- Comparisons between impedance-based and time-based switching bipolar radiofrequency ablation for the treatment of liver cancer
- Yap, Shelley; Ooi, Ean; Foo, Ji; Ooi, Ean Tat
- Text; Journal article
- ISBN:0010-4825 (ISSN)
- Switching bipolar radiofrequency ablation (bRFA) is a cancer treatment technique that activates multiple pairs of electrodes alternately based on a predefined criterion. Various criteria can be used to trigger the switch, such as time (ablation duration) and tissue impedance. In a recent study on time-based switching bRFA, it was determined that a shorter switch interval could produce better treatment outcome than when a longer switch interval was used, which reduces tissue charring and roll-off induced cooling. In this study, it was hypothesized that a more efficacious bRFA treatment can be attained by employing impedance-based switching. This is because ablation per pair can be maximized since there will be no interruption to RF energy delivery until roll-off occurs. This was investigated using a two-compartment 3D computational model. Results showed that impedance-based switching bRFA outperformed time-based switching when the switch interval of the latter is 100 s or higher. When compared to the time-based switching with switch interval of 50 s, the impedance-based model is inferior. It remains to be investigated whether the impedance-based protocol is better than the time-based protocol for a switch interval of 50 s due to the inverse relationship between ablation and treatment efficacies. It was suggested that the choice of impedance-based or time-based switching could ultimately be patient-dependent. © 2021 Elsevier Ltd
- Elsevier Ltd
- Computers in Biology and Medicine Vol. 134, no. (2021), p.
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Copyright © 2021 Elsevier Ltd. All rights reserved.
- 08 Information and Computing Sciences; 09 Engineering; 11 Medical and Health Sciences; Ablation efficacy; bRFA; Thermal coagulation; Thermal therapy; Treatment efficacy
- Hits: 800
- Visitors: 794
- Downloads: 0