- Title
- Acupuncture : a promising approach for Comorbid depression and insomnia in perimenopause
- Creator
- Zhao, Fei; Fu, Qiang-Aiang; Spencer, Sarah; Kennedy, Gerard; Conduit, Russell; Zhang, Wen-Jing; Zheng, Zhen
- Date
- 2021
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/180519
- Identifier
- vital:15799
- Identifier
-
https://doi.org/10.2147/NSS.S332474
- Identifier
- ISBN:1179-1608 (ISSN)
- Abstract
- Comorbid depression and insomnia are ubiquitous mental complaints among women going through the perimenopausal stage of life and can result in major decline in quality of life. Antidepressive agents combined with/without hypnotics, and/or hormone therapy are currently the most common treatment for perimenopausal depression (PMD) and insomnia (PMI). Balancing the benefits of these pharmacotherapies against the risk of adverse events (AEs) is a difficult task for both clinicians and women. There has been a growing body of research regarding the utilization of acupuncture for treatment of PMD or PMI, whereas no studies of acupuncture for comorbid PMD and PMI have appeared. In this review, we summarize the clinical and preclinical evidence of acupuncture as a treatment for PMD or PMI, and then discuss the potential mechanisms involved and the role of acupuncture in helping women during this transition. Most clinical trials indicate that acupuncture ameliorates not only PMD/PMI but also climacteric symptoms with minimal AEs. It also regulates serum hormone levels. The reliability of trials is however limited due to methodological flaws in most studies. Rodent studies suggest that acupuncture prolongs total sleep time and reduces depression-like behavior in PMI and PMD models, respectively. These effects are possibly mediated through multiple mechanisms of action, including modulating sex hormones, neurotransmitters, hypothalamic-pituitary-adrenal axis/hypothalamic-pituitary-ovary axis, oxidative stress, signaling pathways, and other cellular events. In conclusion, acupuncture is a promising therapeutic strategy for comorbid depression and insomnia during perimenopause. Neuroendocrine modulation is likely to play a major role in mediating those effects. High-quality trials are required to further validate acupuncture’s effectiveness. © 2021 Zhao et al.
- Publisher
- Dove Medical Press Ltd
- Relation
- Nature and Science of Sleep Vol. 13, no. (2021), p. 1823-1863
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by-nc/3.0/
- Rights
- Copyright © 2021 Zhao et al.
- Rights
- Open Access
- Subject
- 1103 Clinical Sciences; 1109 Neurosciences; 1701 Psychology; Acupuncture; Comorbid; Depression; Insomnia; Mechanisms; Perimenopause
- Full Text
- Reviewed
- Funder
- This work was sponsored by RMIT Research Stipend Scholarship, RMIT University, Australia, and University?s scientific research project, Shanghai Sanda University [2021zz02-yj] to FYZ; and Three-year Action Plan for Public Health2020-2022 (Key discipline construction-TCM psychology/TCM psychiatry), Shanghai Municipal Health Commission [GWV-10.1-XK20], Project Management and Technical Specifications of Insomnia Treatment Service Key Promotion, Shanghai Municipal Health Commission [ZY(2018-2020)-ZWB- 1001-FWB-07)] to WJZ
- Hits: 5616
- Visitors: 5233
- Downloads: 109
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Published version | 1 MB | Adobe Acrobat PDF | View Details Download |