Presumed guilty: Natural killer T cell defects and human disease

Title: Presumed guilty: Natural killer T cell defects and human disease
Creator: Berzins, Stuart; Smyth, Mark; Baxter, Alan
Date: 2011
Type: Text; Journal article
Identifier: http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/74551
Identifier: vital:7263
Identifier: https://doi.org/10.1038/nri2904
Identifier: ISSN:1474-1733
Abstract: Abstract | Natural killer T (NKT) cells are important regulatory lymphocytes that have been shown in mouse studies, to have a crucial role in promoting immunity to tumours, bacteria and viruses, and in suppressing cell-mediated autoimmunity. Many clinical studies have indicated that NKT cell deficiencies and functional defects might also contribute to similar human diseases, although there is no real consensus about the nature of the NKT cell defects or whether NKT cells could be important for the diagnosis and/or treatment of these conditions. In this Review, we describe the approaches that have been used to analyse the NKT cell populations of various patient groups, suggest new strategies to determine how (or indeed, if) NKT cell defects contribute to human disease, and discuss the prospects for using NKT cells for therapeutic benefit.; C1
Relation: Nature Reviews Immunology Vol. 11, no. 2 (February 2011 2011), p. 131-142
Rights: No open access
Rights: This metadata is freely available under a CCO license
Subject: 1107 Immunology
Reviewed

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