Lifestyle management of hypertension : International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension
- Charchar, Fadi, Prestes, Priscilla, Mills, Charlotte, Ching, Siew, Neupane, Dinesh, Marques, Francine, Sharman, James, Vogt, Liffert, Burrell, Louise, Korostovtseva, Lyudmila, Zec, Manja, Patil, Mansi, Schultz, Martin, Wallen, Matthew, Renna, Nicolás, Islam, Sheikh, Hiremath, Swapnil, Gyeltshen, Tshewang, Chia, Yook-Chin, Gupta, Abhinav, Schutte, Aletta, Klein, Britt, Borghi, Claudio, Browning, Colette, Czesnikiewicz-Guzik, Marta, Lee, Hae-Young, Itoh, Hiroshi, Miura, Katsuyuki, Akinnibosun, Olutope, Shane Thomas
- Authors: Charchar, Fadi , Prestes, Priscilla , Mills, Charlotte , Ching, Siew , Neupane, Dinesh , Marques, Francine , Sharman, James , Vogt, Liffert , Burrell, Louise , Korostovtseva, Lyudmila , Zec, Manja , Patil, Mansi , Schultz, Martin , Wallen, Matthew , Renna, Nicolás , Islam, Sheikh , Hiremath, Swapnil , Gyeltshen, Tshewang , Chia, Yook-Chin , Gupta, Abhinav , Schutte, Aletta , Klein, Britt , Borghi, Claudio , Browning, Colette , Czesnikiewicz-Guzik, Marta , Lee, Hae-Young , Itoh, Hiroshi , Miura, Katsuyuki , Akinnibosun, Olutope , Shane Thomas
- Date: 2024
- Type: Text , Journal article
- Relation: Journal of hypertension Vol. 42, no. 1 (2024), p. 23-49
- Full Text:
- Reviewed:
- Description: Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools. **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliates “Fadi Charchar, Priscilla Prestes, Britt Klein, Colette Browning, Olutope Akinnibosun and Shane Thomas” are provided in this record**
- Description: Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools. **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliates “Fadi Charchar, Priscilla Prestes, Britt Klein, Colette Browning, Olutope Akinnibossun and Shane Thomas” are provided in this record**
- Authors: Charchar, Fadi , Prestes, Priscilla , Mills, Charlotte , Ching, Siew , Neupane, Dinesh , Marques, Francine , Sharman, James , Vogt, Liffert , Burrell, Louise , Korostovtseva, Lyudmila , Zec, Manja , Patil, Mansi , Schultz, Martin , Wallen, Matthew , Renna, Nicolás , Islam, Sheikh , Hiremath, Swapnil , Gyeltshen, Tshewang , Chia, Yook-Chin , Gupta, Abhinav , Schutte, Aletta , Klein, Britt , Borghi, Claudio , Browning, Colette , Czesnikiewicz-Guzik, Marta , Lee, Hae-Young , Itoh, Hiroshi , Miura, Katsuyuki , Akinnibosun, Olutope , Shane Thomas
- Date: 2024
- Type: Text , Journal article
- Relation: Journal of hypertension Vol. 42, no. 1 (2024), p. 23-49
- Full Text:
- Reviewed:
- Description: Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools. **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliates “Fadi Charchar, Priscilla Prestes, Britt Klein, Colette Browning, Olutope Akinnibosun and Shane Thomas” are provided in this record**
- Description: Hypertension, defined as persistently elevated systolic blood pressure (SBP) >140 mmHg and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of Hypertension guidelines), affects over 1.5 billion people worldwide. Hypertension is associated with increased risk of cardiovascular disease (CVD) events (e.g. coronary heart disease, heart failure and stroke) and death. An international panel of experts convened by the International Society of Hypertension College of Experts compiled lifestyle management recommendations as first-line strategy to prevent and control hypertension in adulthood. We also recommend that lifestyle changes be continued even when blood pressure-lowering medications are prescribed. Specific recommendations based on literature evidence are summarized with advice to start these measures early in life, including maintaining a healthy body weight, increased levels of different types of physical activity, healthy eating and drinking, avoidance and cessation of smoking and alcohol use, management of stress and sleep levels. We also discuss the relevance of specific approaches including consumption of sodium, potassium, sugar, fibre, coffee, tea, intermittent fasting as well as integrated strategies to implement these recommendations using, for example, behaviour change-related technologies and digital tools. **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliates “Fadi Charchar, Priscilla Prestes, Britt Klein, Colette Browning, Olutope Akinnibossun and Shane Thomas” are provided in this record**
Telomeres in CKD prognosis improvement : prediction, early detection, and management
- Authors: Akinnibosun, Olutope
- Date: 2024
- Type: Text , Thesis , PhD
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- Description: Chronic kidney disease (CKD) is a significant public health challenge, affecting around 10% of the global population and a leading cause of morbidity and mortality. Its progression is often silent until the advanced stages, underscoring the need for early detection markers to improve patient outcomes. This PhD thesis presents findings on how telomere length and the mechanisms that maintain telomeres might play a crucial role across the CKD spectrum. Renal fibrosis, which is central to CKD advancement, is linked with shortened or dysfunctional telomeres in animal studies. Despite existing studies suggesting a relationship between telomeres and CKD in humans, there is no conclusive evidence. This work proposes that telomere dynamics significantly influence CKD progression. It addresses this gap by examining whether variations in telomere length could serve as early indicators of CKD, potentially offering new avenues for early intervention and improving health outcomes after kidney transplants. It also investigates the relationship between telomeres and the reninangiotensin-aldosterone system (RAAS), which could provide early treatment options. The research finds a correlation between kidney damage (even before a noticeable decline in renal function) and telomere length in both kidney tissue and blood leukocytes. It also establishes a connection between kidney telomere length and age, suggesting that older kidneys might be more prone to CKD due to shorter telomeres. Furthermore, through an observational cohort and using Mendelian randomisation, the study demonstrates that telomere length contributes to a decline in renal function. It also shows a non-causal association between telomere length and kidney diseases, including CKD. Moreover, the thesis explores how telomeres affect the molecular mechanisms behind renal fibrosis using human primary renal cells, identifying a role for telomerase gene TERT in renal fibrogenesis. Among kidney transplant recipients, it suggests that differentiated T-cells could be more indicative of cardiovascular health than telomere length. In animal models, it demonstrates the potential of RAAS inhibition to preserve telomere length and modulate telomere gene expression. This effect persists even after stopping the treatment, indicating a lasting benefit. This comprehensive analysis provides novel insights on telomeres in CKD, pointing to telomere length as an early indicator of kidney damage and a predictor of renal function. It highlights the potential of telomere length as a biomarker for early CKD detection, which could improve CKD outcomes. In addition, it implicates telomerase in renal fibrosis progression, suggesting that therapies targeting telomere dynamics could represent a new approach to CKD management. Moreover, it shows the potential of RAAS inhibition as an early intervention strategy. Future studies are essential to confirm these findings, further elucidate the mechanisms involved in these processes and evaluate the long-term benefits of early RAAS inhibition on patient outcomes.
- Description: Doctor of Philosophy
- Authors: Akinnibosun, Olutope
- Date: 2024
- Type: Text , Thesis , PhD
- Full Text:
- Description: Chronic kidney disease (CKD) is a significant public health challenge, affecting around 10% of the global population and a leading cause of morbidity and mortality. Its progression is often silent until the advanced stages, underscoring the need for early detection markers to improve patient outcomes. This PhD thesis presents findings on how telomere length and the mechanisms that maintain telomeres might play a crucial role across the CKD spectrum. Renal fibrosis, which is central to CKD advancement, is linked with shortened or dysfunctional telomeres in animal studies. Despite existing studies suggesting a relationship between telomeres and CKD in humans, there is no conclusive evidence. This work proposes that telomere dynamics significantly influence CKD progression. It addresses this gap by examining whether variations in telomere length could serve as early indicators of CKD, potentially offering new avenues for early intervention and improving health outcomes after kidney transplants. It also investigates the relationship between telomeres and the reninangiotensin-aldosterone system (RAAS), which could provide early treatment options. The research finds a correlation between kidney damage (even before a noticeable decline in renal function) and telomere length in both kidney tissue and blood leukocytes. It also establishes a connection between kidney telomere length and age, suggesting that older kidneys might be more prone to CKD due to shorter telomeres. Furthermore, through an observational cohort and using Mendelian randomisation, the study demonstrates that telomere length contributes to a decline in renal function. It also shows a non-causal association between telomere length and kidney diseases, including CKD. Moreover, the thesis explores how telomeres affect the molecular mechanisms behind renal fibrosis using human primary renal cells, identifying a role for telomerase gene TERT in renal fibrogenesis. Among kidney transplant recipients, it suggests that differentiated T-cells could be more indicative of cardiovascular health than telomere length. In animal models, it demonstrates the potential of RAAS inhibition to preserve telomere length and modulate telomere gene expression. This effect persists even after stopping the treatment, indicating a lasting benefit. This comprehensive analysis provides novel insights on telomeres in CKD, pointing to telomere length as an early indicator of kidney damage and a predictor of renal function. It highlights the potential of telomere length as a biomarker for early CKD detection, which could improve CKD outcomes. In addition, it implicates telomerase in renal fibrosis progression, suggesting that therapies targeting telomere dynamics could represent a new approach to CKD management. Moreover, it shows the potential of RAAS inhibition as an early intervention strategy. Future studies are essential to confirm these findings, further elucidate the mechanisms involved in these processes and evaluate the long-term benefits of early RAAS inhibition on patient outcomes.
- Description: Doctor of Philosophy
Telomere therapy for chronic kidney disease
- Akinnibosun, Olutope, Maier, Michelle, Eales, James, Tomaszewski, Maciej, Charchar, Fadi
- Authors: Akinnibosun, Olutope , Maier, Michelle , Eales, James , Tomaszewski, Maciej , Charchar, Fadi
- Date: 2022
- Type: Text , Journal article
- Relation: Epigenomics Vol. 14, no. 17 (2022), p. 1039-1054
- Full Text: false
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- Description: Chronic kidney disease (CKD) is estimated to affect almost 10% of individuals worldwide and is one of the leading causes of morbidity and mortality. Renal fibrosis, a central pathway in CKD progression (irrespective of etiology), is associated with shortened or dysfunctional telomeres in animal studies. Telomeres are specialized nucleoprotein structures located at the chromosome end that maintain genomic integrity. The mechanisms of associations between telomere length and CKD have not yet been fully elucidated, however, CKD patients with shorter telomere length may have decreased renal function and a higher mortality rate. A plethora of ongoing research has focused on possible therapeutic applications of telomeres with the overall goal to preserve telomere length as a therapy to treat CKD. Chronic kidney disease or CKD is one of the leading causes of illness and death worldwide. Scarring of the kidney tissue that occurs in CKD has been associated with shorter telomeres in studies using rats. Telomeres, said to act as the cellular ‘shoelace caps’, maintain the structure of chromosomes, allowing for genetic material inside cells to divide correctly. The length of telomeres (TL) is influenced by diverse factors such as genetics and lifestyle. The underlying processes for the associations between TL and CKD are still not understood, however, patients with CKD and shorter TL have reduced kidney function and an increased death rate. Therefore, research is focused on possible ways to preserve TL and treat CKD. Preserving telomere length may reduce rates of chronic kidney disease, thereby decreasing morbidity & mortality worldwide.
Exercise, epigenetics, and aging
- Chilton, Warrick, Maier, Maier, Akinnibosun, Olutope, O’Brien, Brendan, Charchar, Fadi
- Authors: Chilton, Warrick , Maier, Maier , Akinnibosun, Olutope , O’Brien, Brendan , Charchar, Fadi
- Date: 2021
- Type: Text , Book chapter
- Relation: Epigenetics of Exercise and Sports: Concepts, Methods, and Current Research Chapter 27 p. 127-182
- Full Text: false
- Reviewed:
- Description: This chapter introduces the epigenetic processes that govern how exercise affects the aging processes. We begin with an introduction to the molecular changes that occur with aging including methylation and histone and noncoding RNA modifications. We then present the evidence for changes in these processes by exercise and physical activity, Lastly, we present evidence for and against a role for exercise on changes in telomere length and aging. © 2021 Elsevier Inc. All rights reserved.
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