- Title
- Epigenetic modifications in essential hypertension
- Creator
- Wise, Ingrid; Charchar, Fadi
- Date
- 2016
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/100850
- Identifier
- vital:10609
- Identifier
-
https://doi.org/10.3390/ijms17040451
- Identifier
- ISSN:1661-6596
- Abstract
- Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world’s leading public health problems. Furthermore, there is increasing evidence that epigenetic modifications are as important as genetic predisposition in the development of EH. Indeed, a complex and interactive genetic and environmental system exists to determine an individual’s risk of EH. Epigenetics refers to all heritable changes to the regulation of gene expression as well as chromatin remodelling, without involvement of nucleotide sequence changes. Epigenetic modification is recognized as an essential process in biology, but is now being investigated for its role in the development of specific pathologic conditions, including EH. Epigenetic research will provide insights into the pathogenesis of blood pressure regulation that cannot be explained by classic Mendelian inheritance. This review concentrates on epigenetic modifications to DNA structure, including the influence of non-coding RNAs on hypertension development. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
- Publisher
- MDPI AG
- Relation
- International Journal of Molecular Sciences Vol. 17, no. 4 (2016), p. 1-14; http://purl.org/au-research/grants/nhmrc/1009490
- Rights
- Copyright © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license.
- Rights
- Open Access
- Rights
- http://creativecommons.org/licenses/by/4.0/
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences; DNA methylation; Epigenetics; Essential hypertension; Histone modifications; microRNAs; Non-coding RNA
- Full Text
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