- Title
- Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics
- Creator
- Xu, Xiaoguang; Eales, James; Jiang, Xiao; Sanderson, Eleanor; Drzal, Maciej; Saluja, Sushant; Scannali, David; Williams, Bryan; Morris, Andrew; Guzik, Tomasz; Charchar, Fadi; Holmes, Michael; Tomaszewski, Maciej
- Date
- 2022
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/188656
- Identifier
- vital:17325
- Identifier
-
https://doi.org/10.1093/cvr/cvab357
- Identifier
- ISSN:1755-3245 (ISSN)
- Abstract
- AIMS: Obesity and kidney diseases are common complex disorders with an increasing clinical and economic impact on healthcare around the globe. Our objective was to examine if modifiable anthropometric obesity indices show putatively causal association with kidney health and disease and highlight biological mechanisms of potential relevance to the association between obesity and the kidney. METHODS AND RESULTS: We performed observational, one-sample, two-sample Mendelian randomization (MR) and multivariable MR studies in
- Publisher
- NLM (Medline)
- Relation
- Cardiovascular research Vol. 118, no. 15 (2022), p. 3151-3161
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © The Author(s) 2021
- Rights
- Open Access
- Subject
- 3201 Cardiovascular medicine and haematology; Kidney disease; Kidney function; Kidney transcriptome; Mendelian randomization; Obesity
- Full Text
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