Aberrant pregnancy-associated plasma protein-A expression in breast cancers prognosticates clinical outcomes

- Prithviraj, Prashanth, Anaka, Matthew, Thompson, Erik, Sharma, Revati, Walkiewicz, Marzena, Tutuka, Candani, Behren, Andreas, Kannourakis, George, Jayachandran, Aparna

Title
Aberrant pregnancy-associated plasma protein-A expression in breast cancers prognosticates clinical outcomes
Creator
Prithviraj, Prashanth; Anaka, Matthew; Thompson, Erik; Sharma, Revati; Walkiewicz, Marzena; Tutuka, Candani; Behren, Andreas; Kannourakis, George; Jayachandran, Aparna
Date
2020
Type
Text; Journal article
Identifier
http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/173681
Identifier
vital:14735
Identifier
https://doi.org/10.1038/s41598-020-70774-9
Identifier
ISBN:2045-2322 (ISSN)
Abstract
Elevated levels of pregnancy-associated plasma protein-A (PAPP-A) have been implicated in the pathogenesis of various malignancies, including breast cancers. Breast cancer is one of the most frequent carcinomas and is the second most common cancer type detected in women of child-bearing age. Throughout pregnancy PAPP-A is produced and secreted by the placental syncytiotrophoblast cells; co-incidentally pregnancy-associated breast cancers often have an aggressive clinical course. The components of the PAPP-A/IGF axis was assessed in a panel of breast cancer cell lines. Using neutralising antibodies the impact of PAPP-A/IGF axis on cell motility was evaluated. PAPP-A was expressed in four of the twelve breast cancer cell lines tested. Blocking PAPP-A and IGFBP4 with neutralising antibodies significantly decreased motiliy of MDA-MB-231 cells. Upregulation of PAPP-A expression in breast tumours resulted in a trend towards worse overall survival. Notably, PAPP-A expression also positively correlated with epithelial-to-mesenchymal transition markers. In conclusion, these results indicate that PAPP-A plays an important role in breast cancer progression and it may be a promising therapeutic target in breast cancer. © 2020, The Author(s).
Publisher
Nature Research
Relation
Scientific Reports Vol. 10, no. 1 (2020), p.
Rights
https://creativecommons.org/licenses/by/4.0/
Rights
Copyright © The Author(s) 2020
Rights
Open Access
Rights
This metadata is freely available under a CCO license
Subject
MD Multidisciplinary
Full Text
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