- Title
- Commercial Chinese polyherbal preparation Zao Ren An Shen prescription for primary insomnia : a systematic review with meta-analysis and trial sequential analysis
- Creator
- Zhao, Fei-Yi; Xu, Peijie; Kennedy, Gerard; Zheng, Zhen; Zhang, Wen-Jing; Zhu, Jia-Yi; Ho, Yuen-Shan; Yue, Li-Ping; Fu, Qiang-Qiang; Conduit, Russell
- Date
- 2024
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/202157
- Identifier
- vital:19658
- Identifier
-
https://doi.org/10.3389/fphar.2024.1376637
- Identifier
- ISSN:1663-9812 (ISSN)
- Abstract
- Background: Natural products are widely used for primary insomnia (PI). This systematic review with trial sequential analysis (TSA) aimed to summarize evidence pertaining to the effectiveness and safety of Zao Ren An Shen (ZRAS) prescription, a commercial Chinese polyherbal preparation, for treating PI. Methods: Controlled clinical trials appraising ZRAS compared to controls or as an add-on treatment were systematically searched across seven databases until January 2024. Cochrane ROB 2.0 and ROBINS-I tools were adopted to determine risk of bias. Quality of evidence was assessed using the GRADE framework. Results: We analyzed 22 studies, involving 2,142 participants. The effect of ZRAS in reducing Pittsburgh Sleep Quality Index scores was found to be comparable to benzodiazepines [MD = 0.39, 95%CI (
- Publisher
- Frontiers Media SA
- Relation
- Frontiers in Pharmacology Vol. 15, no. (2024), p.
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2024 Zhao, Xu, Kennedy, Zheng, Zhang, Zhu, Ho, Yue, Fu and Conduit
- Rights
- Open Access
- Subject
- 3214 Pharmacology and pharmaceutical sciences; Botanical drugs; Chinese medicine; Clinical trials; Insomnia; Meta-analysis; Sleep quality; Systematic review; Zao Ren An Shen
- Full Text
- Reviewed
- Funder
- This work was supported by Health and Medical Research Fund [20212801], Health Bureau, Hong Kong SAR to YS-H; Shanghai Key Laboratory for Pharmaceutical Metabolite Research Project [SHZYDX 2023\u201301] to FY-Z; TCM Research Project, Yangpu District Health Commission [YPZYQ202301] to JY-Z; and TCM Research Project, Shanghai Municipal Health Commission [2022CX007] to WJ-Z.
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