- Title
- Interleukin-6 and Hepcidin levels during hormone-deplete and hormone-replete phases of an oral contraceptive cycle : A pilot study
- Creator
- Sim, Marc; Dawson, Brian; Landers, Grant; Swinkels, Dorine; Wiegerinck, Erwin; Yeap, Bu Beng; Trinder, Debbie; Peeling, Peter
- Date
- 2017
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/156878
- Identifier
- vital:11498
- Identifier
-
https://doi.org/10.1159/000465530
- Identifier
- ISSN:0250-6807
- Abstract
- Background: In the past, elevated estradiol levels were reported to downregulate the iron regulatory hormone hepcidin, thereby potentially improving iron metabolism. As estrogen plays a role in regulating the menstrual cycle and can influence the cytokine interleukin-6 (IL-6; a hepcidin up-regulator), this investigation examined the effects of estradiol supplementation achieved by the use of a monophasic oral contraceptive pill (OCP) on IL-6, hepcidin levels and iron status during the hormone-deplete versus hormone-replete phases within an oral contraceptive cycle (OCC). Methods: Fifteen healthy female OCP users were recruited and provided a venous blood sample on 2 separate mornings during a 28-day period. These included (a) days 2-4 of the OCC, representing a hormone-free withdrawal period (WD); (b) days 12-14 of the OCC, representing the end of the first week of active hormone therapy (AHT). Results: IL-6 and hepcidin levels were not significantly different at WD and AHT. Serum ferritin was significantly higher (p = 0.039) during AHT as compared to WD. Conclusions: Fluctuations in OCP hormones (estradiol and/or progestogen) had no effect on basal IL-6 and hepcidin levels in young women. Nevertheless, elevated ferritin levels recorded during AHT may indicate that OCP hormones can positively influence iron stores within an OCC despite unchanged hepcidin levels. © 2017 S. Karger AG, Basel.
- Publisher
- S. Karger AG
- Relation
- Annals of Nutrition and Metabolism Vol. 70, no. 2 (2017), p. 100-105
- Rights
- Copyright © 2017 S. Karger AG, Basel.
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1111 Nutrition and Dietetics; Estrogen; Iron deficiency; Iron metabolism; Menstrual cycle; Progesterone
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