- Title
- 121 Telomere attrition is attenuated in ultra-marathon runners
- Creator
- Denham, Joshua; Nankervis, Scott; Debiec, Radek; Harvey, Jack; Pascoe, Deborah; Marques, Francine; O’Brien, Brendan; Zukowska-Szczechowska, Ewa; Tomaszewski, Maciej; Charchar, Fadi
- Date
- 2012
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/74056
- Identifier
- vital:7167
- Identifier
-
https://doi.org/10.1097/01.hjh.0000419945.40065.d0
- Identifier
- ISSN:0263-6352
- Abstract
- Background: Leukocyte telomere length is a marker of biological ageing and its shortening is associated with cardiovascular disease. Engagement in regular moderate-intensity physical activity is a recognised method of cardiovascular disease prevention. However, it is not clear whether repeated exposure to ultra-strenuous physical exercise is beneficial long-term and whether it may attenuate biological ageing. Methods: We compared leukocyte telomere length in context of inflammation and endothelial dysfunction between 67 male ultra-marathon runners and 67 age-, sex- and BMI-matched apparently healthy controls. Genomic DNA was extracted from peripheral blood and leukocyte telomere length was measured by quantitative polymerase chain reaction assays. Adhesion molecules (sICAM-1, sE-selectin) and inflammatory markers (IL-6, C-reactive protein) concentrations were measured in 67 ultra-marathon runners by quantitative sandwich enzyme immunoassay technique, high-sensitive immunoassay and ultra-sensitive double antibody sandwich ELISA, respectively. Results: Adjusted (for age, BMI, blood pressure and lipids) leukocyte telomere length was approximately 13.8% greater in the ultra-marathon runners than in the controls (P<0.001). This translates into approximately 32.9 years difference in age-related telomere length attrition. There was a strong negative linear correlation between sICAM-1 and leukocyte telomere length in the ultra-marathon runners (r=-0.33; P=0.007) and this association retained its statistical significance after adjustment for age, BMI, blood pressure and lipids in multiple regression (P=0.026). Conclusion: Prolonged, intense physical exercise may attenuate cellular ageing possibly through a protective effect on endothelial function.; C1
- Relation
- Journal of Hypertension Vol. 30, no. e-Supplement (September 2012), p. e37
- Rights
- © 2012 Lippincott Williams & Wilkins, Inc.
- Rights
- No open access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1103 Clinical Sciences; 1102 Cardiorespiratory Medicine and Haematology
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