Exploration of associations between occupational exposures and current adult eczema
- Lopez, Diego, Alif, Sheikh, Dharmage, Shyamali, Lodge, Caroline, Bui, Dinh, Le Moual, Nicole, Waidyatillake, Nilakshi, Su, John, Abramson, Michael, Walters, E., Hamilton, Garun, Bowatte, Gayan, Erbas, Bircan, Benke, Geza, Perret, Jennifer, Lowe, Adrian
- Authors: Lopez, Diego , Alif, Sheikh , Dharmage, Shyamali , Lodge, Caroline , Bui, Dinh , Le Moual, Nicole , Waidyatillake, Nilakshi , Su, John , Abramson, Michael , Walters, E. , Hamilton, Garun , Bowatte, Gayan , Erbas, Bircan , Benke, Geza , Perret, Jennifer , Lowe, Adrian
- Date: 2023
- Type: Text , Journal article
- Relation: Occupational and Environmental Medicine Vol. 80, no. 10 (2023), p. 564-571
- Full Text: false
- Reviewed:
- Description: Objectives There is a scarcity of evidence on occupational exposures that may increase eczema in adults. We aimed to investigate potential associations between occupational exposures and eczema in middle-aged adults. Methods A lifetime work history calendar was collected from the Tasmanian Longitudinal Health Study participants when they were at age 53. Their work history was collated with the occupational asthma-specific job exposure matrix to define ever-exposure and cumulative exposure unit-years since no eczema job exposure matrix is available. Eczema was determined using the report of flexural rash that was coming and going for at least 6 months in the last 12 months. Skin prick tests were used to further subgroup eczema and atopic eczema (AE) or non-AE (NAE). Logistic and multinomial regression models were used to investigate the associations. Results Eczema prevalence was 9.1%. Current occupational exposure to animals (adjusted OR, aOR=3.06 (95% CI 1.43 to 6.58)), storage mites (aOR=2.96 (95% CI 1.38 to 6.34)) and endotoxin (aOR=1.95 (95% CI 1.04 to 3.64)) were associated with increased risk of current eczema. Furthermore, increased odds of NAE were associated with current exposure to animals (aOR=5.60 (95% CI 1.45 to 21.7)) and storage mites (aOR=5.63 (95% CI 1.45 to 21.9)). Current exposures to isocyanates (aOR=5.27 (95% CI 1.17 to 23.7)) and acrylates (aOR=8.41 (95% CI 1.60 to 44.3)) were associated with AE. There was no evidence of associations between cumulative exposures and eczema prevalence. Cumulative exposure to metalworking fluids (aOR=1.10 (95% CI 1.01 to 1.22)) was associated with NAE and acrylates (aOR=1.24 (95% CI 1.04 to 1.46)) with AE. Conclusions In this exploratory assessment, multiple occupational exposures were associated with current eczema in middle-aged adults. Raising awareness and limiting these exposures during an individual's productive working life will likely have various health benefits, including reducing eczema prevalence. © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
Geographic variation of the incidence rate of lower limb amputation in Australia from 2007-12
- Dillon, Michael, Fortington, Lauren, Akram, Muhammad, Erbas, Bircan, Kohler, Friedbert
- Authors: Dillon, Michael , Fortington, Lauren , Akram, Muhammad , Erbas, Bircan , Kohler, Friedbert
- Date: 2017
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 12, no. 1 (2017), p. 1-14
- Full Text:
- Reviewed:
- Description: In Australia, little is known about how the incidence rate (IR) of lower limb amputation (LLA) varies across the country. While studies in other economically developed countries have shown considerable geographic variation in the IR-LLA, mostly these have not considered whether the effect of common risk factors are the same across regions. Mapping variation of the IR-LLA, and the effect of common risk factors, is an important first step to focus research into areas of greatest need and support the development of regional specific hypotheses for in-depth examination. The aim of this study was to describe the geographic variation in the IR-LLA across Australia and understand whether the effect of common risk factors was the same across regions. Using hospital episode data from the Australian National Hospital Morbidity database and Australian Bureau of Statistics, the all-cause crude and age-standardised IR-LLA in males and females were calculated for the nation and each state and territory. Generalised Linear Models were developed to understand which factors influenced geographic variation in the crude IR-LLA. While the crude and age-standardised IR-LLA in males and females were similar in most states and territories, they were higher in the Northern Territory. The effect of older age, being male and the presence of type 2 diabetes was associated with an increase of IR-LLA in most states and territories. In the Northern Territory, the younger age at amputation confounded the effect of sex and type 2 diabetes. There are likely to be many factors not included in this investigation, such as Indigenous status, that may explain part of the variation in the IR-LLA not captured in our models. Further research is needed to identify regional- and population-specific factors that could be modified to reduce the IR-LLA in all states and territories of Australia. © 2017 Dillon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Authors: Dillon, Michael , Fortington, Lauren , Akram, Muhammad , Erbas, Bircan , Kohler, Friedbert
- Date: 2017
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 12, no. 1 (2017), p. 1-14
- Full Text:
- Reviewed:
- Description: In Australia, little is known about how the incidence rate (IR) of lower limb amputation (LLA) varies across the country. While studies in other economically developed countries have shown considerable geographic variation in the IR-LLA, mostly these have not considered whether the effect of common risk factors are the same across regions. Mapping variation of the IR-LLA, and the effect of common risk factors, is an important first step to focus research into areas of greatest need and support the development of regional specific hypotheses for in-depth examination. The aim of this study was to describe the geographic variation in the IR-LLA across Australia and understand whether the effect of common risk factors was the same across regions. Using hospital episode data from the Australian National Hospital Morbidity database and Australian Bureau of Statistics, the all-cause crude and age-standardised IR-LLA in males and females were calculated for the nation and each state and territory. Generalised Linear Models were developed to understand which factors influenced geographic variation in the crude IR-LLA. While the crude and age-standardised IR-LLA in males and females were similar in most states and territories, they were higher in the Northern Territory. The effect of older age, being male and the presence of type 2 diabetes was associated with an increase of IR-LLA in most states and territories. In the Northern Territory, the younger age at amputation confounded the effect of sex and type 2 diabetes. There are likely to be many factors not included in this investigation, such as Indigenous status, that may explain part of the variation in the IR-LLA not captured in our models. Further research is needed to identify regional- and population-specific factors that could be modified to reduce the IR-LLA in all states and territories of Australia. © 2017 Dillon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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