The effects of norepinephrine on the proliferation, lipid-uptake and mRNA expression of inflammatory markers in vascular smooth muscle cells
- Authors: Anesi, Jack
- Date: 2020
- Type: Text , Thesis , Master of Applied Science
- Full Text:
- Description: Background: Cardiovascular disease (CVD) is the leading, global cause of death. Elevated levels of norepinephrine (NE) are associated with CVDs such as coronary heart disease with atherosclerosis as the underlying mechanism. Oxidised low-density lipoprotein (OxLDL) has been shown to play an integral role in the formation of atherosclerosis within the vasculature. Previous studies suggest a decrease in NE by renal denervation is associated with enhanced atherosclerosis in mice and NE has anti-inflammatory effects. Therefore, we hypothesised that NE may protect against atherosclerosis. This study aimed to investigate the effects of NE on cellular proliferation, OxLDL uptake and mRNA expression of inflammatory markers in mouse aortic vascular smooth muscle cells (VSMCs), a key cell type involved in atherosclerosis. Methods: Mouse aortic VSMCs were cultured and treated with NE for three consecutive days. Cell proliferation was measured using the trypan blue exclusion and MTS proliferation assays. VSMCs were exposed to fluorescence-labelled OxLDL in the presence or absence of NE for 24 hours. Cellular uptake of fluorescence-labelled OxLDL was visualised by confocal microscopy and analysed for mean fluorescence intensity using ImageJ. To investigate the involvement of NE receptors, the
- Description: Masters
- Authors: Anesi, Jack
- Date: 2020
- Type: Text , Thesis , Master of Applied Science
- Full Text:
- Description: Background: Cardiovascular disease (CVD) is the leading, global cause of death. Elevated levels of norepinephrine (NE) are associated with CVDs such as coronary heart disease with atherosclerosis as the underlying mechanism. Oxidised low-density lipoprotein (OxLDL) has been shown to play an integral role in the formation of atherosclerosis within the vasculature. Previous studies suggest a decrease in NE by renal denervation is associated with enhanced atherosclerosis in mice and NE has anti-inflammatory effects. Therefore, we hypothesised that NE may protect against atherosclerosis. This study aimed to investigate the effects of NE on cellular proliferation, OxLDL uptake and mRNA expression of inflammatory markers in mouse aortic vascular smooth muscle cells (VSMCs), a key cell type involved in atherosclerosis. Methods: Mouse aortic VSMCs were cultured and treated with NE for three consecutive days. Cell proliferation was measured using the trypan blue exclusion and MTS proliferation assays. VSMCs were exposed to fluorescence-labelled OxLDL in the presence or absence of NE for 24 hours. Cellular uptake of fluorescence-labelled OxLDL was visualised by confocal microscopy and analysed for mean fluorescence intensity using ImageJ. To investigate the involvement of NE receptors, the
- Description: Masters
New methodologies, cultural analysis and the politics of research : Re-visiting the lessons of critical ethnography
- Authors: Angus, Lawrence
- Date: 2005
- Type: Text , Book chapter
- Relation: Methodological issues and practices in ethnography Chapter p. 183-205
- Full Text:
- Reviewed:
- Description: B1
- Description: 2003001272
- Authors: Angus, Lawrence
- Date: 2005
- Type: Text , Book chapter
- Relation: Methodological issues and practices in ethnography Chapter p. 183-205
- Full Text:
- Reviewed:
- Description: B1
- Description: 2003001272
Transcending educational inequalities across multiple divides : Schools and communities building equitable and literate futures
- Authors: Angus, Lawrence
- Date: 2006
- Type: Text , Journal article
- Relation: Learning communities Vol. 3, no. (2006), p. 40-64
- Full Text:
- Reviewed:
- Description: This paper explores the complex issues of student engagement and school retention from a critical/sociological perspective. Dominant discourses on youth alienation, estrangement and underachievement are generally couched in a language of blame and deficits with responsibility for the problems being sheeted home to (a) individual students, families, neighbourhoods and/or cultural groups (b) teachers and schools, and (c) public education systems. What is largely missing from these discourses is a lack of recognition of the structural inequalities which pervade society and sustain educational disadvantage. Drawing on Paulo Freire’s philosophy and pedagogy, I argue that an analysis of student engagement and disaffection must involve both a critique of the dehumanising forces that operate within and outside schools, and the development of a renewed project for a critical pedagogy that challenges the logic of instrumental reason and neoliberal approaches to education policy. With reference to recent ethnographic research, I discuss the tensions involved in implementing school-based responses in the current policy environment and highlight some of the innovative responses to concerns of educational disadvantage and student engagement in the secondary years of schooling.
- Description: C1
- Description: 2003002099
- Authors: Angus, Lawrence
- Date: 2006
- Type: Text , Journal article
- Relation: Learning communities Vol. 3, no. (2006), p. 40-64
- Full Text:
- Reviewed:
- Description: This paper explores the complex issues of student engagement and school retention from a critical/sociological perspective. Dominant discourses on youth alienation, estrangement and underachievement are generally couched in a language of blame and deficits with responsibility for the problems being sheeted home to (a) individual students, families, neighbourhoods and/or cultural groups (b) teachers and schools, and (c) public education systems. What is largely missing from these discourses is a lack of recognition of the structural inequalities which pervade society and sustain educational disadvantage. Drawing on Paulo Freire’s philosophy and pedagogy, I argue that an analysis of student engagement and disaffection must involve both a critique of the dehumanising forces that operate within and outside schools, and the development of a renewed project for a critical pedagogy that challenges the logic of instrumental reason and neoliberal approaches to education policy. With reference to recent ethnographic research, I discuss the tensions involved in implementing school-based responses in the current policy environment and highlight some of the innovative responses to concerns of educational disadvantage and student engagement in the secondary years of schooling.
- Description: C1
- Description: 2003002099
Globalization and educational change : Bringing about the reshaping and renorming of practice
- Authors: Angus, Lawrence
- Date: 2004
- Type: Text , Journal article
- Relation: Journal of Education Policy Vol. 19, no. 1 (Jan 2004), p. 23-41
- Full Text:
- Reviewed:
- Description: The tendency in education writing on globalization has been to examine the congruence of educational policies in western societies and the international effects of global governance of education by powerful transnational institutions such as the Organization for Economic Cooperation and Development and the European Union. The authors tend to identify massive changes in approaches to educational governance, including the establishment of a broadly common policy and management agenda that is characterized by 'new managerialism', devolution, and rigid accountability structures, entrepreneurialism, and school effectiveness, that have been imposed largely as a result of globalization. These measures are often seen as being directly related to the 'hollowing out' of the state, and the emergence of neo-liberalism as the informing ideology of both international capitalism and residual nation-states. There are few studies, however, of the dynamics of educational life and micro-political activities that enable or challenge or bring about the kinds of educational reshaping and renorming that are typically associated with globalization. This study attempts to analyse such micro-shaping, which, through reporting an ethnographic study in a site of educational practice, examines how school managers and teachers dealt with government policy intervention and, in the process, both willingly and unwillingly implemented significant educational change.
- Description: C1
- Description: 2003000752
- Authors: Angus, Lawrence
- Date: 2004
- Type: Text , Journal article
- Relation: Journal of Education Policy Vol. 19, no. 1 (Jan 2004), p. 23-41
- Full Text:
- Reviewed:
- Description: The tendency in education writing on globalization has been to examine the congruence of educational policies in western societies and the international effects of global governance of education by powerful transnational institutions such as the Organization for Economic Cooperation and Development and the European Union. The authors tend to identify massive changes in approaches to educational governance, including the establishment of a broadly common policy and management agenda that is characterized by 'new managerialism', devolution, and rigid accountability structures, entrepreneurialism, and school effectiveness, that have been imposed largely as a result of globalization. These measures are often seen as being directly related to the 'hollowing out' of the state, and the emergence of neo-liberalism as the informing ideology of both international capitalism and residual nation-states. There are few studies, however, of the dynamics of educational life and micro-political activities that enable or challenge or bring about the kinds of educational reshaping and renorming that are typically associated with globalization. This study attempts to analyse such micro-shaping, which, through reporting an ethnographic study in a site of educational practice, examines how school managers and teachers dealt with government policy intervention and, in the process, both willingly and unwillingly implemented significant educational change.
- Description: C1
- Description: 2003000752
Educational leadership and the imperative of including student, voices, student interests, and student's lives in the mainstream
- Authors: Angus, Lawrence
- Date: 2006
- Type: Text , Journal article
- Relation: International Journal of Leadership in Education Vol. 9, no. 4 (2006), p. 369-378
- Full Text:
- Reviewed:
- Description: Smyth introduces this special issue with the claim that the question of 'how to pursue forms of leadership that listen to and attend to the voices of...young people' is the 'most urgent issue of our times'. Of special concern to him in recent times has been the increasing number of such students who are poorly served by schools and are, in effect, pushed out of the institution of schooling by a system that is largely uncaring and remote from their needs and interests. This article looks at the hardening of educational policy, student participation in reform efforts, leaders and followers, the moral purpose of educational leadership, and what counts as 'genuine' participation.
- Description: C1
- Description: 2003002105
- Authors: Angus, Lawrence
- Date: 2006
- Type: Text , Journal article
- Relation: International Journal of Leadership in Education Vol. 9, no. 4 (2006), p. 369-378
- Full Text:
- Reviewed:
- Description: Smyth introduces this special issue with the claim that the question of 'how to pursue forms of leadership that listen to and attend to the voices of...young people' is the 'most urgent issue of our times'. Of special concern to him in recent times has been the increasing number of such students who are poorly served by schools and are, in effect, pushed out of the institution of schooling by a system that is largely uncaring and remote from their needs and interests. This article looks at the hardening of educational policy, student participation in reform efforts, leaders and followers, the moral purpose of educational leadership, and what counts as 'genuine' participation.
- Description: C1
- Description: 2003002105
ICT and educational (dis)advantage : Families, computers and contemporary social and educational inequalities
- Angus, Lawrence, Snyder, Ilana, Sutherland-Smith, Wendy
- Authors: Angus, Lawrence , Snyder, Ilana , Sutherland-Smith, Wendy
- Date: 2004
- Type: Text , Journal article
- Relation: British Journal of Sociology of Education Vol. 25, no. 1 (Feb 2004), p. 3-18
- Full Text:
- Reviewed:
- Description: Because access to new technologies is unequally distributed, there has been considerable debate about the growing gap between the so-called information-rich and information-poor. Such concerns have led to high-profile information technology policy initiatives in many countries. In Australia, in an attempt to 'redress the balance between the information rich and poor' by providing 'equal access to the World Wide Web' (Virtual Communities, 2002), the Australian Council of Trade Unions, Virtual Communities (a computer/software distributor) and Primus (an Internet provider) in late 1999 formed an alliance to offer relatively inexpensive computer and Internet access to union members in order to make 'technology affordable for all Australians' (Virtual Communities, 2002). In this paper, we examine four families, one of which had long-term Information and Communication Technologies (ICT) access, and three of which took advantage of the Virtual Communities offer to get home computer and Internet access for the first time. We examine their engagement with ICT and suggest that previously disadvantaged family members are not particularly advantaged by their access to ICT.
- Description: C1
- Description: 2003000750
- Authors: Angus, Lawrence , Snyder, Ilana , Sutherland-Smith, Wendy
- Date: 2004
- Type: Text , Journal article
- Relation: British Journal of Sociology of Education Vol. 25, no. 1 (Feb 2004), p. 3-18
- Full Text:
- Reviewed:
- Description: Because access to new technologies is unequally distributed, there has been considerable debate about the growing gap between the so-called information-rich and information-poor. Such concerns have led to high-profile information technology policy initiatives in many countries. In Australia, in an attempt to 'redress the balance between the information rich and poor' by providing 'equal access to the World Wide Web' (Virtual Communities, 2002), the Australian Council of Trade Unions, Virtual Communities (a computer/software distributor) and Primus (an Internet provider) in late 1999 formed an alliance to offer relatively inexpensive computer and Internet access to union members in order to make 'technology affordable for all Australians' (Virtual Communities, 2002). In this paper, we examine four families, one of which had long-term Information and Communication Technologies (ICT) access, and three of which took advantage of the Virtual Communities offer to get home computer and Internet access for the first time. We examine their engagement with ICT and suggest that previously disadvantaged family members are not particularly advantaged by their access to ICT.
- Description: C1
- Description: 2003000750
Teaching within and against the circle of privilege : reforming teachers, reforming schools
- Authors: Angus, Lawrence
- Date: 2012
- Type: Text , Journal article
- Relation: Journal of Education Policy Vol. 27, no. 2 (2012), p. 231-251
- Relation: http://purl.org/au-research/grants/arc/DP0665569
- Full Text:
- Reviewed:
- Description: Three decades of neo-liberal education in western countries, particularly English-speaking countries, have not served most children well. The evidence is mounting that the neo-liberal experiment has been a failure on many grounds, not least because of its deprofessionalizing effect on teachers. The disciplinary effects of neo-liberal policy frameworks on education remain powerful, but there are numerous teachers and schools who have resisted the regime of managerialism and accountability. This paper celebrates such activists. It argues that the internal focus on the delivery of instruction and test-taking inside schools ignores the point that the major influences on the school performance of children exist outside rather than inside the school. The paper argues that young people who have been 'othered' and put at a disadvantage by the neo-liberal education system deserve to be treated in a more dignified, engaged and respectful manner than seems to be the case within the ideology of accountability and top-down managerialism. © 2012 Copyright Taylor and Francis Group, LLC.
- Authors: Angus, Lawrence
- Date: 2012
- Type: Text , Journal article
- Relation: Journal of Education Policy Vol. 27, no. 2 (2012), p. 231-251
- Relation: http://purl.org/au-research/grants/arc/DP0665569
- Full Text:
- Reviewed:
- Description: Three decades of neo-liberal education in western countries, particularly English-speaking countries, have not served most children well. The evidence is mounting that the neo-liberal experiment has been a failure on many grounds, not least because of its deprofessionalizing effect on teachers. The disciplinary effects of neo-liberal policy frameworks on education remain powerful, but there are numerous teachers and schools who have resisted the regime of managerialism and accountability. This paper celebrates such activists. It argues that the internal focus on the delivery of instruction and test-taking inside schools ignores the point that the major influences on the school performance of children exist outside rather than inside the school. The paper argues that young people who have been 'othered' and put at a disadvantage by the neo-liberal education system deserve to be treated in a more dignified, engaged and respectful manner than seems to be the case within the ideology of accountability and top-down managerialism. © 2012 Copyright Taylor and Francis Group, LLC.
The digital divide : Differences in computer use between home and school in low socio-economic households
- Angus, Lawrence, Sutherland-Smith, Wendy, Snyder, Ilana
- Authors: Angus, Lawrence , Sutherland-Smith, Wendy , Snyder, Ilana
- Date: 2003
- Type: Text , Journal article
- Relation: Educational Studies in Language and Literature Vol. 3, no. (2003), p. 5-19
- Full Text:
- Reviewed:
- Description: This article examines information and communication technologies (ICTs) practices in the home and school settings of four disadvantaged families. It reports the findings of a year-long study that investigated the nexus between computer-mediated literacy practices at home and at school and whether this inter-connectivity could make a difference in school success. The findings indicate that there was disjunction between home and school use. The ``digital divide'' exists for the families of this study, not in terms of access but in the gap between ICT practices at home and school. Schools in this study did not integrate ICT skills learned and demonstrated in the home environment into ICT practices at school. The study concludes that constructing pedagogical connections between home and school ICT practices may begin to bridge the ``digital divide''.
- Description: C1
- Description: 2003000427
- Authors: Angus, Lawrence , Sutherland-Smith, Wendy , Snyder, Ilana
- Date: 2003
- Type: Text , Journal article
- Relation: Educational Studies in Language and Literature Vol. 3, no. (2003), p. 5-19
- Full Text:
- Reviewed:
- Description: This article examines information and communication technologies (ICTs) practices in the home and school settings of four disadvantaged families. It reports the findings of a year-long study that investigated the nexus between computer-mediated literacy practices at home and at school and whether this inter-connectivity could make a difference in school success. The findings indicate that there was disjunction between home and school use. The ``digital divide'' exists for the families of this study, not in terms of access but in the gap between ICT practices at home and school. Schools in this study did not integrate ICT skills learned and demonstrated in the home environment into ICT practices at school. The study concludes that constructing pedagogical connections between home and school ICT practices may begin to bridge the ``digital divide''.
- Description: C1
- Description: 2003000427
On Hölder calmness of solution mappings in parametric equilibrium problems
- Anh, Lam Quoc, Kruger, Alexander, Thao, Nguyen
- Authors: Anh, Lam Quoc , Kruger, Alexander , Thao, Nguyen
- Date: 2012
- Type: Text , Journal article
- Relation: TOP Vol. 22, no. 1 (2012), p. 331-342
- Full Text:
- Reviewed:
- Description: We consider parametric equilibrium problems in metric spaces. Sufficient conditions for the Hölder calmness of solutions are established. We also study the Hölder well-posedness for equilibrium problems in metric spaces.
- Authors: Anh, Lam Quoc , Kruger, Alexander , Thao, Nguyen
- Date: 2012
- Type: Text , Journal article
- Relation: TOP Vol. 22, no. 1 (2012), p. 331-342
- Full Text:
- Reviewed:
- Description: We consider parametric equilibrium problems in metric spaces. Sufficient conditions for the Hölder calmness of solutions are established. We also study the Hölder well-posedness for equilibrium problems in metric spaces.
Exploring monitoring, work environment and flexibility as predictors of job satisfaction within Australian call centres
- Annakis, John, Lobo, Antonio, Pillay, Soma
- Authors: Annakis, John , Lobo, Antonio , Pillay, Soma
- Date: 2011
- Type: Text , Journal article
- Relation: International Journal of Business and Management Vol. 6, no. 8 (2011), p. 75-93
- Full Text:
- Reviewed:
- Description: The purpose of this paper is to investigate predictors of workers’ job satisfaction from the labour process and equity theoretical perspectives. The study employed a qualitative approach and draws on data from in depth focus groups of customer service representatives (CSR). The sample for this study was drawn from three Australian call centres operating in a variety of business sectors. The study highlights that three dimensions: monitoring, flexibility and work environment are significantly correlated to CSR job satisfaction. Developing an understanding of these dimensions is critical to understanding CSR job satisfaction perceptions in an industry which exhibits high labour turnover and absenteeism. This study provides new insights on how to manage effectively job satisfaction within call centre environments through the incorporation of more multi-dimensional aspects that are considered to be strong determinants of CSR job satisfaction. The study contributes to the literature by investigating a more multi-dimensional approach to studying job satisfaction in call centre environments. The intensive case study approach highlights the implications for HRM.
- Authors: Annakis, John , Lobo, Antonio , Pillay, Soma
- Date: 2011
- Type: Text , Journal article
- Relation: International Journal of Business and Management Vol. 6, no. 8 (2011), p. 75-93
- Full Text:
- Reviewed:
- Description: The purpose of this paper is to investigate predictors of workers’ job satisfaction from the labour process and equity theoretical perspectives. The study employed a qualitative approach and draws on data from in depth focus groups of customer service representatives (CSR). The sample for this study was drawn from three Australian call centres operating in a variety of business sectors. The study highlights that three dimensions: monitoring, flexibility and work environment are significantly correlated to CSR job satisfaction. Developing an understanding of these dimensions is critical to understanding CSR job satisfaction perceptions in an industry which exhibits high labour turnover and absenteeism. This study provides new insights on how to manage effectively job satisfaction within call centre environments through the incorporation of more multi-dimensional aspects that are considered to be strong determinants of CSR job satisfaction. The study contributes to the literature by investigating a more multi-dimensional approach to studying job satisfaction in call centre environments. The intensive case study approach highlights the implications for HRM.
Defining timeliness in care for patients with lung cancer : protocol for a scoping review
- Ansar, Adnan, Lewis, Virginia, McDonald, Christine, Liu, Chaojie, Rahman, Muhammad Aziz
- Authors: Ansar, Adnan , Lewis, Virginia , McDonald, Christine , Liu, Chaojie , Rahman, Muhammad Aziz
- Date: 2020
- Type: Text , Journal article
- Relation: BMJ Open Vol. 10, no. 11 (2020), p. 1-7
- Full Text:
- Reviewed:
- Description: Introduction Cancer is the second leading cause of death worldwide, and lung cancer is the single leading cause of cancer mortality worldwide. Early diagnosis of lung cancer is the key to better prognosis and longer survival. While there are substantial literature reporting delays in cancer diagnosis, there is a lack of consensus in the definitions and terms used to describe a € delay' in the treatment pathway. The aim of this scoping review is to identify and critically synthesise the operational definitions and terminologies used to describe the timely initiation of care and consequent treatments over the care pathway for patients with lung cancer. This scoping review will also compare how timeliness was operationalised in Western and Asian countries. Methods and analysis The scoping review will use the methodology described by Arksey and O'Malley and endorsed by the Joanna Briggs Institute. MEDLINE, EMBASE, CINAHL and PsycINFO electronic databases will be searched. Grey literature sources and the reference lists of key studies will be used to identify additional relevant studies. The scoping review will include all studies, irrespective of study methodology and quality. Two reviewers will independently screen all titles and abstracts to identify eligible studies for inclusion. The full texts of identified studies will be further examined and charted using a data extraction form. A narrative synthesis will be performed to assess and categorise available definitions of timeliness. Ethics and dissemination Ethical approval is not needed as this scoping review will be reviewing already published articles. The results produced from this review will be submitted to a scientific peer-reviewed journal for publication and will be presented at scientific meetings. ©
- Authors: Ansar, Adnan , Lewis, Virginia , McDonald, Christine , Liu, Chaojie , Rahman, Muhammad Aziz
- Date: 2020
- Type: Text , Journal article
- Relation: BMJ Open Vol. 10, no. 11 (2020), p. 1-7
- Full Text:
- Reviewed:
- Description: Introduction Cancer is the second leading cause of death worldwide, and lung cancer is the single leading cause of cancer mortality worldwide. Early diagnosis of lung cancer is the key to better prognosis and longer survival. While there are substantial literature reporting delays in cancer diagnosis, there is a lack of consensus in the definitions and terms used to describe a € delay' in the treatment pathway. The aim of this scoping review is to identify and critically synthesise the operational definitions and terminologies used to describe the timely initiation of care and consequent treatments over the care pathway for patients with lung cancer. This scoping review will also compare how timeliness was operationalised in Western and Asian countries. Methods and analysis The scoping review will use the methodology described by Arksey and O'Malley and endorsed by the Joanna Briggs Institute. MEDLINE, EMBASE, CINAHL and PsycINFO electronic databases will be searched. Grey literature sources and the reference lists of key studies will be used to identify additional relevant studies. The scoping review will include all studies, irrespective of study methodology and quality. Two reviewers will independently screen all titles and abstracts to identify eligible studies for inclusion. The full texts of identified studies will be further examined and charted using a data extraction form. A narrative synthesis will be performed to assess and categorise available definitions of timeliness. Ethics and dissemination Ethical approval is not needed as this scoping review will be reviewing already published articles. The results produced from this review will be submitted to a scientific peer-reviewed journal for publication and will be presented at scientific meetings. ©
Duration of intervals in the care seeking pathway for lung cancer in Bangladesh : a journey from symptoms triggering consultation to receipt of treatment
- Ansar, Adnan, Lewis, Virginia, McDonald, Christine, Liu, , Chaojie, Rahman, Muhammad Aziz
- Authors: Ansar, Adnan , Lewis, Virginia , McDonald, Christine , Liu, , Chaojie , Rahman, Muhammad Aziz
- Date: 2021
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 16, no. 9 September (2021), p.
- Full Text:
- Reviewed:
- Description: Timeliness in seeking care is critical for lung cancer patients survival and better prognosis. The care seeking trajectory of patients with lung cancer in Bangladesh has not been explored, despite the differences in health systems and structures compared to high income countries. This study investigated the symptoms triggering healthcare seeking, preferred healthcare providers (including informal healthcare providers such as pharmacy retailers, village doctors, and "traditional healers"), and the duration of intervals in the lung cancer care pathway of patients in Bangladesh. A cross-sectional study was conducted in three tertiary care hospitals in Bangladesh among diagnosed lung cancer patients through face-Toface interview and medical record review. Time intervals from onset of symptom and care seeking events were calculated and compared between those who sought initial care from different providers using Wilcoxon rank sum tests. Among 418 study participants, the majority (90%) of whom were males, with a mean age of 57 ±9.86 years, cough and chest pain were the most common (23%) combination of symptoms triggering healthcare seeking. About two-Thirds of the total respondents (60%) went to informal healthcare providers as their first point of contact. Living in rural areas, lower levels of education and lower income were associated with seeking care from such providers. The median duration between onset of symptom to confirmation of diagnosis was 121 days, between confirmation of diagnosis and initiation of treatment was 22 days, and between onset of symptom and initiation of treatment was 151 days. Pre-diagnosis durations were longer for those who had sought initial care from an informal provider (p<0.05). Time to first contact with a health provider was shorter in this study compared to other developed and developing countries but utilizing informal healthcare providers caused delays in diagnosis and initiation of treatment. Encouraging people to seek care from a formal healthcare provider may reduce the overall duration of the care seeking pathway. © 2021 Public Library of Science. All rights reserved.
- Authors: Ansar, Adnan , Lewis, Virginia , McDonald, Christine , Liu, , Chaojie , Rahman, Muhammad Aziz
- Date: 2021
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 16, no. 9 September (2021), p.
- Full Text:
- Reviewed:
- Description: Timeliness in seeking care is critical for lung cancer patients survival and better prognosis. The care seeking trajectory of patients with lung cancer in Bangladesh has not been explored, despite the differences in health systems and structures compared to high income countries. This study investigated the symptoms triggering healthcare seeking, preferred healthcare providers (including informal healthcare providers such as pharmacy retailers, village doctors, and "traditional healers"), and the duration of intervals in the lung cancer care pathway of patients in Bangladesh. A cross-sectional study was conducted in three tertiary care hospitals in Bangladesh among diagnosed lung cancer patients through face-Toface interview and medical record review. Time intervals from onset of symptom and care seeking events were calculated and compared between those who sought initial care from different providers using Wilcoxon rank sum tests. Among 418 study participants, the majority (90%) of whom were males, with a mean age of 57 ±9.86 years, cough and chest pain were the most common (23%) combination of symptoms triggering healthcare seeking. About two-Thirds of the total respondents (60%) went to informal healthcare providers as their first point of contact. Living in rural areas, lower levels of education and lower income were associated with seeking care from such providers. The median duration between onset of symptom to confirmation of diagnosis was 121 days, between confirmation of diagnosis and initiation of treatment was 22 days, and between onset of symptom and initiation of treatment was 151 days. Pre-diagnosis durations were longer for those who had sought initial care from an informal provider (p<0.05). Time to first contact with a health provider was shorter in this study compared to other developed and developing countries but utilizing informal healthcare providers caused delays in diagnosis and initiation of treatment. Encouraging people to seek care from a formal healthcare provider may reduce the overall duration of the care seeking pathway. © 2021 Public Library of Science. All rights reserved.
Defining timeliness in care for patients with lung cancer : a scoping review
- Ansar, Adnan, Lewis, Virginia, McDonald, Christine, Liu, Chaojie, Rahman, Muhammad Aziz
- Authors: Ansar, Adnan , Lewis, Virginia , McDonald, Christine , Liu, Chaojie , Rahman, Muhammad Aziz
- Date: 2022
- Type: Text , Journal article , Review
- Relation: BMJ Open Vol. 12, no. 4 (2022), p.
- Full Text:
- Reviewed:
- Description: Objectives Early diagnosis and reducing the time taken to achieve each step of lung cancer care is essential. This scoping review aimed to examine time points and intervals used to measure timeliness and to critically assess how they are defined by existing studies of the care seeking pathway for lung cancer. Methods This scoping review was guided by the methodological framework for scoping reviews by Arksey and O'Malley. MEDLINE, EMBASE, CINAHL and PsycINFO electronic databases were searched for articles published between 1999 and 2019. After duplicate removal, all publications went through title and abstract screening followed by full text review and inclusion of articles in the review against the selection criteria. A narrative synthesis describes the time points, intervals and measurement guidelines used by the included articles. Results A total of 2113 articles were identified from the initial search. Finally, 68 articles were included for data charting process. Eight time points and 14 intervals were identified as the most common events researched by the articles. Eighteen different lung cancer care guidelines were used to benchmark intervals in the included articles; all were developed in Western countries. The British Thoracic Society guideline was the most frequently used guideline (20%). Western guidelines were used by the studies in Asian countries despite differences in the health system structure. Conclusion This review identified substantial variations in definitions of some of the intervals used to describe timeliness of care for lung cancer. The differences in healthcare delivery systems of Asian and Western countries, and between high-income countries and low-income-middle-income countries may suggest different sets of time points and intervals need to be developed. ©
- Authors: Ansar, Adnan , Lewis, Virginia , McDonald, Christine , Liu, Chaojie , Rahman, Muhammad Aziz
- Date: 2022
- Type: Text , Journal article , Review
- Relation: BMJ Open Vol. 12, no. 4 (2022), p.
- Full Text:
- Reviewed:
- Description: Objectives Early diagnosis and reducing the time taken to achieve each step of lung cancer care is essential. This scoping review aimed to examine time points and intervals used to measure timeliness and to critically assess how they are defined by existing studies of the care seeking pathway for lung cancer. Methods This scoping review was guided by the methodological framework for scoping reviews by Arksey and O'Malley. MEDLINE, EMBASE, CINAHL and PsycINFO electronic databases were searched for articles published between 1999 and 2019. After duplicate removal, all publications went through title and abstract screening followed by full text review and inclusion of articles in the review against the selection criteria. A narrative synthesis describes the time points, intervals and measurement guidelines used by the included articles. Results A total of 2113 articles were identified from the initial search. Finally, 68 articles were included for data charting process. Eight time points and 14 intervals were identified as the most common events researched by the articles. Eighteen different lung cancer care guidelines were used to benchmark intervals in the included articles; all were developed in Western countries. The British Thoracic Society guideline was the most frequently used guideline (20%). Western guidelines were used by the studies in Asian countries despite differences in the health system structure. Conclusion This review identified substantial variations in definitions of some of the intervals used to describe timeliness of care for lung cancer. The differences in healthcare delivery systems of Asian and Western countries, and between high-income countries and low-income-middle-income countries may suggest different sets of time points and intervals need to be developed. ©
Automated segmentation of mouse OCT volumes (ASiMOV): Validation & clinical study of a light damage model
- Antony, Bhavna, Kim, Byung-Jin, Lang, Andrew, Carass, Aaron, Prince, Jerry, Zack, Donald
- Authors: Antony, Bhavna , Kim, Byung-Jin , Lang, Andrew , Carass, Aaron , Prince, Jerry , Zack, Donald
- Date: 2017
- Type: Text , Journal article
- Relation: PLoS One Vol. 12, no. 8 (2017), p. e0181059-e0181059
- Full Text:
- Reviewed:
- Description: The use of spectral-domain optical coherence tomography (SD-OCT) is becoming commonplace for the in vivo longitudinal study of murine models of ophthalmic disease. Longitudinal studies, however, generate large quantities of data, the manual analysis of which is very challenging due to the time-consuming nature of generating delineations. Thus, it is of importance that automated algorithms be developed to facilitate accurate and timely analysis of these large datasets. Furthermore, as the models target a variety of diseases, the associated structural changes can also be extremely disparate. For instance, in the light damage (LD) model, which is frequently used to study photoreceptor degeneration, the outer retina appears dramatically different from the normal retina. To address these concerns, we have developed a flexible graph-based algorithm for the automated segmentation of mouse OCT volumes (ASiMOV). This approach incorporates a machine-learning component that can be easily trained for different disease models. To validate ASiMOV, the automated results were compared to manual delineations obtained from three raters on healthy and BALB/cJ mice post LD. It was also used to study a longitudinal LD model, where five control and five LD mice were imaged at four timepoints post LD. The total retinal thickness and the outer retina (comprising the outer nuclear layer, and inner and outer segments of the photoreceptors) were unchanged the day after the LD, but subsequently thinned significantly (p < 0.01). The retinal nerve fiber-ganglion cell complex and the inner plexiform layers, however, remained unchanged for the duration of the study.
- Authors: Antony, Bhavna , Kim, Byung-Jin , Lang, Andrew , Carass, Aaron , Prince, Jerry , Zack, Donald
- Date: 2017
- Type: Text , Journal article
- Relation: PLoS One Vol. 12, no. 8 (2017), p. e0181059-e0181059
- Full Text:
- Reviewed:
- Description: The use of spectral-domain optical coherence tomography (SD-OCT) is becoming commonplace for the in vivo longitudinal study of murine models of ophthalmic disease. Longitudinal studies, however, generate large quantities of data, the manual analysis of which is very challenging due to the time-consuming nature of generating delineations. Thus, it is of importance that automated algorithms be developed to facilitate accurate and timely analysis of these large datasets. Furthermore, as the models target a variety of diseases, the associated structural changes can also be extremely disparate. For instance, in the light damage (LD) model, which is frequently used to study photoreceptor degeneration, the outer retina appears dramatically different from the normal retina. To address these concerns, we have developed a flexible graph-based algorithm for the automated segmentation of mouse OCT volumes (ASiMOV). This approach incorporates a machine-learning component that can be easily trained for different disease models. To validate ASiMOV, the automated results were compared to manual delineations obtained from three raters on healthy and BALB/cJ mice post LD. It was also used to study a longitudinal LD model, where five control and five LD mice were imaged at four timepoints post LD. The total retinal thickness and the outer retina (comprising the outer nuclear layer, and inner and outer segments of the photoreceptors) were unchanged the day after the LD, but subsequently thinned significantly (p < 0.01). The retinal nerve fiber-ganglion cell complex and the inner plexiform layers, however, remained unchanged for the duration of the study.
A systematic review of Lean in healthcare : a global prospective
- Antony, Jiju, Sunder, Vijaya, Sreedharan, Raja, Chakraborty, Ayon, Gunasekaran, Angappa
- Authors: Antony, Jiju , Sunder, Vijaya , Sreedharan, Raja , Chakraborty, Ayon , Gunasekaran, Angappa
- Date: 2019
- Type: Text , Journal article , Review
- Relation: International Journal of Quality and Reliability Management Vol. 36, no. 8 (2019), p. 1370-1391
- Full Text:
- Reviewed:
- Description: Purpose: Fostered by a rapid spread beyond the manufacturing sector, Lean philosophy for continuous improvement has been widely used in service organizations, primarily in the healthcare sector. However, there is a limited research on the motivating factors, challenges and benefits of implementing Lean in healthcare. Taking this as a valuable opportunity, the purpose of this paper is to present the key motivating factors, limitations or challenges of Lean deployment, benefits of Lean in healthcare and key gaps in the literature as an agenda for future research. Design/methodology/approach: The authors used the secondary data from the literature (peer-reviewed journal articles) published between 2000 and 2016 to understand the state of the art. The systematic review identified 101 articles across 88 journals recognized by the Association of Business Schools ranking guide 2015. Findings: The systematic review helped the authors to identify the evolution, current trends, research gaps and an agenda for future research for Lean in healthcare. A bouquet of motivating factors, challenges/limitations and benefits of Lean in healthcare are presented. Practical implications: The implications of this work include directions for managers and healthcare professionals in healthcare organizations to embark on a focused Lean journey aligned with the strategic objectives. This work could serve as a valuable resource to both practitioners and researchers for learning, investigating and rightly adapting the Lean in the healthcare sector. Originality/value: This study is perhaps one of the comprehensive systematic literature reviews covering an important agenda of Lean in Healthcare. All the text, figures and tables featured here are original work carried by five authors in collaboration (from three countries, namely, India, the USA and the UK). © 2019, Emerald Publishing Limited.
- Authors: Antony, Jiju , Sunder, Vijaya , Sreedharan, Raja , Chakraborty, Ayon , Gunasekaran, Angappa
- Date: 2019
- Type: Text , Journal article , Review
- Relation: International Journal of Quality and Reliability Management Vol. 36, no. 8 (2019), p. 1370-1391
- Full Text:
- Reviewed:
- Description: Purpose: Fostered by a rapid spread beyond the manufacturing sector, Lean philosophy for continuous improvement has been widely used in service organizations, primarily in the healthcare sector. However, there is a limited research on the motivating factors, challenges and benefits of implementing Lean in healthcare. Taking this as a valuable opportunity, the purpose of this paper is to present the key motivating factors, limitations or challenges of Lean deployment, benefits of Lean in healthcare and key gaps in the literature as an agenda for future research. Design/methodology/approach: The authors used the secondary data from the literature (peer-reviewed journal articles) published between 2000 and 2016 to understand the state of the art. The systematic review identified 101 articles across 88 journals recognized by the Association of Business Schools ranking guide 2015. Findings: The systematic review helped the authors to identify the evolution, current trends, research gaps and an agenda for future research for Lean in healthcare. A bouquet of motivating factors, challenges/limitations and benefits of Lean in healthcare are presented. Practical implications: The implications of this work include directions for managers and healthcare professionals in healthcare organizations to embark on a focused Lean journey aligned with the strategic objectives. This work could serve as a valuable resource to both practitioners and researchers for learning, investigating and rightly adapting the Lean in the healthcare sector. Originality/value: This study is perhaps one of the comprehensive systematic literature reviews covering an important agenda of Lean in Healthcare. All the text, figures and tables featured here are original work carried by five authors in collaboration (from three countries, namely, India, the USA and the UK). © 2019, Emerald Publishing Limited.
Introduced birds in urban remnant vegetation: Does remnant size really matter?
- Antos, Mark, Fitzsimons, John, Palmer, Grant, White, James
- Authors: Antos, Mark , Fitzsimons, John , Palmer, Grant , White, James
- Date: 2006
- Type: Text , Journal article
- Relation: Austral Ecology Vol. 31, no. 2 (2006), p. 254-261
- Full Text:
- Reviewed:
- Description: Introduced birds are a pervasive and dominant element of urban ecosystems. We examined the richness and relative abundance of introduced bird species in small (1-5 ha) medium (6-15 ha) and large (>15 ha) remnants of native vegetation within an urban matrix. Transects were surveyed during breeding and non-breeding seasons. There was a significant relationship between introduced species richness and remnant size with larger remnants supporting more introduced species. There was no significant difference in relative abundance of introduced species in remnants of different sizes. Introduced species, as a proportion of the relative abundance of the total avifauna (native and introduced species), did not vary significantly between remnants of differing sizes. There were significant differences in the composition of introduced bird species between the different remnant sizes, with large remnants supporting significantly different assemblages than medium and small remnants. Other variables also have substantial effects on the abundance of introduced bird species. The lack of significant differences in abundance between remnant sizes suggests they were all equally susceptible to invasion. No patches in the urban matrix are likely to be unaffected by introduced species. The effective long-term control of introduced bird species is difficult and resources may be better spent managing habitat in a way which renders it less suitable for introduced species (e.g. reducing areas of disturbed ground and weed dominated areas).
- Description: C1
- Description: 2003001638
- Authors: Antos, Mark , Fitzsimons, John , Palmer, Grant , White, James
- Date: 2006
- Type: Text , Journal article
- Relation: Austral Ecology Vol. 31, no. 2 (2006), p. 254-261
- Full Text:
- Reviewed:
- Description: Introduced birds are a pervasive and dominant element of urban ecosystems. We examined the richness and relative abundance of introduced bird species in small (1-5 ha) medium (6-15 ha) and large (>15 ha) remnants of native vegetation within an urban matrix. Transects were surveyed during breeding and non-breeding seasons. There was a significant relationship between introduced species richness and remnant size with larger remnants supporting more introduced species. There was no significant difference in relative abundance of introduced species in remnants of different sizes. Introduced species, as a proportion of the relative abundance of the total avifauna (native and introduced species), did not vary significantly between remnants of differing sizes. There were significant differences in the composition of introduced bird species between the different remnant sizes, with large remnants supporting significantly different assemblages than medium and small remnants. Other variables also have substantial effects on the abundance of introduced bird species. The lack of significant differences in abundance between remnant sizes suggests they were all equally susceptible to invasion. No patches in the urban matrix are likely to be unaffected by introduced species. The effective long-term control of introduced bird species is difficult and resources may be better spent managing habitat in a way which renders it less suitable for introduced species (e.g. reducing areas of disturbed ground and weed dominated areas).
- Description: C1
- Description: 2003001638
Investigating lebanese primary school teachers’ perceptions of gifted and highly able students
- Antoun, Maya, Kronborg, Leonie, Plunkett, Margaret
- Authors: Antoun, Maya , Kronborg, Leonie , Plunkett, Margaret
- Date: 2020
- Type: Text , Journal article
- Relation: Gifted and Talented International Vol. 35, no.1 (2020), p. 39-57
- Full Text:
- Reviewed:
- Description: This article outlines findings of a study that investigated perceptions of Lebanese primary school teachers in relation to gifted/highly able students. While there are no specific policy or formal school practices for gifted students in Lebanon, education is nonetheless highly regarded. The aim of the study was to determine whether there were cultural differences in the way giftedness in students was perceived and supported by teachers at the primary school level in comparison to Western conceptualizations and provisions. A study utilizing qualitative and quantitative methods underpinned the gathering of data from 281 teachers across three governorates of Lebanon. Of the 281 teachers who completed the survey, 12 also participated in the qualitative component, which involved individual semistructured interviews. Findings suggested a generally positive attitude by teachers but also an acknowledgment of limited awareness of evidence based on Western understandings and practices associated with gifted education. The resultant data provided insights regarding the implementation of effective teacher education and concomitant support to improve identification. © 2020, © 2020 World Council for Gifted and Talented Children.
- Authors: Antoun, Maya , Kronborg, Leonie , Plunkett, Margaret
- Date: 2020
- Type: Text , Journal article
- Relation: Gifted and Talented International Vol. 35, no.1 (2020), p. 39-57
- Full Text:
- Reviewed:
- Description: This article outlines findings of a study that investigated perceptions of Lebanese primary school teachers in relation to gifted/highly able students. While there are no specific policy or formal school practices for gifted students in Lebanon, education is nonetheless highly regarded. The aim of the study was to determine whether there were cultural differences in the way giftedness in students was perceived and supported by teachers at the primary school level in comparison to Western conceptualizations and provisions. A study utilizing qualitative and quantitative methods underpinned the gathering of data from 281 teachers across three governorates of Lebanon. Of the 281 teachers who completed the survey, 12 also participated in the qualitative component, which involved individual semistructured interviews. Findings suggested a generally positive attitude by teachers but also an acknowledgment of limited awareness of evidence based on Western understandings and practices associated with gifted education. The resultant data provided insights regarding the implementation of effective teacher education and concomitant support to improve identification. © 2020, © 2020 World Council for Gifted and Talented Children.
Secure big data ecosystem architecture : challenges and solutions
- Anwar, Memoona, Gill, Asif, Hussain, Farookh, Imran, Muhammad
- Authors: Anwar, Memoona , Gill, Asif , Hussain, Farookh , Imran, Muhammad
- Date: 2021
- Type: Text , Journal article , Review
- Relation: Eurasip Journal on Wireless Communications and Networking Vol. 2021, no. 1 (2021), p.
- Full Text:
- Reviewed:
- Description: Big data ecosystems are complex data-intensive, digital–physical systems. Data-intensive ecosystems offer a number of benefits; however, they present challenges as well. One major challenge is related to the privacy and security. A number of privacy and security models, techniques and algorithms have been proposed over a period of time. The limitation is that these solutions are primarily focused on an individual or on an isolated organizational context. There is a need to study and provide complete end-to-end solutions that ensure security and privacy throughout the data lifecycle across the ecosystem beyond the boundary of an individual system or organizational context. The results of current study provide a review of the existing privacy and security challenges and solutions using the systematic literature review (SLR) approach. Based on the SLR approach, 79 applicable articles were selected and analyzed. The information from these articles was extracted to compile a catalogue of security and privacy challenges in big data ecosystems and to highlight their interdependencies. The results were categorized from theoretical viewpoint using adaptive enterprise architecture and practical viewpoint using DAMA framework as guiding lens. The findings of this research will help to identify the research gaps and draw novel research directions in the context of privacy and security in big data-intensive ecosystems. © 2021, The Author(s).
- Authors: Anwar, Memoona , Gill, Asif , Hussain, Farookh , Imran, Muhammad
- Date: 2021
- Type: Text , Journal article , Review
- Relation: Eurasip Journal on Wireless Communications and Networking Vol. 2021, no. 1 (2021), p.
- Full Text:
- Reviewed:
- Description: Big data ecosystems are complex data-intensive, digital–physical systems. Data-intensive ecosystems offer a number of benefits; however, they present challenges as well. One major challenge is related to the privacy and security. A number of privacy and security models, techniques and algorithms have been proposed over a period of time. The limitation is that these solutions are primarily focused on an individual or on an isolated organizational context. There is a need to study and provide complete end-to-end solutions that ensure security and privacy throughout the data lifecycle across the ecosystem beyond the boundary of an individual system or organizational context. The results of current study provide a review of the existing privacy and security challenges and solutions using the systematic literature review (SLR) approach. Based on the SLR approach, 79 applicable articles were selected and analyzed. The information from these articles was extracted to compile a catalogue of security and privacy challenges in big data ecosystems and to highlight their interdependencies. The results were categorized from theoretical viewpoint using adaptive enterprise architecture and practical viewpoint using DAMA framework as guiding lens. The findings of this research will help to identify the research gaps and draw novel research directions in the context of privacy and security in big data-intensive ecosystems. © 2021, The Author(s).
Regulation of the rabbit's once-daily pattern of nursing : A circadian or hourglass-dependent process?
- Apel, Sabine, Hudson, Robyn, Coleman, Grahame, Rodel, Heiko, Kennedy, Gerard
- Authors: Apel, Sabine , Hudson, Robyn , Coleman, Grahame , Rodel, Heiko , Kennedy, Gerard
- Date: 2020
- Type: Text , Journal article
- Relation: Chronobiology International Vol. 37, no. 8 (2020), p. 1151-1162
- Full Text:
- Reviewed:
- Description: The European rabbitOryctolagus cuniculushas an unusual pattern of nursing behavior. After giving birth in a nursery burrow (or laboratory nest box), the mother immediately leaves the young and only returns to nurse for a few minutes once approximately every 24 h. It has been assumed this schedule, like a variety of other functions in the rabbit, is under circadian control. This assumption has been largely based on findings from mothers only permitted restricted access to their young once every 24 h. However, in nature and in the laboratory, mothers with free access to young show nursing visits with a periodicity shorter than 24 h, that does not correspond to other behavioral and physiological rhythms entrained to the prevailing 24 h light/dark (LD) cycle. To investigate how this unusual, apparently non-circadian pattern might be regulated, we conducted two experiments using female Dutch-belted rabbits housed individually in cages designed to automatically register feeding activity and nest box visits. In Experiment 1 we recorded the behavior of 17 mothers with free access to their young under five different LD cycles with long photo and short scotoperiods, spanning the limits of entrainment of the rabbit's circadian system. Whereas feeding rhythms were entrained by LD cycles within the rabbit's circadian range of entrainment, nursing visits showed a consistently shorter periodicity regardless of the LD regimen, largely independent of the circadian system. In Experiment 2 we tested further 12 mothers under more conventional LD 16:8 cycles but "trained" by having access to the nest box restricted to 1 h at the same time each day for the first 7 d of nursing. Mothers were then allowed free access either when their young were left in the box (n= 6), or when the litter had been permanently removed (n= 6). Mothers with pups still present returned to nurse them on the following days according to a similarly advancing pattern to the mothers of Experiment 1 despite the previous 7 d of "training" to an experimentally enforced 24 h nursing schedule as commonly used in previous studies of rabbit maternal behavior. Mothers whose pups had been removed entered the box repeatedly several times on the first day of unrestricted access, but on subsequent days did so only rarely, and at times of day apparently unrelated to the previously scheduled access. We conclude that the pattern of the rabbit's once-daily nursing visits has a periodicity largely independent of the circadian system, and that this is reset at each nursing. When nursing fails to occur nest box visits cease abruptly, with mothers making few or no subsequent visits. Together, these findings suggest that the rabbit's once-daily pattern of nursing is regulated by an hourglass-type process with a period less than 24 h that is reset at each nursing, rather than by a circadian oscillator. Such a mechanism might be particularly adaptive for rhythms of short duration that should end abruptly with a sudden change in context such as death or weaning of the young.
- Description: This work was supported by the Australian Federal Government via a Postgraduate PhD Scholarship for Sabibe Apel [APA SA 1].
- Authors: Apel, Sabine , Hudson, Robyn , Coleman, Grahame , Rodel, Heiko , Kennedy, Gerard
- Date: 2020
- Type: Text , Journal article
- Relation: Chronobiology International Vol. 37, no. 8 (2020), p. 1151-1162
- Full Text:
- Reviewed:
- Description: The European rabbitOryctolagus cuniculushas an unusual pattern of nursing behavior. After giving birth in a nursery burrow (or laboratory nest box), the mother immediately leaves the young and only returns to nurse for a few minutes once approximately every 24 h. It has been assumed this schedule, like a variety of other functions in the rabbit, is under circadian control. This assumption has been largely based on findings from mothers only permitted restricted access to their young once every 24 h. However, in nature and in the laboratory, mothers with free access to young show nursing visits with a periodicity shorter than 24 h, that does not correspond to other behavioral and physiological rhythms entrained to the prevailing 24 h light/dark (LD) cycle. To investigate how this unusual, apparently non-circadian pattern might be regulated, we conducted two experiments using female Dutch-belted rabbits housed individually in cages designed to automatically register feeding activity and nest box visits. In Experiment 1 we recorded the behavior of 17 mothers with free access to their young under five different LD cycles with long photo and short scotoperiods, spanning the limits of entrainment of the rabbit's circadian system. Whereas feeding rhythms were entrained by LD cycles within the rabbit's circadian range of entrainment, nursing visits showed a consistently shorter periodicity regardless of the LD regimen, largely independent of the circadian system. In Experiment 2 we tested further 12 mothers under more conventional LD 16:8 cycles but "trained" by having access to the nest box restricted to 1 h at the same time each day for the first 7 d of nursing. Mothers were then allowed free access either when their young were left in the box (n= 6), or when the litter had been permanently removed (n= 6). Mothers with pups still present returned to nurse them on the following days according to a similarly advancing pattern to the mothers of Experiment 1 despite the previous 7 d of "training" to an experimentally enforced 24 h nursing schedule as commonly used in previous studies of rabbit maternal behavior. Mothers whose pups had been removed entered the box repeatedly several times on the first day of unrestricted access, but on subsequent days did so only rarely, and at times of day apparently unrelated to the previously scheduled access. We conclude that the pattern of the rabbit's once-daily nursing visits has a periodicity largely independent of the circadian system, and that this is reset at each nursing. When nursing fails to occur nest box visits cease abruptly, with mothers making few or no subsequent visits. Together, these findings suggest that the rabbit's once-daily pattern of nursing is regulated by an hourglass-type process with a period less than 24 h that is reset at each nursing, rather than by a circadian oscillator. Such a mechanism might be particularly adaptive for rhythms of short duration that should end abruptly with a sudden change in context such as death or weaning of the young.
- Description: This work was supported by the Australian Federal Government via a Postgraduate PhD Scholarship for Sabibe Apel [APA SA 1].
To remain, migrate abroad or resettle : a complex dynamic process affecting Pakistani physicians' career decisions
- Arif, Muhammad, Cruickshank, Mary, Fraser, John
- Authors: Arif, Muhammad , Cruickshank, Mary , Fraser, John
- Date: 2019
- Type: Text , Journal article
- Relation: Asia Pacific Journal of Health Management Vol. 14, no. 3 (2019), p.
- Full Text:
- Reviewed:
- Description: OBJECTIVE This study investigated Pakistani physicians' decision-making concerning their decisions to stay in Pakistan, migrate abroad, or resettle back into their country after working abroad. METHODS This qualitative study employed a phenomenological research design. Thirteen Pakistani physicians characterised as 'stayers', 'leavers' and 'resettlers' were interviewed via telephone to explore their lived experience in 2008-2009. RESULTS Results show a dynamic nature of the physicians' career decision-making depending on their constant weighing of complex personal, family, professional and societal factors. Stayers, leavers and resettlers are not mutually exclusive groups but rather individual physicians' can move between these groups at different stages of career and life. Physicians vary in their decision making. Stayers and resettlers place more emphasis on personal and family reasons and societal factors providing there is a permanent job for them. Leavers focus on health system problems and recent societal problems of personal and societal insecurity. CONCLUSIONS The findings of this study indicates that physician migration, retention and resettlement is a complex issue and there are multiple personal, social, political and economic factors that affect their decisions to stay, move abroad or resettle back into their countries. Therefore, it is recommended that future research focusing on health workers retention, migration and resettlement issues look at it from a holistic perspective rather than focusing only on the economic and professional imperatives. The findings of this study have international implications for health care managers dealing with a highly mobile international medical workforce. Strategies considering different stages of the physician career/ life cycle need to highlight the importance of identity, belonging and place as doctors weigh this with career goals. © 2019 Asia Pacific Journal of Health Management. All Rights Reserved.
- Authors: Arif, Muhammad , Cruickshank, Mary , Fraser, John
- Date: 2019
- Type: Text , Journal article
- Relation: Asia Pacific Journal of Health Management Vol. 14, no. 3 (2019), p.
- Full Text:
- Reviewed:
- Description: OBJECTIVE This study investigated Pakistani physicians' decision-making concerning their decisions to stay in Pakistan, migrate abroad, or resettle back into their country after working abroad. METHODS This qualitative study employed a phenomenological research design. Thirteen Pakistani physicians characterised as 'stayers', 'leavers' and 'resettlers' were interviewed via telephone to explore their lived experience in 2008-2009. RESULTS Results show a dynamic nature of the physicians' career decision-making depending on their constant weighing of complex personal, family, professional and societal factors. Stayers, leavers and resettlers are not mutually exclusive groups but rather individual physicians' can move between these groups at different stages of career and life. Physicians vary in their decision making. Stayers and resettlers place more emphasis on personal and family reasons and societal factors providing there is a permanent job for them. Leavers focus on health system problems and recent societal problems of personal and societal insecurity. CONCLUSIONS The findings of this study indicates that physician migration, retention and resettlement is a complex issue and there are multiple personal, social, political and economic factors that affect their decisions to stay, move abroad or resettle back into their countries. Therefore, it is recommended that future research focusing on health workers retention, migration and resettlement issues look at it from a holistic perspective rather than focusing only on the economic and professional imperatives. The findings of this study have international implications for health care managers dealing with a highly mobile international medical workforce. Strategies considering different stages of the physician career/ life cycle need to highlight the importance of identity, belonging and place as doctors weigh this with career goals. © 2019 Asia Pacific Journal of Health Management. All Rights Reserved.