- Title
- Fasting status modifies the association between triglyceride and all-cause mortality : a cohort study
- Creator
- Fang, Yan; Wang, Yutang
- Date
- 2022
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/189231
- Identifier
- vital:17406
- Identifier
-
https://doi.org/10.1002/hsr2.642
- Identifier
- ISSN:2398-8835 (ISSN)
- Abstract
- Background and Aims: Both fasting and non-fasting levels of triglyceride have been shown positively associated with all-cause mortality. It is unknown whether fasting status modifies this association. This study aimed to address this question. Methods: This study included 34,512 US adults (27,036 fasting and 7476 nonfasting participants). All-cause mortality was ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios of triglyceride for mortality. Results: This cohort was followed up for a mean of 13.0 years. During the follow-up, 8491 all-cause deaths were recorded. A 1-natural-log-unit increase in triglyceride was associated with an 8% higher multivariate-adjusted risk of all-cause mortality. Interaction analyses showed that fasting status interacted with triglyceride in predicting all-cause mortality. Sub-analyses showed that a 1-natural-log-unit increase in triglyceride was associated with a 17% higher multivariate-adjusted risk of all-cause mortality in the nonfasting subcohort; however, there lacked such an association in the fasting sub-cohort. Similarly, high (200–499 mg/dL) and very high levels of triglyceride (
- Publisher
- John Wiley and Sons Inc
- Relation
- Health Science Reports Vol. 5, no. 3 (2022), p.
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright © 2022 The Authors
- Rights
- Open Access
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Subject
- 32 Biomedical and clinical sciences; 42 Health Sciences; Biomarker; Fasting; Mortality; Nonfasting; Triglyceride
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