Multimodal image registration (MMIR) is the alignment of contents in images captured from different sensors or instruments. MMIR is important in medical applications as it enables the visualization of the complementary contents in biomedical microscopic images. The registration for such images can be challenging as the structures of their contents are usually only partially similar. Thus in this paper, we propose a new method to maximize the structural similarity of the contents in such images by utilizing intensity relationships among Red-Green-Blue color channels. Our experimental results will demonstrate that our proposed method substantially improves the accuracy of registering such images as compared to the state-of-the-art methods.