- Title
- Zinc transporters maintain longevity by influencing insulin/IGF-1 activity in Caenorhabditis elegans
- Creator
- Novakovic, Stevan; Molesworth, Luke; Gourley, Taylin; Boag, Peter; Davis, Gregory
- Date
- 2020
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/174281
- Identifier
- vital:14854
- Identifier
-
https://doi.org/10.1002/1873-3468.13725
- Identifier
- ISBN:0014-5793 (ISSN)
- Abstract
- Adequate dietary intake of essential metals such as zinc is important for maintaining homeostasis. Abnormal zinc intake in Caenorhabditis elegans has been shown to increase or decrease normal lifespan by influencing the insulin/IGF-1 pathway. Distribution of zinc is achieved by a family of highly conserved zinc transport proteins (ZIPT in C. elegans). This study investigated the role of the zipt family of genes and showed that depletion of individual zipt genes results in a decreased lifespan. Moreover, zipt-16 and zipt-17 mutants synthetically interact with the insulin/IGF cofactors daf-16 and skn-1, and cause abnormal localisation of DAF-16. This study suggests that the zipt family of genes are required for maintaining normal lifespan through influencing the insulin/IGF-1 pathway. © 2019 Federation of European Biochemical Societies; This study was supported by the resources at Federation University; no external funding was used to fund this study. We acknowledge the Caenorhabditis elegans Genetics Centre for the strains used in this study and Hannah Tatnell (Federation University) for technical assistance.
- Publisher
- Wiley Blackwell
- Relation
- FEBS Letters Vol. 594, no. 9 (2020), p. 1424-1432
- Rights
- Metadata is freely available under a CCO license
- Rights
- Copyright @ 2019 Federation of European Biochemical Societies
- Rights
- Open Access
- Subject
- 0304 Medicinal and Biomolecular Chemistry; 0601 Biochemistry and Cell Biology; 0603 Evolutionary Biology; Caenorhabditis elegans; Development; Insulin signalling; Transcription factor; Zinc
- Full Text
- Reviewed
- Funder
- This study was supported by the resources at Federation University; no external funding was used to fund this study. We acknowledge the Caenorhabditis elegans Genetics Centre for the strains used in this study and Hannah Tatnell (Federation University) for technical assistance.
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