- Title
- A computational framework to simulate the thermochemical process during thermochemical ablation of biological tissues
- Creator
- Mak, Nguoy; Ooi, Ean H.; Lau, Ee; Ooi, Ean Tat; Pamidi, N.; Foo, Ji; Mohd Ali, Ahmad
- Date
- 2022
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/187924
- Identifier
- vital:17183
- Identifier
-
https://doi.org/10.1016/j.compbiomed.2022.105494
- Identifier
- ISSN:0010-4825 (ISSN)
- Abstract
- Thermochemical ablation (TCA) is a thermal ablation therapy that utilises heat released from acid-base neutralisation reaction to destroy tumours. This procedure is a promising low-cost solution to existing thermal ablation treatments such as radiofrequency ablation (RFA) and microwave ablation (MWA). Studies have demonstrated that TCA can produce thermal damage that is on par with RFA and MWA when employed properly. Nevertheless, TCA remains a concept that is tested only in a few animal trials due to the risks involved as the result of uncontrolled infusion and incomplete acid-base reaction. In this study, a computational framework that simulates the thermochemical process of TCA is developed. The proposed framework consists of three physics, namely chemical flow, neutralisation reaction and heat transfer. An important parameter in the TCA framework is the neutralisation reaction rate constant, which has values in the order of 108 m3/(mol
- Publisher
- Elsevier Ltd
- Relation
- Computers in Biology and Medicine Vol. 145, no. (2022), p.
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright © 2022 Elsevier Ltd
- Subject
- 3102 Bioinformatics and computational biology; 4203 Health services and systems; 4601 Applied computing; Acid-base; Cancer treatment; Exothermic heat; Neutralisation reaction; Thermal ablation
- Reviewed
- Funder
- The authors would like to acknowledge the financial support from the Ministry of Higher Education Malaysia through the Fundamental Research Grant Scheme (FRGS) under the project FRGS/1/2019/STG03/MUSM/02/2.
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