- Title
- Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
- Creator
- Nakai, Michael; Prestes, Priscilla; O’Brien, Brendan; Charchar, Fadi; Marques, Francine
- Date
- 2021
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/175959
- Identifier
- vital:15041
- Identifier
-
https://doi.org/10.1038/s41598-021-83472-x
- Identifier
- ISBN:2045-2322 (ISSN)
- Abstract
- Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypertrophy and plays a role in maladaptive remodelling of the heart and has been associated with renal injury. While lifestyle factors such as diet and exercise are known to attenuate low-grade inflammation, their ability to modulate plasma LCN2 levels is unknown. Forty-eight endurance athletes and 52 controls (18–55 years) underwent measurement for various cardiovascular health indicators, along with plasma LCN2 concentration. No significant difference in LCN2 concentration was seen between the two groups. LCN2 was a very weak predictor or absent from models describing blood pressures or predicting athlete status. In another cohort, 57 non-diabetic overweight or obese men and post-menopausal women who fulfilled Adult Treatment Panel III metabolic syndrome criteria were randomly allocated into either a control, modified Dietary Approaches to Stop Hypertension (DASH) diet, or DASH and exercise group. Pre- and post-intervention demographic, cardiovascular health indicators, and plasma LCN2 expression were measured in each individual. While BMI fell in intervention groups, LCN2 levels remained unchanged within and between all groups, as illustrated by strong correlations between LCN2 concentrations pre- and 12 weeks post-intervention (r = 0.743, P < 0.0001). This suggests that circulating LCN2 expression are stable over a period of at least 12 weeks and is not modifiable by diet and exercise. © 2021, The Author(s). *Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Priscilla Prestes, Brendan O'Brien, Fadi Charchar and Francine Marques” is provided in this record** .
- Publisher
- Nature Research
- Relation
- Scientific Reports Vol. 11, no. 1 (2021), p.
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder
- Rights
- Open Access
- Subject
- MD Multidisciplinary
- Full Text
- Reviewed
- Funder
- MPS has received research support from Medtronic, Abbott, Novartis, Servier, Pfizer, and Boehringer-Ingelheim. GWL has acted as a consultant for Medtronic. FZM is supported by a National Heart Foundation Future Leader Fellowship, a National Health and Medical Research Council Project Grant and a National Heart Foundation Vanguard Grant. GWL, NE and EAL are supported by Swinburne Research, Swinburne University of technology. MPS is supported by an NHMRC Research Fellowship. All other authors declare no competing interests. Data used in this manuscript is available upon request.
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