Most people find times of transition stressful, such as commencing a new job or moving house. In this study, our aim was to investigate stress reported by students as they commenced university. Specifically, we aimed to investigate whether stress levels and perceived social support levels differed among students (i.e., metropolitan and rural and regional) who moved house to commence university and those who did not. Results from 551 students (144 males) indicated that 88% of all students rated the level of stress associated with commencing university as being above the mid-point on a 5-pt Likert scale. The stress of commencing university was higher among rural and regional students who left home to study than it was among metropolitan students who shifted house. In addition, the stress associated with moving house significantly predicted both metropolitan and rural and regional students’ ratings on the stress of commencing university. There were no group differences in perceptions of available social support when commencing university. Results of this study, especially for rural and regional students, are discussed in terms of student welfare, and ways to ameliorate the potential stress and depression associated with commencing university and shifting house.