  • Authors: Martin-Smith, Rhona , Cox, Ashley , Buchan, Duncan , Baker, Julien , Grace, Fergal , Sculthorpe, Nicholas
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: International Journal of Environmental Research and Public Health Vol. 17, no. 8 (2020), p.
  • Full Text:
  • Reviewed:
  • Description: Background: High Intensity Interval Training (HIIT) is a sustainable and effective method for improving Cardiorespiratory Fitness (CRF) in adolescents. HIIT is proven to produce equal or greater improvements in CRF when compared to moderate intensity continuous exercise (MICE) in adolescents. Methods: The studies included were considered eligible if: (1) Participants were adolescents (11–18 years old); (2) Examined changes in CRF measured either directly or indirectly; (3) Included a non-exercising control group or MICE comparison group; (4) Participants were matched at enrolment; (5) Reported HIIT protocol information; (6) Provided HIIT intensity. A meta-analysis was conducted to determine the effect of HIIT on CRF. Meta-regression and moderator analyses were performed out to quantitatively examine moderators of protocol design on CRF improvements. Results: HIIT displays a moderate effect to improve CRF (g = 0.86, 95% CI 0.518–1.106, p < 0.001). Neither study duration (weeks), nor total or weekly accumulated HIIT volume (min) displayed any significant moderation effect on pooled improvement on CRF (p > 0.05). Conclusions: HIIT is an effective method to improve CRF in adolescents, irrespective of body composition. Notably, meta regression analysis identified that prolonged high volume HIIT programs are similarly effective to short term low volume HIIT programs. This becomes of particular interest for those involved in school curricula, where short HIIT exercise may provide a pragmatic adjunct to the health benefits of Physical Education (PE) lessons. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

High-intensity interval training improves cardiorespiratory fitness in cancer patients and survivors : a meta-analysis

- Wallen, Matthew, Hennessy, Declan, Brown, Stephen, Evans, Luke, Rawstorn, Jonathan, Wong Shee, Anna, Hall, Adrian

  • Authors: Wallen, Matthew , Hennessy, Declan , Brown, Stephen , Evans, Luke , Rawstorn, Jonathan , Wong Shee, Anna , Hall, Adrian
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: European Journal of Cancer Care Vol. 29, no. 4 (2020), p.
  • Full Text: false
  • Reviewed:
  • Description: Objective: The primary objective of this systematic review and meta-analysis was to compare the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) and usual care (UC) on cardiorespiratory fitness (peak V̇O2) in cancer patients and survivors. Secondary objectives were to compare the effects of HIIT versus MICT and UC on other cardiopulmonary exercise testing (CPET) indices. Safety and adherence to HIIT were also evaluated. Methods: A systematic review and meta-analysis of controlled trials were undertaken using eligible studies from electronic database searching (inception—December 2019). Mean differences (MD) with 95% confidence intervals (CI) were compared and heterogeneity assessed using Cochran's Q and I2 statistic. Results: Twelve eligible studies included 516 participants with post-intervention CPET data. No serious adverse events occurred. Adherence to HIIT ranged between 71.2% and 95.6%. HIIT had significantly higher peak V̇O2 compared with UC (MD = 2.11 ml kg−1 min−1, 95% CI 0.75–3.47, p =.002). No significant difference was found between HIIT and MICT (MD = 2.03 ml kg−1 min−1, 95%CI −0.75–4.83, p =.15). HIIT was more effective than UC to improve peak oxygen pulse (MD = 1.59 ml/beat, 95%CI 0.06–3.12, p =.04). Conclusions: Quantitative assessment of HIIT studies indicates good compliance, with a significant effect on peak V̇O2 and peak oxygen pulse compared with UC in cancer patients and survivors. HIIT demonstrates a comparable effect with MICT to improve peak V̇O2. © 2020 John Wiley & Sons Ltd
  • Description: Western Alliance Academic Health Science Centre , WA-739501

Hospital nurses? Simulation-based education regarding patient safety : a scoping review

- Cant, Robyn, Cooper, Simon, Lam, Louisa

Levels of support for the licensing of tobacco retailers in Australia : findings from the National Drug Strategy Household Survey 2004-2016

- Baker, John, Masood, Mohd, Rahman, Muhammad, Begg, Stephen

  • Authors: Baker, John , Masood, Mohd , Rahman, Muhammad , Begg, Stephen
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: BMC Public Health Vol. 20, no. 1 (2020)
  • Full Text:
  • Reviewed:
  • Description: Background: Assessing public opinion towards tobacco policies is important, particularly when determining the possible direction of future public health policies. The aim of this study was to describe the implementation of tobacco retailer licensing systems by state and territory governments in Australia, and to use the National Drug Strategy Household Survey (NDSHS) to assess levels of public support for a retailer licensing system in each jurisdiction over time and by a range of socio-demographic and behavioural attributes. Methods: National and state/territory estimates of public support for a tobacco retailer licensing system were derived as proportions using NDSHS data from 2004 to 2016. The effect of one's jurisdiction of residence on the likelihood of supporting such an initiative in 2016 was assessed using logistic regression while controlling for various socio-demographic and behavioural characteristics. Results: Public support for a tobacco retailer licensing system ranged from a high of 67.2% (95% CI 66.5-67.9%) nationally in 2007 and declined to 59.5% (95% CI 58.9-60.2%) in 2016. In 2016, support was greatest amongst those from Tasmania, those aged 50 years and older, females, those from the least disadvantaged areas, those living in major cities, never-smokers and never-drinkers. After adjusting for the socio-demographic and behavioural attributes of respondents, those from Queensland were significantly less likely to support a licensing system (adjusted OR = 0.85, 95% CI 0.77-0.94) compared to those from other jurisdictions, while those from Tasmania were significantly more likely to support a licensing system compared to those from other jurisdictions (adjusted OR = 1.29, 95% CI 1.09-1.52). Conclusions: A clear majority of the public support a tobacco retailer licensing system, regardless of whether or not such a system is already in place in their jurisdiction of residence. Tobacco control initiatives other than a retailer licensing system may explain some of the residual variations in support observed between jurisdictions. © 2020 The Author(s).

Marine ecosystem assessment for the Southern Ocean : Birds and marine mammals in a changing climate

- Bestley, Sophie, Ropert-Coudert, Yan, Bengtson Nash, Susan, Brooks, Cassandra, Cotté, Cedric, Dewar, Meagan, Friedlaender, Ari, Jackson, Jennifer, Labrousse, Sara, Lowther, Andrew, McMahon, Clive, Phillips, Richard, Pistorius, Pierre, Puskic, Peter, Reis, Ana, Reisinger, Ryan, Santos, Mercedes, Tarszisz, Esther, Tixier, Paul, Trathan, Philip, Wege, Mia, Wienecke, Barbara

  • Authors: Bestley, Sophie , Ropert-Coudert, Yan , Bengtson Nash, Susan , Brooks, Cassandra , Cotté, Cedric , Dewar, Meagan , Friedlaender, Ari , Jackson, Jennifer , Labrousse, Sara , Lowther, Andrew , McMahon, Clive , Phillips, Richard , Pistorius, Pierre , Puskic, Peter , Reis, Ana , Reisinger, Ryan , Santos, Mercedes , Tarszisz, Esther , Tixier, Paul , Trathan, Philip , Wege, Mia , Wienecke, Barbara
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Frontiers in Ecology and Evolution Vol. 8, no. (2020), p. 1-39
  • Full Text:
  • Reviewed:
  • Description: The massive number of seabirds (penguins and procellariiformes) and marine mammals (cetaceans and pinnipeds) – referred to here as top predators – is one of the most iconic components of the Antarctic and Southern Ocean. They play an important role as highly mobile consumers, structuring and connecting pelagic marine food webs and are widely studied relative to other taxa. Many birds and mammals establish dense breeding colonies or use haul-out sites, making them relatively easy to study. Cetaceans, however, spend their lives at sea and thus aspects of their life cycle are more complicated to monitor and study. Nevertheless, they all feed at sea and their reproductive success depends on the food availability in the marine environment, hence they are considered useful indicators of the state of the marine resources. In general, top predators have large body sizes that allow for instrumentation with miniature data-recording or transmitting devices to monitor their activities at sea. Development of scientific techniques to study reproduction and foraging of top predators has led to substantial scientific literature on their population trends, key biological parameters, migratory patterns, foraging and feeding ecology, and linkages with atmospheric or oceanographic dynamics, for a number of species and regions. We briefly summarize the vast literature on Southern Ocean top predators, focusing on the most recent syntheses. We also provide an overview on the key current and emerging pressures faced by these animals as a result of both natural and human causes. We recognize the overarching impact that environmental changes driven by climate change have on the ecology of these species. We also evaluate direct and indirect interactions between marine predators and other factors such as disease, pollution, land disturbance and the increasing pressure from global fisheries in the Southern Ocean. Where possible we consider the data availability for assessing the status and trends for each of these components, their capacity for resilience or recovery, effectiveness of management responses, risk likelihood of key impacts and future outlook. © Copyright © 2020 Bestley, Ropert-Coudert, Bengtson Nash, Brooks, Cotté, Dewar, Friedlaender, Jackson, Labrousse, Lowther, McMahon, Phillips, Pistorius, Puskic, Reis, Reisinger, Santos, Tarszisz, Tixier, Trathan, Wege and Wienecke.

Medical-attention injuries in community cricket : a systematic review

- McLeod, Geordie, O'Connor, Siobhan, Morgan, Damian, Kountouris, Alex, Finch, Caroline, Fortington, Lauren

Mental health nurses’ attitudes towards consumers with co-existing mental health and drug and alcohol problems : a scoping review

- Anandan, Roopalal, Cross, Wendy, Olasoji, Michael

  • Authors: Anandan, Roopalal , Cross, Wendy , Olasoji, Michael
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Issues in Mental Health Nursing Vol. 42, no. 4 (2020), p. 346-357
  • Full Text: false
  • Reviewed:
  • Description: Consumers with co-existing mental health and drug/alcohol problems are exposed to more stigma than those with any other health problems. This scoping review aimed to systematically map the available literature regarding mental health nurses' attitudes, empathy, and caring efficacy towards consumers with a dual diagnosis. Twenty studies reported outcomes regarding nurse attitudes; however, none reported nurses' empathy or caring efficacy towards consumers with a dual diagnosis. Further research is required to advance the evidence on the impact of mental health nurses' attitudes, empathy and caring effectiveness, and the outcomes should lead to improved service delivery for consumers with a dual diagnosis. © 2020 Taylor & Francis Group, LLC.

Organophosphate exposure and the chronic effects on farmers : a narrative review

- Perry, Jessica, Cotton, Jacqueline, Rahman, Muhammad, Brumby, Susan

  • Authors: Perry, Jessica , Cotton, Jacqueline , Rahman, Muhammad , Brumby, Susan
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Rural and Remote Health Vol. 20, no. 1 (2020), p. 17
  • Full Text:
  • Reviewed:
  • Description: Introduction: Organophosphates are a class of insecticides used globally by the agricultural industry for insect control. Acute consequences of organophosphate exposures are well known, while there has been limited research on their long-term effects. The objective of this review was to discuss the health effects of chronic organophosphate exposure in farmers. Methods: Medline, Scopus and Web of Science were searched to find the relevant articles. Articles published only in English and until December 2018 were reviewed. The selected articles were then categorised as neurological (neurobehaviour, neurodevelopmental, neurological signs and symptoms) or non-neurological subheadings. Results: A total of 53 articles for neurological effects and 17 articles for non-neurological effects were identified. Chronic organophosphates exposure was associated with deficits in the neurobehaviour subsets of attention and short-term memory, increased incidence of neurodegenerative diseases and effects on peripheral nerves and neurodevelopment. However, research to support non-neurological effects such as respiratory symptoms, increased cancer risk, endocrine disruption, cardiac issues, chronic fatigue and infertility was limited. Conclusion: Chronic organophosphate exposure was found to affect four of the five areas of described neurological effects in the literature. A large proportion of the research in this area was not methodologically strong, therefore few recommendations can be conclusively made. Future research is warranted to investigate the non-neurological effects of chronic exposure to ensure the occupational risks of low-level chronic exposure are clearly communicated to farmers and farm workers.

Ovarian cancer, cancer stem cells and current treatment strategies : a potential role of magmas in the current treatment methods

- Ahmed, Nuzhat, Kadife, Elif, Raza, Ali, Short, Mary, Jubinsky, Paul, Kannourakis, George

  • Authors: Ahmed, Nuzhat , Kadife, Elif , Raza, Ali , Short, Mary , Jubinsky, Paul , Kannourakis, George
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Cells Vol. 9, no. 3 (Mar 2020), p. 35
  • Full Text:
  • Reviewed:
  • Description: Epithelial ovarian cancer (EOC) constitutes 90% of ovarian cancers (OC) and is the eighth most common cause of cancer-related death in women. The cancer histologically and genetically is very complex having a high degree of tumour heterogeneity. The pathogenic variability in OC causes significant impediments in effectively treating patients, resulting in a dismal prognosis. Disease progression is predominantly influenced by the peritoneal tumour microenvironment rather than properties of the tumor and is the major contributor to prognosis. Standard treatment of OC patients consists of debulking surgery, followed by chemotherapy, which in most cases end in recurrent chemoresistant disease. This review discusses the different origins of high-grade serous ovarian cancer (HGSOC), the major sub-type of EOC. Tumour heterogeneity, genetic/epigenetic changes, and cancer stem cells (CSC) in facilitating HGSOC progression and their contribution in the circumvention of therapy treatments are included. Several new treatment strategies are discussed including our preliminary proof of concept study describing the role of mitochondria-associated granulocyte macrophage colony-stimulating factor signaling protein (Magmas) in HGSOC and its unique potential role in chemotherapy-resistant disease.

Perceptions of shared decision-making in severe mental illness : an integrative review

- Huang, Chongmei, Plummer, Virginia, Lam, Louisa, Cross, Wendy

  • Authors: Huang, Chongmei , Plummer, Virginia , Lam, Louisa , Cross, Wendy
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Journal of Psychiatric and Mental Health Nursing Vol. 27, no. 2 (Apr 2020), p. 103-127
  • Full Text: false
  • Reviewed:
  • Description: Accessible SummaryWhat is known about shared decision-making? There is increasing evidence of the positive impact of shared decision-making on health outcomes. There has been little exploration of shared decision-making regarding people diagnosed with serious mental illness from the perspectives of key stakeholders including consumers, families and mental health professionals. What this paper adds to existing knowledge? Consumers show variability in the preference for their involvement. Most stakeholders acknowledge the importance of family involvement. MHPs should share the responsibility and right to facilitate consumer involvement. There is bidirectional association between shared decision-making and therapeutic relationships. The practice of shared decision-making is related to multiple factors, and one main perceived barrier is time. The majority of studies are from Western countries. What are the implications for practice? Elicit consumer preferences and establish a collaborative therapeutic relationship. Encourage and engage families in treatment decision-making. Inter-professional collaboration should be integrated into shared decision-making. It might require lengthier consultation time. Studies in non-Western countries are needed to fully understand the impact of culture on shared decision-making. Shared decision-making (SDM) has been broadly advocated in health services and constitutes an important component of patient-centred care and relationship-based care. To review available literature related to perceptions of key stakeholders about shared decision-making in serious mental illness. An integrative review was conducted through a search of four online databases from January 2012 to June 2019. Forty-six articles were included. Six themes were generated from the data analysis: (a) dynamic preferences for SDM, (b) various stakeholders are rarely involved, (c) SDM is not routinely implemented, (d) multiple facilitators and barriers to SDM, (e) SDM and therapeutic relationships interact, (f) SDM has a promising impact on health outcomes. Overall, most stakeholders have recognized the importance and flexibility of SDM in serious mental illness, although it is not routine in mental health service. Consumer preferences show variability in their involvement. Most stakeholders acknowledged the importance of family involvement to treatment decision-making. There are several significant challenges to practice SDM. It may require extended consultation times and increasing empirical evidence regarding the SDM outcomes, as well as integrating inter-professional collaboration into SDM. Most studies were conducted in Western culture. Mental health nurses should elicit consumer preferences and establish a collaborative therapeutic relationship. Encourage and engage families in treatment decision-making when consumers prefer their families to be involved. Inter-professional collaboration should be integrated into shared decision-making. The practice of shared decision-making might need extended consultation time and more robust evidence about the outcome of shared decision-making. Studies in non-Western cultures are needed to fully understand cultural issues of shared decision-making. IntroductionAimMethodResultsDiscussionImplications for practice

Sequential sampling models without random between-trial variability : the racing diffusion model of speeded decision making

- Tillman, Gabriel, Van Zandt, Trish, Logan, Gordon

  • Authors: Tillman, Gabriel , Van Zandt, Trish , Logan, Gordon
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Psychonomic Bulletin and Review Vol. 27, no. 5 (2020), p. 911-936
  • Full Text: false
  • Reviewed:
  • Description: Most current sequential sampling models have random between-trial variability in their parameters. These sources of variability make the models more complex in order to fit response time data, do not provide any further explanation to how the data were generated, and have recently been criticised for allowing infinite flexibility in the models. To explore and test the need of between-trial variability parameters we develop a simple sequential sampling model of N-choice speeded decision making: the racing diffusion model. The model makes speeded decisions from a race of evidence accumulators that integrate information in a noisy fashion within a trial. The racing diffusion does not assume that any evidence accumulation process varies between trial, and so, the model provides alternative explanations of key response time phenomena, such as fast and slow error response times relative to correct response times. Overall, our paper gives good reason to rethink including between-trial variability parameters in sequential sampling models. © 2020, The Psychonomic Society, Inc.

The consequences of general medication beliefs measured by the Beliefs about Medicine Questionnaire on medication adherence : A systematic review

- Shahin, Wejdan, Kennedy, Gerard, Stupans, Ieva

  • Authors: Shahin, Wejdan , Kennedy, Gerard , Stupans, Ieva
  • Date: 2020
  • Type: Text , Journal article , Review
  • Relation: Pharmacy Vol. 8, no. 3 (2020), p. 1-15
  • Full Text:
  • Reviewed:
  • Description: (1) Background: Medication adherence is a key determinant of patient health outcomes in chronic illnesses. However, adherence to long-term therapy remains poor. General beliefs about medicine are considered factors influencing medication adherence. It is essential to address the gap in the literature regarding understanding the impact of general beliefs about medicine on medication adherence to promote adherence in chronic illnesses. (2) Methods: PubMed, CINHAL, and EMBASE databases were searched. Studies were included if they examined medication beliefs using the Beliefs about Medicine Questionnaire in one of four chronic illnesses: hypertension, diabetes, chronic obstructive pulmonary disease, and/or asthma. (3) Results: From 1799 articles obtained by the search, only 11 met the inclusion criteria. Hypertension and diabetes represented 91% of included studies, while asthma represented 9%. Higher medication adherence was associated with negative general medication beliefs; 65% of the included studies found a negative association between harm beliefs and adherence, while 30% of studies found a negative association with overuse beliefs. (4) Conclusions: This review evaluated the impact of harm and overuse beliefs about medicines on medication adherence, highlighting the gap in literature regarding the impact of harm and overuse beliefs on adherence. Further research is needed to fully identify the association between general beliefs and medication adherence in people with different cultural backgrounds, and to explore these beliefs in patients diagnosed with chronic illnesses, particularly asthma and chronic obstructive pulmonary disease (COPD). Healthcare providers need to be aware of the impact of patients' cultural backgrounds on general medication beliefs and adherence.