- Title
- A cut above the rest : oxidative stress in chronic wounds and the potential role of polyphenols as therapeutics
- Creator
- Johnson, Joel; Broszczak, Daniel; Mani, Janice; Anesi, Jack; Naiker, Mani
- Date
- 2022
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/188538
- Identifier
- vital:17272
- Identifier
-
https://doi.org/10.1093/jpp/rgab038
- Identifier
- ISSN:0022-3573 (ISSN)
- Abstract
- Objectives: The pathophysiology of chronic wounds typically involves redox imbalance and inflammation pathway dysregulation, often with concomitant microbial infection. Endogenous antioxidants such as glutathione and tocopherols are notably reduced or absent, indicative of significant oxidative imbalance. However, emerging evidence suggests that polyphenols could be effective agents for the amelioration of this condition. This review aims to summarise the current state of knowledge surrounding redox imbalance in the chronic wound environment and the potential use of polyphenols for the treatment of chronic wounds. Key findings: Polyphenols provide a multi-faceted approach towards the treatment of chronic wounds. Firstly, their antioxidant activity allows direct neutralisation of harmful free radicals and reactive oxygen species, assisting in restoring redox balance. Upregulation of pro-healing and anti-inflammatory gene pathways and enzymes by specific polyphenols further acts to reduce redox imbalance and promote wound healing actions, such as proliferation, extracellular matrix deposition and tissue remodelling. Finally, many polyphenols possess antimicrobial activity, which can be beneficial for preventing or resolving infection of the wound site. Summary: Exploration of this diverse group of natural compounds may yield effective and economical options for the prevention or treatment of chronic wounds. © 2021 The Author(s).
- Publisher
- Oxford University Press
- Relation
- Journal of Pharmacy and Pharmacology Vol. 74, no. 4 (2022), p. 485-502
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright © 2021 The Author(s)
- Subject
- 3214 Pharmacology and pharmaceutical sciences; Antioxidants; Chronic wound; Natural therapeutics; Reactive oxygen species
- Reviewed
- Funder
- One of the authors (M.N.) acknowledges support from CQ University in the form of a New Staff Research Grant [RSH/5343].
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