- Title
- Abnormalities in T cell lineages from patients with Langerhans cell histiocytosis
- Creator
- Mitchell, Jenée
- Date
- 2018
- Type
- Text; Thesis; PhD
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/175257
- Identifier
- vital:14952
- Identifier
- https://library.federation.edu.au/record=b2846323
- Abstract
- Langerhans cell histiocytosis (LCH) is a rare inflammatory disease characterised by lesions containing CD1a+ myeloid lineage ‘LCH’ cells. Other immune cells such as T cells are also present within LCH lesions and the cytokine milieu suggests T cell activation. T cells have an established role in regulating cellular immunity and there is already evidence that multiple T cell lineages are enriched in LCH lesions, implying that they may have a role in LCH pathogenesis. Foxp3+ regulatory T cells (Tregs) and the immune suppressive cytokine, transforming growth factor beta (TGF-; Doctor of Philosophy
- Publisher
- Federation University Australia
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Subject
- Langerhans cell hisriocytosis; LCH; CD1a; T cell; T lymphocyte; Foxp3; Foxp3+; Treg; MAIT cell
- Full Text
- Thesis Supervisor
- Kannourakis, George
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