Divergent molecular networks program functionally distinct CD8+skin-resident memory T cells
- Park, Simone, Christo, Susan, Wells, Alexandria, Gandolfo, Luke, Zaid, Ali, Alexandre, Yannick, Burn, Thomas, Schröder, Jan, Collins, Nicholas, Han, Seong-Ji, Guillaume, Stephane, Evrard, Maximilien, Castellucci, Clara, Davies, Brooke, Osman, Maleika, Obers, Andreas, McDonald, Keely, Wang, Huimeng, Mueller, Scott, Kannourakis, George, Berzins, Stuart, Mielke, Lisa, Carbone, Francis, Kallies, Axel, Speed, Terence, Belkaid, Yasmine, MacKay, Laura
- Authors: Park, Simone , Christo, Susan , Wells, Alexandria , Gandolfo, Luke , Zaid, Ali , Alexandre, Yannick , Burn, Thomas , Schröder, Jan , Collins, Nicholas , Han, Seong-Ji , Guillaume, Stephane , Evrard, Maximilien , Castellucci, Clara , Davies, Brooke , Osman, Maleika , Obers, Andreas , McDonald, Keely , Wang, Huimeng , Mueller, Scott , Kannourakis, George , Berzins, Stuart , Mielke, Lisa , Carbone, Francis , Kallies, Axel , Speed, Terence , Belkaid, Yasmine , MacKay, Laura
- Date: 2023
- Type: Text , Journal article
- Relation: Science Vol. 382, no. 6674 (2023), p. 1073-1079
- Full Text: false
- Reviewed:
- Description: Skin-resident CD8+T cells include distinct interferon-g-producing [tissue-resident memory T type 1 (TRM1)] and interleukin-17 (IL-17)-producing (TRM17) subsets that differentially contribute to immune responses. However, whether these populations use common mechanisms to establish tissue residence is unknown. In this work, we show that TRM1 and TRM17 cells navigate divergent trajectories to acquire tissue residency in the skin. TRM1 cells depend on a T-bet-Hobit-IL-15 axis, whereas TRM17 cells develop independently of these factors. Instead, c-Maf commands a tissue-resident program in TRM17 cells parallel to that induced by Hobit in TRM1 cells, with an ICOS-c-Maf-IL-7 axis pivotal to TRM17 cell commitment. Accordingly, by targeting this pathway, skin TRM17 cells can be ablated without compromising their TRM1 counterparts. Thus, skin-resident T cells rely on distinct molecular circuitries, which can be exploited to strategically modulate local immunity. © 2023 American Association for the Advancement of Science. All rights reserved.
DMD-associated dilated cardiomyopathy : genotypes, phenotypes, and phenocopies
- Johnson, Renee, Otway, Robyn, Chin, Ephrem, Horvat, Claire, Ohanian, Monique, Wilcox, Jon, Su, Zheng, Prestes, Priscilla, Smolnikov, Andrei, Soka, Magdalena, Guo, Guanglan, Rath, Emma, Chakravorty, Samya, Chrzanowski, Lukasz, Hayward, Christopher, Keogh, Anne, MacDonald, Peter, Giannoulatou, Eleni, Chang, Alex, Oates, Emily, Charchar, Fadi, Seidman, Jonathan, Seidman, Christine, Hegde, Madhuri, Fatkin, Diane
- Authors: Johnson, Renee , Otway, Robyn , Chin, Ephrem , Horvat, Claire , Ohanian, Monique , Wilcox, Jon , Su, Zheng , Prestes, Priscilla , Smolnikov, Andrei , Soka, Magdalena , Guo, Guanglan , Rath, Emma , Chakravorty, Samya , Chrzanowski, Lukasz , Hayward, Christopher , Keogh, Anne , MacDonald, Peter , Giannoulatou, Eleni , Chang, Alex , Oates, Emily , Charchar, Fadi , Seidman, Jonathan , Seidman, Christine , Hegde, Madhuri , Fatkin, Diane
- Date: 2023
- Type: Text , Journal article
- Relation: Circulation: Genomic and Precision Medicine Vol. 16, no. 5 (2023), p. 421-430
- Full Text:
- Reviewed:
- Description: Background: Variants in the DMD gene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heart failure, heart transplantation, and ventricular arrhythmias. Improved early detection of individuals at risk is needed. Methods: Genetic testing of 40 male probands with a potential X-linked genetic cause of primary DCM was undertaken using multi-gene panel sequencing, multiplex polymerase chain reaction, and array comparative genomic hybridization. Variant location was assessed with respect to dystrophin isoform patterns and exon usage. Telomere length was evaluated as a marker of myocardial dysfunction in left ventricular tissue and blood. Results: Four pathogenic/likely pathogenic DMD variants were found in 5 probands (5/40: 12.5%). Only one rare variant was identified by gene panel testing with 3 additional multi-exon deletion/duplications found following targeted assays for structural variants. All of the pathogenic/likely pathogenic DMD variants involved dystrophin exons that had percent spliced-in scores >90, indicating high levels of constitutive expression in the human adult heart. Fifteen DMD variant-negative probands (15/40: 37.5%) had variants in autosomal genes including TTN, BAG3, LMNA, and RBM20. Myocardial telomere length was reduced in patients with DCM irrespective of genotype. No differences in blood telomere length were observed between genotype-positive family members with/without DCM and controls. Conclusions: Primary genetic testing using multi-gene panels has a low yield and specific assays for structural variants are required if DMD-associated cardiomyopathy is suspected. Distinguishing X-linked causes of DCM from autosomal genes that show sex differences in clinical presentation is crucial for informed family management. © 2023 American Heart Association, Inc.
- Authors: Johnson, Renee , Otway, Robyn , Chin, Ephrem , Horvat, Claire , Ohanian, Monique , Wilcox, Jon , Su, Zheng , Prestes, Priscilla , Smolnikov, Andrei , Soka, Magdalena , Guo, Guanglan , Rath, Emma , Chakravorty, Samya , Chrzanowski, Lukasz , Hayward, Christopher , Keogh, Anne , MacDonald, Peter , Giannoulatou, Eleni , Chang, Alex , Oates, Emily , Charchar, Fadi , Seidman, Jonathan , Seidman, Christine , Hegde, Madhuri , Fatkin, Diane
- Date: 2023
- Type: Text , Journal article
- Relation: Circulation: Genomic and Precision Medicine Vol. 16, no. 5 (2023), p. 421-430
- Full Text:
- Reviewed:
- Description: Background: Variants in the DMD gene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heart failure, heart transplantation, and ventricular arrhythmias. Improved early detection of individuals at risk is needed. Methods: Genetic testing of 40 male probands with a potential X-linked genetic cause of primary DCM was undertaken using multi-gene panel sequencing, multiplex polymerase chain reaction, and array comparative genomic hybridization. Variant location was assessed with respect to dystrophin isoform patterns and exon usage. Telomere length was evaluated as a marker of myocardial dysfunction in left ventricular tissue and blood. Results: Four pathogenic/likely pathogenic DMD variants were found in 5 probands (5/40: 12.5%). Only one rare variant was identified by gene panel testing with 3 additional multi-exon deletion/duplications found following targeted assays for structural variants. All of the pathogenic/likely pathogenic DMD variants involved dystrophin exons that had percent spliced-in scores >90, indicating high levels of constitutive expression in the human adult heart. Fifteen DMD variant-negative probands (15/40: 37.5%) had variants in autosomal genes including TTN, BAG3, LMNA, and RBM20. Myocardial telomere length was reduced in patients with DCM irrespective of genotype. No differences in blood telomere length were observed between genotype-positive family members with/without DCM and controls. Conclusions: Primary genetic testing using multi-gene panels has a low yield and specific assays for structural variants are required if DMD-associated cardiomyopathy is suspected. Distinguishing X-linked causes of DCM from autosomal genes that show sex differences in clinical presentation is crucial for informed family management. © 2023 American Heart Association, Inc.
Do health service waiting areas contribute to the health literacy of consumers? A scoping review
- McDonald, Cassie, Voutier, Catherine, Govil, Dhruv, D'Souza, Aruska, Truong, Dominic, Abo, Shaza, Remedios, Louisa, Granger, Catherine
- Authors: McDonald, Cassie , Voutier, Catherine , Govil, Dhruv , D'Souza, Aruska , Truong, Dominic , Abo, Shaza , Remedios, Louisa , Granger, Catherine
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Health Promotion International Vol. 38, no. 4 (2023), p.
- Full Text:
- Reviewed:
- Description: Health service waiting areas commonly provide health information, resources and supports for consumers; however, the effect on health literacy and related outcomes remains unclear. This scoping review of the literature aimed to explore the use of waiting areas as a place to contribute to the health literacy and related outcomes of consumers attending health appointments. Articles were included if they focussed on health literacy or health literacy responsiveness (concept) in outpatient or primary care health service waiting areas (context) for adult consumers (population) and were published after 2010. Ten bibliographic databases, one full-text archive, dissertation repositories and web sources were searched. The search yielded 5095 records. After duplicate removal, 3942 title/abstract records were screened and 360 full-text records assessed. Data were charted into a standardized data extraction tool. A total of 116 unique articles (published empirical and grey literature) were included. Most articles were set in primary and community care (49%) waiting areas. A diverse range of health topics and resource types were available, but results demonstrated they were not always used by consumers. Outcomes measured in intervention studies were health knowledge, intentions and other psychological factors, self-reported and observed behaviours, clinical outcomes and health service utilization. Intervention studies overall demonstrated positive trends in health literacy-related outcomes, although the benefit declined after 3-6 months. Research on using waiting areas for health literacy purposes is increasing globally. Future research investigating the needs of consumers to inform optimal intervention design is needed. © 2023 The Author(s). Published by Oxford University Press.
- Authors: McDonald, Cassie , Voutier, Catherine , Govil, Dhruv , D'Souza, Aruska , Truong, Dominic , Abo, Shaza , Remedios, Louisa , Granger, Catherine
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Health Promotion International Vol. 38, no. 4 (2023), p.
- Full Text:
- Reviewed:
- Description: Health service waiting areas commonly provide health information, resources and supports for consumers; however, the effect on health literacy and related outcomes remains unclear. This scoping review of the literature aimed to explore the use of waiting areas as a place to contribute to the health literacy and related outcomes of consumers attending health appointments. Articles were included if they focussed on health literacy or health literacy responsiveness (concept) in outpatient or primary care health service waiting areas (context) for adult consumers (population) and were published after 2010. Ten bibliographic databases, one full-text archive, dissertation repositories and web sources were searched. The search yielded 5095 records. After duplicate removal, 3942 title/abstract records were screened and 360 full-text records assessed. Data were charted into a standardized data extraction tool. A total of 116 unique articles (published empirical and grey literature) were included. Most articles were set in primary and community care (49%) waiting areas. A diverse range of health topics and resource types were available, but results demonstrated they were not always used by consumers. Outcomes measured in intervention studies were health knowledge, intentions and other psychological factors, self-reported and observed behaviours, clinical outcomes and health service utilization. Intervention studies overall demonstrated positive trends in health literacy-related outcomes, although the benefit declined after 3-6 months. Research on using waiting areas for health literacy purposes is increasing globally. Future research investigating the needs of consumers to inform optimal intervention design is needed. © 2023 The Author(s). Published by Oxford University Press.
Do maturation, anthropometrics and leg muscle qualities influence repeated change of direction performance in adolescent boys and girls?
- Giuriato, Matteo, Pellino, Vittoria, Lovecchio, Nicola, Codella, Roberto, Vandoni, Matteo, Talpey, Scott
- Authors: Giuriato, Matteo , Pellino, Vittoria , Lovecchio, Nicola , Codella, Roberto , Vandoni, Matteo , Talpey, Scott
- Date: 2023
- Type: Text , Journal article
- Relation: Biology of Sport Vol. 40, no. 4 (2023), p. 1033-1038
- Full Text:
- Reviewed:
- Description: The ability to change direction rapidly is a key fitness quality especially in invasive sports where young players perform approximately 300 changes of direction in a game. There is currently limited understanding of how anthropometric characteristics and maturation status influence change of direction ability in adolescent. Therefore, the purpose of this investigation is to assess the influence of anthropometrics and maturation status on change of direction ability in young people. The study involved 706 adolescents (367 girls) aged 14-19-year-old attending the same high school in Northern Italy. Stature, body mass, seated height and leg length were measured to determine the anthropometrics and maturation status of the participants. Repeated change of direction ability (10 × 5 m shuttle run test), lower limb power and muscle strength were evaluated using field tests from the Eurofit test battery. Maturity offset was calculated separately for boys and girls, in accord with the equation proposed by Mirwald. Preliminary analysis with 10 × 5 m as a dependent variable and sex and PHV as a fixed factor, suggests a significant difference between sex (p < 0.001; d = 0.35) but not with PHV (p = 0.986; d = 0.000) and interaction PHV × sex (p = 0.836; d = 0.000). Our results suggested that repeated change of direction performance was influenced by anthropometrics, maturation and muscle qualities in adolescent boys and girls. © 2023 Institute of Sport. All rights reserved.
- Authors: Giuriato, Matteo , Pellino, Vittoria , Lovecchio, Nicola , Codella, Roberto , Vandoni, Matteo , Talpey, Scott
- Date: 2023
- Type: Text , Journal article
- Relation: Biology of Sport Vol. 40, no. 4 (2023), p. 1033-1038
- Full Text:
- Reviewed:
- Description: The ability to change direction rapidly is a key fitness quality especially in invasive sports where young players perform approximately 300 changes of direction in a game. There is currently limited understanding of how anthropometric characteristics and maturation status influence change of direction ability in adolescent. Therefore, the purpose of this investigation is to assess the influence of anthropometrics and maturation status on change of direction ability in young people. The study involved 706 adolescents (367 girls) aged 14-19-year-old attending the same high school in Northern Italy. Stature, body mass, seated height and leg length were measured to determine the anthropometrics and maturation status of the participants. Repeated change of direction ability (10 × 5 m shuttle run test), lower limb power and muscle strength were evaluated using field tests from the Eurofit test battery. Maturity offset was calculated separately for boys and girls, in accord with the equation proposed by Mirwald. Preliminary analysis with 10 × 5 m as a dependent variable and sex and PHV as a fixed factor, suggests a significant difference between sex (p < 0.001; d = 0.35) but not with PHV (p = 0.986; d = 0.000) and interaction PHV × sex (p = 0.836; d = 0.000). Our results suggested that repeated change of direction performance was influenced by anthropometrics, maturation and muscle qualities in adolescent boys and girls. © 2023 Institute of Sport. All rights reserved.
Do the qualifications of vocational teachers make a difference to their teaching?
- Smith, Erica, Tuck, Jacqueline
- Authors: Smith, Erica , Tuck, Jacqueline
- Date: 2023
- Type: Text , Journal article
- Relation: Research in Post-Compulsory Education Vol. 28, no. 1 (2023), p. 1-25
- Full Text: false
- Reviewed:
- Description: A survey of over 500 teachers and trainers in the Australian Vocational Education and Training (VET) sector was carried out to examine whether their teaching practices and approaches varied with their qualification levels. The survey, carried out with teachers and trainers from different types of training providers–public and private–formed a major part of a larger research project on the topic. The project was carried out because of an overall decline in the qualification levels of the VET teaching workforce over a 20-year period, and national debate on the appropriate qualification level. Analysis of the survey results showed that those with pedagogical qualifications above the regulatory minimum were more confident overall, and were more able to deal with the demands of different teaching contexts and of diverse learner groups. Teachers with higher level qualifications also reported, in qualitative questions, specific gains from their qualifications. They were also more likely to undertake professional development, challenging an often-cited view that professional development activities can compensate for lower qualification levels. The findings have implications for policy development in Australia and elsewhere. © 2023 Association for Research in Post-Compulsory Education.
Does multisession cathodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex prime the effects of cognitive behavioral therapy on fear of pain, fear of movement, and disability in patients with nonspecific low back pain? A randomized clinical trial study
- Ehsani, Fatemeh, Hafez Yousefi, Mohaddeseh, Jafarzadeh, Abbas, Zoghi, Maryam, Jaberzadeh, Shapour
- Authors: Ehsani, Fatemeh , Hafez Yousefi, Mohaddeseh , Jafarzadeh, Abbas , Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2023
- Type: Text , Journal article
- Relation: Brain Sciences Vol. 13, no. 10 (2023), p.
- Full Text:
- Reviewed:
- Description: Many studies have shown that low back pain (LBP) is associated with psychosomatic symptoms which may lead to brain changes. This study aimed to investigate the effect of the concurrent application of cognitive behavioral therapy (CBT) and transcranial direct electrical stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on fear of pain, fear of movement, and disability in patients with nonspecific LBP. This study was performed on 45 LBP patients (23 women, 22 men; mean age 33.00 ± 1.77 years) in three groups: experimental (2 mA cathodal tDCS (c-tDCS)), sham (c-tDCS turned off after 30 s), and control (only received CBT). In all groups, CBT was conducted for 20 min per session, with two sessions per week for four weeks. Fear of pain, fear of movement, and disability were evaluated using questionnaires at baseline, immediately after, and one month after completion of interventions. Results indicated that all three different types of intervention could significantly reduce fear and disability immediately after intervention (p > 0.05). However, improvement in the experimental group was significantly higher than in the other groups immediately after and at the one-month follow-up after interventions (p < 0.05). DLPFC c-tDCS can prime the immediate effects of CBT and also the lasting effects on the reduction in the fear of pain, fear of movement, and disability in LBP patients. © 2023 by the authors.
- Authors: Ehsani, Fatemeh , Hafez Yousefi, Mohaddeseh , Jafarzadeh, Abbas , Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2023
- Type: Text , Journal article
- Relation: Brain Sciences Vol. 13, no. 10 (2023), p.
- Full Text:
- Reviewed:
- Description: Many studies have shown that low back pain (LBP) is associated with psychosomatic symptoms which may lead to brain changes. This study aimed to investigate the effect of the concurrent application of cognitive behavioral therapy (CBT) and transcranial direct electrical stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on fear of pain, fear of movement, and disability in patients with nonspecific LBP. This study was performed on 45 LBP patients (23 women, 22 men; mean age 33.00 ± 1.77 years) in three groups: experimental (2 mA cathodal tDCS (c-tDCS)), sham (c-tDCS turned off after 30 s), and control (only received CBT). In all groups, CBT was conducted for 20 min per session, with two sessions per week for four weeks. Fear of pain, fear of movement, and disability were evaluated using questionnaires at baseline, immediately after, and one month after completion of interventions. Results indicated that all three different types of intervention could significantly reduce fear and disability immediately after intervention (p > 0.05). However, improvement in the experimental group was significantly higher than in the other groups immediately after and at the one-month follow-up after interventions (p < 0.05). DLPFC c-tDCS can prime the immediate effects of CBT and also the lasting effects on the reduction in the fear of pain, fear of movement, and disability in LBP patients. © 2023 by the authors.
Domestic load management with coordinated photovoltaics, battery storage and electric vehicle operation
- Das, Narottam, Haque, Akramul, Zaman, Hasneen, Morsalin, Sayidul, Islam, Syed
- Authors: Das, Narottam , Haque, Akramul , Zaman, Hasneen , Morsalin, Sayidul , Islam, Syed
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Access Vol. 11, no. (2023), p. 12075-12087
- Full Text:
- Reviewed:
- Description: Coordinated power demand management at residential or domestic levels allows energy participants to efficiently manage load profiles, increase energy efficiency and reduce operational cost. In this paper, a hierarchical coordination framework to optimally manage domestic load using photovoltaic (PV) units, battery-energy-storage-systems (BESs) and electric vehicles (EVs) is presented. The bidirectional power flow of EV with vehicle to grid (V2G) operation manages real-time domestic load profile and takes appropriate coordinated action using its controller when necessary. The proposed system has been applied to a real power distribution network and tested with real load patterns and load dynamics. This also includes various test scenarios and prosumer's preferences e.g., with or without EVs, number of EV owners, number of households, and prosumer's daily activities. This is a combined hybrid system for hierarchical coordination that consists of PV units, BES systems and EVs. The system performance was analyzed with different commercial EV types with charging/ discharging constraints and the result shows that the domestic load demand on the distribution grid during the peak period has been reduced significantly. In the end, this proposed system's performance was compared with the prediction-based test techniques and the financial benefits were estimated. © 2013 IEEE.
- Authors: Das, Narottam , Haque, Akramul , Zaman, Hasneen , Morsalin, Sayidul , Islam, Syed
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Access Vol. 11, no. (2023), p. 12075-12087
- Full Text:
- Reviewed:
- Description: Coordinated power demand management at residential or domestic levels allows energy participants to efficiently manage load profiles, increase energy efficiency and reduce operational cost. In this paper, a hierarchical coordination framework to optimally manage domestic load using photovoltaic (PV) units, battery-energy-storage-systems (BESs) and electric vehicles (EVs) is presented. The bidirectional power flow of EV with vehicle to grid (V2G) operation manages real-time domestic load profile and takes appropriate coordinated action using its controller when necessary. The proposed system has been applied to a real power distribution network and tested with real load patterns and load dynamics. This also includes various test scenarios and prosumer's preferences e.g., with or without EVs, number of EV owners, number of households, and prosumer's daily activities. This is a combined hybrid system for hierarchical coordination that consists of PV units, BES systems and EVs. The system performance was analyzed with different commercial EV types with charging/ discharging constraints and the result shows that the domestic load demand on the distribution grid during the peak period has been reduced significantly. In the end, this proposed system's performance was compared with the prediction-based test techniques and the financial benefits were estimated. © 2013 IEEE.
DQN-based resource allocation for NOMA-MEC-aided multi-source data stream
- Ling, Jing, Xia, Junjuan, Zhu, Fusheng, Gao, Chongzhi, Lai, Shiwei, Balasubramanian, Venki
- Authors: Ling, Jing , Xia, Junjuan , Zhu, Fusheng , Gao, Chongzhi , Lai, Shiwei , Balasubramanian, Venki
- Date: 2023
- Type: Text , Journal article
- Relation: Eurasip Journal on Advances in Signal Processing Vol. 2023, no. 1 (2023), p.
- Full Text:
- Reviewed:
- Description: This paper investigates a non-orthogonal multiple access (NOMA)-aided mobile edge computing (MEC) network with multiple sources and one computing access point (CAP), in which NOMA technology is applied to transmit multi-source data streams to CAP for computing. To measure the performance of the considered NOMA-aided MEC network, we first design the system cost as a linear weighting function of energy consumption and delay under the NOMA-aided MEC network. Moreover, we propose a deep Q network (DQN)-based offloading strategy to minimize the system cost by jointly optimizing the offloading ratio and transmission power allocation. Finally, we design experiments to demonstrate the effectiveness of the proposed strategy. Specifically, the designed strategy can decrease the system cost by about 15% compared with local computing when the number of sources is 5. © 2023, The Author(s).
- Authors: Ling, Jing , Xia, Junjuan , Zhu, Fusheng , Gao, Chongzhi , Lai, Shiwei , Balasubramanian, Venki
- Date: 2023
- Type: Text , Journal article
- Relation: Eurasip Journal on Advances in Signal Processing Vol. 2023, no. 1 (2023), p.
- Full Text:
- Reviewed:
- Description: This paper investigates a non-orthogonal multiple access (NOMA)-aided mobile edge computing (MEC) network with multiple sources and one computing access point (CAP), in which NOMA technology is applied to transmit multi-source data streams to CAP for computing. To measure the performance of the considered NOMA-aided MEC network, we first design the system cost as a linear weighting function of energy consumption and delay under the NOMA-aided MEC network. Moreover, we propose a deep Q network (DQN)-based offloading strategy to minimize the system cost by jointly optimizing the offloading ratio and transmission power allocation. Finally, we design experiments to demonstrate the effectiveness of the proposed strategy. Specifically, the designed strategy can decrease the system cost by about 15% compared with local computing when the number of sources is 5. © 2023, The Author(s).
Dynamics of transforming growth factor
- Wu, Siqi, Luwor, Rodney, Zhu, Hong-Jian
- Authors: Wu, Siqi , Luwor, Rodney , Zhu, Hong-Jian
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Growth Factors Vol. 41, no. 2 (2023), p. 82-100
- Full Text: false
- Reviewed:
- Description: Transforming growth factor
E-cigarette use among male smokers in Al-Ahsa, Kingdom of Saudi Arabia : a cross-sectional study
- Al Rajeh, Ahmed, Mahmud, Ilias, Al Imam, Mahmudul, Rahman, Muhammad Aziz, Al Shehri, Fariss, Alomayrin, Salman, Alfazae, Nawaf, Elmosaad, Yousif, Alasqah, Ibrahim
- Authors: Al Rajeh, Ahmed , Mahmud, Ilias , Al Imam, Mahmudul , Rahman, Muhammad Aziz , Al Shehri, Fariss , Alomayrin, Salman , Alfazae, Nawaf , Elmosaad, Yousif , Alasqah, Ibrahim
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Environmental Research and Public Health Vol. 20, no. 1 (2023), p.
- Full Text:
- Reviewed:
- Description: E-cigarette use is increasing globally. Recent evidence suggests that e-cigarettes contain harmful substances that could cause adverse health outcomes. This study investigated the prevalence and associated factors of e-cigarette use among male current smokers in Saudi Arabia. We conducted a cross-sectional survey of adult male current smokers in the Al-Ahsa province of Saudi Arabia. Data were collected using a structured questionnaire. We performed logistic regression analyses to investigate the factors associated with e-cigarette use among adult male current smokers. 325 current smokers participated in the study. A third of them (33.5%) were e-cigarette users. Almost all the study participants (97.0%) had heard about e-cigarettes. Participants who were occasional smokers (Odds Ratio (OR): 2.28; 95% Confidence Interval (CI): 1.17–4.41) and had good knowledge perception of e-cigarettes (OR 3.49; 95% CI: 2.07–5.90) had higher odds of using e-cigarettes when compared to regular smokers of conventional cigarettes and current smokers with poor knowledge perception of e-cigarettes, respectively. In contrast, private employees (OR: 0.25, 95% CI: 0.07–0.85), and business owners (OR: 0.09, 95% CI: 0.01–0.63) had lower odds of using e-cigarettes compared to unemployed individuals. Compared with non-e-cigarette users, the rate of conventional cigarette smoking per day was significantly lower among e-cigarette users. Use of e-cigarette (OR: 3.57, 95% CI: 2.14–5.98), believing that e-cigarette quitting is hard (OR: 2.02, 95% CI: 1.17–3.49) and trying to quit e-cigarettes (OR: 2.17, 95% CI: 1.1–4.25) were found to be significant predictors of good knowledge perception of e-cigarettes among the current smokers. The use and knowledge perception of e-cigarettes were higher among occasional conventional male cigarette smokers than regular male smokers in Al-Ahsa province. The use of e-cigarettes as smoking cessation aids should be examined further in the Saudi Arabian setting. © 2022 by the authors.
- Authors: Al Rajeh, Ahmed , Mahmud, Ilias , Al Imam, Mahmudul , Rahman, Muhammad Aziz , Al Shehri, Fariss , Alomayrin, Salman , Alfazae, Nawaf , Elmosaad, Yousif , Alasqah, Ibrahim
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Environmental Research and Public Health Vol. 20, no. 1 (2023), p.
- Full Text:
- Reviewed:
- Description: E-cigarette use is increasing globally. Recent evidence suggests that e-cigarettes contain harmful substances that could cause adverse health outcomes. This study investigated the prevalence and associated factors of e-cigarette use among male current smokers in Saudi Arabia. We conducted a cross-sectional survey of adult male current smokers in the Al-Ahsa province of Saudi Arabia. Data were collected using a structured questionnaire. We performed logistic regression analyses to investigate the factors associated with e-cigarette use among adult male current smokers. 325 current smokers participated in the study. A third of them (33.5%) were e-cigarette users. Almost all the study participants (97.0%) had heard about e-cigarettes. Participants who were occasional smokers (Odds Ratio (OR): 2.28; 95% Confidence Interval (CI): 1.17–4.41) and had good knowledge perception of e-cigarettes (OR 3.49; 95% CI: 2.07–5.90) had higher odds of using e-cigarettes when compared to regular smokers of conventional cigarettes and current smokers with poor knowledge perception of e-cigarettes, respectively. In contrast, private employees (OR: 0.25, 95% CI: 0.07–0.85), and business owners (OR: 0.09, 95% CI: 0.01–0.63) had lower odds of using e-cigarettes compared to unemployed individuals. Compared with non-e-cigarette users, the rate of conventional cigarette smoking per day was significantly lower among e-cigarette users. Use of e-cigarette (OR: 3.57, 95% CI: 2.14–5.98), believing that e-cigarette quitting is hard (OR: 2.02, 95% CI: 1.17–3.49) and trying to quit e-cigarettes (OR: 2.17, 95% CI: 1.1–4.25) were found to be significant predictors of good knowledge perception of e-cigarettes among the current smokers. The use and knowledge perception of e-cigarettes were higher among occasional conventional male cigarette smokers than regular male smokers in Al-Ahsa province. The use of e-cigarettes as smoking cessation aids should be examined further in the Saudi Arabian setting. © 2022 by the authors.
EAGLE : contrastive learning for efficient graph anomaly detection
- Ren, Jing, Hou, Mingliang, Liu, Zhixuan, Bai, Xiaomei
- Authors: Ren, Jing , Hou, Mingliang , Liu, Zhixuan , Bai, Xiaomei
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Intelligent Systems Vol. 38, no. 2 (2023), p. 55-63
- Full Text: false
- Reviewed:
- Description: Graph anomaly detection is a popular and vital task in various real-world scenarios, which has been studied for several decades. Recently, many studies extending deep learning-based methods have shown preferable performance on graph anomaly detection. However, existing methods lack efficiency that is definitely necessary for embedded devices. Toward this end, we propose an Efficient Anomaly detection model on heterogeneous Graphs via contrastive LEarning (EAGLE) by contrasting abnormal nodes with normal ones in terms of their distances to the local context. The proposed method first samples instance pairs on meta-path level for contrastive learning. Then, a Graph AutoEncoder-based model is applied to learn informative node embeddings in an unsupervised way, which will be further combined with the discriminator to predict the anomaly scores of nodes. Experimental results show that EAGLE outperforms the state-of-the-art methods on three heterogeneous network datasets. © 2001-2011 IEEE.
Edge connectivity of simplicial polytopes
- Pilaud, Vincent, Pineda-Villavicencio, Guillermo, Ugon, Julien
- Authors: Pilaud, Vincent , Pineda-Villavicencio, Guillermo , Ugon, Julien
- Date: 2023
- Type: Text , Journal article
- Relation: European Journal of Combinatorics Vol. 113, no. (2023), p.
- Relation: https://purl.org/au-research/grants/arc/DP180100602
- Full Text: false
- Reviewed:
- Description: We show that the graph of a simplicial polytope of dimension d ≥ 3 has no nontrivial minimum edge cut with fewer than d(d+1)/2 edges, hence the graph is min{δ,d(d+1)/2}-edgeconnected where δ denotes the minimum degree. When d = 3, this implies that every minimum edge cut in a plane triangulation is trivial. When d ≥ 4, we construct a simplicial d-polytope whose graph has a nontrivial minimum edge cut of cardinality d(d + 1)/2, proving that the aforementioned result is best possible.
- Description: We show that the graph of a simplicial polytope of dimension d
- Fields, Sally, Unsworth, Carolyn, Harreveld, Bobby
- Authors: Fields, Sally , Unsworth, Carolyn , Harreveld, Bobby
- Date: 2023
- Type: Text , Journal article
- Relation: Scandinavian Journal of Occupational Therapy Vol. 30, no. 6 (2023), p. 837-852
- Full Text: false
- Reviewed:
- Description: Background: Occupational therapy competency standards provide an evidence-base to inform clinical best practice, however it is not known whether education about competency standards will increase occupational therapists’ adherence to their use. Aims/objectives: To investigate if education about the ‘Australian Competency Standards for Occupational Therapy Driver Assessors’ leads to increased adherence to the competency standards in the clinical practice of occupational therapy driver assessors. Materials and methods: A mixed methods multiple case study design was used to evaluate 5 occupational therapy driver assessors’ adherence to the competency standards. An audit of 25 client files and interviews were conducted to evaluate practice against the competency standards prior to an education session, followed by an audit of a further 25 files, interview and feedback after education. Results: Qualitative and quantitative analyses suggest that education about the ‘Australian Competency Standards for Occupational Therapy Driver Assessors’ was associated with increased adherence to the competency standards in clinical practice. The results also support the use of competency standards in clinical practice. Conclusions and significance: Competency standards can be used to inform and guide clinical practice, and individualised education and feedback of practice against the competency standards can increase occupational therapists’ adherence to these standards. © 2022 Scandinavian Journal of Occupational Therapy Foundation.
Educational leaders’ perceptions of STEM education revealed by their drawings and texts
- Hatisaru, Vesife, Falloon, Garry, Seen, Andrew, Fraser, Sharon, Powling, Markus, Beswick, Kim
- Authors: Hatisaru, Vesife , Falloon, Garry , Seen, Andrew , Fraser, Sharon , Powling, Markus , Beswick, Kim
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Mathematical Education in Science and Technology Vol. 54, no. 8 (2023), p. 1437-1457
- Full Text:
- Reviewed:
- Description: This study explored school principals' and teacher educators' perceptions of STEM education based on how they described STEM as a discipline, their understanding of the nature of teaching and learning of STEM, and the capabilities of a STEM-educated person. Data were generated through the Draw a STEM Learning Environment (D-STEM) instrument comprising drawn and written descriptions where participants drew a picture of a STEM learning environment and completed five prompt statements about what STEM is and how an individual develops personal STEM capability. The Legitimation Code Theory (LCT) specialization codes were used for data analysis (198 individual response items in total) to understand how the participants perceive STEM education. Almost half the participant responses indicated knowledge-code perceptions with a smaller but significant number (approximately a third of responses) indicating knower-code perceptions. The remaining responses showed élite-code perceptions, indicating a small proportion of participants valued the development of both disciplinary knowledge/practices and generic skills/attributes in STEM education. We posit that curriculum structure and reporting requirements influence these perceptions. Further research in relation to the influence of such understandings on enacted curriculum is warranted. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
- Authors: Hatisaru, Vesife , Falloon, Garry , Seen, Andrew , Fraser, Sharon , Powling, Markus , Beswick, Kim
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Mathematical Education in Science and Technology Vol. 54, no. 8 (2023), p. 1437-1457
- Full Text:
- Reviewed:
- Description: This study explored school principals' and teacher educators' perceptions of STEM education based on how they described STEM as a discipline, their understanding of the nature of teaching and learning of STEM, and the capabilities of a STEM-educated person. Data were generated through the Draw a STEM Learning Environment (D-STEM) instrument comprising drawn and written descriptions where participants drew a picture of a STEM learning environment and completed five prompt statements about what STEM is and how an individual develops personal STEM capability. The Legitimation Code Theory (LCT) specialization codes were used for data analysis (198 individual response items in total) to understand how the participants perceive STEM education. Almost half the participant responses indicated knowledge-code perceptions with a smaller but significant number (approximately a third of responses) indicating knower-code perceptions. The remaining responses showed élite-code perceptions, indicating a small proportion of participants valued the development of both disciplinary knowledge/practices and generic skills/attributes in STEM education. We posit that curriculum structure and reporting requirements influence these perceptions. Further research in relation to the influence of such understandings on enacted curriculum is warranted. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Effect of corrosion on the bond behavior of steel-reinforced, alkali-activated slag concrete
- Cui, Yifei, Qu, Shihao, Gao, Kaikai, Tekle, Biruk, Bao, Jiuwen, Zhang, Peng
- Authors: Cui, Yifei , Qu, Shihao , Gao, Kaikai , Tekle, Biruk , Bao, Jiuwen , Zhang, Peng
- Date: 2023
- Type: Text , Journal article
- Relation: Materials Vol. 16, no. 6 (2023), p.
- Full Text:
- Reviewed:
- Description: Alkali-activated slag concrete (ASC) is regarded as one of the most promising sustainable construction materials for replacing ordinary Portland cement concrete (OPC) due to its comparable strength and outstanding durability in challenging environments. In this study, the corrosion of steel bars embedded in ASC and OPC was studied by means of an electrically accelerated corrosion test of steel bars in concrete. Meanwhile, the bond performance of the corroded steel bars embedded in ASC was tested and compared with corresponding OPC groups. The results showed that ASC and OPC behaved differently in terms of bond deterioration. The high chemical resistance of ASC decreased the corrosion of steel bars and, thus, increased the residue bond strength and the bond stiffness. © 2023 by the authors.
- Authors: Cui, Yifei , Qu, Shihao , Gao, Kaikai , Tekle, Biruk , Bao, Jiuwen , Zhang, Peng
- Date: 2023
- Type: Text , Journal article
- Relation: Materials Vol. 16, no. 6 (2023), p.
- Full Text:
- Reviewed:
- Description: Alkali-activated slag concrete (ASC) is regarded as one of the most promising sustainable construction materials for replacing ordinary Portland cement concrete (OPC) due to its comparable strength and outstanding durability in challenging environments. In this study, the corrosion of steel bars embedded in ASC and OPC was studied by means of an electrically accelerated corrosion test of steel bars in concrete. Meanwhile, the bond performance of the corroded steel bars embedded in ASC was tested and compared with corresponding OPC groups. The results showed that ASC and OPC behaved differently in terms of bond deterioration. The high chemical resistance of ASC decreased the corrosion of steel bars and, thus, increased the residue bond strength and the bond stiffness. © 2023 by the authors.
Effect of hydralazine on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein e-deficient mice
- Wang, Yutang, Sargisson, Owen, Nguyen, Dinh, Parker, Ketura, Pyke, Stephan, Alramahi, Ahmed, Thihlum, Liam, Fang, Yan, Wallace, Morgan, Berzins, Stuart, Oqueli, Ernesto, Magliano, Dianna, Golledge, Jonathan
- Authors: Wang, Yutang , Sargisson, Owen , Nguyen, Dinh , Parker, Ketura , Pyke, Stephan , Alramahi, Ahmed , Thihlum, Liam , Fang, Yan , Wallace, Morgan , Berzins, Stuart , Oqueli, Ernesto , Magliano, Dianna , Golledge, Jonathan
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Molecular Sciences Vol. 24, no. 21 (2023), p.
- Full Text:
- Reviewed:
- Description: The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks. In cultured VSMCs, hydralazine (100
- Authors: Wang, Yutang , Sargisson, Owen , Nguyen, Dinh , Parker, Ketura , Pyke, Stephan , Alramahi, Ahmed , Thihlum, Liam , Fang, Yan , Wallace, Morgan , Berzins, Stuart , Oqueli, Ernesto , Magliano, Dianna , Golledge, Jonathan
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Molecular Sciences Vol. 24, no. 21 (2023), p.
- Full Text:
- Reviewed:
- Description: The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks. In cultured VSMCs, hydralazine (100
Effect of selected environmental factors on the seed germination of the invasive species Polygala myrtifolia (Polygalaceae) in Australia
- Roberts, Natalie, Moloney, Katrina, Monie, Kristin, Florentine, Singarayer
- Authors: Roberts, Natalie , Moloney, Katrina , Monie, Kristin , Florentine, Singarayer
- Date: 2023
- Type: Text , Journal article
- Relation: Australian Journal of Botany Vol. 71, no. 6 (2023), p. 286-295
- Full Text:
- Reviewed:
- Description: Context. Polygala myrtifolia L. has become a significant environmental weed in Australia, where it has invaded coastal ecosystems in temperate regions and there is a high risk of extensive further spread. Knowledge of seed-germination behaviour is essential to understand the potential future impact of this species. Aims. We investigated the effects of selected environmental factors and dormancy on P. myrtifolia seed germination and emergence to improve management strategies. Methods. Seeds were exposed to light, temperature, pH, salinity, osmotic potential and burial depth treatments to assess germination responses, dormancy and viability. Key results. Non-dormant seeds readily germinated to high percentages (93.0–95.0%) under specific day–night temperatures of 25°C–15°C regardless of light conditions and across all soil pH (75.0–100.0%). Salinities were tolerated up to 100 mM NaCl (70.0% germination) before sharply declining. Germination reduced from 98.3% to 40.0% at osmotic potentials of
- Authors: Roberts, Natalie , Moloney, Katrina , Monie, Kristin , Florentine, Singarayer
- Date: 2023
- Type: Text , Journal article
- Relation: Australian Journal of Botany Vol. 71, no. 6 (2023), p. 286-295
- Full Text:
- Reviewed:
- Description: Context. Polygala myrtifolia L. has become a significant environmental weed in Australia, where it has invaded coastal ecosystems in temperate regions and there is a high risk of extensive further spread. Knowledge of seed-germination behaviour is essential to understand the potential future impact of this species. Aims. We investigated the effects of selected environmental factors and dormancy on P. myrtifolia seed germination and emergence to improve management strategies. Methods. Seeds were exposed to light, temperature, pH, salinity, osmotic potential and burial depth treatments to assess germination responses, dormancy and viability. Key results. Non-dormant seeds readily germinated to high percentages (93.0–95.0%) under specific day–night temperatures of 25°C–15°C regardless of light conditions and across all soil pH (75.0–100.0%). Salinities were tolerated up to 100 mM NaCl (70.0% germination) before sharply declining. Germination reduced from 98.3% to 40.0% at osmotic potentials of
Effect of traumatic upper-limb injury on cognitive functions : a cross-sectional observational study
- Zhang, Xue, Tse, Tamara, Chen, Shao-Zhen, Qiu, Kai-Yi, Li, Xia, Zoghi, Maryam
- Authors: Zhang, Xue , Tse, Tamara , Chen, Shao-Zhen , Qiu, Kai-Yi , Li, Xia , Zoghi, Maryam
- Date: 2023
- Type: Text , Journal article
- Relation: Hand Surgery and Rehabilitation Vol. 42, no. 5 (2023), p. 413-418
- Full Text:
- Reviewed:
- Description: Objectives: There is growing evidence of cognitive impairment after traumatic peripheral lesions. The purpose of this study was to explore the association between cognitive function and traumatic upper-limb injury. We assessed difference in cognitive function between participants with and without upper-limb injury, and explored the association between cognitive function and certain variables in injured individuals: gender, age, body mass index (BMI), educational level, and occupation. We sought to identify the factors associated with cognitive function in injured subjects: time since injury, injury side, nerve injury, hand function, pain, and finger sensation. Material and methods: A cross-sectional observational study was conducted, with 2 groups: observational group (with traumatic upper-limb injury) and control group (uninjured). The 2 groups were matched for age, gender, BMI, educational level and occupation. Short-term memory and executive functions were assessed using the Rey Auditory and Verbal Learning Test (RAVLT) and Stroop Color and Word Test (SCWT), respectively. Results: 104 participants with traumatic upper-limb injury and 104 uninjured control subjects were included. There was a significant inter-group difference only in RAVLT (p < 0.01; Cohen d, of 0.38). Regression analysis demonstrated an association of pain on VAS (beta =
Effect of traumatic upper-limb injury on cognitive functions : a cross-sectional observational study
- Authors: Zhang, Xue , Tse, Tamara , Chen, Shao-Zhen , Qiu, Kai-Yi , Li, Xia , Zoghi, Maryam
- Date: 2023
- Type: Text , Journal article
- Relation: Hand Surgery and Rehabilitation Vol. 42, no. 5 (2023), p. 413-418
- Full Text:
- Reviewed:
- Description: Objectives: There is growing evidence of cognitive impairment after traumatic peripheral lesions. The purpose of this study was to explore the association between cognitive function and traumatic upper-limb injury. We assessed difference in cognitive function between participants with and without upper-limb injury, and explored the association between cognitive function and certain variables in injured individuals: gender, age, body mass index (BMI), educational level, and occupation. We sought to identify the factors associated with cognitive function in injured subjects: time since injury, injury side, nerve injury, hand function, pain, and finger sensation. Material and methods: A cross-sectional observational study was conducted, with 2 groups: observational group (with traumatic upper-limb injury) and control group (uninjured). The 2 groups were matched for age, gender, BMI, educational level and occupation. Short-term memory and executive functions were assessed using the Rey Auditory and Verbal Learning Test (RAVLT) and Stroop Color and Word Test (SCWT), respectively. Results: 104 participants with traumatic upper-limb injury and 104 uninjured control subjects were included. There was a significant inter-group difference only in RAVLT (p < 0.01; Cohen d, of 0.38). Regression analysis demonstrated an association of pain on VAS (beta =
- Ali, Sajid, Abusabha, Omar, Ali, Farman, Imran, Muhammad, Abuhmed, Tamer
- Authors: Ali, Sajid , Abusabha, Omar , Ali, Farman , Imran, Muhammad , Abuhmed, Tamer
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Transactions on Network and Service Management Vol. 20, no. 2 (2023), p. 1199-1209
- Full Text: false
- Reviewed:
- Description: Despite the benefits of the Internet of Things (IoT), the growing influx of IoT-specific malware coordinating large-scale cyberattacks via infected IoT devices has created a substantial threat to the Internet ecosystem. Assessing IoT systems' security and developing mitigation measures to prevent the spread of IoT malware is therefore critical. Furthermore, for training and testing the fidelity of cyber security-based Machine Learning (ML) and Deep Learning (DL) approaches, the collection and exploration of information from multiple sources from the IoT are crucial. In this regard, we propose a multitask DL model for detecting IoT malware. Our proposed Long Short-Term Memory (LSTM) based model efficiently performs two tasks: 1) determination of whether the provided traffic is benign or malicious, and 2) determination of the malware type for identifying malicious network traffic. We used large-scale traffic data of 145. pcap files of benign and malicious traffic collected from 18 different IoT devices. We performed a time-series analysis on the packets of traffic flows, which were then used to train the proposed model. The features extracted from the dataset were categorized into three modalities: flow-related, traffic flag-related, and packet payload-related features. A feature selection approach was employed at the feature and modality levels, and the best modalities and features were utilized for performance enhancement. For tasks 1 and 2 and multitask classification, the flow-related and flag-related modalities showed the best testing accuracies of 92.63%, 88.45%, and 95.83%, respectively. © 2004-2012 IEEE.
Effects of a structured reflective interview on parental reflective functioning : a pilot randomised controlled trial
- Low, Yu, Lewis, Andrew, Serfaty, Irene
- Authors: Low, Yu , Lewis, Andrew , Serfaty, Irene
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Child and Family Studies Vol. 32, no. 2 (2023), p. 516-529
- Full Text:
- Reviewed:
- Description: The Parental Reflective Interview Procedure was developed as part of an initial assessment interview for an attachment-based intervention for child mental health conditions. This study was a pilot randomised controlled trial that utilised a parallel, single-blind trial design to evaluate the differences in the effects of the Parental Reflective Interview Procedure compared to a diagnostic interview on parental reflective functioning. The control group was administered a structured diagnostic interview (Mini International Neuropsychiatric Interview for Children and Adolescents—Parent Version) and matched for time with clinician. The study sample were 25 parents of clinic-referred children who scored above the clinical cut-off score on the Child Behaviour Checklist. Parental reflective functioning was measured with the Parental Reflective Functioning Questionnaire at baseline and repeated post-intervention, and then again at a two-week follow up. Results showed that the Parental Reflective Interview Procedure produced moderate improvements in parents’ understanding of their children’s mental states and maintenance in their reflections on intergenerational parent-child relationship patterns. The diagnostic interview showed decreases in both these dimensions. The findings suggest that the Parental Reflective Interview Procedure is a promising format for initial assessment when referral indicates difficulty in the parent-child relationship. The interview acts as a good orientation for parents to an intervention focused on parent-child relationship dynamics. Further work refining this interview, its coding and integration into a tailored feedback session is required. © 2023, The Author(s).
- Authors: Low, Yu , Lewis, Andrew , Serfaty, Irene
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Child and Family Studies Vol. 32, no. 2 (2023), p. 516-529
- Full Text:
- Reviewed:
- Description: The Parental Reflective Interview Procedure was developed as part of an initial assessment interview for an attachment-based intervention for child mental health conditions. This study was a pilot randomised controlled trial that utilised a parallel, single-blind trial design to evaluate the differences in the effects of the Parental Reflective Interview Procedure compared to a diagnostic interview on parental reflective functioning. The control group was administered a structured diagnostic interview (Mini International Neuropsychiatric Interview for Children and Adolescents—Parent Version) and matched for time with clinician. The study sample were 25 parents of clinic-referred children who scored above the clinical cut-off score on the Child Behaviour Checklist. Parental reflective functioning was measured with the Parental Reflective Functioning Questionnaire at baseline and repeated post-intervention, and then again at a two-week follow up. Results showed that the Parental Reflective Interview Procedure produced moderate improvements in parents’ understanding of their children’s mental states and maintenance in their reflections on intergenerational parent-child relationship patterns. The diagnostic interview showed decreases in both these dimensions. The findings suggest that the Parental Reflective Interview Procedure is a promising format for initial assessment when referral indicates difficulty in the parent-child relationship. The interview acts as a good orientation for parents to an intervention focused on parent-child relationship dynamics. Further work refining this interview, its coding and integration into a tailored feedback session is required. © 2023, The Author(s).