- Title
- Pre-existing COPD is associated with an increased risk of mortality and severity in COVID-19: a rapid systematic review and meta-analysis
- Creator
- Rabbani, Golam; Shariful Islam, Sheikh Mohammad; Rahman, Muhammad Aziz; Amin, Nuhu; Marzan, Bushra
- Date
- 2021
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/179790
- Identifier
- vital:15667
- Identifier
-
https://doi.org/10.1080/17476348.2021.1866547
- Identifier
- ISBN:1747-6348
- Abstract
- Objectives: The objective of this systematic review and meta-analysis was to investigate COVID-19 mortality and severity among patients with pre-existing COPD. Methods: We performed systematic searches in Ovid Medline, Embase via Ovid, PubMed, and Scopus from 15 December 2019 to 7 July 2020. Studies which reported the association and presented data on risk estimate (Hazard Ratio [HR]) with 95% confidence intervals (95%CIs) were extracted. A random-effects model was used to obtain the pooled estimates, and a pooled Risk Ratio (RR) was calculated. Study quality was assessed using a modified version of the Newcastle-Ottawa Scale. Results: Our meta-analysis showed an increased likelihood of mortality in COVID-19 patients with pre-existing COPD (RR 3.18, 95% CI 2.11-4.80, HR 1.90, 95%CI 1.11-3.26). Furthermore, the pooled estimate for the association between pre-existing COPD and severity due to COVID-19 was also significant (RR 3.63, 95%CI 2.48-5.31). Males had an increased risk of mortality (RR 1.20, 95%CI 1.12-1.29) compared to females. Conclusion: We found that patients with pre-existing COPD had more than 3 times higher risk of mortality and severe COVID-19. There is a need to identify patients with pre-existing COPD during the pandemic so that early interventions can be aimed at this group of patients. **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Muhammad Aziz Rahman” is provided in this record**
- Publisher
- Taylor & Francis
- Relation
- Expert Review of Respiratory Medicine Vol. 15, no. 5 (2021), p. 705-716
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2021 Informa UK Limited, trading as Taylor & Francis Group
- Rights
- Open Access
- Subject
- 1117 Public Health and Health Services; Co-morbidity; COPD; COVID-19
- Full Text
- Reviewed
- Funder
- SMS Islam has declared that he has received grants from NHMRC, grants from National Heart Foundation of Australia, personal fees from WHO, grants from Swedish Development Cooperation, grants and personal fees from Fogarty Foundation, outside the submitted work.
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