A case study of grinding coarse 5 mm particles into sand grade particles less than 2.36 mm
- Reed, Aaron, Koroznikova, Larissa, Khandelwal, Manoj
- Authors: Reed, Aaron , Koroznikova, Larissa , Khandelwal, Manoj
- Date: 2021
- Type: Text , Journal article
- Relation: Vietnam Journal of Earth Sciences Vol. 43, no. 1 (2021), p. 57-70
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- Description: This paper presents the viability study of utilising a rod or ball mill to grind a ‘5 mm grit’ to 100% passing 2.36 mm and fit in with a desired particle size analysis. The aim is to introduce this grit into the concrete grade sand produced at the Hanson owned Axedale Sand & Gravel quarry to reduce generated waste and improve the process efficiency. A ball mill and rod mill were used to grind the samples at an interval of 5 and 10 minutes. From the laboratory experimental analysis, it was found that a ball mill with 5 minutes grinding time in closed-circuit using a classifier to remove undersize and reintroduce oversize to the mill would be a viable option in an industrial setting. A Bond Ball Mill Grindability Test was undertaken to determine the grindability of the 5 mm grit, which served to determine the power (kWh/t) required to grind it to 100% passing 2.36 mm. The bond ball mill grindability test showed that the grit had a work index value of 17.66 kWh/t. This work index gives an actual work input of 13.54 kWh/t, meaning that for every ton of feed material introduced to the mill, 13.54 kWh of work input is required to grind it to 150 microns. © 2021 Vietnam Academy of Science and Technology.
- Authors: Reed, Aaron , Koroznikova, Larissa , Khandelwal, Manoj
- Date: 2021
- Type: Text , Journal article
- Relation: Vietnam Journal of Earth Sciences Vol. 43, no. 1 (2021), p. 57-70
- Full Text:
- Reviewed:
- Description: This paper presents the viability study of utilising a rod or ball mill to grind a ‘5 mm grit’ to 100% passing 2.36 mm and fit in with a desired particle size analysis. The aim is to introduce this grit into the concrete grade sand produced at the Hanson owned Axedale Sand & Gravel quarry to reduce generated waste and improve the process efficiency. A ball mill and rod mill were used to grind the samples at an interval of 5 and 10 minutes. From the laboratory experimental analysis, it was found that a ball mill with 5 minutes grinding time in closed-circuit using a classifier to remove undersize and reintroduce oversize to the mill would be a viable option in an industrial setting. A Bond Ball Mill Grindability Test was undertaken to determine the grindability of the 5 mm grit, which served to determine the power (kWh/t) required to grind it to 100% passing 2.36 mm. The bond ball mill grindability test showed that the grit had a work index value of 17.66 kWh/t. This work index gives an actual work input of 13.54 kWh/t, meaning that for every ton of feed material introduced to the mill, 13.54 kWh of work input is required to grind it to 150 microns. © 2021 Vietnam Academy of Science and Technology.
A critical review of intrusion detection systems in the internet of things : techniques, deployment strategy, validation strategy, attacks, public datasets and challenges
- Khraisat, Ansam, Alazab, Ammar
- Authors: Khraisat, Ansam , Alazab, Ammar
- Date: 2021
- Type: Text , Journal article
- Relation: Cybersecurity Vol. 4, no. 1 (2021), p.
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- Description: The Internet of Things (IoT) has been rapidly evolving towards making a greater impact on everyday life to large industrial systems. Unfortunately, this has attracted the attention of cybercriminals who made IoT a target of malicious activities, opening the door to a possible attack on the end nodes. To this end, Numerous IoT intrusion detection Systems (IDS) have been proposed in the literature to tackle attacks on the IoT ecosystem, which can be broadly classified based on detection technique, validation strategy, and deployment strategy. This survey paper presents a comprehensive review of contemporary IoT IDS and an overview of techniques, deployment Strategy, validation strategy and datasets that are commonly applied for building IDS. We also review how existing IoT IDS detect intrusive attacks and secure communications on the IoT. It also presents the classification of IoT attacks and discusses future research challenges to counter such IoT attacks to make IoT more secure. These purposes help IoT security researchers by uniting, contrasting, and compiling scattered research efforts. Consequently, we provide a unique IoT IDS taxonomy, which sheds light on IoT IDS techniques, their advantages and disadvantages, IoT attacks that exploit IoT communication systems, corresponding advanced IDS and detection capabilities to detect IoT attacks. © 2021, The Author(s).
- Authors: Khraisat, Ansam , Alazab, Ammar
- Date: 2021
- Type: Text , Journal article
- Relation: Cybersecurity Vol. 4, no. 1 (2021), p.
- Full Text:
- Reviewed:
- Description: The Internet of Things (IoT) has been rapidly evolving towards making a greater impact on everyday life to large industrial systems. Unfortunately, this has attracted the attention of cybercriminals who made IoT a target of malicious activities, opening the door to a possible attack on the end nodes. To this end, Numerous IoT intrusion detection Systems (IDS) have been proposed in the literature to tackle attacks on the IoT ecosystem, which can be broadly classified based on detection technique, validation strategy, and deployment strategy. This survey paper presents a comprehensive review of contemporary IoT IDS and an overview of techniques, deployment Strategy, validation strategy and datasets that are commonly applied for building IDS. We also review how existing IoT IDS detect intrusive attacks and secure communications on the IoT. It also presents the classification of IoT attacks and discusses future research challenges to counter such IoT attacks to make IoT more secure. These purposes help IoT security researchers by uniting, contrasting, and compiling scattered research efforts. Consequently, we provide a unique IoT IDS taxonomy, which sheds light on IoT IDS techniques, their advantages and disadvantages, IoT attacks that exploit IoT communication systems, corresponding advanced IDS and detection capabilities to detect IoT attacks. © 2021, The Author(s).
A field investigation of the relationship between rotating shifts, sleep, mental health and physical activity of Australian paramedics
- Khan, Wahaj, Jackson, Melinda, Kennedy, Gerard, Conduit, Russell
- Authors: Khan, Wahaj , Jackson, Melinda , Kennedy, Gerard , Conduit, Russell
- Date: 2021
- Type: Text , Journal article
- Relation: Scientific Reports Vol. 11, no. 1 (2021), p.
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- Description: Paramedics working on a rotating shift are at an increased risk of developing chronic health issues due to continuous circadian rhythm disruption. The acute effects of shift rotation and objectively measured sleep have rarely been reported in paramedics. This study investigated the relationships between a rotating shift schedule and sleep (using actigraphy), subjective reports of sleepiness, mood, stress and fatigue. Galvanic Skin Response, energy expenditure and physical activity (BodyMedia SenseWear Armband) were also recorded across the shift schedule. Paramedics were monitored for a period of eight consecutive days across pre-shift, day shift, night shift, and 2 days off. Fifteen paramedics (M age = 39.5 and SD = 10.7 years) who worked rotational shifts experienced sleep restriction during night shift compared to pre-shift, day shift and days off (p < 0.001). Night shift was also associated with higher levels of stress (p < 0.05), fatigue (p < 0.05), and sleepiness (p < 0.05). One day off was related to a return to pre-shift functioning. Such shift-related issues have a compounding negative impact on an already stressful occupation with high rates of physical and mental health issues. Therefore, there is an urgent need to investigate methods to reduce rotating shift burden on the health of paramedics. This could be through further research aimed at providing recommendations for shift work schedules with sufficient periods for sleep and recovery from stress. © 2021, The Author(s).
- Authors: Khan, Wahaj , Jackson, Melinda , Kennedy, Gerard , Conduit, Russell
- Date: 2021
- Type: Text , Journal article
- Relation: Scientific Reports Vol. 11, no. 1 (2021), p.
- Full Text:
- Reviewed:
- Description: Paramedics working on a rotating shift are at an increased risk of developing chronic health issues due to continuous circadian rhythm disruption. The acute effects of shift rotation and objectively measured sleep have rarely been reported in paramedics. This study investigated the relationships between a rotating shift schedule and sleep (using actigraphy), subjective reports of sleepiness, mood, stress and fatigue. Galvanic Skin Response, energy expenditure and physical activity (BodyMedia SenseWear Armband) were also recorded across the shift schedule. Paramedics were monitored for a period of eight consecutive days across pre-shift, day shift, night shift, and 2 days off. Fifteen paramedics (M age = 39.5 and SD = 10.7 years) who worked rotational shifts experienced sleep restriction during night shift compared to pre-shift, day shift and days off (p < 0.001). Night shift was also associated with higher levels of stress (p < 0.05), fatigue (p < 0.05), and sleepiness (p < 0.05). One day off was related to a return to pre-shift functioning. Such shift-related issues have a compounding negative impact on an already stressful occupation with high rates of physical and mental health issues. Therefore, there is an urgent need to investigate methods to reduce rotating shift burden on the health of paramedics. This could be through further research aimed at providing recommendations for shift work schedules with sufficient periods for sleep and recovery from stress. © 2021, The Author(s).
A new global index for short term voltage stability assessment
- Alshareef, Abdulrhman, Shah, Rakibuzzaman, Mithulananthan, Nadarajah, Alzahrani, Saeed
- Authors: Alshareef, Abdulrhman , Shah, Rakibuzzaman , Mithulananthan, Nadarajah , Alzahrani, Saeed
- Date: 2021
- Type: Text , Journal article
- Relation: IEEE Access Vol. 9, no. (2021), p. 36114-36124
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- Description: The utility scale of non-conventional generators (NCGs), such as wind and photovoltaic (PV) plants, are competitive alternatives to synchronous machines (SMs) for power generation. Higher penetration of NCGs has been respondent of causing several recent incidents leading up to voltage collapse in power systems due to the distinct characteristics of NCGs under different operating conditions. Consequently, the so-called system strength has been reduced with higher NCGs penetration. A number of indices have been developed to quantify system strength from the short-term voltage stability (STVS) perspective. None of the indices capture the overall performances of power systems on dynamic voltage recovery. In this paper, an improvement in one of the STVS indices namely, the Voltage Recovery Index (VRI), is proposed to overcome shortcomings in the original index. Moreover, the improved index is globalized to establish a new index defined as system voltage recovery index (VRIsys) to quantify STVS at the system level. The amended VRI and developed VRIsys are used in systematic simulations to quantify the impact and interaction of various factors that could affect system strength. The assessment was conducted using time-domain simulation with direct connected induction motors (DCIMs) and a proliferation of converter-based technologies on both the generation and load sides, namely, NCGs and Variable Speed Drives (VSDs), respectively. © 2013 IEEE.
- Authors: Alshareef, Abdulrhman , Shah, Rakibuzzaman , Mithulananthan, Nadarajah , Alzahrani, Saeed
- Date: 2021
- Type: Text , Journal article
- Relation: IEEE Access Vol. 9, no. (2021), p. 36114-36124
- Full Text:
- Reviewed:
- Description: The utility scale of non-conventional generators (NCGs), such as wind and photovoltaic (PV) plants, are competitive alternatives to synchronous machines (SMs) for power generation. Higher penetration of NCGs has been respondent of causing several recent incidents leading up to voltage collapse in power systems due to the distinct characteristics of NCGs under different operating conditions. Consequently, the so-called system strength has been reduced with higher NCGs penetration. A number of indices have been developed to quantify system strength from the short-term voltage stability (STVS) perspective. None of the indices capture the overall performances of power systems on dynamic voltage recovery. In this paper, an improvement in one of the STVS indices namely, the Voltage Recovery Index (VRI), is proposed to overcome shortcomings in the original index. Moreover, the improved index is globalized to establish a new index defined as system voltage recovery index (VRIsys) to quantify STVS at the system level. The amended VRI and developed VRIsys are used in systematic simulations to quantify the impact and interaction of various factors that could affect system strength. The assessment was conducted using time-domain simulation with direct connected induction motors (DCIMs) and a proliferation of converter-based technologies on both the generation and load sides, namely, NCGs and Variable Speed Drives (VSDs), respectively. © 2013 IEEE.
A survey of early-career researchers in Australia
- Christian, Katherine, Johnstone, Carolyn, Larkins, Jo-ann, Wright, Wendy, Doran, Michael
- Authors: Christian, Katherine , Johnstone, Carolyn , Larkins, Jo-ann , Wright, Wendy , Doran, Michael
- Date: 2021
- Type: Text , Journal article
- Relation: eLife Vol. 10, no. (2021), p. 1-19
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- Description: Early-career researchers (ECRs) make up a large portion of the academic workforce and their experiences often reflect the wider culture of the research system. Here we surveyed 658 ECRs working in Australia to better understand the needs and challenges faced by this community. Although most respondents indicated a ‘love of science’, many also expressed an intention to leave their research position. The responses highlight how job insecurity, workplace culture, mentorship and ‘questionable research practices’ are impacting the job satisfaction of ECRs and potentially compromising science in Australia. We also make recommendations for addressing some of these concerns. © Christian et al.
- Authors: Christian, Katherine , Johnstone, Carolyn , Larkins, Jo-ann , Wright, Wendy , Doran, Michael
- Date: 2021
- Type: Text , Journal article
- Relation: eLife Vol. 10, no. (2021), p. 1-19
- Full Text:
- Reviewed:
- Description: Early-career researchers (ECRs) make up a large portion of the academic workforce and their experiences often reflect the wider culture of the research system. Here we surveyed 658 ECRs working in Australia to better understand the needs and challenges faced by this community. Although most respondents indicated a ‘love of science’, many also expressed an intention to leave their research position. The responses highlight how job insecurity, workplace culture, mentorship and ‘questionable research practices’ are impacting the job satisfaction of ECRs and potentially compromising science in Australia. We also make recommendations for addressing some of these concerns. © Christian et al.
An efficient hybrid system for anomaly detection in social networks
- Rahman, Md Shafiur, Halder, Sajal, Uddin, Ashraf, Acharjee, Uzzal
- Authors: Rahman, Md Shafiur , Halder, Sajal , Uddin, Ashraf , Acharjee, Uzzal
- Date: 2021
- Type: Text , Journal article
- Relation: Cybersecurity Vol. 4, no. 1 (2021), p.
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- Description: Anomaly detection has been an essential and dynamic research area in the data mining. A wide range of applications including different social medias have adopted different state-of-the-art methods to identify anomaly for ensuring user’s security and privacy. The social network refers to a forum used by different groups of people to express their thoughts, communicate with each other, and share the content needed. This social networks also facilitate abnormal activities, spread fake news, rumours, misinformation, unsolicited messages, and propaganda post malicious links. Therefore, detection of abnormalities is one of the important data analysis activities for the identification of normal or abnormal users on the social networks. In this paper, we have developed a hybrid anomaly detection method named DT-SVMNB that cascades several machine learning algorithms including decision tree (C5.0), Support Vector Machine (SVM) and Naïve Bayesian classifier (NBC) for classifying normal and abnormal users in social networks. We have extracted a list of unique features derived from users’ profile and contents. Using two kinds of dataset with the selected features, the proposed machine learning model called DT-SVMNB is trained. Our model classifies users as depressed one or suicidal one in the social network. We have conducted an experiment of our model using synthetic and real datasets from social network. The performance analysis demonstrates around 98% accuracy which proves the effectiveness and efficiency of our proposed system. © 2021, The Author(s).
- Authors: Rahman, Md Shafiur , Halder, Sajal , Uddin, Ashraf , Acharjee, Uzzal
- Date: 2021
- Type: Text , Journal article
- Relation: Cybersecurity Vol. 4, no. 1 (2021), p.
- Full Text:
- Reviewed:
- Description: Anomaly detection has been an essential and dynamic research area in the data mining. A wide range of applications including different social medias have adopted different state-of-the-art methods to identify anomaly for ensuring user’s security and privacy. The social network refers to a forum used by different groups of people to express their thoughts, communicate with each other, and share the content needed. This social networks also facilitate abnormal activities, spread fake news, rumours, misinformation, unsolicited messages, and propaganda post malicious links. Therefore, detection of abnormalities is one of the important data analysis activities for the identification of normal or abnormal users on the social networks. In this paper, we have developed a hybrid anomaly detection method named DT-SVMNB that cascades several machine learning algorithms including decision tree (C5.0), Support Vector Machine (SVM) and Naïve Bayesian classifier (NBC) for classifying normal and abnormal users in social networks. We have extracted a list of unique features derived from users’ profile and contents. Using two kinds of dataset with the selected features, the proposed machine learning model called DT-SVMNB is trained. Our model classifies users as depressed one or suicidal one in the social network. We have conducted an experiment of our model using synthetic and real datasets from social network. The performance analysis demonstrates around 98% accuracy which proves the effectiveness and efficiency of our proposed system. © 2021, The Author(s).
Cable disc elevator : static friction investigation
- Authors: Webb, Colin , Tuck, Michael
- Date: 2021
- Type: Text , Journal article
- Relation: Mining, Metallurgy and Exploration Vol. 38, no. 2 (2021), p. 979-994
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- Description: This paper describes the application of a cable disc elevator to continuous lift ore vertically from underground mines. Application of this system requires the tensions developed within the cable must remain within the carrying capacity of the cable including applicable safety margins. A critical element occurs at starting the system when it is fully loaded which requires the force developed by the system to exceed the static friction forces. This paper describes the laboratory rig developed to investigate the static friction forces. Details of the results of tests on three different ores for both dry and wet conditions are given. These results are discussed. © 2020, Society for Mining, Metallurgy & Exploration Inc.
- Authors: Webb, Colin , Tuck, Michael
- Date: 2021
- Type: Text , Journal article
- Relation: Mining, Metallurgy and Exploration Vol. 38, no. 2 (2021), p. 979-994
- Full Text:
- Reviewed:
- Description: This paper describes the application of a cable disc elevator to continuous lift ore vertically from underground mines. Application of this system requires the tensions developed within the cable must remain within the carrying capacity of the cable including applicable safety margins. A critical element occurs at starting the system when it is fully loaded which requires the force developed by the system to exceed the static friction forces. This paper describes the laboratory rig developed to investigate the static friction forces. Details of the results of tests on three different ores for both dry and wet conditions are given. These results are discussed. © 2020, Society for Mining, Metallurgy & Exploration Inc.
Can optimum solar radiation exposure or supplemented vitamin D intake reduce the severity of COVID-19 symptoms?
- Abraham, Joji, Dowling, Kim, Florentine, Singarayer
- Authors: Abraham, Joji , Dowling, Kim , Florentine, Singarayer
- Date: 2021
- Type: Text , Journal article , Review
- Relation: International Journal of Environmental Research and Public Health Vol. 18, no. 2 (2021), p. 1-21
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- Reviewed:
- Description: The foremost mortality-causing symptom associated with COVID-19 is acute respiratory distress syndrome (ARDS). A significant correlation has been identified between the deficiency in vitamin D and the risk of developing ARDS. It has been suggested that if we can reduce or modify ARDS in COVID-19 patients, we may significantly reduce the severity of COVID-19 symptoms and associated mortality rates. The increased mortality of dark-skinned people, who have a reduced UV absorption capacity, may be consistent with diminished vitamin D status. The factors associated with COVID-19 mortality, such as old age, ethnicity, obesity, hypertension, cardiovascular diseases, and diabetes, are all found to be linked with vitamin D deficiency. Based on this review and as a precautionary measure, it is suggested that the adoption of appropriate and safe solar exposure and vitamin D enriched foods and supplements should be considered to reduce the possible severity of COVID-19 symptoms. Safe sun exposure is deemed beneficial globally, specifically in low and middle- income countries, as there is no cost involved. It is also noted that improved solar exposure and vitamin D levels can reduce the impact of other diseases as well, thus assisting in maintaining general human well-being. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- Authors: Abraham, Joji , Dowling, Kim , Florentine, Singarayer
- Date: 2021
- Type: Text , Journal article , Review
- Relation: International Journal of Environmental Research and Public Health Vol. 18, no. 2 (2021), p. 1-21
- Full Text:
- Reviewed:
- Description: The foremost mortality-causing symptom associated with COVID-19 is acute respiratory distress syndrome (ARDS). A significant correlation has been identified between the deficiency in vitamin D and the risk of developing ARDS. It has been suggested that if we can reduce or modify ARDS in COVID-19 patients, we may significantly reduce the severity of COVID-19 symptoms and associated mortality rates. The increased mortality of dark-skinned people, who have a reduced UV absorption capacity, may be consistent with diminished vitamin D status. The factors associated with COVID-19 mortality, such as old age, ethnicity, obesity, hypertension, cardiovascular diseases, and diabetes, are all found to be linked with vitamin D deficiency. Based on this review and as a precautionary measure, it is suggested that the adoption of appropriate and safe solar exposure and vitamin D enriched foods and supplements should be considered to reduce the possible severity of COVID-19 symptoms. Safe sun exposure is deemed beneficial globally, specifically in low and middle- income countries, as there is no cost involved. It is also noted that improved solar exposure and vitamin D levels can reduce the impact of other diseases as well, thus assisting in maintaining general human well-being. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Canonical duality theory and algorithm for solving bilevel knapsack problems with applications
- Authors: Gao, David
- Date: 2021
- Type: Text , Journal article
- Relation: IEEE Transactions on Systems, Man, and Cybernetics: Systems Vol. 51, no. 2 (2021), p. 893-904
- Full Text:
- Reviewed:
- Description: A novel canonical duality theory (CDT) is presented for solving general bilevel mixed integer nonlinear optimization governed by linear and quadratic knapsack problems. It shows that the challenging knapsack problems can be solved analytically in term of their canonical dual solutions. The existence and uniqueness of these analytical solutions are proved. NP-hardness of the knapsack problems is discussed. A powerful CDT algorithm combined with an alternative iteration and a volume reduction method is proposed for solving the NP-hard bilevel knapsack problems. Application is illustrated by benchmark problems in optimal topology design. The performance and novelty of the proposed method are compared with the popular commercial codes. © 2013 IEEE.
- Authors: Gao, David
- Date: 2021
- Type: Text , Journal article
- Relation: IEEE Transactions on Systems, Man, and Cybernetics: Systems Vol. 51, no. 2 (2021), p. 893-904
- Full Text:
- Reviewed:
- Description: A novel canonical duality theory (CDT) is presented for solving general bilevel mixed integer nonlinear optimization governed by linear and quadratic knapsack problems. It shows that the challenging knapsack problems can be solved analytically in term of their canonical dual solutions. The existence and uniqueness of these analytical solutions are proved. NP-hardness of the knapsack problems is discussed. A powerful CDT algorithm combined with an alternative iteration and a volume reduction method is proposed for solving the NP-hard bilevel knapsack problems. Application is illustrated by benchmark problems in optimal topology design. The performance and novelty of the proposed method are compared with the popular commercial codes. © 2013 IEEE.
Challenges faced by early-career researchers in the sciences in Australia and the consequent effect of those challenges on their careers : a mixed methods project
- Authors: Christian, Katherine
- Date: 2021
- Type: Text , Thesis , PhD
- Full Text:
- Description: The purpose of the study was to explore the challenges faced by early-career researchers (ECRs) in the sciences in Australia and the consequent effect of those challenges on their careers. Using a realist/postpositivist paradigm, an evaluative approach, and a framework of job satisfaction, this project has explored and compared the views of ECRs to evaluate the factors which shape the ECR experience and contribute to job satisfaction or dissatisfaction and intention to leave, and to define the features which are necessary to keep an ECR in research. Data collection for this mixed methods study entailed a national survey of researchers working in universities and research institutes (n=658), a focus group discussion and semistructured in-depth interviews with eight women from a variety of scientific disciplines who had recently left academic research workplaces. I focussed particularly on the difficulties consequent to job insecurity: the constant need to attracting funding and a permanent position, lack of work-life balance and associated stress; and evidence of workplace difficulties such as bullying, harassment or inequity and support – or lack of it – offered by the research institutions. I examined the factors which contribute to and barriers which prevent job satisfaction of this population, and the consequent intention (if any) for ECRs to leave research or change their career path. I found an interesting situation whereby the satisfaction derived from a “love of science” was counterbalanced by stress and poor working conditions which are a consequence of lack of job security, typified by poor supervision, bullying or harassment, inequitable hiring practices, a concerning rate of impact from “questionable research practices” (impacting 34%-41% of respondents) and evidence of very high (80%) intention of ECRs to leave their position. The most significant predictor of intention to leave is time as a postdoctoral scientist: eventually the job insecurity and its associated stresses become too much and the ECRs leave their chosen career for work elsewhere. This decision, too, provides interesting findings as many of the ECRs have difficulty planning what to do next. They feel ill-prepared for an alternate career and suffer from a sense of failure as a result of having to leave academia. While addressing the shortage of funding is outside the scope of this study, in addition to offering my findings I put forward a range of recommendations which could lead to ar change of culture and benefit the wellbeing of ECRs in STEMM without incurring significant cost. The Australian Government, higher education institutions and the research community need to improve job security and workplace conditions and take better care of our people in STEMM disciplines or we will not have the scientists we need to deliver the “innovative Australia” planned for 2030 (Department of Industry Innovation and Science, 2018)
- Description: Doctor of Philosophy
- Authors: Christian, Katherine
- Date: 2021
- Type: Text , Thesis , PhD
- Full Text:
- Description: The purpose of the study was to explore the challenges faced by early-career researchers (ECRs) in the sciences in Australia and the consequent effect of those challenges on their careers. Using a realist/postpositivist paradigm, an evaluative approach, and a framework of job satisfaction, this project has explored and compared the views of ECRs to evaluate the factors which shape the ECR experience and contribute to job satisfaction or dissatisfaction and intention to leave, and to define the features which are necessary to keep an ECR in research. Data collection for this mixed methods study entailed a national survey of researchers working in universities and research institutes (n=658), a focus group discussion and semistructured in-depth interviews with eight women from a variety of scientific disciplines who had recently left academic research workplaces. I focussed particularly on the difficulties consequent to job insecurity: the constant need to attracting funding and a permanent position, lack of work-life balance and associated stress; and evidence of workplace difficulties such as bullying, harassment or inequity and support – or lack of it – offered by the research institutions. I examined the factors which contribute to and barriers which prevent job satisfaction of this population, and the consequent intention (if any) for ECRs to leave research or change their career path. I found an interesting situation whereby the satisfaction derived from a “love of science” was counterbalanced by stress and poor working conditions which are a consequence of lack of job security, typified by poor supervision, bullying or harassment, inequitable hiring practices, a concerning rate of impact from “questionable research practices” (impacting 34%-41% of respondents) and evidence of very high (80%) intention of ECRs to leave their position. The most significant predictor of intention to leave is time as a postdoctoral scientist: eventually the job insecurity and its associated stresses become too much and the ECRs leave their chosen career for work elsewhere. This decision, too, provides interesting findings as many of the ECRs have difficulty planning what to do next. They feel ill-prepared for an alternate career and suffer from a sense of failure as a result of having to leave academia. While addressing the shortage of funding is outside the scope of this study, in addition to offering my findings I put forward a range of recommendations which could lead to ar change of culture and benefit the wellbeing of ECRs in STEMM without incurring significant cost. The Australian Government, higher education institutions and the research community need to improve job security and workplace conditions and take better care of our people in STEMM disciplines or we will not have the scientists we need to deliver the “innovative Australia” planned for 2030 (Department of Industry Innovation and Science, 2018)
- Description: Doctor of Philosophy
Detecting outlier patterns with query-based artificially generated searching conditions
- Yu, Shuo, Xia, Feng, Sun, Yuchen, Tang, Tao, Yan, Xiaoran, Lee, Ivan
- Authors: Yu, Shuo , Xia, Feng , Sun, Yuchen , Tang, Tao , Yan, Xiaoran , Lee, Ivan
- Date: 2021
- Type: Text , Journal article
- Relation: IEEE Transactions on Computational Social Systems Vol. 8, no. 1 (2021), p. 134-147
- Full Text:
- Reviewed:
- Description: In the age of social computing, finding interesting network patterns or motifs is significant and critical for various areas, such as decision intelligence, intrusion detection, medical diagnosis, social network analysis, fake news identification, and national security. However, subgraph matching remains a computationally challenging problem, let alone identifying special motifs among them. This is especially the case in large heterogeneous real-world networks. In this article, we propose an efficient solution for discovering and ranking human behavior patterns based on network motifs by exploring a user's query in an intelligent way. Our method takes advantage of the semantics provided by a user's query, which in turn provides the mathematical constraint that is crucial for faster detection. We propose an approach to generate query conditions based on the user's query. In particular, we use meta paths between the nodes to define target patterns as well as their similarities, leading to efficient motif discovery and ranking at the same time. The proposed method is examined in a real-world academic network using different similarity measures between the nodes. The experiment result demonstrates that our method can identify interesting motifs and is robust to the choice of similarity measures. © 2014 IEEE.
- Authors: Yu, Shuo , Xia, Feng , Sun, Yuchen , Tang, Tao , Yan, Xiaoran , Lee, Ivan
- Date: 2021
- Type: Text , Journal article
- Relation: IEEE Transactions on Computational Social Systems Vol. 8, no. 1 (2021), p. 134-147
- Full Text:
- Reviewed:
- Description: In the age of social computing, finding interesting network patterns or motifs is significant and critical for various areas, such as decision intelligence, intrusion detection, medical diagnosis, social network analysis, fake news identification, and national security. However, subgraph matching remains a computationally challenging problem, let alone identifying special motifs among them. This is especially the case in large heterogeneous real-world networks. In this article, we propose an efficient solution for discovering and ranking human behavior patterns based on network motifs by exploring a user's query in an intelligent way. Our method takes advantage of the semantics provided by a user's query, which in turn provides the mathematical constraint that is crucial for faster detection. We propose an approach to generate query conditions based on the user's query. In particular, we use meta paths between the nodes to define target patterns as well as their similarities, leading to efficient motif discovery and ranking at the same time. The proposed method is examined in a real-world academic network using different similarity measures between the nodes. The experiment result demonstrates that our method can identify interesting motifs and is robust to the choice of similarity measures. © 2014 IEEE.
Draft genome sequences of four citrobacter isolates recovered from wild australian shorebirds
- Smith, Hannah, Bean, David, Pitchers, William, Valcanis, Mary, Clarke, Rohan, Loyn, Richard, Hassell, Chris, Greenhill, Andrew
- Authors: Smith, Hannah , Bean, David , Pitchers, William , Valcanis, Mary , Clarke, Rohan , Loyn, Richard , Hassell, Chris , Greenhill, Andrew
- Date: 2021
- Type: Text , Journal article
- Relation: Microbiology Resource Announcements Vol. 10, no. 1 (2021), p.
- Full Text:
- Reviewed:
- Description: Citrobacter is a ubiquitous bacterial genus whose members inhabit a variety of niches. Some species are clinically important for both antimicrobial resistance (AMR) carriage and as the cause of nosocomial infections. Surveillance of Citrobacter species in the environment can provide indicators of the spread of AMR genes outside clinical spaces. In this study, we present draft genome sequences of four Citrobacter isolates obtained from three species of wild Australian shorebirds. Copyright © 2021 Smith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- Authors: Smith, Hannah , Bean, David , Pitchers, William , Valcanis, Mary , Clarke, Rohan , Loyn, Richard , Hassell, Chris , Greenhill, Andrew
- Date: 2021
- Type: Text , Journal article
- Relation: Microbiology Resource Announcements Vol. 10, no. 1 (2021), p.
- Full Text:
- Reviewed:
- Description: Citrobacter is a ubiquitous bacterial genus whose members inhabit a variety of niches. Some species are clinically important for both antimicrobial resistance (AMR) carriage and as the cause of nosocomial infections. Surveillance of Citrobacter species in the environment can provide indicators of the spread of AMR genes outside clinical spaces. In this study, we present draft genome sequences of four Citrobacter isolates obtained from three species of wild Australian shorebirds. Copyright © 2021 Smith et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Importance of environmental flows in the Wimmera catchment, Southeast Australia
- Atazadeh, Ehsan, Barton, Andrew, Razeghi, Jafar
- Authors: Atazadeh, Ehsan , Barton, Andrew , Razeghi, Jafar
- Date: 2021
- Type: Text , Journal article
- Relation: Limnological Review Vol. 20, no. 4 (2021), p. 185-198
- Full Text:
- Reviewed:
- Description: In this paper the environment, climate, vegetation, indigenous and European settlement history, stream flow patterns, water quality and water resources development in western Victoria, Australia are studied. The last part of the paper focuses on the MacKenzie River, a tributary of the Wimmera River located on the northern slopes of the Grampians Ranges in western Victoria, Australia. Water release along the MacKenzie River was regulated to improve water quality, stream condition and river health especially in the downstream reaches. The upstream section tends to receive water most days of the year due to releases to secure the requirements of water supply for the city of Horsham and its recreational and conservation values, which is diverted into Mt Zero Channel. Below this the middle and downstream sections receive a more intermittent supply. Annually, a total of 10,000 dam3 of water is released from Wartook Reservoir into the MacKenzie River. Of this volume, only about 4,000 dam3 was released explicitly for environmental purposes. The remaining 6,000 dam3 was released to meet consumptive demands and to transfer water to downstream reservoirs. The empirical data and models showed the lower reaches of the river to be in poor condition under low flows, but this condition improved under flows of 35 dam3 per day, as indicated. The results are presented to tailor discharge and duration of the river flows by amalgamation of consumptive and environmental flows to improve the condition of the stream, thereby supplementing the flows dedicated to environmental outcomes. Ultimately the findings can be used by management to configure consumptive flows that would enhance the ecological condition of the MacKenzie River. © 2020 Ehsan Atazadeh et al., published by Sciendo 2020.
- Authors: Atazadeh, Ehsan , Barton, Andrew , Razeghi, Jafar
- Date: 2021
- Type: Text , Journal article
- Relation: Limnological Review Vol. 20, no. 4 (2021), p. 185-198
- Full Text:
- Reviewed:
- Description: In this paper the environment, climate, vegetation, indigenous and European settlement history, stream flow patterns, water quality and water resources development in western Victoria, Australia are studied. The last part of the paper focuses on the MacKenzie River, a tributary of the Wimmera River located on the northern slopes of the Grampians Ranges in western Victoria, Australia. Water release along the MacKenzie River was regulated to improve water quality, stream condition and river health especially in the downstream reaches. The upstream section tends to receive water most days of the year due to releases to secure the requirements of water supply for the city of Horsham and its recreational and conservation values, which is diverted into Mt Zero Channel. Below this the middle and downstream sections receive a more intermittent supply. Annually, a total of 10,000 dam3 of water is released from Wartook Reservoir into the MacKenzie River. Of this volume, only about 4,000 dam3 was released explicitly for environmental purposes. The remaining 6,000 dam3 was released to meet consumptive demands and to transfer water to downstream reservoirs. The empirical data and models showed the lower reaches of the river to be in poor condition under low flows, but this condition improved under flows of 35 dam3 per day, as indicated. The results are presented to tailor discharge and duration of the river flows by amalgamation of consumptive and environmental flows to improve the condition of the stream, thereby supplementing the flows dedicated to environmental outcomes. Ultimately the findings can be used by management to configure consumptive flows that would enhance the ecological condition of the MacKenzie River. © 2020 Ehsan Atazadeh et al., published by Sciendo 2020.
Improved shear strength performance of compacted rubberized clays treated with sodium alginate biopolymer
- Soltani, Amin, Raeesi, Ramin, Taheri, Abbas, Deng, An, Mirzababaei, Mehdi
- Authors: Soltani, Amin , Raeesi, Ramin , Taheri, Abbas , Deng, An , Mirzababaei, Mehdi
- Date: 2021
- Type: Text , Journal article
- Relation: Polymers Vol. 13, no. 5 (2021), p. 1-21
- Full Text:
- Reviewed:
- Description: This study examines the potential use of sodium alginate (SA) biopolymer as an environmentally sustainable agent for the stabilization of rubberized soil blends prepared using a high plasticity clay soil and tire-derived ground rubber (GR). The experimental program consisted of uniaxial compression and scanning electron microscopy (SEM) tests; the former was performed on three soil–GR blends (with GR-to-soil mass ratios of 0%, 5% and 10%) compacted (and cured for 1, 4, 7 and 14 d) employing distilled water and three SA solutions—prepared at SA-to-water (mass-tovolume) dosage ratios of 5, 10 and 15 g/L—as the compaction liquid. For any given GR content, the greater the SA dosage and/or the longer the curing duration, the higher the uniaxial compressive strength (UCS), with only minor added benefits beyond seven days of curing. This behaviour was attributed to the formation and propagation of so-called “cationic bridges” (developed as a result of a “Ca2+/Mg2+
- Authors: Soltani, Amin , Raeesi, Ramin , Taheri, Abbas , Deng, An , Mirzababaei, Mehdi
- Date: 2021
- Type: Text , Journal article
- Relation: Polymers Vol. 13, no. 5 (2021), p. 1-21
- Full Text:
- Reviewed:
- Description: This study examines the potential use of sodium alginate (SA) biopolymer as an environmentally sustainable agent for the stabilization of rubberized soil blends prepared using a high plasticity clay soil and tire-derived ground rubber (GR). The experimental program consisted of uniaxial compression and scanning electron microscopy (SEM) tests; the former was performed on three soil–GR blends (with GR-to-soil mass ratios of 0%, 5% and 10%) compacted (and cured for 1, 4, 7 and 14 d) employing distilled water and three SA solutions—prepared at SA-to-water (mass-tovolume) dosage ratios of 5, 10 and 15 g/L—as the compaction liquid. For any given GR content, the greater the SA dosage and/or the longer the curing duration, the higher the uniaxial compressive strength (UCS), with only minor added benefits beyond seven days of curing. This behaviour was attributed to the formation and propagation of so-called “cationic bridges” (developed as a result of a “Ca2+/Mg2+
Influences on Islamists : an analysis of radicalisation and terrorism in an Australian context
- Authors: Dimaksyan, Margarita
- Date: 2021
- Type: Text , Thesis , PhD
- Full Text:
- Description: Terrorism has long existed throughout history. However the Islamist terrorist attacks of 11 September 2001 (known as 9/11) in the United States represented a fundamental turning point and a significant change in the terrorism landscape. Since 9/11, terrorism discourse has dominated not only the media, but also a sense of security and safety globally. Over a decade after 9/11, there was another significant shift with the declaration of a caliphate in June 2014 by terrorist organisation, Daesh. The atrocities committed by and in the name of this terrorist group sparked global outrage and horror and have had long lasting impacts around the world. Despite the fact that the conflict originated in the Middle East, the impact was felt domestically with a number of terrorist attacks perpetrated and planned in Australia in the name of an extremist neojihadist ideology. To understand Islamist terrorism in an Australian context, this thesis explores the factors which have influenced the radicalisation of domestic Islamist terrorists who have engaged in terrorist acts. This is achieved having regard to the characteristics of 194 Islamist terrorists from Australia who engaged in a multitude of terrorist acts between 2001 and 2018 (either domestically or overseas), their motives and the role of social and familial networks on their radicalisation and involvement in terrorism. In responding to the central research question – In an Australian context, what has influenced the radicalisation of Islamist terrorists who have engaged in terrorist acts? – this thesis:
- Description: Doctor of Philosophy
- Authors: Dimaksyan, Margarita
- Date: 2021
- Type: Text , Thesis , PhD
- Full Text:
- Description: Terrorism has long existed throughout history. However the Islamist terrorist attacks of 11 September 2001 (known as 9/11) in the United States represented a fundamental turning point and a significant change in the terrorism landscape. Since 9/11, terrorism discourse has dominated not only the media, but also a sense of security and safety globally. Over a decade after 9/11, there was another significant shift with the declaration of a caliphate in June 2014 by terrorist organisation, Daesh. The atrocities committed by and in the name of this terrorist group sparked global outrage and horror and have had long lasting impacts around the world. Despite the fact that the conflict originated in the Middle East, the impact was felt domestically with a number of terrorist attacks perpetrated and planned in Australia in the name of an extremist neojihadist ideology. To understand Islamist terrorism in an Australian context, this thesis explores the factors which have influenced the radicalisation of domestic Islamist terrorists who have engaged in terrorist acts. This is achieved having regard to the characteristics of 194 Islamist terrorists from Australia who engaged in a multitude of terrorist acts between 2001 and 2018 (either domestically or overseas), their motives and the role of social and familial networks on their radicalisation and involvement in terrorism. In responding to the central research question – In an Australian context, what has influenced the radicalisation of Islamist terrorists who have engaged in terrorist acts? – this thesis:
- Description: Doctor of Philosophy
Medicinal value of three agricultural weed species of the asteraceae family : a review
- Jayasundera, Mithila, Florentine, Singarayer, Tennakoon, Kushan, Chauhan, Bhagirath
- Authors: Jayasundera, Mithila , Florentine, Singarayer , Tennakoon, Kushan , Chauhan, Bhagirath
- Date: 2021
- Type: Text , Journal article , Review
- Relation: Pharmacognosy Journal Vol. 13, no. 1 (2021), p. 264-277
- Full Text:
- Reviewed:
- Description: Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. are well known plant species of the Asteraceae family that are considered weeds in intensive agriculture. These weeds are traditionally known to have medicinal properties and have been used for therapeutic treatments. However, it is only the lack of proper knowledge, awareness and screening that have limited their use in pharmaceutical sectors. This review attempts to consolidate the traditional, phytochemical and pharmacological studies that have been carried out on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L., which we note are widely spread throughout the world. This study was conducted through a coherent search on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. with respect to traditional uses, phytochemical and pharmacological studies that have been performed on these three agricultural weeds all over the world. An exploration of reported descriptions of the potential medical importance of three agricultural weed species (A. conyzoides, T. procumbens and B. pilosa) has been presented. The present review would encourage further clinical investigations into these three plants and their extracts to more closely define the range of uses of these herbs for clinical applications. This, in turn, would give a clear understanding whether these weed species might be targeted to be conserved in a sustainable manner rather than eradicated. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- Authors: Jayasundera, Mithila , Florentine, Singarayer , Tennakoon, Kushan , Chauhan, Bhagirath
- Date: 2021
- Type: Text , Journal article , Review
- Relation: Pharmacognosy Journal Vol. 13, no. 1 (2021), p. 264-277
- Full Text:
- Reviewed:
- Description: Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. are well known plant species of the Asteraceae family that are considered weeds in intensive agriculture. These weeds are traditionally known to have medicinal properties and have been used for therapeutic treatments. However, it is only the lack of proper knowledge, awareness and screening that have limited their use in pharmaceutical sectors. This review attempts to consolidate the traditional, phytochemical and pharmacological studies that have been carried out on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L., which we note are widely spread throughout the world. This study was conducted through a coherent search on Ageratum conyzoides L., Tridax procumbens L. and Bidens pilosa L. with respect to traditional uses, phytochemical and pharmacological studies that have been performed on these three agricultural weeds all over the world. An exploration of reported descriptions of the potential medical importance of three agricultural weed species (A. conyzoides, T. procumbens and B. pilosa) has been presented. The present review would encourage further clinical investigations into these three plants and their extracts to more closely define the range of uses of these herbs for clinical applications. This, in turn, would give a clear understanding whether these weed species might be targeted to be conserved in a sustainable manner rather than eradicated. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Patients with both langerhans cell histiocytosis and crohn’s disease highlight a common role of interleukin-23
- Kvedaraite, Egle, Lourda, Magda, Han, Hong, Tesi, Biance, Mitchell, Jenée
- Authors: Kvedaraite, Egle , Lourda, Magda , Han, Hong , Tesi, Biance , Mitchell, Jenée
- Date: 2021
- Type: Text , Journal article
- Relation: Acta Paediatrica, International Journal of Paediatrics Vol. 110, no. 4 (2021), p. 1315-1321
- Full Text:
- Reviewed:
- Description: Aim: To present the first case series of patients with Langerhans cell histiocytosis (LCH) also affected by Crohn's disease (CD), both of which are granulomatous diseases, and in LCH investigate the role of interleukin (IL)-23, which is a well-described disease mediator in CD. Methods: A case series of three patients with LCH and CD were described; a cohort of LCH patients (n = 55) as well as controls (n = 55) were analysed for circulating IL-23 levels; and the relation between the percentage of LCH cells in lesions and circulating IL-23 levels was analysed in seven LCH patients. Results: Differential diagnostic challenges for these two granulomatous diseases were highlighted in the case series, and it took up to 3 years to diagnose CD. Elevated IL-23 levels were found in LCH patients. The amount of lesional LCH cells correlated with the levels of circulating IL-23. Conclusion: Both CD and LCH should be considered in patients with inflammatory gastrointestinal involvement. The IL-23 pathway is a common immunological trait between these two granulomatous diseases. ©2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. ***Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Jenée Mitchell” is provided in this record***
- Authors: Kvedaraite, Egle , Lourda, Magda , Han, Hong , Tesi, Biance , Mitchell, Jenée
- Date: 2021
- Type: Text , Journal article
- Relation: Acta Paediatrica, International Journal of Paediatrics Vol. 110, no. 4 (2021), p. 1315-1321
- Full Text:
- Reviewed:
- Description: Aim: To present the first case series of patients with Langerhans cell histiocytosis (LCH) also affected by Crohn's disease (CD), both of which are granulomatous diseases, and in LCH investigate the role of interleukin (IL)-23, which is a well-described disease mediator in CD. Methods: A case series of three patients with LCH and CD were described; a cohort of LCH patients (n = 55) as well as controls (n = 55) were analysed for circulating IL-23 levels; and the relation between the percentage of LCH cells in lesions and circulating IL-23 levels was analysed in seven LCH patients. Results: Differential diagnostic challenges for these two granulomatous diseases were highlighted in the case series, and it took up to 3 years to diagnose CD. Elevated IL-23 levels were found in LCH patients. The amount of lesional LCH cells correlated with the levels of circulating IL-23. Conclusion: Both CD and LCH should be considered in patients with inflammatory gastrointestinal involvement. The IL-23 pathway is a common immunological trait between these two granulomatous diseases. ©2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. ***Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Jenée Mitchell” is provided in this record***
Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
- Nakai, Michael, Prestes, Priscilla, O’Brien, Brendan, Charchar, Fadi, Marques, Francine
- Authors: Nakai, Michael , Prestes, Priscilla , O’Brien, Brendan , Charchar, Fadi , Marques, Francine
- Date: 2021
- Type: Text , Journal article
- Relation: Scientific Reports Vol. 11, no. 1 (2021), p.
- Full Text:
- Reviewed:
- Description: Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypertrophy and plays a role in maladaptive remodelling of the heart and has been associated with renal injury. While lifestyle factors such as diet and exercise are known to attenuate low-grade inflammation, their ability to modulate plasma LCN2 levels is unknown. Forty-eight endurance athletes and 52 controls (18–55 years) underwent measurement for various cardiovascular health indicators, along with plasma LCN2 concentration. No significant difference in LCN2 concentration was seen between the two groups. LCN2 was a very weak predictor or absent from models describing blood pressures or predicting athlete status. In another cohort, 57 non-diabetic overweight or obese men and post-menopausal women who fulfilled Adult Treatment Panel III metabolic syndrome criteria were randomly allocated into either a control, modified Dietary Approaches to Stop Hypertension (DASH) diet, or DASH and exercise group. Pre- and post-intervention demographic, cardiovascular health indicators, and plasma LCN2 expression were measured in each individual. While BMI fell in intervention groups, LCN2 levels remained unchanged within and between all groups, as illustrated by strong correlations between LCN2 concentrations pre- and 12 weeks post-intervention (r = 0.743, P < 0.0001). This suggests that circulating LCN2 expression are stable over a period of at least 12 weeks and is not modifiable by diet and exercise. © 2021, The Author(s). *Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Priscilla Prestes, Brendan O'Brien, Fadi Charchar and Francine Marques” is provided in this record** .
- Authors: Nakai, Michael , Prestes, Priscilla , O’Brien, Brendan , Charchar, Fadi , Marques, Francine
- Date: 2021
- Type: Text , Journal article
- Relation: Scientific Reports Vol. 11, no. 1 (2021), p.
- Full Text:
- Reviewed:
- Description: Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypertrophy and plays a role in maladaptive remodelling of the heart and has been associated with renal injury. While lifestyle factors such as diet and exercise are known to attenuate low-grade inflammation, their ability to modulate plasma LCN2 levels is unknown. Forty-eight endurance athletes and 52 controls (18–55 years) underwent measurement for various cardiovascular health indicators, along with plasma LCN2 concentration. No significant difference in LCN2 concentration was seen between the two groups. LCN2 was a very weak predictor or absent from models describing blood pressures or predicting athlete status. In another cohort, 57 non-diabetic overweight or obese men and post-menopausal women who fulfilled Adult Treatment Panel III metabolic syndrome criteria were randomly allocated into either a control, modified Dietary Approaches to Stop Hypertension (DASH) diet, or DASH and exercise group. Pre- and post-intervention demographic, cardiovascular health indicators, and plasma LCN2 expression were measured in each individual. While BMI fell in intervention groups, LCN2 levels remained unchanged within and between all groups, as illustrated by strong correlations between LCN2 concentrations pre- and 12 weeks post-intervention (r = 0.743, P < 0.0001). This suggests that circulating LCN2 expression are stable over a period of at least 12 weeks and is not modifiable by diet and exercise. © 2021, The Author(s). *Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Priscilla Prestes, Brendan O'Brien, Fadi Charchar and Francine Marques” is provided in this record** .
Prevalence of and factors associated with anaemia in women of reproductive age in Bangladesh, Maldives and Nepal : evidence from nationally-representative survey data
- Ashfikur Rahman, Md, Sazedur Rahman, Md, Rahman, Muhammad, Szymlek-Gay, Ewa, Uddin, Riaz, Islam, Sheikh
- Authors: Ashfikur Rahman, Md , Sazedur Rahman, Md , Rahman, Muhammad , Szymlek-Gay, Ewa , Uddin, Riaz , Islam, Sheikh
- Date: 2021
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 16, no. 1 January (2021), p.
- Full Text:
- Reviewed:
- Description: Background Anaemia is a significant public health problem in most South-Asian countries, causing increased maternal and child mortality and morbidity. This study aimed to estimate the prevalence of and factors associated with anaemia in women of reproductive age in Bangladesh, Maldives, and Nepal. Methods We used the nationally-representative Demographic and Health Surveys Program data collected from women of reproductive age (15-49 years) in 2011 in Bangladesh (n = 5678), 2016 in Maldives (n = 6837), and 2016 in Nepal (n = 6419). Anaemia was categorized as mild (haemoglobin [Hb] of 10.0-10.9 g/dL for pregnant women and 11.0-11.9 g/dL for non-pregnant women), moderate (Hb of 7.0-9.9 g/dL for pregnant women and 8.0-10.9 g/dL for non-pregnant women), and severe (Hb <7.0 g/dL for pregnant women and <8.0 g/dL for non-pregnant women). Multinomial logistic regression analyses were used to identify factors associated with anaemia. Results The prevalence of anaemia was 41.8% in Bangladesh, 58.5% in Maldives, and 40.6% in Nepal. In Bangladesh, postpartum amenorrhoeic, non-educated, and pregnant women were more likely to have moderate/severe anaemia compared to women who were menopausal, had secondary education, and were not pregnant, respectively. In Maldives, residence in urban areas, underweight, having undergone female sterilization, current pregnancy, and menstruation in the last six weeks were associated with increased odds of moderate/severe anaemia. In Nepal, factors associated with increased odds of moderate/ severe anaemia were having undergone female sterilization and current pregnancy. Conclusion Anaemia remains a significant public health issue among 15-49-year-old women in Bangladesh, Maldives, and Nepal, which requires urgent attention. Effective policies and programmes for the control and prevention of anaemia should take into account the unique factors associated with anaemia identified in each country. In all three countries, strategies for the prevention and control of anaemia should particularly focus on women who are pregnant, underweight, or have undergone sterilization. © 2021 Rahman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Ashfikur Rahman, Md , Sazedur Rahman, Md , Rahman, Muhammad , Szymlek-Gay, Ewa , Uddin, Riaz , Islam, Sheikh
- Date: 2021
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 16, no. 1 January (2021), p.
- Full Text:
- Reviewed:
- Description: Background Anaemia is a significant public health problem in most South-Asian countries, causing increased maternal and child mortality and morbidity. This study aimed to estimate the prevalence of and factors associated with anaemia in women of reproductive age in Bangladesh, Maldives, and Nepal. Methods We used the nationally-representative Demographic and Health Surveys Program data collected from women of reproductive age (15-49 years) in 2011 in Bangladesh (n = 5678), 2016 in Maldives (n = 6837), and 2016 in Nepal (n = 6419). Anaemia was categorized as mild (haemoglobin [Hb] of 10.0-10.9 g/dL for pregnant women and 11.0-11.9 g/dL for non-pregnant women), moderate (Hb of 7.0-9.9 g/dL for pregnant women and 8.0-10.9 g/dL for non-pregnant women), and severe (Hb <7.0 g/dL for pregnant women and <8.0 g/dL for non-pregnant women). Multinomial logistic regression analyses were used to identify factors associated with anaemia. Results The prevalence of anaemia was 41.8% in Bangladesh, 58.5% in Maldives, and 40.6% in Nepal. In Bangladesh, postpartum amenorrhoeic, non-educated, and pregnant women were more likely to have moderate/severe anaemia compared to women who were menopausal, had secondary education, and were not pregnant, respectively. In Maldives, residence in urban areas, underweight, having undergone female sterilization, current pregnancy, and menstruation in the last six weeks were associated with increased odds of moderate/severe anaemia. In Nepal, factors associated with increased odds of moderate/ severe anaemia were having undergone female sterilization and current pregnancy. Conclusion Anaemia remains a significant public health issue among 15-49-year-old women in Bangladesh, Maldives, and Nepal, which requires urgent attention. Effective policies and programmes for the control and prevention of anaemia should take into account the unique factors associated with anaemia identified in each country. In all three countries, strategies for the prevention and control of anaemia should particularly focus on women who are pregnant, underweight, or have undergone sterilization. © 2021 Rahman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Reduced renal function may explain the higher prevalence of hyperuricemia in older people
- Wang, Yutang, Zhang, Wanlin, Qian, Tingting, Sun, Hui, Xu, Qun, Hou, Xujuan, Hu, Wenqi, Zhang, Guang, Drummond, Grant, Sobey, Chris, Charchar, Fadi, Golledge, Jonathan, Yang, Guang
- Authors: Wang, Yutang , Zhang, Wanlin , Qian, Tingting , Sun, Hui , Xu, Qun , Hou, Xujuan , Hu, Wenqi , Zhang, Guang , Drummond, Grant , Sobey, Chris , Charchar, Fadi , Golledge, Jonathan , Yang, Guang
- Date: 2021
- Type: Text , Journal article
- Relation: Scientific Reports Vol. 11, no. 1 (2021), p.
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
- Full Text:
- Reviewed:
- Description: This study aimed to investigate the contribution of renal dysfunction to enhanced hyperuricemia prevalence in older people. A cohort of 13,288 Chinese people aged between 40 and 95 years were recruited from January to May 2019. Serum uric acid concentration and estimated glomerular filtration rate [eGFR] were measured. The associations between age or eGFR and serum uric acid or hyperuricemia were analyzed using linear or binary logistic regression adjusting for risk factors. Uric acid concentration and prevalence of hyperuricemia were greater in older participants. Adjustment for reduced renal function (eGFR < 60 mL/min/1.73 m2) eliminated the associations between older age and higher uric acid concentration and between older age and higher prevalence of hyperuricemia diagnosis, whereas adjustment for other risk factors did not change those associations. Lower eGFR was associated with higher uric acid concentration both before (β = − 0.296, P < 0.001) and after adjustment for age (β = − 0.313, P < 0.001). Reduced renal function was associated with hyperuricemia diagnosis both before (odds ratio, OR, 3.64; 95% CI 3.10–4.28; P < 0.001) and after adjustment for age (adjusted OR, 3.82; 95% CI 3.22–4.54; P < 0.001). Mean serum uric acid and prevalence of hyperuricemia were higher in people with eGFR < 60 mL/min/1.73 m2 than those with eGFR ≥ 60 mL/min/1.73 m2. The prevalence of reduced renal function increased with older age (P < 0.001). This study suggests that reduced renal function can explain the increased uric acid levels and hyperuricemia diagnoses in older people. © 2021, The Author(s).
- Authors: Wang, Yutang , Zhang, Wanlin , Qian, Tingting , Sun, Hui , Xu, Qun , Hou, Xujuan , Hu, Wenqi , Zhang, Guang , Drummond, Grant , Sobey, Chris , Charchar, Fadi , Golledge, Jonathan , Yang, Guang
- Date: 2021
- Type: Text , Journal article
- Relation: Scientific Reports Vol. 11, no. 1 (2021), p.
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
- Full Text:
- Reviewed:
- Description: This study aimed to investigate the contribution of renal dysfunction to enhanced hyperuricemia prevalence in older people. A cohort of 13,288 Chinese people aged between 40 and 95 years were recruited from January to May 2019. Serum uric acid concentration and estimated glomerular filtration rate [eGFR] were measured. The associations between age or eGFR and serum uric acid or hyperuricemia were analyzed using linear or binary logistic regression adjusting for risk factors. Uric acid concentration and prevalence of hyperuricemia were greater in older participants. Adjustment for reduced renal function (eGFR < 60 mL/min/1.73 m2) eliminated the associations between older age and higher uric acid concentration and between older age and higher prevalence of hyperuricemia diagnosis, whereas adjustment for other risk factors did not change those associations. Lower eGFR was associated with higher uric acid concentration both before (β = − 0.296, P < 0.001) and after adjustment for age (β = − 0.313, P < 0.001). Reduced renal function was associated with hyperuricemia diagnosis both before (odds ratio, OR, 3.64; 95% CI 3.10–4.28; P < 0.001) and after adjustment for age (adjusted OR, 3.82; 95% CI 3.22–4.54; P < 0.001). Mean serum uric acid and prevalence of hyperuricemia were higher in people with eGFR < 60 mL/min/1.73 m2 than those with eGFR ≥ 60 mL/min/1.73 m2. The prevalence of reduced renal function increased with older age (P < 0.001). This study suggests that reduced renal function can explain the increased uric acid levels and hyperuricemia diagnoses in older people. © 2021, The Author(s).