- De Silva, Daswin, Burstein, Frada, Stranieri, Andrew, Williams, Katrina, Rinehart, Nicole
- Authors: De Silva, Daswin , Burstein, Frada , Stranieri, Andrew , Williams, Katrina , Rinehart, Nicole
- Date: 2013
- Type: Text , Conference paper
- Relation: Information systems: Transforming the future 24th Australasian Conference on Information p. 2-11
- Full Text: false
- Reviewed:
Association of ankle brachial pressure index with heart rate variability in a rural screening clinic
- Jelinek, Herbert, De Silva, Daswin, Burstein, Frada, Stranieri, Andrew, Khalaf, Kinda, Khandoker, Ahsan, Al-Aubaidy, Hayder
- Authors: Jelinek, Herbert , De Silva, Daswin , Burstein, Frada , Stranieri, Andrew , Khalaf, Kinda , Khandoker, Ahsan , Al-Aubaidy, Hayder
- Date: 2013
- Type: Text , Conference paper
- Relation: 40th Computing in Cardiology Conference, CinC 2013; Vol. 40, p. 755-758
- Full Text: false
- Reviewed:
- Description: Peripheral vascular disease (PVD) can be associated with atherosclerosis and/ or peripheral neuropathy, which can be characterized by impairment of sensory, motor or autonomic nervous system. A noninvasive test to detect PVD is the ankle brachial pressure index (ABPI). Autonomic nervous system function can be determined by assessing heart rate variability from an ECG recording. No clear association between PVD and cardiac autonomic dysfunction has been demonstrated to date. © 2013 CCAL.
Addressing the complexities of big data analytics in healthcare : The diabetes screening case
- De Silva, Daswin, Burstein, Frada, Jelinek, Herbert, Stranieri, Andrew
- Authors: De Silva, Daswin , Burstein, Frada , Jelinek, Herbert , Stranieri, Andrew
- Date: 2015
- Type: Text , Journal article
- Relation: Australasian Journal of Information Systems Vol. 19, no. (2015), p. S99-S115
- Full Text:
- Reviewed:
- Description: The healthcare industry generates a high throughput of medical, clinical and omics data of varying complexity and features. Clinical decision-support is gaining widespread attention as medical institutions and governing bodies turn towards better management of this data for effective and efficient healthcare delivery and quality assured outcomes. Amass of data across all stages, from disease diagnosis to palliative care, is further indication of the opportunities and challenges to effective data management, analysis, prediction and optimization techniques as parts of knowledge management in clinical environments. Big Data analytics (BDA) presents the potential to advance this industry with reforms in clinical decision-support and translational research. However, adoption of big data analytics has been slow due to complexities posed by the nature of healthcare data. The success of these systems is hard to predict, so further research is needed to provide a robust framework to ensure investment in BDA is justified. In this paper we investigate these complexities from the perspective of updated Information Systems (IS) participation theory. We present a case study on a large diabetes screening project to integrate, converge and derive expedient insights from such an accumulation of data and make recommendations for a successful BDA implementation grounded in a participatory framework and the specificities of big data in healthcare context. © 2015 De Silva, Burstein, Jelinek, Stranieri.
- Authors: De Silva, Daswin , Burstein, Frada , Jelinek, Herbert , Stranieri, Andrew
- Date: 2015
- Type: Text , Journal article
- Relation: Australasian Journal of Information Systems Vol. 19, no. (2015), p. S99-S115
- Full Text:
- Reviewed:
- Description: The healthcare industry generates a high throughput of medical, clinical and omics data of varying complexity and features. Clinical decision-support is gaining widespread attention as medical institutions and governing bodies turn towards better management of this data for effective and efficient healthcare delivery and quality assured outcomes. Amass of data across all stages, from disease diagnosis to palliative care, is further indication of the opportunities and challenges to effective data management, analysis, prediction and optimization techniques as parts of knowledge management in clinical environments. Big Data analytics (BDA) presents the potential to advance this industry with reforms in clinical decision-support and translational research. However, adoption of big data analytics has been slow due to complexities posed by the nature of healthcare data. The success of these systems is hard to predict, so further research is needed to provide a robust framework to ensure investment in BDA is justified. In this paper we investigate these complexities from the perspective of updated Information Systems (IS) participation theory. We present a case study on a large diabetes screening project to integrate, converge and derive expedient insights from such an accumulation of data and make recommendations for a successful BDA implementation grounded in a participatory framework and the specificities of big data in healthcare context. © 2015 De Silva, Burstein, Jelinek, Stranieri.
Multivariate data-driven decision guidance for clinical scientists
- Burstein, Frada, De Silva, Daswin, Jelinek, Herbert, Stranieri, Andrew
- Authors: Burstein, Frada , De Silva, Daswin , Jelinek, Herbert , Stranieri, Andrew
- Date: 2013
- Type: Text , Conference paper
- Relation: 29th International Conference on Data Engineering Workshops, ICDEW 2013; Proceedings - International Conference on Data Engineering p. 193-199
- Full Text:
- Reviewed:
- Description: Clinical decision-support is gaining widespread attention as medical institutions and governing bodies turn towards utilising better information management for effective and efficient healthcare delivery and quality assured outcomes. Amass of data across all stages, from disease diagnosis to palliative care, is further indication of the opportunities and challenges created for effective data management, analysis, prediction and optimization techniques as parts of knowledge management in clinical environments. A Data-driven Decision Guidance Management System (DD-DGMS) architecture can encompass solutions into a single closed-loop integrated platform to empower clinical scientists to seamlessly explore a multivariate data space in search of novel patterns and correlations to inform their research and practice. The paper describes the components of such an architecture, which includes a robust data warehouse as an infrastructure for comprehensive clinical knowledge management. The proposed DD-DGMS architecture incorporates the dynamic dimensional data model as its elemental core. Given the heterogeneous nature of clinical contexts and corresponding data, the dimensional data model presents itself as an adaptive model that facilitates knowledge discovery, distribution and application, which is essential for clinical decision support. The paper reports on a trial of the DD-DGMS system prototype conducted on diabetes screening data which further establishes the relevance of the proposed architecture to a clinical context.
- Description: E1
- Authors: Burstein, Frada , De Silva, Daswin , Jelinek, Herbert , Stranieri, Andrew
- Date: 2013
- Type: Text , Conference paper
- Relation: 29th International Conference on Data Engineering Workshops, ICDEW 2013; Proceedings - International Conference on Data Engineering p. 193-199
- Full Text:
- Reviewed:
- Description: Clinical decision-support is gaining widespread attention as medical institutions and governing bodies turn towards utilising better information management for effective and efficient healthcare delivery and quality assured outcomes. Amass of data across all stages, from disease diagnosis to palliative care, is further indication of the opportunities and challenges created for effective data management, analysis, prediction and optimization techniques as parts of knowledge management in clinical environments. A Data-driven Decision Guidance Management System (DD-DGMS) architecture can encompass solutions into a single closed-loop integrated platform to empower clinical scientists to seamlessly explore a multivariate data space in search of novel patterns and correlations to inform their research and practice. The paper describes the components of such an architecture, which includes a robust data warehouse as an infrastructure for comprehensive clinical knowledge management. The proposed DD-DGMS architecture incorporates the dynamic dimensional data model as its elemental core. Given the heterogeneous nature of clinical contexts and corresponding data, the dimensional data model presents itself as an adaptive model that facilitates knowledge discovery, distribution and application, which is essential for clinical decision support. The paper reports on a trial of the DD-DGMS system prototype conducted on diabetes screening data which further establishes the relevance of the proposed architecture to a clinical context.
- Description: E1
Complete solutions and triality theory to a nonconvex optimization problem with double-well potential in Rn
- Morales-Silva, Daniel, Gao, David
- Authors: Morales-Silva, Daniel , Gao, David
- Date: 2013
- Type: Text , Journal article
- Relation: Numerical Algebra, Control and Optimization Vol. 3, no. 2 (2013), p. 271-282
- Full Text:
- Reviewed:
- Description: The main purpose of this research note is to show that the triality theory can always be used to identify both global minimizer and the biggest local maximizer in global optimization. An open problem left on the double- min duality is solved for a nonconvex optimization problem with double-well potential in ℝn, which leads to a complete set of analytical solutions. Also a convergency theorem is proved for linear perturbation canonical dual method, which can be used for solving global optimization problems with multiple so- lutions. The methods and results presented in this note pave the way towards the proof of the triality theory in general cases.
- Authors: Morales-Silva, Daniel , Gao, David
- Date: 2013
- Type: Text , Journal article
- Relation: Numerical Algebra, Control and Optimization Vol. 3, no. 2 (2013), p. 271-282
- Full Text:
- Reviewed:
- Description: The main purpose of this research note is to show that the triality theory can always be used to identify both global minimizer and the biggest local maximizer in global optimization. An open problem left on the double- min duality is solved for a nonconvex optimization problem with double-well potential in ℝn, which leads to a complete set of analytical solutions. Also a convergency theorem is proved for linear perturbation canonical dual method, which can be used for solving global optimization problems with multiple so- lutions. The methods and results presented in this note pave the way towards the proof of the triality theory in general cases.
Canonical duality theory and triality for solving general global optimization problems in complex systems
- Morales-Silva, Daniel, Gao, David
- Authors: Morales-Silva, Daniel , Gao, David
- Date: 2015
- Type: Text , Journal article
- Relation: Mathematics and Mechanics of Complex Systems Vol. 3, no. 2 (2015), p. 139-161
- Full Text:
- Reviewed:
- Description: General nonconvex optimization problems are studied by using the canonical duality-triality theory. The triality theory is proved for sums of exponentials and quartic polynomials, which solved an open problem left in 2003. This theory can be used to find the global minimum and local extrema, which bridges a gap between global optimization and nonconvex mechanics. Detailed applications are illustrated by several examples. © 2015 Mathematical Sciences Publishers.
- Authors: Morales-Silva, Daniel , Gao, David
- Date: 2015
- Type: Text , Journal article
- Relation: Mathematics and Mechanics of Complex Systems Vol. 3, no. 2 (2015), p. 139-161
- Full Text:
- Reviewed:
- Description: General nonconvex optimization problems are studied by using the canonical duality-triality theory. The triality theory is proved for sums of exponentials and quartic polynomials, which solved an open problem left in 2003. This theory can be used to find the global minimum and local extrema, which bridges a gap between global optimization and nonconvex mechanics. Detailed applications are illustrated by several examples. © 2015 Mathematical Sciences Publishers.
Properties of strongly star shaped cones
- Authors: Morales-Silva, Daniel
- Date: 2007
- Type: Text , Journal article
- Relation: Pacific Journal of Optimization Vol. 3, no. 2 (2007), p. 379-386
- Full Text: false
- Reviewed:
- Description: In problems of vector optimization, with preferences that are not necessarily a pre-order relation, the strongly star shaped cones are very important in order to get a scalarization of these problems. In this work we present some properties of these cones and also a characterization for a special type.
- Description: C1
- Description: 2003004940
Survival, fermentation activity and storage stability of spray dried Lactococcus lactis produced via different atomization regimes
- Ghandi, Amir, Powell, Ian, Broome, Melcolm, Adhikari, Benu
- Authors: Ghandi, Amir , Powell, Ian , Broome, Melcolm , Adhikari, Benu
- Date: 2013
- Type: Text , Journal article
- Relation: Journal of Food Engineering Vol. 115, no. 1 (2013), p. 83-90
- Full Text:
- Reviewed:
- Description: Dried powders containing Lactococcus lactis ssp. cremoris were produced using laboratory and pilot scale spray dryers with lactose:whey protein isolate (3:1) as a protective medium. The effects of storage temperature (25, 4 and -18 °C) and time (30, 60 and 90 days) were studied. The survival and fermentation activity of the dried bacterial cells were significantly lower when the powders were stored at 25 °C compared to those stored at 4 and -18 °C; powders stored at 4 and -18 °C were statistically similar. The survival and fermentation activity of bacterial cells obtained from a laboratory scale two-fluid nozzle spray dryer were found to be higher than those of cells obtained from a pilot scale two-fluid spray dryer. A rotary wheel atomizer gave significantly higher survival and activity in the same dryer. These observations are consistent with cell damage due to high characteristic shear rates in the atomization process in nozzle type atomizers. The presence of ascorbic acid (oxygen scavenger) in the powder composition was found to improve both the survival and the maintenance of fermentation activity of the dried bacterial cells significantly during storage. The survival and fermentation activity of dried bacterial cells in stored powders indicated that these parameters are system-specific and can be strongly affected by the storage temperature and presence or absence of antioxidant, and also by upstream processing conditions such as the mode of atomization and presence or absence of antioxidants in the dryer feed. © 2012 Elsevier Ltd. All rights reserved.
- Description: 2003010581
- Authors: Ghandi, Amir , Powell, Ian , Broome, Melcolm , Adhikari, Benu
- Date: 2013
- Type: Text , Journal article
- Relation: Journal of Food Engineering Vol. 115, no. 1 (2013), p. 83-90
- Full Text:
- Reviewed:
- Description: Dried powders containing Lactococcus lactis ssp. cremoris were produced using laboratory and pilot scale spray dryers with lactose:whey protein isolate (3:1) as a protective medium. The effects of storage temperature (25, 4 and -18 °C) and time (30, 60 and 90 days) were studied. The survival and fermentation activity of the dried bacterial cells were significantly lower when the powders were stored at 25 °C compared to those stored at 4 and -18 °C; powders stored at 4 and -18 °C were statistically similar. The survival and fermentation activity of bacterial cells obtained from a laboratory scale two-fluid nozzle spray dryer were found to be higher than those of cells obtained from a pilot scale two-fluid spray dryer. A rotary wheel atomizer gave significantly higher survival and activity in the same dryer. These observations are consistent with cell damage due to high characteristic shear rates in the atomization process in nozzle type atomizers. The presence of ascorbic acid (oxygen scavenger) in the powder composition was found to improve both the survival and the maintenance of fermentation activity of the dried bacterial cells significantly during storage. The survival and fermentation activity of dried bacterial cells in stored powders indicated that these parameters are system-specific and can be strongly affected by the storage temperature and presence or absence of antioxidant, and also by upstream processing conditions such as the mode of atomization and presence or absence of antioxidants in the dryer feed. © 2012 Elsevier Ltd. All rights reserved.
- Description: 2003010581
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation
- Stanley, Christopher, Maghzal, Ghassan, Ayer, Anita, Talib, Jihan, Giltrap, Andrew, Shengule, Sudhir, Wolhuter, Kathryn, Wang, Yutang, Chadha, Preet, Suarna, Cacang, Prysyazhna, Oleksandra, Scotcher, Jenna, Dunn, Louise, Prado, Fernanda, Nguyen, Nghi, Odiba, Jephthah, Baell, Johathan, Stasch, Johannes-Peter, Yamamoto, Yorihiro, Di Mascio, Paolo, Eaton, Philip, Payne, Richard, Stocker, Roland
- Authors: Stanley, Christopher , Maghzal, Ghassan , Ayer, Anita , Talib, Jihan , Giltrap, Andrew , Shengule, Sudhir , Wolhuter, Kathryn , Wang, Yutang , Chadha, Preet , Suarna, Cacang , Prysyazhna, Oleksandra , Scotcher, Jenna , Dunn, Louise , Prado, Fernanda , Nguyen, Nghi , Odiba, Jephthah , Baell, Johathan , Stasch, Johannes-Peter , Yamamoto, Yorihiro , Di Mascio, Paolo , Eaton, Philip , Payne, Richard , Stocker, Roland
- Date: 2019
- Type: Text , Journal article , Letter
- Relation: Nature Vol. 566, no. 7745 (2019), p. 548-552
- Full Text:
- Reviewed:
- Description: Singlet molecular oxygen (O-1(2)) has well-established roles in photosynthetic plants, bacteria and fungi(1-3), but not in mammals. Chemically generated O-1(2) oxidizes the amino acid tryptophan to precursors of a key metabolite called N-formylkynurenine(4), whereas enzymatic oxidation of tryptophan to N-formylkynurenine is catalysed by a family of dioxygenases, including indoleamine 2,3-dioxygenase 1(5). Under inflammatory conditions, this haem-containing enzyme is expressed in arterial endothelial cells, where it contributes to the regulation of blood pressure(6). However, whether indoleamine 2,3-dioxygenase 1 forms O-1(2) and whether this contributes to blood pressure control have remained unknown. Here we show that arterial indoleamine 2,3-dioxygenase 1 regulates blood pressure via formation of O-1(2). We observed that in the presence of hydrogen peroxide, the enzyme generates O-1(2) and that this is associated with the stereoselective oxidation of L-tryptophan to a tricyclic hydroperoxide via a previously unrecognized oxidative activation of the dioxygenase activity. The tryptophan-derived hydroperoxide acts in vivo as a signalling molecule, inducing arterial relaxation and decreasing blood pressure; this activity is dependent on Cys42 of protein kinase G1 alpha. Our findings demonstrate a pathophysiological role for O-1(2) in mammals through formation of an amino acid-derived hydroperoxide that regulates vascular tone and blood pressure under inflammatory conditions.
- Authors: Stanley, Christopher , Maghzal, Ghassan , Ayer, Anita , Talib, Jihan , Giltrap, Andrew , Shengule, Sudhir , Wolhuter, Kathryn , Wang, Yutang , Chadha, Preet , Suarna, Cacang , Prysyazhna, Oleksandra , Scotcher, Jenna , Dunn, Louise , Prado, Fernanda , Nguyen, Nghi , Odiba, Jephthah , Baell, Johathan , Stasch, Johannes-Peter , Yamamoto, Yorihiro , Di Mascio, Paolo , Eaton, Philip , Payne, Richard , Stocker, Roland
- Date: 2019
- Type: Text , Journal article , Letter
- Relation: Nature Vol. 566, no. 7745 (2019), p. 548-552
- Full Text:
- Reviewed:
- Description: Singlet molecular oxygen (O-1(2)) has well-established roles in photosynthetic plants, bacteria and fungi(1-3), but not in mammals. Chemically generated O-1(2) oxidizes the amino acid tryptophan to precursors of a key metabolite called N-formylkynurenine(4), whereas enzymatic oxidation of tryptophan to N-formylkynurenine is catalysed by a family of dioxygenases, including indoleamine 2,3-dioxygenase 1(5). Under inflammatory conditions, this haem-containing enzyme is expressed in arterial endothelial cells, where it contributes to the regulation of blood pressure(6). However, whether indoleamine 2,3-dioxygenase 1 forms O-1(2) and whether this contributes to blood pressure control have remained unknown. Here we show that arterial indoleamine 2,3-dioxygenase 1 regulates blood pressure via formation of O-1(2). We observed that in the presence of hydrogen peroxide, the enzyme generates O-1(2) and that this is associated with the stereoselective oxidation of L-tryptophan to a tricyclic hydroperoxide via a previously unrecognized oxidative activation of the dioxygenase activity. The tryptophan-derived hydroperoxide acts in vivo as a signalling molecule, inducing arterial relaxation and decreasing blood pressure; this activity is dependent on Cys42 of protein kinase G1 alpha. Our findings demonstrate a pathophysiological role for O-1(2) in mammals through formation of an amino acid-derived hydroperoxide that regulates vascular tone and blood pressure under inflammatory conditions.
Injury and burnout in Australian athletes
- Grylls, Elizabeth, Spittle, Michael
- Authors: Grylls, Elizabeth , Spittle, Michael
- Date: 2008
- Type: Text , Journal article
- Relation: Perceptual and Motor Skills Vol. 107, no. 3 (2008), p. 873-880
- Full Text:
- Description: The relationship between injury and burnout in a sample of 264 local to international Australian athletes (124 men and 140 women) was studied. Injury can be a stressful experience for athletes; coupled with the demands of rehabilitation, it could increase feelings of burnout. Experiencing more than one injury could have a cumulative effect on feelings of burnout. Alternatively, for some athletes the break from training or competing caused by an injury could alleviate burnout symptoms. Participants completed a demographic questionnaire and a modified version of the Maslach Burnout Inventory. Independent sample t tests indicated that currendy injured athletes (n = 150) had significandy lower mean Burnout scores than currendy uninjured athletes (n= 113). Small, but statistically significant, positive correlations were found between number of injuries and Burnout scores. Possible explanations are that injury provides a temporary break from intense sporting involvement and, thus, lower scores on Burnout, but multiple injuries might have a cumulative effect on burnout. © Perceptual and Motor Skills 2008.
- Authors: Grylls, Elizabeth , Spittle, Michael
- Date: 2008
- Type: Text , Journal article
- Relation: Perceptual and Motor Skills Vol. 107, no. 3 (2008), p. 873-880
- Full Text:
- Description: The relationship between injury and burnout in a sample of 264 local to international Australian athletes (124 men and 140 women) was studied. Injury can be a stressful experience for athletes; coupled with the demands of rehabilitation, it could increase feelings of burnout. Experiencing more than one injury could have a cumulative effect on feelings of burnout. Alternatively, for some athletes the break from training or competing caused by an injury could alleviate burnout symptoms. Participants completed a demographic questionnaire and a modified version of the Maslach Burnout Inventory. Independent sample t tests indicated that currendy injured athletes (n = 150) had significandy lower mean Burnout scores than currendy uninjured athletes (n= 113). Small, but statistically significant, positive correlations were found between number of injuries and Burnout scores. Possible explanations are that injury provides a temporary break from intense sporting involvement and, thus, lower scores on Burnout, but multiple injuries might have a cumulative effect on burnout. © Perceptual and Motor Skills 2008.
The Zinc Transporter, Slc39a7 (Zip7) Is Implicated in Glycaemic Control in Skeletal Muscle Cells
- Myers, Stephen, Nield, Alex, Chew, Guatsiew, Myers, Mark
- Authors: Myers, Stephen , Nield, Alex , Chew, Guatsiew , Myers, Mark
- Date: 2013
- Type: Text , Journal article
- Relation: Plos One Vol. 8, no. 11 (November 2013 2013), p. 15
- Full Text:
- Reviewed:
- Description: Dysfunctional zinc signaling is implicated in disease processes including cardiovascular disease, Alzheimer's disease and diabetes. Of the twenty-four mammalian zinc transporters, ZIP7 has been identified as an important mediator of the 'zinc wave' and in cellular signaling. Utilizing siRNA targeting Zip7 mRNA we have identified that Zip7 regulates glucose metabolism in skeletal muscle cells. An siRNA targeting Zip7 mRNA down regulated Zip7 mRNA 4.6-fold (p = 0.0006) when compared to a scramble control. This was concomitant with a reduction in the expression of genes involved in glucose metabolism including Agl, Dlst, Galm, Gbe1, Idh3g, Pck2, Pgam2, Pgm2, Phkb, Pygm, Tpi1, Gusb and Glut4. Glut4 protein expression was also reduced and insulin-stimulated glycogen synthesis was decreased. This was associated with a reduction in the mRNA expression of Insr, Irs1 and Irs2, and the phosphorylation of Akt. These studies provide a novel role for Zip7 in glucose metabolism in skeletal muscle and highlight the importance of this transporter in contributing to glycaemic control in this tissue.
- Authors: Myers, Stephen , Nield, Alex , Chew, Guatsiew , Myers, Mark
- Date: 2013
- Type: Text , Journal article
- Relation: Plos One Vol. 8, no. 11 (November 2013 2013), p. 15
- Full Text:
- Reviewed:
- Description: Dysfunctional zinc signaling is implicated in disease processes including cardiovascular disease, Alzheimer's disease and diabetes. Of the twenty-four mammalian zinc transporters, ZIP7 has been identified as an important mediator of the 'zinc wave' and in cellular signaling. Utilizing siRNA targeting Zip7 mRNA we have identified that Zip7 regulates glucose metabolism in skeletal muscle cells. An siRNA targeting Zip7 mRNA down regulated Zip7 mRNA 4.6-fold (p = 0.0006) when compared to a scramble control. This was concomitant with a reduction in the expression of genes involved in glucose metabolism including Agl, Dlst, Galm, Gbe1, Idh3g, Pck2, Pgam2, Pgm2, Phkb, Pygm, Tpi1, Gusb and Glut4. Glut4 protein expression was also reduced and insulin-stimulated glycogen synthesis was decreased. This was associated with a reduction in the mRNA expression of Insr, Irs1 and Irs2, and the phosphorylation of Akt. These studies provide a novel role for Zip7 in glucose metabolism in skeletal muscle and highlight the importance of this transporter in contributing to glycaemic control in this tissue.
ADRA2A polymorphisms and ADHD in adults : Possible mediating effect of personality
- de Cerqueira, Caio, Polina, Evelise, Contini, Veronica, Marques, Francine, Grevet, Eugenio, Salgado, Carlos, da Silva, Paula, Picon, Felipe, Belmonte-De-Abreu, Paulo, Bau, Claiton
- Authors: de Cerqueira, Caio , Polina, Evelise , Contini, Veronica , Marques, Francine , Grevet, Eugenio , Salgado, Carlos , da Silva, Paula , Picon, Felipe , Belmonte-De-Abreu, Paulo , Bau, Claiton
- Date: 2011
- Type: Text , Journal article
- Relation: Psychiatry Research Vol. 186, no. 2-3 (2011), p. 345-350
- Full Text: false
- Reviewed:
- Description: Several studies have tested for the association between polymorphisms in the ADRA2A gene and childhood ADHD. A meta-analysis of these results, however, has pointed towards a significant heterogeneity, raising the need for explanatory studies. As the effect of other relevant clinical characteristics could be a possible source, we studied three polymorphisms in the ADRA2A gene (−1291 C>G–MspI or rs1800544; −262 G>A–HhaI or rs1800544; 1780 C>T–DraI or rs553668) in 403 adult patients with ADHD assessed in relation to comorbidity and personality characteristics, as well as in 232 controls. The diagnosis followed DSM-IV criteria, and personality dimensions were evaluated with the Temperament and Character Inventory (TCI). There were no significant differences in allele and genotype frequencies between cases and controls. Patients carrying the G allele of rs1800544 presented lower scores in harm avoidance, and carriers of the T allele of rs553668 had more novelty seeking and less harm avoidance and persistence. Additionally, the haplotype carrying the G-G-T alleles (rs1800544–rs1800545–rs553668) was associated with lower scores in harm avoidance and persistence, and higher scores in novelty seeking compared to other haplotypes. These findings suggest that the conflicting findings obtained in association studies between ADRA2A polymorphisms and ADHD might be related to temperament profiles, and support additional studies addressing these effects in larger samples.
Glyphosate Resistance of C-3 and C-4 Weeds under Rising Atmospheric CO2
- Fernando, Nimesha, Manalil, Sudheesh, Florentine, Singarayer, Chauhan, Bhagirath, Seneweera, Saman
- Authors: Fernando, Nimesha , Manalil, Sudheesh , Florentine, Singarayer , Chauhan, Bhagirath , Seneweera, Saman
- Date: 2016
- Type: Text , Journal article , Review
- Relation: Frontiers in Plant Science Vol. 7, no. (Jun 2016), p. 1-11
- Full Text:
- Reviewed:
- Description: The present paper reviews current knowledge on how changes of plant metabolism under elevated CO2 concentrations (e[CO2]) can affect the development of the glyphosate resistance of C-3 and C-4 weeds. Among the chemical herbicides, glyphosate, which is a non-selective and post-emergence herbicide, is currently the most widely used herbicide in global agriculture. As a consequence, glyphosate resistant weeds, particularly in major field crops, are a widespread problem and are becoming a significant challenge to future global food production. Of particular interest here it is known that the biochemical processes involved in photosynthetic pathways of C-3 and C-4 plants are different, which may have relevance to their competitive development under changing environmental conditions. It has already been shown that plant anatomical, morphological, and physiological changes under e[CO2] can be different, based on (i) the plant's functional group, (ii) the available soil nutrients, and (iii) the governing water status. In this respect, C-3 species are likely to have a major developmental advantage under a CO2 rich atmosphere, by being able to capitalize on the overall stimulatory effect of e[CO2]. For example, many tropical weed grass species fix CO2 from the atmosphere via the C-4 photosynthetic pathway, which is a complex anatomical and biochemical variant of the C-3 pathway. Thus, based on our current knowledge of CO2 fixing, it would appear obvious that the development of a glyphosate-resistant mechanism would be easier under an e[CO2] in C-3 weeds which have a simpler photosynthetic pathway, than for C-4 weeds. However, notwithstanding this logical argument, a better understanding of the biochemical, genetic, and molecular measures by which plants develop glyphosate resistance and how e[CO2] affects these measures will be important before attempting to innovate sustainable technology to manage the glyphosate-resistant evolution of weeds under e[CO2]. Such information will be of essential in managing weed control by herbicide use, and to thus ensure an increase in global food production in the event of increased atmospheric [CO2] levels.
- Authors: Fernando, Nimesha , Manalil, Sudheesh , Florentine, Singarayer , Chauhan, Bhagirath , Seneweera, Saman
- Date: 2016
- Type: Text , Journal article , Review
- Relation: Frontiers in Plant Science Vol. 7, no. (Jun 2016), p. 1-11
- Full Text:
- Reviewed:
- Description: The present paper reviews current knowledge on how changes of plant metabolism under elevated CO2 concentrations (e[CO2]) can affect the development of the glyphosate resistance of C-3 and C-4 weeds. Among the chemical herbicides, glyphosate, which is a non-selective and post-emergence herbicide, is currently the most widely used herbicide in global agriculture. As a consequence, glyphosate resistant weeds, particularly in major field crops, are a widespread problem and are becoming a significant challenge to future global food production. Of particular interest here it is known that the biochemical processes involved in photosynthetic pathways of C-3 and C-4 plants are different, which may have relevance to their competitive development under changing environmental conditions. It has already been shown that plant anatomical, morphological, and physiological changes under e[CO2] can be different, based on (i) the plant's functional group, (ii) the available soil nutrients, and (iii) the governing water status. In this respect, C-3 species are likely to have a major developmental advantage under a CO2 rich atmosphere, by being able to capitalize on the overall stimulatory effect of e[CO2]. For example, many tropical weed grass species fix CO2 from the atmosphere via the C-4 photosynthetic pathway, which is a complex anatomical and biochemical variant of the C-3 pathway. Thus, based on our current knowledge of CO2 fixing, it would appear obvious that the development of a glyphosate-resistant mechanism would be easier under an e[CO2] in C-3 weeds which have a simpler photosynthetic pathway, than for C-4 weeds. However, notwithstanding this logical argument, a better understanding of the biochemical, genetic, and molecular measures by which plants develop glyphosate resistance and how e[CO2] affects these measures will be important before attempting to innovate sustainable technology to manage the glyphosate-resistant evolution of weeds under e[CO2]. Such information will be of essential in managing weed control by herbicide use, and to thus ensure an increase in global food production in the event of increased atmospheric [CO2] levels.
Sport injuries sustained by athletes with disability : A systematic review
- Weiler, Richard, van Mechelen, Willem, Fuller, Colin, Verhagen, Evert
- Authors: Weiler, Richard , van Mechelen, Willem , Fuller, Colin , Verhagen, Evert
- Date: 2016
- Type: Text , Journal article , Review
- Relation: Sports Medicine Vol. 46, no. 8 (2016), p. 1141-1153
- Full Text:
- Reviewed:
- Description: Background Fifteen percent of the world's population live with disability, and many of these individuals choose to play sport. There are barriers to sport participation for athletes with disability and sports injury can greatly impact on daily life, which makes sports injury prevention additionally important. Objective The purpose of this review is to systematically review the definitions, methodologies and injury rates in disability sport, which should assist future identification of risk factors and development of injury prevention strategies. A secondary aim is to highlight the most pressing issues for improvement of the quality of injury epidemiology research for disability sport. Methods A search of NICE, AMED, British Nursing Index, CINAHL, EMBASE and Medline was conducted to identify all publications up to 16 June 2015. Of 489 potentially relevant articles and reference searching, a total of 15 studies were included. Wide study sample heterogeneity prevented data pooling and meta-analysis. Results Results demonstrated an evolving field of epidemiology, but with wide differences in sports injury definition and with studies focused on short competitions. Background data were generally sparse; there was minimal exposure analysis, and no analysis of injury severity, all of which made comparison of injury risk and injury severity difficult. Conclusion There is an urgent need for consensus on sports injury definition and methodology in disability sports. The quality of studies is variable, with inconsistent sports injury definitions, methodologies and injury rates, which prevents comparison, conclusions and development of injury prevention strategies. The authors highlight the most pressing issues for improvement of the quality in injury epidemiology research for disability sport.
- Authors: Weiler, Richard , van Mechelen, Willem , Fuller, Colin , Verhagen, Evert
- Date: 2016
- Type: Text , Journal article , Review
- Relation: Sports Medicine Vol. 46, no. 8 (2016), p. 1141-1153
- Full Text:
- Reviewed:
- Description: Background Fifteen percent of the world's population live with disability, and many of these individuals choose to play sport. There are barriers to sport participation for athletes with disability and sports injury can greatly impact on daily life, which makes sports injury prevention additionally important. Objective The purpose of this review is to systematically review the definitions, methodologies and injury rates in disability sport, which should assist future identification of risk factors and development of injury prevention strategies. A secondary aim is to highlight the most pressing issues for improvement of the quality of injury epidemiology research for disability sport. Methods A search of NICE, AMED, British Nursing Index, CINAHL, EMBASE and Medline was conducted to identify all publications up to 16 June 2015. Of 489 potentially relevant articles and reference searching, a total of 15 studies were included. Wide study sample heterogeneity prevented data pooling and meta-analysis. Results Results demonstrated an evolving field of epidemiology, but with wide differences in sports injury definition and with studies focused on short competitions. Background data were generally sparse; there was minimal exposure analysis, and no analysis of injury severity, all of which made comparison of injury risk and injury severity difficult. Conclusion There is an urgent need for consensus on sports injury definition and methodology in disability sports. The quality of studies is variable, with inconsistent sports injury definitions, methodologies and injury rates, which prevents comparison, conclusions and development of injury prevention strategies. The authors highlight the most pressing issues for improvement of the quality in injury epidemiology research for disability sport.
A feature agnostic approach for glaucoma detection in OCT volumes
- Maetschke, Stefan, Antony, Bhavna, Ishikawa, Hiroshi, Wollstein, Gadi, Schuman, Joel, Garnavi, Rahil
- Authors: Maetschke, Stefan , Antony, Bhavna , Ishikawa, Hiroshi , Wollstein, Gadi , Schuman, Joel , Garnavi, Rahil
- Date: 2019
- Type: Text , Journal article
- Relation: PLoS One Vol. 14, no. 7 (2019), p. e0219126
- Full Text:
- Reviewed:
- Description: Optical coherence tomography (OCT) based measurements of retinal layer thickness, such as the retinal nerve fibre layer (RNFL) and the ganglion cell with inner plexiform layer (GCIPL) are commonly employed for the diagnosis and monitoring of glaucoma. Previously, machine learning techniques have relied on segmentation-based imaging features such as the peripapillary RNFL thickness and the cup-to-disc ratio. Here, we propose a deep learning technique that classifies eyes as healthy or glaucomatous directly from raw, unsegmented OCT volumes of the optic nerve head (ONH) using a 3D Convolutional Neural Network (CNN). We compared the accuracy of this technique with various feature-based machine learning algorithms and demonstrated the superiority of the proposed deep learning based method. Logistic regression was found to be the best performing classical machine learning technique with an AUC of 0.89. In direct comparison, the deep learning approach achieved a substantially higher AUC of 0.94 with the additional advantage of providing insight into which regions of an OCT volume are important for glaucoma detection. Computing Class Activation Maps (CAM), we found that the CNN identified neuroretinal rim and optic disc cupping as well as the lamina cribrosa (LC) and its surrounding areas as the regions significantly associated with the glaucoma classification. These regions anatomically correspond to the well established and commonly used clinical markers for glaucoma diagnosis such as increased cup volume, cup diameter, and neuroretinal rim thinning at the superior and inferior segments.
- Authors: Maetschke, Stefan , Antony, Bhavna , Ishikawa, Hiroshi , Wollstein, Gadi , Schuman, Joel , Garnavi, Rahil
- Date: 2019
- Type: Text , Journal article
- Relation: PLoS One Vol. 14, no. 7 (2019), p. e0219126
- Full Text:
- Reviewed:
- Description: Optical coherence tomography (OCT) based measurements of retinal layer thickness, such as the retinal nerve fibre layer (RNFL) and the ganglion cell with inner plexiform layer (GCIPL) are commonly employed for the diagnosis and monitoring of glaucoma. Previously, machine learning techniques have relied on segmentation-based imaging features such as the peripapillary RNFL thickness and the cup-to-disc ratio. Here, we propose a deep learning technique that classifies eyes as healthy or glaucomatous directly from raw, unsegmented OCT volumes of the optic nerve head (ONH) using a 3D Convolutional Neural Network (CNN). We compared the accuracy of this technique with various feature-based machine learning algorithms and demonstrated the superiority of the proposed deep learning based method. Logistic regression was found to be the best performing classical machine learning technique with an AUC of 0.89. In direct comparison, the deep learning approach achieved a substantially higher AUC of 0.94 with the additional advantage of providing insight into which regions of an OCT volume are important for glaucoma detection. Computing Class Activation Maps (CAM), we found that the CNN identified neuroretinal rim and optic disc cupping as well as the lamina cribrosa (LC) and its surrounding areas as the regions significantly associated with the glaucoma classification. These regions anatomically correspond to the well established and commonly used clinical markers for glaucoma diagnosis such as increased cup volume, cup diameter, and neuroretinal rim thinning at the superior and inferior segments.
Optimization of the vehicle suspension systems for improved comfort levels and advanced steering properties
- Authors: Kuznetsov, Alexey
- Date: 2011
- Type: Text , Thesis
- Full Text:
- Description: There is a considerable body of research on the modelling and optimization of vehicle suspension systems. The main focus in most publications is an optimization procedure undertaken to find the values of the model parameters that satisfy certain operating requirements. However, the methods proposed do not always offer a broad variety of concepts and techniques. Most of these methods aim to find optimal values of suspension system parameters with respect to some optimality criteria that are often not explicitly formulated. In addition, none of the reviewed works utilizes existing guidelines and standards, on the vibration exposure on humans, to formulate optimization criteria. This would produce more applicable results of industrial and commercial merit. It is also important to mention that only a limited number of works offered numerical examples where real road conditions are employed for the optimization procedure. The presented thesis is devoted to development of a methodology for the optimization of vehicle suspension systems on the basis of two criteria: the improved comfort levels and advanced steering properties. The developed methodology is applied to various Australian roads, including highways, city roads, and country roads. It consists of a few steps as detailed below. The first step features the construction of a mathematical model for the vibration analysis of the vehicle suspension system. In the thesis different types of the quarter-car models and different biomechanical models for the driver are considered. All models considered are described by the corresponding systems of linear differential equations. The second step is undertaken to construct criteria to evaluate the comfort levels for the driver and passengers. For this purpose, a criterion was adopted from the ISO 2631 (1997) standards to quantify the comfort levels during a ride. To utilize this criterion, the steady-state vibrations, obtained from the system Differential Equations for various excitation frequencies, have been combined via a novel mathematical approach undertaken to eliminate the need to include the time of exposure in the calculations. This will enhance the applicability of the proposed method and simplify its implementation. 3 The third step is devoted to constructing a criterion to quantify the steering properties of a vehicle. The developed formula, which is based on an engineering understanding of how wheel vibration impacts the force interaction between the wheel and road, is proposed for the first time in the current thesis. The formula will serve as a criterion for advanced handling performance of passenger vehicles. The final step is undertaken to formulate optimization problems for finding the suspension system parameters which ensure improved comfort levels as well as admissible steering performance for the vehicle. For the analysis, these two criteria were employed to construct multi-criteria optimization problems and also singlecriteria optimization problems that incorporate both criteria. The developed methodology for the optimization of vehicle suspension systems is tested in a number of numerical examples using power spectral densities of several highways, city roads and country roads in Australia. Thus, it allows to offer recommendations for the optimal tuning of vehicle suspension systems taking into account real road conditions, steering performances and ISO 2631 (1997) standards for comfort levels.
- Description: Professional Doctorate
- Authors: Kuznetsov, Alexey
- Date: 2011
- Type: Text , Thesis
- Full Text:
- Description: There is a considerable body of research on the modelling and optimization of vehicle suspension systems. The main focus in most publications is an optimization procedure undertaken to find the values of the model parameters that satisfy certain operating requirements. However, the methods proposed do not always offer a broad variety of concepts and techniques. Most of these methods aim to find optimal values of suspension system parameters with respect to some optimality criteria that are often not explicitly formulated. In addition, none of the reviewed works utilizes existing guidelines and standards, on the vibration exposure on humans, to formulate optimization criteria. This would produce more applicable results of industrial and commercial merit. It is also important to mention that only a limited number of works offered numerical examples where real road conditions are employed for the optimization procedure. The presented thesis is devoted to development of a methodology for the optimization of vehicle suspension systems on the basis of two criteria: the improved comfort levels and advanced steering properties. The developed methodology is applied to various Australian roads, including highways, city roads, and country roads. It consists of a few steps as detailed below. The first step features the construction of a mathematical model for the vibration analysis of the vehicle suspension system. In the thesis different types of the quarter-car models and different biomechanical models for the driver are considered. All models considered are described by the corresponding systems of linear differential equations. The second step is undertaken to construct criteria to evaluate the comfort levels for the driver and passengers. For this purpose, a criterion was adopted from the ISO 2631 (1997) standards to quantify the comfort levels during a ride. To utilize this criterion, the steady-state vibrations, obtained from the system Differential Equations for various excitation frequencies, have been combined via a novel mathematical approach undertaken to eliminate the need to include the time of exposure in the calculations. This will enhance the applicability of the proposed method and simplify its implementation. 3 The third step is devoted to constructing a criterion to quantify the steering properties of a vehicle. The developed formula, which is based on an engineering understanding of how wheel vibration impacts the force interaction between the wheel and road, is proposed for the first time in the current thesis. The formula will serve as a criterion for advanced handling performance of passenger vehicles. The final step is undertaken to formulate optimization problems for finding the suspension system parameters which ensure improved comfort levels as well as admissible steering performance for the vehicle. For the analysis, these two criteria were employed to construct multi-criteria optimization problems and also singlecriteria optimization problems that incorporate both criteria. The developed methodology for the optimization of vehicle suspension systems is tested in a number of numerical examples using power spectral densities of several highways, city roads and country roads in Australia. Thus, it allows to offer recommendations for the optimal tuning of vehicle suspension systems taking into account real road conditions, steering performances and ISO 2631 (1997) standards for comfort levels.
- Description: Professional Doctorate
Oogenesis in Caenorhabditis elegans
- Davis, Gregory, Hipwell, Hayleigh, Boag, Peter
- Authors: Davis, Gregory , Hipwell, Hayleigh , Boag, Peter
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Sexual Development Vol. 17, no. 2-3 (2023), p. 73-83
- Full Text:
- Reviewed:
- Description: Background: The nematode, Caenorhabditis elegans has proven itself as a valuable model for investigating metazoan biology. C. elegans have a transparent body, an invariant cell lineage, and a high level of genetic conservation which makes it a desirable model organism. Although used to elucidate many aspects of somatic biology, a distinct advantage of C. elegans is its well annotated germline which allows all aspects of oogenesis to be observed in real time within a single animal. C. elegans hermaphrodites have two U-shaped gonad arms which produce their own sperm that is later stored to fertilise their own oocytes. These two germlines take up much of the internal space of each animal and germ cells are therefore the most abundant cell present within each animal. This feature and the genetic phenotypes observed for mutant worm gonads have allowed many novel findings that established our early understanding of germ cell dynamics. The mutant phenotypes also allowed key features of meiosis and germ cell maturation to be unveiled. Summary: This review will focus on the key aspects that make C. elegans an outstanding model for exploring each feature of oogenesis. This will include the fundamental steps associated with germline function and germ cell maturation and will be of use for those interested in exploring reproductive metazoan biology. Key Messages: Since germ cell biology is highly conserved in animals, much can be gained from study of a simple metazoan like C. elegans. Past findings have enhanced understanding on topics that would be more laborious or challenging in more complex animal models. © 2023 The Author(s). Published by S. Karger AG, Basel.
- Authors: Davis, Gregory , Hipwell, Hayleigh , Boag, Peter
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Sexual Development Vol. 17, no. 2-3 (2023), p. 73-83
- Full Text:
- Reviewed:
- Description: Background: The nematode, Caenorhabditis elegans has proven itself as a valuable model for investigating metazoan biology. C. elegans have a transparent body, an invariant cell lineage, and a high level of genetic conservation which makes it a desirable model organism. Although used to elucidate many aspects of somatic biology, a distinct advantage of C. elegans is its well annotated germline which allows all aspects of oogenesis to be observed in real time within a single animal. C. elegans hermaphrodites have two U-shaped gonad arms which produce their own sperm that is later stored to fertilise their own oocytes. These two germlines take up much of the internal space of each animal and germ cells are therefore the most abundant cell present within each animal. This feature and the genetic phenotypes observed for mutant worm gonads have allowed many novel findings that established our early understanding of germ cell dynamics. The mutant phenotypes also allowed key features of meiosis and germ cell maturation to be unveiled. Summary: This review will focus on the key aspects that make C. elegans an outstanding model for exploring each feature of oogenesis. This will include the fundamental steps associated with germline function and germ cell maturation and will be of use for those interested in exploring reproductive metazoan biology. Key Messages: Since germ cell biology is highly conserved in animals, much can be gained from study of a simple metazoan like C. elegans. Past findings have enhanced understanding on topics that would be more laborious or challenging in more complex animal models. © 2023 The Author(s). Published by S. Karger AG, Basel.
Photosynthetic responses of Invasive Acacia mangium and co-existing native heath forest species to elevated temperature and CO2 concentrations
- Ibrahim, Mohamad, Sukri, Rahayu, Tennakoon, Kushan, Le, Quang-Vuong, Metali, Faizah
- Authors: Ibrahim, Mohamad , Sukri, Rahayu , Tennakoon, Kushan , Le, Quang-Vuong , Metali, Faizah
- Date: 2021
- Type: Text , Journal article
- Relation: Journal of Sustainable Forestry Vol. 40, no. 6 (2021), p. 573-593
- Full Text:
- Reviewed:
- Description: The impacts of climate change, in particular via elevated temperature and atmospheric CO2 concentrations, cause differential photosynthetic responses between native and invasive alien plants, often resulting in varying magnitudes of plant growth and productivity. This study investigated variations in photosynthetic responses of an invasive alien Acacia species and two successional groups of tropical heath forest species: early secondary (Buchanania arborescens and Dillenia suffruticosa) and secondary (Calophyllum inophyllum and Ploiarium alternifolium) groups at elevated temperature (25 to 30°C) and CO2 levels (400 to 700 ppm). Invasive A.mangium appears better adapted to higher temperature and CO2. High temperature improved CO2 assimilation of A.mangium compared to heath species, which was attributed to increased transpiration rate and stomatal conductance but decreased water-use efficiency. Photosynthetic responses showed no differences in early secondary species at elevated temperature and CO2 but invasive A.mangium and P.alternifolium were stimulated by elevated CO2. The greater maximum net photosynthesis of A.mangium coincided with lower light compensation point and electron transport rate for RuBP regeneration, to a certain extent. Findings provide insights into possible underlying ecophysiological mechanisms contributing to the invasion success of Acacias in degraded tropical heath forests in response to future climate change. © 2020 Taylor & Francis.
- Authors: Ibrahim, Mohamad , Sukri, Rahayu , Tennakoon, Kushan , Le, Quang-Vuong , Metali, Faizah
- Date: 2021
- Type: Text , Journal article
- Relation: Journal of Sustainable Forestry Vol. 40, no. 6 (2021), p. 573-593
- Full Text:
- Reviewed:
- Description: The impacts of climate change, in particular via elevated temperature and atmospheric CO2 concentrations, cause differential photosynthetic responses between native and invasive alien plants, often resulting in varying magnitudes of plant growth and productivity. This study investigated variations in photosynthetic responses of an invasive alien Acacia species and two successional groups of tropical heath forest species: early secondary (Buchanania arborescens and Dillenia suffruticosa) and secondary (Calophyllum inophyllum and Ploiarium alternifolium) groups at elevated temperature (25 to 30°C) and CO2 levels (400 to 700 ppm). Invasive A.mangium appears better adapted to higher temperature and CO2. High temperature improved CO2 assimilation of A.mangium compared to heath species, which was attributed to increased transpiration rate and stomatal conductance but decreased water-use efficiency. Photosynthetic responses showed no differences in early secondary species at elevated temperature and CO2 but invasive A.mangium and P.alternifolium were stimulated by elevated CO2. The greater maximum net photosynthesis of A.mangium coincided with lower light compensation point and electron transport rate for RuBP regeneration, to a certain extent. Findings provide insights into possible underlying ecophysiological mechanisms contributing to the invasion success of Acacias in degraded tropical heath forests in response to future climate change. © 2020 Taylor & Francis.
An exploratory trial implementing a community-based child oral health promotion intervention for Australian families from refugee and migrant backgrounds : A protocol paper for Teeth Tales
- Gibbs, Lisa, Waters, Elizabeth, De Silva, Andrea, Riggs, Elisha, Moore, Laurence, Armit, Christine, Johnson, Britt, Morris, Michal, Calache, Hanny, Gussy, Mark, Young, Dana, Tadic, Maryanne, Christian, Bradley, Gondal, Iqbal, Watt, Richard, Pradel, Veronika, Truong, Mandy, Gold, Lisa
- Authors: Gibbs, Lisa , Waters, Elizabeth , De Silva, Andrea , Riggs, Elisha , Moore, Laurence , Armit, Christine , Johnson, Britt , Morris, Michal , Calache, Hanny , Gussy, Mark , Young, Dana , Tadic, Maryanne , Christian, Bradley , Gondal, Iqbal , Watt, Richard , Pradel, Veronika , Truong, Mandy , Gold, Lisa
- Date: 2014
- Type: Text , Journal article
- Relation: BMJ Open Vol. 4, no. 3 (2014), p. 1-14
- Full Text:
- Reviewed:
- Description: Introduction: Inequalities are evident in early childhood caries rates with the socially disadvantaged experiencing greater burden of disease. This study builds on formative qualitative research, conducted in the Moreland/Hume local government areas of Melbourne, Victoria 2006-2009, in response to community concerns for oral health of children from refugee and migrant backgrounds. Development of the community-based intervention described here extends the partnership approach to cogeneration of contemporary evidence with continued and meaningful involvement of investigators, community, cultural and government partners. This trial aims to establish a model for child oral health promotion for culturally diverse communities in Australia. Methods and analysis: This is an exploratory trial implementing a community-based child oral health promotion intervention for Australian families from refugee and migrant backgrounds. Families from an Iraqi, Lebanese or Pakistani background with children aged 1-4 years, residing in metropolitan Melbourne, were invited to participate in the trial by peer educators from their respective communities using snowball and purposive sampling techniques. Target sample size was 600. Moreland, a culturally diverse, inner-urban metropolitan area of Melbourne, was chosen as the intervention site. The intervention comprised peer educator led community oral health education sessions and reorienting of dental health and family services through cultural Competency Organisational Review (CORe). Ethics and dissemination: Ethics approval for this trial was granted by the University of Melbourne Human Research Ethics Committee and the Department of Education and Early Childhood Development Research Committee. Study progress and output will be disseminated via periodic newsletters, peer-reviewed research papers, reports, community seminars and at National and International conferences. Trial registration number: Australian New Zealand Clinical Trials Registry (ACTRN12611000532909).
- Authors: Gibbs, Lisa , Waters, Elizabeth , De Silva, Andrea , Riggs, Elisha , Moore, Laurence , Armit, Christine , Johnson, Britt , Morris, Michal , Calache, Hanny , Gussy, Mark , Young, Dana , Tadic, Maryanne , Christian, Bradley , Gondal, Iqbal , Watt, Richard , Pradel, Veronika , Truong, Mandy , Gold, Lisa
- Date: 2014
- Type: Text , Journal article
- Relation: BMJ Open Vol. 4, no. 3 (2014), p. 1-14
- Full Text:
- Reviewed:
- Description: Introduction: Inequalities are evident in early childhood caries rates with the socially disadvantaged experiencing greater burden of disease. This study builds on formative qualitative research, conducted in the Moreland/Hume local government areas of Melbourne, Victoria 2006-2009, in response to community concerns for oral health of children from refugee and migrant backgrounds. Development of the community-based intervention described here extends the partnership approach to cogeneration of contemporary evidence with continued and meaningful involvement of investigators, community, cultural and government partners. This trial aims to establish a model for child oral health promotion for culturally diverse communities in Australia. Methods and analysis: This is an exploratory trial implementing a community-based child oral health promotion intervention for Australian families from refugee and migrant backgrounds. Families from an Iraqi, Lebanese or Pakistani background with children aged 1-4 years, residing in metropolitan Melbourne, were invited to participate in the trial by peer educators from their respective communities using snowball and purposive sampling techniques. Target sample size was 600. Moreland, a culturally diverse, inner-urban metropolitan area of Melbourne, was chosen as the intervention site. The intervention comprised peer educator led community oral health education sessions and reorienting of dental health and family services through cultural Competency Organisational Review (CORe). Ethics and dissemination: Ethics approval for this trial was granted by the University of Melbourne Human Research Ethics Committee and the Department of Education and Early Childhood Development Research Committee. Study progress and output will be disseminated via periodic newsletters, peer-reviewed research papers, reports, community seminars and at National and International conferences. Trial registration number: Australian New Zealand Clinical Trials Registry (ACTRN12611000532909).
Study on the tribological characteristics of plant oil-based bio-lubricant with automotive liner-piston ring materials
- Shahabuddin, M., Mofijur, M., Rizwanul Fattah, I. M., Kalam, M. A., Masjuki, H. H., Chowdhury, M. A., Hossain, N.
- Authors: Shahabuddin, M. , Mofijur, M. , Rizwanul Fattah, I. M. , Kalam, M. A. , Masjuki, H. H. , Chowdhury, M. A. , Hossain, N.
- Date: 2022
- Type: Text , Journal article
- Relation: Current Research in Green and Sustainable Chemistry Vol. 5, no. (2022), p.
- Full Text:
- Reviewed:
- Description: The development of bio-lubricant is an immerging area of research considering the rapid depletion of petroleum reserve and environmental concern. This study aims to develop non-edible jatropha oil-based bio-lubricant and investigate the tribological properties considering commonly used piston ring-cylinder liner materials of stainless steel and cast iron due to their interaction under lubricated conditions in an internal combustion engine. The bio-lubricant was prepared by blending different percentages of vegetable oil with commercial lubricants. The tribological test was carried out using a Reo-Bicerihigh-frequency reciprocating rig (HFRR) for the duration of 6 h under standard operating conditions. Different properties of bio-lubricants were measured before and after the HFRR test using various analytical instruments. The morphology of the worn material surfaces was examined via Hitachi S-4700 FE-SEM cold field emission high resolution scanning electron microscopy (SEM). The result showed that addition of vegetable oil lubricant up to 7.5% concentration can be compared with commercial lubricant in case of wear rate and coefficient of wear as weight loss reduced significantly. Minimum change in viscosity was observed at the addition of 7.5% bio-lubricant. Surface morphology analysis confirmed less damage of metal surface when tribological analysis were performed at mixed lubricated condition. © 2022 The Authors
- Authors: Shahabuddin, M. , Mofijur, M. , Rizwanul Fattah, I. M. , Kalam, M. A. , Masjuki, H. H. , Chowdhury, M. A. , Hossain, N.
- Date: 2022
- Type: Text , Journal article
- Relation: Current Research in Green and Sustainable Chemistry Vol. 5, no. (2022), p.
- Full Text:
- Reviewed:
- Description: The development of bio-lubricant is an immerging area of research considering the rapid depletion of petroleum reserve and environmental concern. This study aims to develop non-edible jatropha oil-based bio-lubricant and investigate the tribological properties considering commonly used piston ring-cylinder liner materials of stainless steel and cast iron due to their interaction under lubricated conditions in an internal combustion engine. The bio-lubricant was prepared by blending different percentages of vegetable oil with commercial lubricants. The tribological test was carried out using a Reo-Bicerihigh-frequency reciprocating rig (HFRR) for the duration of 6 h under standard operating conditions. Different properties of bio-lubricants were measured before and after the HFRR test using various analytical instruments. The morphology of the worn material surfaces was examined via Hitachi S-4700 FE-SEM cold field emission high resolution scanning electron microscopy (SEM). The result showed that addition of vegetable oil lubricant up to 7.5% concentration can be compared with commercial lubricant in case of wear rate and coefficient of wear as weight loss reduced significantly. Minimum change in viscosity was observed at the addition of 7.5% bio-lubricant. Surface morphology analysis confirmed less damage of metal surface when tribological analysis were performed at mixed lubricated condition. © 2022 The Authors