Can optimum solar radiation exposure or supplemented vitamin D intake reduce the severity of COVID-19 symptoms?
- Abraham, Joji, Dowling, Kim, Florentine, Singarayer
- Authors: Abraham, Joji , Dowling, Kim , Florentine, Singarayer
- Date: 2021
- Type: Text , Journal article , Review
- Relation: International Journal of Environmental Research and Public Health Vol. 18, no. 2 (2021), p. 1-21
- Full Text:
- Reviewed:
- Description: The foremost mortality-causing symptom associated with COVID-19 is acute respiratory distress syndrome (ARDS). A significant correlation has been identified between the deficiency in vitamin D and the risk of developing ARDS. It has been suggested that if we can reduce or modify ARDS in COVID-19 patients, we may significantly reduce the severity of COVID-19 symptoms and associated mortality rates. The increased mortality of dark-skinned people, who have a reduced UV absorption capacity, may be consistent with diminished vitamin D status. The factors associated with COVID-19 mortality, such as old age, ethnicity, obesity, hypertension, cardiovascular diseases, and diabetes, are all found to be linked with vitamin D deficiency. Based on this review and as a precautionary measure, it is suggested that the adoption of appropriate and safe solar exposure and vitamin D enriched foods and supplements should be considered to reduce the possible severity of COVID-19 symptoms. Safe sun exposure is deemed beneficial globally, specifically in low and middle- income countries, as there is no cost involved. It is also noted that improved solar exposure and vitamin D levels can reduce the impact of other diseases as well, thus assisting in maintaining general human well-being. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- Authors: Abraham, Joji , Dowling, Kim , Florentine, Singarayer
- Date: 2021
- Type: Text , Journal article , Review
- Relation: International Journal of Environmental Research and Public Health Vol. 18, no. 2 (2021), p. 1-21
- Full Text:
- Reviewed:
- Description: The foremost mortality-causing symptom associated with COVID-19 is acute respiratory distress syndrome (ARDS). A significant correlation has been identified between the deficiency in vitamin D and the risk of developing ARDS. It has been suggested that if we can reduce or modify ARDS in COVID-19 patients, we may significantly reduce the severity of COVID-19 symptoms and associated mortality rates. The increased mortality of dark-skinned people, who have a reduced UV absorption capacity, may be consistent with diminished vitamin D status. The factors associated with COVID-19 mortality, such as old age, ethnicity, obesity, hypertension, cardiovascular diseases, and diabetes, are all found to be linked with vitamin D deficiency. Based on this review and as a precautionary measure, it is suggested that the adoption of appropriate and safe solar exposure and vitamin D enriched foods and supplements should be considered to reduce the possible severity of COVID-19 symptoms. Safe sun exposure is deemed beneficial globally, specifically in low and middle- income countries, as there is no cost involved. It is also noted that improved solar exposure and vitamin D levels can reduce the impact of other diseases as well, thus assisting in maintaining general human well-being. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Does climate play any role in covid-19 spreading? : an Australian perspective
- Abraham, Joji, Turville, Christopher, Dowling, Kim, Florentine, Singarayer
- Authors: Abraham, Joji , Turville, Christopher , Dowling, Kim , Florentine, Singarayer
- Date: 2021
- Type: Text , Journal article
- Relation: International Journal of Environmental Research and Public Health Vol. 18, no. 17 (2021), p.
- Full Text:
- Reviewed:
- Description: Compared to other countries, the COVID-19 pandemic did not severely affect Australia as measured by total deaths until mid-2021. Though a substantial number of daily confirmed cases (up to 698) were reported during the second wave, most of them were from the southern state of Victoria. This study examined the possible correlations between climate variables and the number of daily confirmed COVID-19 cases in Victoria, Australia, from 25 January to 31 October 2020. Appropriate regression models and cross-correlation diagnostics were used to examine the effect of temperature, rainfall, solar exposure, and ultraviolet index (UVI) with the number of daily confirmed cases. Significant positive associations were identified for solar exposure and maximum and average UVI for confirmed cases one and 19 days later. Negative associations for these variables were found for confirmed cases five days later. Minimum temperature had a significant negative correlation one day later and a positive effect 21 days later. No significant correlation was found for maximum temperature and rainfall. The most significant relationships were found for confirmed cases 19 days after changes in the meteorological variables. A 1% increase in solar exposure, maximum UVI, and average UVI was associated with a 0.31% (95% CI: 0.13 to 0.51), 0.71% (95% CI: 0.43 to 0.98), and 0.63% (95%CI: 0.20 to 1.61) increase 19 days later in the number of confirmed cases, respectively. The implications of these results can be used in the public health management of any possible future events in Australia. It also highlights the significance of considering the climatic variables and seasonality in all kinds of epidemics and pandemics. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- Authors: Abraham, Joji , Turville, Christopher , Dowling, Kim , Florentine, Singarayer
- Date: 2021
- Type: Text , Journal article
- Relation: International Journal of Environmental Research and Public Health Vol. 18, no. 17 (2021), p.
- Full Text:
- Reviewed:
- Description: Compared to other countries, the COVID-19 pandemic did not severely affect Australia as measured by total deaths until mid-2021. Though a substantial number of daily confirmed cases (up to 698) were reported during the second wave, most of them were from the southern state of Victoria. This study examined the possible correlations between climate variables and the number of daily confirmed COVID-19 cases in Victoria, Australia, from 25 January to 31 October 2020. Appropriate regression models and cross-correlation diagnostics were used to examine the effect of temperature, rainfall, solar exposure, and ultraviolet index (UVI) with the number of daily confirmed cases. Significant positive associations were identified for solar exposure and maximum and average UVI for confirmed cases one and 19 days later. Negative associations for these variables were found for confirmed cases five days later. Minimum temperature had a significant negative correlation one day later and a positive effect 21 days later. No significant correlation was found for maximum temperature and rainfall. The most significant relationships were found for confirmed cases 19 days after changes in the meteorological variables. A 1% increase in solar exposure, maximum UVI, and average UVI was associated with a 0.31% (95% CI: 0.13 to 0.51), 0.71% (95% CI: 0.43 to 0.98), and 0.63% (95%CI: 0.20 to 1.61) increase 19 days later in the number of confirmed cases, respectively. The implications of these results can be used in the public health management of any possible future events in Australia. It also highlights the significance of considering the climatic variables and seasonality in all kinds of epidemics and pandemics. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Licorice (glycyrrhiza glabra) extracts-suitable pharmacological interventions for covid-19? a review
- Abraham, Joji, Florentine, Singarayer
- Authors: Abraham, Joji , Florentine, Singarayer
- Date: 2021
- Type: Text , Journal article , Review
- Relation: Plants Vol. 10, no. 12 (2021), p.
- Full Text:
- Reviewed:
- Description: Even though vaccination has started against COVID-19, people should continue maintaining personal and social caution as it takes months or years to get everyone vaccinated, and we are not sure how long the vaccine remains efficacious. In order to contribute to the mitigation of COVID-19 symptoms, the pharmaceutical industry aims to develop antiviral drugs to inhibit the SARS-CoV-2 replication and produce anti-inflammatory medications that will inhibit the acute respiratory distress syndrome (ARDS), which is the primary cause of mortality among the COVID-19 patients. In reference to these tasks, this article considers the properties of a medicinal plant named licorice (Glycyrrhiza glabra), whose phytochemicals have shown both antiviral and anti-inflammatory tendencies through previous studies. All the literature was selected through extensive search in various databases such as google scholar, Scopus, the Web of Science, and PubMed. In addition to the antiviral and anti-inflammatory properties, one of the licorice components has an autophagy-enhancing mechanism that studies have suggested to be necessary for COVID-19 treatment. Based on reviewing relevant professional and historical literature regarding the medicinal properties of licorice, it is suggested that it may be worthwhile to conduct in vitro and in vivo studies, including clinical trials with glycyrrhizic and glycyrrhetinic acids together with other flavonoids found in licorice, as there is the potentiality to provide natural interventions against COVID-19 symptoms. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Licorice (glycyrrhiza glabra) extracts-suitable pharmacological interventions for covid-19? a review
- Authors: Abraham, Joji , Florentine, Singarayer
- Date: 2021
- Type: Text , Journal article , Review
- Relation: Plants Vol. 10, no. 12 (2021), p.
- Full Text:
- Reviewed:
- Description: Even though vaccination has started against COVID-19, people should continue maintaining personal and social caution as it takes months or years to get everyone vaccinated, and we are not sure how long the vaccine remains efficacious. In order to contribute to the mitigation of COVID-19 symptoms, the pharmaceutical industry aims to develop antiviral drugs to inhibit the SARS-CoV-2 replication and produce anti-inflammatory medications that will inhibit the acute respiratory distress syndrome (ARDS), which is the primary cause of mortality among the COVID-19 patients. In reference to these tasks, this article considers the properties of a medicinal plant named licorice (Glycyrrhiza glabra), whose phytochemicals have shown both antiviral and anti-inflammatory tendencies through previous studies. All the literature was selected through extensive search in various databases such as google scholar, Scopus, the Web of Science, and PubMed. In addition to the antiviral and anti-inflammatory properties, one of the licorice components has an autophagy-enhancing mechanism that studies have suggested to be necessary for COVID-19 treatment. Based on reviewing relevant professional and historical literature regarding the medicinal properties of licorice, it is suggested that it may be worthwhile to conduct in vitro and in vivo studies, including clinical trials with glycyrrhizic and glycyrrhetinic acids together with other flavonoids found in licorice, as there is the potentiality to provide natural interventions against COVID-19 symptoms. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
The influence of controlled fire on the mobilization of Potentially Toxic Elements (PTE) in a mined landscape : Implications for land management and environmental health
- Authors: Abraham, Joji
- Date: 2018
- Type: Text , Thesis , PhD
- Full Text:
- Description: Controlled fires conducted in fire prone areas are an efficient and economic option to reduce the frequency and intensity of wild fires that result in damage to human property, infrastructure and ecosystems. However, in a similar way to wild fires, controlled fires affect many of the physical and bio-geochemical properties of the forest soil, and may remobilize Potentially Toxic Elements (PTE) from vegetation and soil organic matter. The objective of this study is to investigate the mobilization of PTEs in a mined landscape after a controlled fire and to describe their temporal variations in concentrations. Soil samples were collected two days before and two days after the controlled fire, at the end of each season, and after a major rainfall in September 2016, from a legacy mine site in Maldon, Central Victoria, Australia, and analysed for PTE concentrations. The results revealed PTE mobility after the controlled fire, and most of the PTEs (As, Cd, Cu, Mn, and Zn) evidenced an increase in concentration (1.2, 1.5, 1.1, 2.9, and 1.7 times respectively) and other PTEs (Hg, Cr and Pb) shown a decrease (1.4, 1.1 and 1.1 times respectively) immediately after the fire. The increase in PTE concentration immediately after the fire is postulated to be associated with the addition of PTE enriched ash to the soil and the reduction is due to the volatilization of elements during fire. The PTEs, which increased their concentrations immediately after the fire show a temporal decrease in concentration in the post-fire soil environment due to the removal of ash and surface soil by rainfall runoff, leaching and wind activity. However, Hg shows an increase in concentration after the major rainfall event. Although, median concentrations of As, Hg, Pb, Cu and Zn exceeded the Australian and Victorian top soil averages, only As and Hg are considered to be a risk to human and aquatic ecosystems health due to their elevated concentration and toxicity. Climate change and the resulting projection for increased forest fire frequency illustrates a growing concern given the expected concomitant increase in PTE mobilization. Preparing appropriate land and water management strategies, and addressing environmental health practice and policy, specifically at the legacy mining areas require a review. This study highlights the significant risk these sites pose.
- Description: Doctor of Philosophy
- Authors: Abraham, Joji
- Date: 2018
- Type: Text , Thesis , PhD
- Full Text:
- Description: Controlled fires conducted in fire prone areas are an efficient and economic option to reduce the frequency and intensity of wild fires that result in damage to human property, infrastructure and ecosystems. However, in a similar way to wild fires, controlled fires affect many of the physical and bio-geochemical properties of the forest soil, and may remobilize Potentially Toxic Elements (PTE) from vegetation and soil organic matter. The objective of this study is to investigate the mobilization of PTEs in a mined landscape after a controlled fire and to describe their temporal variations in concentrations. Soil samples were collected two days before and two days after the controlled fire, at the end of each season, and after a major rainfall in September 2016, from a legacy mine site in Maldon, Central Victoria, Australia, and analysed for PTE concentrations. The results revealed PTE mobility after the controlled fire, and most of the PTEs (As, Cd, Cu, Mn, and Zn) evidenced an increase in concentration (1.2, 1.5, 1.1, 2.9, and 1.7 times respectively) and other PTEs (Hg, Cr and Pb) shown a decrease (1.4, 1.1 and 1.1 times respectively) immediately after the fire. The increase in PTE concentration immediately after the fire is postulated to be associated with the addition of PTE enriched ash to the soil and the reduction is due to the volatilization of elements during fire. The PTEs, which increased their concentrations immediately after the fire show a temporal decrease in concentration in the post-fire soil environment due to the removal of ash and surface soil by rainfall runoff, leaching and wind activity. However, Hg shows an increase in concentration after the major rainfall event. Although, median concentrations of As, Hg, Pb, Cu and Zn exceeded the Australian and Victorian top soil averages, only As and Hg are considered to be a risk to human and aquatic ecosystems health due to their elevated concentration and toxicity. Climate change and the resulting projection for increased forest fire frequency illustrates a growing concern given the expected concomitant increase in PTE mobilization. Preparing appropriate land and water management strategies, and addressing environmental health practice and policy, specifically at the legacy mining areas require a review. This study highlights the significant risk these sites pose.
- Description: Doctor of Philosophy
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