List of Titles

A multifactorial evaluation of illness risk factors in athletes preparing for the Summer Olympic Games

- Drew, Michael, Vlahovich, Nicole, Hughes, David, Appaneal, Renee, Peterson, Kirsten, Burke, Louise, Lundy, Bronwen, Toomey, Mary, Watts, David, Lovell, Gregory, Praet, Stephan, Halson, Shona, Colbey, Candice, Manzanero, Silvia, Welvaert, Marijke, West, Nic, Pyne, David, Waddington, Gordon

Authors: Drew, Michael , Vlahovich, Nicole , Hughes, David , Appaneal, Renee , Peterson, Kirsten , Burke, Louise , Lundy, Bronwen , Toomey, Mary , Watts, David , Lovell, Gregory , Praet, Stephan , Halson, Shona , Colbey, Candice , Manzanero, Silvia , Welvaert, Marijke , West, Nic , Pyne, David , Waddington, Gordon
Date: 2017
Type: Text , Journal article
Relation: Journal of Science and Medicine in Sport Vol. 20, no. 8 (2017), p. 745-750
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Description: Objectives Illness can disrupt training and competition performance of athletes. Few studies have quantified the relative contribution of the known medical, behavioural and lifestyle risk factors. Design Cross-sectional. Methods Olympic athletes from 11 sports (n = 221) were invited to complete questionnaires administered nine months before the Rio 2016 Olympic Games. These included the Depression, Anxiety and Stress Questionnaire (DASS-21), Perceived Stress Scale (PSS), Dispositional Resilience Scale (DRS), Recovery-Stress Questionnaire (REST-Q-52 item), Low Energy in Females Questionnaire (LEAF-Q), a modified Personal and Household Hygiene questionnaire, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and custom-made questionnaires on probiotic usage and travel. An illness (case) was defined as an event which limited training or competition for greater hours in the prior month. Odds ratios and attributable fractions in the population (AFP) were utilised for categorical variables with independent t-tests or Wilcoxon rank-sum for continuous variables. Results Eighty-one athletes responded (male, n = 26; female, n = 55). There were 16 illness cases and 65 controls. Female athletes were at higher odds of illness (OR = 9.4, 95%CI 1.3–410, p = 0.01, AFP = 0.84). Low energy availability (LEAF-Q score ≥8: OR = 7.4, 95%CI 0.78–352, p = 0.04, AFP = 0.76), depression symptoms (DASS-21: depression score >4, OR = 8.4, 95%CI 1.1–59, p < 0.01; AFP = 0.39) and higher perceived stress (PSS: 10-item, p = 0.04) were significantly associated with illness. Conclusions Female sex, low energy availability, and mental health are associated with sports incapacity (time loss) due to illness. Low energy availability had high attributable fractions in the population and stands out as a primary association with illness. © 2017

Key viral immune genes and pathways identify elite athletes with URS

- Colbey, Candice, Drew, Michael, Cox, Amanda, Vider, Jelena, Pyne, David, Vlahonich, Nicole, Hughes, David, Waddington, Gordon, Appaneal, Renee, Burke, Louise, Lundy, Bronwen, Toomey, Mary, Watts, David, Lovell, Gregory, Praet, Stephan, Halson, Shona, Welvaert, Marijke, Zhang, Ping, Cripps, Aallan, West, Nicholas

Authors: Colbey, Candice , Drew, Michael , Cox, Amanda , Vider, Jelena , Pyne, David , Vlahonich, Nicole , Hughes, David , Waddington, Gordon , Appaneal, Renee , Burke, Louise , Lundy, Bronwen , Toomey, Mary , Watts, David , Lovell, Gregory , Praet, Stephan , Halson, Shona , Welvaert, Marijke , Zhang, Ping , Cripps, Aallan , West, Nicholas
Date: 2020
Type: Text , Journal article
Relation: Exercise immunology review Vol. 26, no. (2020), p. 56-78
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Description: PURPOSE: Habitual intense exercise may increase the incidence of upper respiratory symptoms (URS) in elite athletes. This study investigated whether immune gene expression could identify gene markers that discriminate athletes with a higher prevalence of URS. METHODS: This cross-sectional analysis of elite Australian athletes from various sports investigated whether athletes retrospectively reporting URS for two days or more in a month (n=38), had an altered immune gene expression profile compared with asymptomatic athletes (n=33). Peripheral blood samples were collected during Olympic selection events with corresponding URS data collected for the one-month period before sampling. Digital immune gene expression analysis was undertaken using the NanoString PanCancer Immune Profiling panel. RESULTS: Fifty immune genes were differentially expressed between the groups (p<0.05) and approximately 78% of these genes were more highly expressed in athletes reporting URS. Many of these genes were interferon-stimulated genes or genes involved in the Jak/Stat signalling pathway. Only interferon alpha inducible protein 27 (IFI27), an interferon stimulated gene involved in viral response, remained significantly higher in athletes reporting URS (log2 fold-difference=2.49, odds ratio 1.02 per unit increase; p<0.01) post-adjustment and discriminated athletes reporting URS from asymptomatic athletes with 78% accuracy. CONCLUSIONS: Expression of IFI27 could differentiate athletes reporting URS from asymptomatic athletes, a gene that is upregulated in the immune response to viral infection. Upregulation of viral signalling pathways provides novel information on the potential aetiology of URS in elite Olympic athletes. Copyright © 2020 International Society of Exercise and Immunology. All rights reserved.

Normative MRI, ultrasound and muscle functional MRI findings in the forearms of asymptomatic elite rowers

- Drew, Michael, Trease, Larissa, Caneiro, J. P., Hooper, Ivan, Ooi, Chin-Chin, Counsel, Peter, Connell, David, Rice, Anthony, Knight, Emma, Hoy, Gregory, Lovell, Gregory

Authors: Drew, Michael , Trease, Larissa , Caneiro, J. P. , Hooper, Ivan , Ooi, Chin-Chin , Counsel, Peter , Connell, David , Rice, Anthony , Knight, Emma , Hoy, Gregory , Lovell, Gregory
Date: 2016
Type: Text , Journal article
Relation: Journal of Science and Medicine in Sport Vol. 19, no. 2 (2016), p. 103-108
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Description: Objectives Forearm injuries are common and debilitating to elite rowers. Chronic exertional compartment syndrome, intersection syndrome and proximal radial bone stress injuries have been documented in this population. This paper explores the imaging findings related to these conditions in asymptomatic elite rowers. Design Observational study. Methods 19 asymptomatic senior elite and under-23 rowers currently competing at National level or above underwent ultrasound (US), Magnetic Resonance Imaging (MRI) and muscle functional MRI evaluation of their forearms. A comprehensive evaluation sheet identifying characteristics of bone stress, intersection syndrome and chronic exertional compartment syndrome was utilised based on a literature search and review by senior clinicians working with this population. Results Peritendinous fluid of Extensor Carpi Radialis Longus (n=10, 53%) or Extensor Carpi Radialis Brevis (n=6, 32%) was a common finding on US. MRI had a higher rate of identification than US. Extensor Digitorum (Coeff=−1.76, 95%CI −3.04 to −0.49), Flexor Carpi Radialis (Coeff=−2.86, 95%CI −5.35 to −0.38) and Flexor Carpi Ulnaris (Coeff=−3.31, 95%CI −5.30 to −1.32), Pronator Teres (Coeff=−3.94, 95%CI −6.89 to −0.99), and Supinator (Coeff=−168, 95%CI −3.28 to −0.02) showed statistically significant changes immediately post-exercise. Mild proximal radial marrow hyperintensity was present (n=15, 78.9%) with three participants (15.8%) also having mild periosteal oedema of the radius. Conclusions Imaging findings commonly seen in symptomatic populations are observed in elite, asymptomatic rowers. Care should be taken when diagnosing bone stress injuries, intersection syndrome and compartment syndrome on imaging findings alone. Data presented can be utilised as a normative dataset for future case studies.

Prevalence of illness, poor mental health and sleep quality and low energy availability prior to the 2016 Summer Olympic Games

- Drew, Michael, Vlahovich, Nicole, Hughes, David, Appaneal, Renee, Burke, Louise, Lundy, Bronwen, Rogers, Margot, Toomey, Mary, Watts, David, Lovell, Gregory, Praet, Stephan, Halson, Shona, Colbey, Candice, Manzanero, Silvia, Welvaert, Marijke, West, Nicholas, Pyne, David, Waddington, Gordon

Authors: Drew, Michael , Vlahovich, Nicole , Hughes, David , Appaneal, Renee , Burke, Louise , Lundy, Bronwen , Rogers, Margot , Toomey, Mary , Watts, David , Lovell, Gregory , Praet, Stephan , Halson, Shona , Colbey, Candice , Manzanero, Silvia , Welvaert, Marijke , West, Nicholas , Pyne, David , Waddington, Gordon
Date: 2017
Type: Text , Journal article
Relation: British Journal of Sports Medicine Vol. , no. (2017), p. 1-8
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Description: Objective: Establish the prevalence of illness symptoms, poor sleep quality, poor mental health symptoms, low energy availability and stress-recovery state in an Olympic cohort late in the 3months prior to the Summer Olympic Games. Methods: Olympic athletes (n=317) from 11 sports were invited to complete questionnaires administered 3months before the Rio 2016 Olympic Games. These questionnaires included the Depression, Anxiety and Stress Questionnaire, Perceived Stress Scale, Dispositional Resilience Scale, Recovery-Stress Questionnaire (REST-Q-52 item), Low Energy Availability in Females Questionnaire (LEAF-Q), Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index and custom-made questionnaires on probiotic usage and travel. Multiple illness (case) definitions were applied. ORs and attributable fractions in the population were used. Factor analyses were used to explore the relationships between variables. Results: The response rate was of 42% (male, n=47, age 25.8±4.1 years; female, n=85, age 24.3±3.9 years). Low energy availability was associated with sustaining an illness in the previous month (upper respiratory, OR=3.8, 95%CI 1.2 to 12). The main factor relating to illness pertained to a combination of anxiety and stress recovery states (as measured by the REST-Q-52 item). All participants reported at least one episode of illness in the last month (100% prevalence). Conclusions: All participants reported at least one illness symptom in the previous month. Low energy availability was a leading variable associated with illness in Olympic-class athletes. The estimates duration of symptoms ranged from 2 to 7 days. Factor analyses show the interdependence of various health domains and support multidisciplinary care.

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