- Title
- A review of analytical techniques and their application in disease diagnosis in breathomics and salivaomics research
- Creator
- Beale, David; Jones, Oliver; Karpe, Avinash; Dayalan, Saravanan; Oh, Ding; Kouremenos, Konstantinos; Ahmed, Warish; Palombo, Enzo
- Date
- 2017
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/154351
- Identifier
- vital:11084
- Identifier
-
https://doi.org/10.3390/ijms18010024
- Identifier
- ISSN:1422-0067
- Abstract
- The application of metabolomics to biological samples has been a key focus in systems biology research, which is aimed at the development of rapid diagnostic methods and the creation of personalized medicine. More recently, there has been a strong focus towards this approach applied to non-invasively acquired samples, such as saliva and exhaled breath. The analysis of these biological samples, in conjunction with other sample types and traditional diagnostic tests, has resulted in faster and more reliable characterization of a range of health disorders and diseases. As the sampling process involved in collecting exhaled breath and saliva is non-intrusive as well as comparatively low-cost and uses a series of widely accepted methods, it provides researchers with easy access to the metabolites secreted by the human body. Owing to its accuracy and rapid nature, metabolomic analysis of saliva and breath (known as salivaomics and breathomics, respectively) is a rapidly growing field and has shown potential to be effective in detecting and diagnosing the early stages of numerous diseases and infections in preclinical studies. This review discusses the various collection and analyses methods currently applied in two of the least used non-invasive sample types in metabolomics, specifically their application in salivaomics and breathomics research. Some of the salient research completed in this field to date is also assessed and discussed in order to provide a basis to advocate their use and possible future scientific directions. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
- Publisher
- MDPI AG
- Relation
- International Journal of Molecular Sciences Vol. 18, no. 1 (2017), p. 1-26
- Rights
- Copyright © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences; Bioinformatics; Breath; Gas chromatography; Liquid chromatography; Mass spectrometry; Metabolomics; Saliva
- Full Text
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