Showing items 1 - 2 of 2

Salt Loading in Canola Oil Fed SHRSP Rats Induces Endothelial Dysfunction

- Papazzo, Annateresa, Conlan, Xavier, Lexis, Louise, Charchar, Fadi, Lewandowski, Paul

  • Authors: Papazzo, Annateresa , Conlan, Xavier , Lexis, Louise , Charchar, Fadi , Lewandowski, Paul
  • Date: 2013
  • Type: Text , Journal article
  • Relation: PLoS ONE Vol. 8, no. 6 (2013), p.
  • Full Text:
  • Reviewed:
  • Description: This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt loading affects: (1) antioxidant and oxidative stress markers, (2) aortic mRNA of NADPH oxidase (NOX) subunits and superoxide dismutase (SOD) isoforms and (3) endothelial function in SHRSP rats. SHRSP rats were fed a diet containing 10 wt/wt% soybean oil or 10 wt/wt% canola oil, and given tap water or water containing 1% NaCl for 50 days. Without salt, canola oil significantly increased RBC SOD, plasma cholesterol and triglycerides, aortic p22phox, NOX2 and CuZn-SOD mRNA, and decreased RBC glutathione peroxidase activity. With salt, canola oil reduced RBC SOD and catalase activity, LDL-C, and p22phox mRNA compared with canola oil alone, whereas plasma malondialdehyde (MDA) was reduced and RBC MDA and LDL-C were higher. With salt, the canola oil group had significantly reduced endothelium-dependent vasodilating responses to ACh and contractile responses to norepinephrine compared with the canola oil group without salt and to the WKY rats. These results indicate that ingestion of canola oil increases O2 - generation, and that canola oil ingestion in combination with salt leads to endothelial dysfunction in the SHRSP model. © 2013 Papazzo et al.
  • Description: 2003011096

The effects of hydrated lime and bleach on carrion decomposition and associated insect succession

- McIntyre, Donna, Conlan, Xavier, Harvey, Michelle

  • Authors: McIntyre, Donna , Conlan, Xavier , Harvey, Michelle
  • Date: 2023
  • Type: Text , Journal article
  • Relation: Australian Journal of Forensic Sciences Vol. 55, no. 4 (2023), p. 492-510
  • Full Text:
  • Reviewed:
  • Description: Necrophagous insect species are used in forensic entomology to assist with the estimation of the minimum post-mortem interval (PMImin). However, chemical substances applied to a corpse in a bid to conceal remains may affect the attractiveness of a corpse to insects and consequently the insect succession and decomposition. This study investigated the potential for two readily obtainable substances, hydrated lime and bleach to affect decomposition and associated insect succession in porcine remains outdoors and above ground during autumn, winter and spring in the Geelong region of Victoria, Australia. The substances were correlated with a significantly longer pre-appearance interval (PAI) (>12 hours) and delayed oviposition during colder months. Further, remains deposited during autumn and spring did not skeletonize when substances were present. These findings show the importance of considering the presence of bleach and hydrated lime on remains when estimating PMI. © 2022 Australian Academy of Forensic Sciences.
  • 1